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Gene: Sec31a MGI:1916412

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Gene Summary

Name:
SEC31 homolog A, COPII coat complex component
Synonyms:
Sec31l1,  1810024J13Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to organogenesis Sec31aem3(IMPC)H HOM   E9.5 0.00
increased circulating alanine transaminase level Sec31aem3(IMPC)H HET Early adult 0.00
increased circulating aspartate transaminase level Sec31aem3(IMPC)H HET Early adult 1.28×10-20
increased grip strength Sec31aem3(IMPC)H HET Early adult 7.06×10-07
decreased fasting circulating glucose level Sec31aem3(IMPC)H HET Early adult 3.36×10-05
embryonic lethality prior to tooth bud stage Sec31aem3(IMPC)H HOM   E12.5 0.00
abnormal locomotor behavior Sec31aem3(IMPC)H HET   Early adult 5.93×10-05
preweaning lethality, complete penetrance Sec31aem3(IMPC)H HOM   Early adult 0.00
increased circulating alkaline phosphatase level Sec31aem3(IMPC)H HET Early adult 6.25×10-07

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Sec31a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Sec31a by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Halperin-Birk Syndrome
Inability to walk OMIM:618651

The table below shows human diseases predicted to be associated to Sec31a by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cramps, Familial Adolescent
Elevated circulating creatine kinase concentration OMIM:218050
Muscle Cramps, Familial
Elevated circulating creatine kinase concentration OMIM:158400
Pentosuria
Abnormal circulating carbohydrate concentration, Abnormality of circulating enzyme level ORPHA:2843
Hyperinsulinism Due To Insr Deficiency
Insulin resistance, Hyperinsulinemic hypoglycemia, Hypoglycemia, Recurrent hypoglycemia, Fasting ... ORPHA:263458
Halperin-Birk Syndrome
Inability to walk OMIM:618651

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Sec31a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Sec31a.

No publications found that use IMPC mice or data for Sec31a.

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MGI Allele Allele Type Produced
Sec31aem4(IMPC)H Exon Deletion Mice
Sec31atm462983(L1L2_GT2_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Sec31aem3(IMPC)H Exon Deletion Mice

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