Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Vstm5 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Adult Acute Respiratory Distress Syndrome | Increased circulating interleukin 6 concentration, Abnormal circulating interleukin concentration... | ORPHA:70578 | |
Car T Cell Therapy-Associated Cytokine Release Syndrome | Increased circulating interleukin 6 concentration, Abnormal circulating interleukin concentration... | ORPHA:542323 | |
Macrophage Activation Syndrome | Increased circulating interleukin 6 concentration, Abnormal circulating interleukin concentration... | ORPHA:158061 | |
Oligoarticular Juvenile Idiopathic Arthritis | Abnormal circulating interleukin concentration, Increased circulating interferon-gamma concentration | ORPHA:85410 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Vstm5tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Vstm5tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Vstm5em1(IMPC)Hmgu | Inter-exon deletion | Mice |
Vstm5tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
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