Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
zinc finger protein 467
Synonyms:
MNCb-3350,  EZI,  1190001I08Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Zfp467 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Zfp467 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Melorheostosis With Osteopoikilosis
Multiple lipomas, Abnormal cortical bone morphology, Osteopoikilosis ORPHA:1879
Osteomesopyknosis
Abnormal cortical bone morphology, Increased bone mineral density ORPHA:2777
Hyperostosis Corticalis Generalisata
Cranial hyperostosis, Generalized osteosclerosis, Abnormal cortical bone morphology ORPHA:3416
Endosteal Hyperostosis, Worth Type
Craniofacial hyperostosis, Clavicular sclerosis, Generalized osteosclerosis, Abnormal cortical bo... ORPHA:2790
Osteochondrosis Of The Metatarsal Bone
Sclerosis of foot bone, Joint stiffness, Thickened cortex of bones, Arthritis ORPHA:564003
Ghosal Hematodiaphyseal Dysplasia
Craniofacial hyperostosis, Anemia, Abnormal cortical bone morphology, Splenomegaly ORPHA:1802
Sclerosteosis
Craniofacial hyperostosis, Abnormal cortical bone morphology, Increased bone mineral density ORPHA:3152
Caffey Disease
Cellulitis, Periosteal thickening of long tubular bones, Increased circulating antibody level, Co... ORPHA:1310
Wormian Bone-Multiple Fractures-Dentinogenesis Imperfecta-Skeletal Dysplasia
Dentinogenesis imperfecta, Pathologic fracture, Limitation of joint mobility, Abnormal cortical b... ORPHA:166277
Dysplastic Cortical Hyperostosis
Splenomegaly, Abnormal cortical bone morphology, Increased bone mineral density ORPHA:2204
Gnathodiaphyseal Dysplasia
Osteopenia, Mandibular osteomyelitis, Recurrent fractures, Thickened cortex of long bones ORPHA:53697
Hereditary Sensory And Autonomic Neuropathy Type 2
Foot acroosteolysis, Reduced bone mineral density, Osteolysis, Abnormal cortical bone morphology ORPHA:970
Eiken Syndrome
Abnormal bone ossification, Abnormal trabecular bone morphology, Limited hip movement, Limited el... ORPHA:79106
Metatropic Dysplasia
Camptodactyly of finger, Abnormal enchondral ossification, Abnormal cortical bone morphology, Coa... ORPHA:2635
Familial Expansile Osteolysis
Osteolysis, Pathologic fracture, Thin bony cortex OMIM:174810
Proteus Syndrome
Multiple lipomas, Mandibular hyperostosis, Thin bony cortex, Splenomegaly, Facial hyperostosis, C... OMIM:176920
Cranio-Osteoarthropathy
Joint stiffness, Osteoarthritis, Abnormal cortical bone morphology, Arthritis ORPHA:1525
Ck Syndrome
Slender build, Joint hypermobility, Abnormal cortical bone morphology OMIM:300831
Autosomal Recessive Primary Microcephaly
Abnormal cortical bone morphology ORPHA:2512
Vitamin D-Dependent Rickets, Type 2B, With Normal Vitamin D Receptor
Generalized bone demineralization, Rickets, Rickets of the lower limbs, Thin bony cortex, Delayed... OMIM:600785
Grant Syndrome
Joint hyperflexibility, Abnormal cortical bone morphology, Decreased skull ossification ORPHA:2097
Caffey Disease
Cortical irregularity, Calvarial hyperostosis, Periosteal thickening of long tubular bones OMIM:114000
Dentin Dysplasia With Sclerotic Bones
Cortical sclerosis, Dentinogenesis imperfecta limited to primary teeth OMIM:125440
Ossification Of The Posterior Longitudinal Ligament Of Spine
Ectopic ossification, Diabetes mellitus, Increased bone mineral density OMIM:602475
Lethal Congenital Contracture Syndrome Type 1
Recurrent fractures, Limitation of joint mobility, Abnormal cortical bone morphology ORPHA:1486
Vitamin D Hydroxylation-Deficient Rickets, Type 1B
Rickets, Recurrent fractures, Thin bony cortex, Delayed epiphyseal ossification, Failure to thriv... OMIM:600081
Endosteal Hyperostosis, Autosomal Dominant
Metacarpal diaphyseal endosteal sclerosis, Metatarsal diaphyseal endosteal sclerosis, Hyperostosi... OMIM:144750
Coronary Artery Disease, Autosomal Dominant 2
Osteoporosis, Glucose intolerance, Impaired glucose tolerance, Gout, Diabetes mellitus OMIM:610947
Ghosal Hematodiaphyseal Dysplasia
Myelofibrosis, Increased bone mineral density, Thrombocytopenia, Refractory anemia, Leukopenia, B... OMIM:231095
Van Buchem Disease
Cranial hyperostosis, Thickened cortex of long bones, Increased bone mineral density OMIM:239100
Gorham-Stout Disease
Osteolysis, Abnormal bone ossification, Patchy reduction of bone mineral density, Osteolysis invo... ORPHA:73
Osteopetrosis, Autosomal Dominant 1
Osteopetrosis, Calvarial osteosclerosis, Generalized osteosclerosis, Thickened cortex of long bones OMIM:607634
Weismann-Netter Syndrome
Anemia, Abnormal cortical bone morphology ORPHA:3344
Vitamin D Hydroxylation-Deficient Rickets, Type 1A
Enamel hypoplasia, Rickets, Recurrent fractures, Thin bony cortex, Delayed epiphyseal ossificatio... OMIM:264700
Osteogenesis Imperfecta, Type Xviii
Joint hypermobility, Joint laxity, Recurrent fractures, Umbilical hernia, Generalized osteoporosi... OMIM:617952
Hypophosphatemic Rickets With Hypercalciuria, Hereditary
Rickets, Hypophosphatemic rickets, Recurrent fractures, Thin bony cortex, Delayed epiphyseal ossi... OMIM:241530
Vitamin D-Dependent Rickets, Type 2A
Enamel hypoplasia, Rickets, Recurrent fractures, Thin bony cortex, Delayed epiphyseal ossificatio... OMIM:277440
Hypophosphatemic Rickets, X-Linked Recessive
Rickets, Hypophosphatemic rickets, Recurrent fractures, Osteomalacia, Thin bony cortex, Delayed e... OMIM:300554
Craniodiaphyseal Dysplasia, Autosomal Dominant
Cortical sclerosis, Craniofacial osteosclerosis, Craniofacial hyperostosis, Diaphyseal sclerosis OMIM:122860
Melnick-Needles Syndrome
Craniofacial hyperostosis, Joint hyperflexibility, Omphalocele, Abnormal cortical bone morphology... ORPHA:2484
Thrombocytopenia 6
Osteoporosis, Thrombocytopenia, Myelofibrosis OMIM:616937
Peroxisome Biogenesis Disorder 12A (Zellweger)
Decreased body weight, Wide anterior fontanel, Abnormal cortical bone morphology OMIM:614886
Thrombocytopenia, Anemia, And Myelofibrosis
Myelofibrosis, Thrombocytopenia, Anisopoikilocytosis, Anemia, Splenomegaly OMIM:617441
Nasu-Hakola Disease
Bone cyst, Reduced bone mineral density, Abnormal adipose tissue morphology, Limitation of joint ... ORPHA:2770
Essential Thrombocythemia
Acute leukemia, Abnormal platelet morphology, Myelofibrosis, Splenomegaly ORPHA:3318
Autosomal Recessive Hypophosphatemic Rickets
Craniosynostosis, Abnormal trabecular bone morphology, Hypophosphatemic rickets, Tooth abscess, E... ORPHA:289176
Hypocalcemic Vitamin D-Dependent Rickets
Enamel hypoplasia, Rickets, Osteomalacia, Increased susceptibility to fractures, Thin bony cortex... ORPHA:289157
Osteopetrosis, Autosomal Recessive 6
Osteopetrosis OMIM:611497
Acute Panmyelosis With Myelofibrosis
Lymphocytosis, Myelofibrosis, Acute myelomonocytic leukemia, Pancytopenia, Acute myeloid leukemia... ORPHA:86843
Dent Disease 1
Rickets, Recurrent fractures, Glycosuria, Osteomalacia, Thin bony cortex, Delayed epiphyseal ossi... OMIM:300009
Craniometadiaphyseal Dysplasia, Wormian Bone Type
Osteopenia, Wide anterior fontanel, Thin bony cortex, Increased bone mineral density ORPHA:85184
Osteopetrosis, Autosomal Recessive 8
Osteopetrosis, Thrombocytopenia, Splenomegaly, Failure to thrive, Anemia OMIM:615085
Estrogen Resistance
Glucose intolerance, Osteopenia, Impaired glucose tolerance, Hyperinsulinemia OMIM:615363
Intermediate Osteopetrosis
Cortical sclerosis, Recurrent fractures, Generalized osteosclerosis, Osteosclerosis of the base o... ORPHA:210110
Gray Platelet Syndrome
Myelofibrosis, Abnormal number of alpha granules, Impaired thrombin-induced platelet aggregation,... OMIM:139090
Myelofibrosis
Myeloproliferative disorder, Myelofibrosis, Splenomegaly OMIM:254450
Chromosome 14Q32 Duplication Syndrome, 700-Kb
Myeloid leukemia, Myelofibrosis OMIM:616604
Osteopetrosis, Autosomal Dominant 2
Hip osteoarthritis, Recurrent fractures, Osteopetrosis, Generalized osteosclerosis, Bone marrow h... OMIM:166600
Osteopetrosis, Autosomal Recessive 7
Abnormal trabecular bone morphology, Osteopetrosis, Decreased circulating IgA level, Anemia, Sple... OMIM:612301
Osteopetrosis And Infantile Neuroaxonal Dystrophy
Osteopetrosis OMIM:600329
Pachydermoperiostosis
Osteoporosis, Osteolysis, Abnormal cortical bone morphology, Limitation of joint mobility, Anemia... ORPHA:2796
Craniofacial Dysostosis With Diaphyseal Hyperplasia
Massively thickened long bone cortices OMIM:122900
Bleeding Disorder, Platelet-Type, 17
Thrombocytopenia, Myelofibrosis, Absence of alpha granules OMIM:187900
Hypocalcemic Vitamin D-Resistant Rickets
Osteolysis, Bone cyst, Recurrent fractures, Coarse metaphyseal trabecularization, Osteomalacia, A... ORPHA:93160
Osteopetrosis With Renal Tubular Acidosis
Recurrent fractures, Osteopetrosis, Thrombocytopenia, Reduced bone mineral density, Anemia, Splen... ORPHA:2785
Stüve-Wiedemann Syndrome
Osteoporosis, Camptodactyly of finger, Flexion contracture of finger, Flexion contracture, Recurr... ORPHA:3206
Osteopetrosis, Autosomal Recessive 4
Reticulocytosis, Recurrent fractures, Osteopetrosis, Thrombocytopenia, Anemia, Splenomegaly, Hepa... OMIM:611490
Craniometaphyseal Dysplasia
Craniofacial hyperostosis, Osteopetrosis ORPHA:1522
Dent Disease
Rickets, Recurrent fractures, Glycosuria, Osteomalacia, Thin bony cortex, Delayed epiphyseal ossi... ORPHA:1652
Fibrous Dysplasia Of Bone
Osteolysis, Patchy reduction of bone mineral density, Rickets, Fibrous dysplasia of the bones, Os... ORPHA:249
Rothmund-Thomson Syndrome
Abnormal dental enamel morphology, Abnormal trabecular bone morphology, Neutropenia, Reduced bone... ORPHA:2909
Mandibuloacral Dysplasia With Type B Lipodystrophy
Osteolytic defects of the distal phalanges of the hand, Acroosteolysis of distal phalanges (feet)... OMIM:608612
Familial Osteodysplasia, Anderson Type
Recurrent fractures, Increased susceptibility to fractures, Abnormal cortical bone morphology ORPHA:2769
Lenz-Majewski Hyperostotic Dwarfism
Abnormal dental enamel morphology, Joint hyperflexibility, Elbow ankylosis, Osteopetrosis, Abnorm... ORPHA:2658
Melorheostosis, Isolated
Hyperostosis, Increased bone mineral density OMIM:155950
Leukocyte Adhesion Deficiency, Type Iii
Leukocytosis, Extramedullary hematopoiesis, Osteopetrosis, Anemia, Splenomegaly, Hepatosplenomegaly OMIM:612840
Osteopetrosis, Autosomal Recessive 2
Extramedullary hematopoiesis, Recurrent fractures, Osteopetrosis, Pancytopenia, Cranial hyperosto... OMIM:259710
Polycythemia Vera
Acute leukemia, Myelofibrosis, Weight loss, Splenomegaly ORPHA:729
Rothmund-Thomson Syndrome Type 1
Abnormal dental enamel morphology, Abnormal trabecular bone morphology, Neutropenia, Finger symph... ORPHA:221008
Rajab Interstitial Lung Disease With Brain Calcifications 1
Slender build, Joint laxity, Rickets, Pancytopenia, Reduced bone mineral density, Inguinal hernia... OMIM:613658
Rothmund-Thomson Syndrome Type 2
Abnormal dental enamel morphology, Abnormal trabecular bone morphology, Synostosis involving bone... ORPHA:221016
Oculodentodigital Dysplasia
Camptodactyly of finger, Abnormal dental enamel morphology, Abnormal cortical bone morphology, Um... ORPHA:2710
Mulibrey Nanism
Enamel hypoplasia, Thickened cortex of long bones OMIM:253250
Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, And Deafness
Osteopetrosis OMIM:617306
Osteopetrosis, Autosomal Recessive 1
Craniosynostosis, Osteopetrosis, Increased bone mineral density, Pancytopenia, Thrombocytopenia, ... OMIM:259700
Mandibuloacral Dysplasia With Type A Lipodystrophy
Osteolytic defects of the distal phalanges of the hand, Acroosteolysis of distal phalanges (feet)... OMIM:248370
Mandibuloacral Dysplasia
Osteolytic defects of the distal phalanges of the hand, Acroosteolysis of distal phalanges (feet)... ORPHA:2457
Faciocardiomelic Syndrome
Osteopenia, Large for gestational age, Thin bony cortex OMIM:612731
Frank-Ter Haar Syndrome
Osteoporosis, Wide anterior fontanel, Camptodactyly, Cortical irregularity, Osteopenia OMIM:249420
Weill-Marchesani Syndrome 1
Joint stiffness, Thin bony cortex OMIM:277600
Aspartylglucosaminuria
Umbilical hernia, Abnormal cortical bone morphology, Inguinal hernia, Joint stiffness, Splenomega... ORPHA:93
Castleman Disease
Myelofibrosis, Weight loss, Thrombocytopenia, Anemia, Decreased mean corpuscular volume ORPHA:160
Estrogen Resistance Syndrome
Osteoporosis, Hyperinsulinemia, Glucose intolerance, Delayed epiphyseal ossification, Osteopenia ORPHA:785
Noonan Syndrome-Like Disorder With Loose Anagen Hair 1
Joint laxity, Myelofibrosis, Inguinal hernia, Failure to thrive, Large for gestational age OMIM:607721
Weill-Marchesani Syndrome 2
Flexion contracture of toe, Umbilical hernia, Joint stiffness, Thin bony cortex, Elbow flexion co... OMIM:608328
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis
Osteopetrosis OMIM:618476
Osteopetrosis, Autosomal Recessive 5
Extramedullary hematopoiesis, Osteopetrosis, Pancytopenia, Thrombocytopenia, Anemia, Splenomegaly... OMIM:259720
Osteogenesis Imperfecta
Osteoporosis, Joint hypermobility, Abnormal dental enamel morphology, Joint hyperflexibility, Fle... ORPHA:666
Osteopathia Striata-Cranial Sclerosis Syndrome
Osteopetrosis, Increased bone mineral density, Coarse metaphyseal trabecularization, Spina bifida... ORPHA:2780
Osteopetrosis, Autosomal Recessive 3
Extramedullary hematopoiesis, Osteopetrosis, Cranial hyperostosis, Anemia, Hepatosplenomegaly, Di... OMIM:259730
Dysostosis, Stanescu Type
Abnormal dental enamel morphology, Massively thickened long bone cortices, Increased bone mineral... ORPHA:1798
Kenny-Caffey Syndrome, Type 2
Anemia, Small for gestational age, Thickened cortex of long bones, Increased bone mineral density OMIM:127000
Idiopathic Hypereosinophilic Syndrome
Thrombocytosis, Myelofibrosis, Leukocytosis, Thrombocytopenia, Anemia, Splenomegaly, Neutrophilia... ORPHA:3260
Stuve-Wiedemann Syndrome
Osteoporosis, Abnormal dental enamel morphology, Flexion contracture of toe, Pathologic fracture,... OMIM:601559
Sclerosteosis 1
Cortically dense long tubular bones, Facial palsy secondary to cranial hyperostosis, Sclerotic sc... OMIM:269500
Camptodactyly Syndrome, Guadalajara Type 3
Osteopenia, Thickened cortex of long bones, Spina bifida occulta ORPHA:488434
Pituitary Adenoma 4, Acth-Secreting
Osteoporosis, Glucose intolerance, Impaired glucose tolerance, Abdominal obesity, Obesity OMIM:219090
Schinzel-Giedion Midface Retraction Syndrome
Increased density of long bones, Splenopancreatic fusion, Failure to thrive, Sclerosis of skull b... OMIM:269150
Autosomal Recessive Malignant Osteopetrosis
Craniosynostosis, Recurrent fractures, Osteopetrosis, Reduced bone mineral density, Anemia, Splen... ORPHA:667
17Q11 Microdeletion Syndrome
Osteoporosis, Osteolysis, Osteopenia, Leukemia, Thickened cortex of long bones ORPHA:97685

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zfp467

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zfp467.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
The role of Zfp467 in mediating the pro-osteogenic and anti-adipogenic effects on bone and bone marrow niche. Bone (December 2020) Zfp467tm1(KOMP)Vlcg 33359894

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Zfp467tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter