Gene: Ldah

Name lipid droplet associated hydrolase

Synonyms 1110057K04Rik

Status ES CellsMice
tm1b
Mice
tm1a
phenotype data available

Links MGI:1916082   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Ldah

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Ldah data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal lens morphology Ldahtm1b(EUCOMM)Wtsi HOM Female Male postpartum stage 7.9E-10

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (4/276)
Aorta 2 No (3/448)
Blood 2 No
Bone 2 No (1/396)
Bone marrow 2 No
Brain 2 No (11/448) (2/2)
Brainstem 2 No (8/448)
Brown adipose tissue 2 No (2/264) (1/2)
Cartilage tissue 2 No (2/448)
Cecum 2 No (19/246)
Cerebellum 2 No (7/448)
Cerebral cortex 2 No (6/448)
Chest bone 2 No
Colon 2 No (19/119) (2/2)
Cranium 2 No
Diaphragm 2 No
Epididymis 2 No (16/125)
Esophagus 2 No (7/276)
Eye 2 No (3/448)
Gall bladder 2 No
Harderian gland 2 No (1/119)
Heart 2 No (5/448)
Hindlimb 2 No
Hippocampus 2 No (7/448)
Hypothalamus 2 No (7/448)
Kidney 2 No (26/448)
Large intestine 2 No (10/448)
Liver 2 No (4/448)
Lower urinary tract 2 No (4/448)
Lung 2 No (7/448)
Lymph node 2 No (1/448)
Main olfactory bulb 2 No
Mammary gland 2 No
Mesenteric lymph node 2 No (1/179)
Olfactory lobe 2 No (4/276)
Oral epithelium 2 No
Ovary 2 No (4/448)
Oviduct 2 No (3/448)
Pancreas 2 No (3/448)
Parathyroid gland 2 No (2/430)
Parotid gland 2 No
Penis 2 No
Peripheral nervous system 2 No (6/448)
Peyer's patch 2 No
Pituitary gland 2 No (3/448)
Prostate gland 2 No (13/448)
Sciatic nerve 2 No
Skeletal muscle 2 No (2/276)
Skin 2 No (4/448)
Small intestine 2 No (7/448) (2/2)
Spinal cord 2 No (6/448)
Spleen 2 No (5/448)
Stomach 2 No (19/448)
Stomach pyloric region 2 No
Striatum 2 No (6/448)
Sublingual gland 2 No
Submandibular gland 2 No (4/125)
Testis 2 No (11/448) (1/2)
Thymus 2 No (5/448)
Thyroid gland 2 No (15/448)
Tongue 2 No (4/119)
Trachea 2 No (9/448)
Trigeminal V nerve 2 No
Urinary bladder 2 No (2/185)
Uterus 2 No (5/448)
Vagina 2 No
Vas deferens 2 No (16/251)
Vascular system 2 No (2/276)
Vesicular gland 2 No
White adipose tissue 2 No (1/448)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    digestive system
    nervous system
    set of connective tissues
    reproductive system
    adipose tissue
    trunk

LacZ Wholemount Images

  • exocrine system(1)
    Prostate gland tissue not available
    Vas Deferens no expression
    MA:0000404
    MA:0000413

LacZ Section Images

No expression data was found for this embryo tab


Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • Adult LacZ: LacZ Images Wholemount
    9 Images

Disease Models

No disease model association by gene orthology was found

Disease Name Source In Disease Locus MGIMouse Phenotype Evidence (Phenodigm) IMPCMouse Phenotype Evidence (Phenodigm)
Cataract, Crystalline Coralliform OMIM:115800 Yes 96.82
Cataract, Autosomal Recessive Congenital 4 OMIM:613887 96.82
Cataract, Posterior Polar, 4 OMIM:610623 96.82
Cataract, Autosomal Recessive Congenital 2 OMIM:610019 96.82
Cataract 15, Multiple Types OMIM:615274 96.82
Cataract 35 OMIM:609376 96.82
Cataract, Lamellar 2 OMIM:610425 93.93
Ectopia Lentis, Isolated OMIM:129600 93.93
Cataract, Congenital Or Juvenilecataract, Juvenile, Hutterite Type, Included OMIM:212500 93.93
Cataract, Autosomal Recessive Congenital 5 OMIM:614691 93.93
Cataract, Zonular Pulverulent 3 OMIM:601885 93.93
116700 Cataract, Total Congenital OMIM:116700 93.93
Cataract, Congenital, Cerulean Type, 5 OMIM:614422 93.93
Cataract, Multiple Types OMIM:615188 93.93
Ectopia Lentis OMIM:225100 93.93
116100 Cataract, Membranous OMIM:116100 93.93
Cataract, Crystalline Aculeiform OMIM:115700 93.93
Cataract, Congenital Nuclear, Autosomal Recessive 3 OMIM:611544 93.49
Cataract, Nuclear Total OMIM:116400 93.49
Cataract, Congenital Zonular, With Sutural Opacities OMIM:600881 93.09
Cataract, Congenital, Cerulean Type, 2 OMIM:601547 92.97
Cataract, Zonular Pulverulent 1 OMIM:116200 92.97
Cataract, Age-Related Nuclear OMIM:601371 91.29
Cataract, Anterior Polar, 2 OMIM:601202 91.29
Cataract 43 OMIM:616279 91.29
Cataract, Cortical, Juvenile-Onset OMIM:611391 91.29
Cataract, Anterior Polar, 1 OMIM:115650 91.29
Pupillary Membrane, Persistence Of OMIM:178900 89.33
Cataract, Posterior Polar, 2 OMIM:613763 89.22
Cataract, Nuclear Diffuse Nonprogressive OMIM:116300 88.85
Kyrle Disease OMIM:149500 88.85
Cataract, Posterior Polar, 3 OMIM:605387 88.85
Vitreoretinal Degeneration, Snowflake Type OMIM:193230 88.25
Anterior Segment Mesenchymal Dysgenesis OMIM:107250 87.81
Microphthalmia, Isolated, With Coloboma 3 OMIM:610092 87.4
Megalocornea OMIM:309300 87.34
Moved To 302200 OMIM:302300 87.25
Cataract 19 OMIM:615277 86.6
Cataract, Lamellar OMIM:116800 86.48
Hyperferritinemia With Or Without Cataract OMIM:600886 85.32
Groenouw Type I Corneal Dystrophy OMIM:121900 83.0
Ring Dermoid Of Cornea OMIM:180550 82.76
Cataract, Posterior Polar, 1 OMIM:116600 82.62
Microcornea - Posterior Megalolenticonus - Persistent Fetal Vasculature - Coloboma ORPHANET:231736 82.55
Cataract, Juvenile, With Microcornea And Glucosuria OMIM:612018 82.42
Ectopia Lentis Et Pupillae OMIM:225200 82.33
Aphakia, Congenital Primary OMIM:610256 82.27
Cataract, Autosomal Dominant, Multiple Types 1 OMIM:611597 82.19
Cataract, Congenital, Volkmann Type OMIM:115665 81.86
Aniridia-Intellectual Disability Syndrome ORPHANET:1068 81.83
217520 Corneal Degeneration, Band-Shaped Spheroid OMIM:217520 80.69
Weill-Marchesani Syndrome, Autosomal Dominant OMIM:608328 54.43
Mevalonic Aciduria OMIM:610377 51.44
Koolen-De Vries Syndrome OMIM:610443 49.94
Xeroderma Pigmentosum, Complementation Group B OMIM:610651 55.42
Cerebrooculofacioskeletal Syndrome 2 OMIM:610756 57.44
Retinitis Pigmentosa 37 OMIM:611131 64.51
Chromosome 3q29 Duplication Syndrome OMIM:611936 54.73
Bone Fragility With Contractures, Arterial Rupture, And Deafness OMIM:612394 52.25
Microphthalmia, Syndromic 5 OMIM:610125 63.38
Ehlers-Danlos Syndrome, Beasley-Cohen Type OMIM:608763 57.28
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal OMIM:608836 50.08
Spastic Paraplegia 26, Autosomal Recessive OMIM:609195 52.81
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions,Autosomal Dominant, 3 OMIM:609286 51.18
Mental Retardation, Enteropathy, Deafness, Peripheral Neuropathy,Ichthyosis, And Keratoderma OMIM:609313 54.11
Eye Defects - Arachnodactyly - Cardiopathy OMIM:609465 54.12
Pseudohypoparathyroidism, Type Ic OMIM:612462 52.91
Chromosome 1q21.1 Deletion Syndrome, 1.35-Mb OMIM:612474 52.94
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 2 OMIM:614052 50.43
Leber Congenital Amaurosis 16 OMIM:614186 62.24
Warburg Micro Syndrome 2 OMIM:614225 56.73
Short-Rib Thoracic Dysplasia 5 With Or Without Polydactyly OMIM:614376 53.79
Spastic Paraplegia 46, Autosomal Recessive OMIM:614409 52.29
Peroxisome Biogenesis Disorder 5a (Zellweger) OMIM:614866 53.92
Chromosome 13q14 Deletion Syndrome OMIM:613884 54.14
Kahrizi Syndrome OMIM:612713 58.53
Chromosome 19q13.11 Deletion Syndrome OMIM:613026 51.08
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eyeanomalies), Type A, 2 OMIM:613150 54.64
Leukodystrophy, Hypomyelinating, 5 OMIM:610532 54.66
Microphthalmia, Isolated 5 OMIM:611040 66.91
Oculoauricular Syndrome OMIM:612109 77.64
Joubert Syndrome 9 OMIM:612285 65.43
Mental Retardation, Truncal Obesity, Retinal Dystrophy, And Micropenis OMIM:610156 62.44
Myopathy, Myofibrillar, 2, Mfm2 OMIM:608810 54.46
Pierson Syndrome OMIM:609049 58.37
Limb-Girdle Muscular Dystrophy, Type 1g OMIM:609115 55.86
Schindler Disease, Type I OMIM:609241 51.81
Chromosome 3q29 Deletion Syndrome OMIM:609425 51.28
Pseudopseudohypoparathyroidism OMIM:612463 54.11
Beta-Thalassemia OMIM:613985 50.61
Warburg Micro Syndrome 3 OMIM:614222 55.23
Chromosome 8q21.11 Deletion Syndrome OMIM:614230 54.52
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eyeanomalies), Type A, 7 OMIM:614643 57.39
Peroxisome Biogenesis Disorder 8b OMIM:614877 61.89
Leber Congenital Amaurosis 8 OMIM:613835 67.2
Chromosome 1q21.1 Duplication Syndrome OMIM:612475 53.87
612947 Microcephaly, Growth Retardation, Cataract, Hearing Loss, And Unusualappearance OMIM:612947 52.81
Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearingloss, And Developmental Delay OMIM:613076 64.55
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eyeanomalies), Type A, 6 OMIM:613154 58.6
Hemorrhagic Destruction Of The Brain, Subependymal Calcification,And Cataracts OMIM:613730 55.33
Retinitis Pigmentosa 4 OMIM:613731 67.89

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Ldahtm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Ldahtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Ldahtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Ldahtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene