Armc2 | armadillo repeat containing 2

GeneMGI:1916449Synonyms: 2610018I05Rik

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Hematopoietic system Mortality/aging

13 No significant impact

7 Not tested

Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetArmc2tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
increased circulating alanine transaminase level1 supporting datasetArmc2tm1b(EUCOMM)HmguheterozygoteEarly adult4.78x10-9 
decreased circulating fructosamine level1 supporting datasetArmc2tm1b(EUCOMM)HmguheterozygoteEarly adult1.15x10-5 
embryonic lethality prior to tooth bud stage1 supporting datasetArmc2tm1b(EUCOMM)HmguhomozygoteE12.5N/A * 
increased circulating aspartate transaminase level1 supporting datasetArmc2tm1b(EUCOMM)HmguheterozygoteEarly adult5.26x10-12 
increased neutrophil cell number1 supporting datasetArmc2tm1b(EUCOMM)HmguheterozygoteEarly adult5.92x10-6 
decreased circulating serum albumin level1 supporting datasetArmc2tm1b(EUCOMM)HmguheterozygoteEarly adult9.33x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Armc2tm1(KOMP)MbpReporter-tagged deletion allele (with selection cassette)targeting vector
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Armc2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
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Armc2tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse

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