Gene: Vars2 MGI:1916165
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The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
increased cardiac output | Vars2em1(IMPC)Bay | HET | Early adult | 6.55×10-05 | ||
abnormal eye anterior chamber depth | Vars2em1(IMPC)Bay | HET | Early adult | 7.65×10-06 | ||
abnormal body wall morphology | Vars2em1(IMPC)Bay | HOM | E18.5 | 0.00 | ||
preweaning lethality, complete penetrance | Vars2em1(IMPC)Bay | HOM | Early adult | 0.00 |
Human diseases caused by Vars2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Vars2 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Combined Oxidative Phosphorylation Deficiency 20 | Hypertrophic cardiomyopathy | OMIM:615917 |
The table below shows human diseases predicted to be associated to Vars2 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Combined Oxidative Phosphorylation Deficiency 20 | Hypertrophic cardiomyopathy | OMIM:615917 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Vars2em1(IMPC)Bay | Exon Deletion | Mice |
Vars2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Vars2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
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