Gene: Isca1

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to tooth bud stage Isca1tm1b(KOMP)Wtsi HOM E12.5 0.00
decreased exploration in new environment Isca1tm1b(KOMP)Wtsi HET Early adult 1.01×10-05
abnormal behavior Isca1tm1b(KOMP)Wtsi HET Early adult 3.88×10-05
preweaning lethality, complete penetrance Isca1tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased vertical activity Isca1tm1b(KOMP)Wtsi HET Early adult 3.32×10-06
decreased fasting circulating glucose level Isca1tm1b(KOMP)Wtsi HET Early adult 3.24×10-05
embryonic growth retardation Isca1tm1b(KOMP)Wtsi HET E12.5 0.00
abnormal embryo size Isca1tm1b(KOMP)Wtsi HET E12.5 0.00
abnormal behavioral response to light Isca1tm1b(KOMP)Wtsi HET Early adult 3.22×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Section images
Aorta 2 No  (2/2)  Section images
Brain 2 No  (2/2)  Section images
Brainstem 2 No  (2/2)  Section images
Brown adipose tissue 2 No  (2/2)  Section images
Cartilage tissue 2 No  (2/2)  Section images
Cerebellum 2 No  (2/2)  Section images
Cerebral cortex 2 No  (2/2)  Section images
Epididymis 2 No  (18/134)  (1/2)  Section images
Esophagus 2 No  (7/415)  (2/2)  Section images
Eye 2 No  (2/2)  Section images
Heart 2 No  (2/2)  Section images
Hippocampus 2 No  (2/2)  Section images
Hypothalamus 2 No  (2/2)  Section images
Kidney 2 No  (18/584)  (2/2)  Section images
Large intestine 2 No  (10/584)  (2/2)  Section images
Liver 2 No  (2/2)  Section images
Lower urinary tract 2 No N/A
Lung 2 No  (2/2)  Section images
Lymph node 2 No N/A
Mammary gland 2 No  (1/2)  Section images
Midbrain 2 No  (2/2)  Section images
Olfactory lobe 2 No  (2/2)  Section images
Ovary 2 No  (1/584)  (1/2)  Section images
Oviduct 2 No  (1/2)  Section images
Pancreas 2 No  (5/584)  (2/2)  Section images
Peripheral nervous system 2 No  (2/2)  Section images
Peyer's patch 2 No  (2/2)  Section images
Pituitary gland 2 No  (2/2)  Section images
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No  (2/2)  Section images
Skin 2 No  (2/2)  Section images
Small intestine 2 No  (9/584)  (2/2)  Section images
Spinal cord 2 No  (2/2)  Section images
Spleen 2 No  (2/584)  (2/2)  Section images
Stomach 2 No  (12/584)  (2/2)  Section images
Striatum 2 No  (2/2)  Section images
Submandibular gland 2 No  (2/132)  (2/2)  Section images
Testis 2 No  (2/584)  (1/2)  Section images
Thalamus 2 No  (2/2)  Section images
Thymus 2 No  (2/2)  Section images
Thyroid gland 2 No  (15/584)  (2/2)  Section images
Trachea 2 No  Section images
Urinary bladder 2 No  (2/2)  Section images
Uterus 2 No  (1/2)  Section images
Vascular system 2 No  (2/2)  Section images
Vesicular gland 2 No N/A
White adipose tissue 2 No  (2/2)  Section images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504)  (2/2) N/A
Dorsal root ganglion 1  (1/57) N/A
Ear 2  (1/504) N/A
Embryo 2  (1/505)  (2/2)  Wholemount images
Eye 2  (1/504)  (2/2) N/A
Foot 2  (1/504)  (2/2) N/A
Forebrain 2  (1/504)  (2/2) N/A
Forelimb 2  (1/504)  (2/2) N/A
Fronto-nasal process 1  (1/58) Image Only N/A
Hand 2  (1/503)  (2/2) N/A
Head 2  (5/504)  (2/2) N/A
Heart 2  (1/504)  (1/2) N/A
Hindbrain 2  (6/504)  (2/2) N/A
Hindlimb 2  (1/503)  (2/2) N/A
Liver 2  (1/504)  (1/2) N/A
Lung 2  (1/500)  (1/2) N/A
Mandibular process 2  (1/504)  (2/2) N/A
Maxillary process 2  (1/504)  (2/2) N/A
Midbrain 2  (1/504)  (2/2) N/A
Nose 1  (1/70)  (1/1) N/A
Oral cavity 2  (1/504)  (1/2) N/A
Skin 2  (1/504)  (2/2) N/A
Spinal cord 1  (1/69)  (1/1) N/A
Tail 2  (1/504)  (2/2) N/A
Tail somite 2  (1/504)  (2/2) N/A

 Associated Images

Original Image
Adult LacZ: LacZ Images Section
44 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Forepaw
9 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
Embryo LacZ: LacZ images wholemount
12 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Isca1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Isca1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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