Adamts9 | ADAM metallopeptidase with thrombospondin type 1 motif 9

GeneMGI:1916320Synonyms: Gsfund3, UND4, +6 more

Physiological systems

22 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Immune system Embryo Growth/size/body region Vision/eye Mortality/aging

17 No significant impact

2 Not tested

Gene metrics:7Significant phenotypes
1Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

embryonic growth retardation1 supporting datasetAdamts9tm1b(KOMP)WtsiheterozygoteE9.5N/A * 
abnormal embryo size1 supporting datasetAdamts9tm1b(KOMP)WtsiheterozygoteE9.5N/A * 
embryonic lethality prior to organogenesis1 supporting datasetAdamts9tm1b(KOMP)WtsihomozygoteE9.5N/A * 
abnormal lymph node morphology1 supporting datasetAdamts9tm1b(KOMP)WtsiheterozygoteEarly adultN/A * 
abnormal eye morphology1 supporting datasetAdamts9tm1b(KOMP)WtsiheterozygoteEarly adultN/A * 
preweaning lethality, complete penetrance1 supporting datasetAdamts9tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
preweaning lethality, incomplete penetrance2 supporting datasetsAdamts9tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/1)0.19% (1/533)
bloodheterozygoten/a0% (0/2)0% (0/17)
bone marrowheterozygoten/a0% (0/1)0% (0/22)
brainheterozygoten/a0% (0/2)0.86% (5/579)
brainstemheterozygoten/an/a0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/an/a0.22% (1/454)
cecumheterozygoten/a0% (0/1)7.75% (22/284)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
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Histopathology

IMPC related publications

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Adamts9tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Adamts9tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Adamts9tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
mouse

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