Zc3hc1 | zinc finger, C3HC type 1
Physiological systems
20 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Reproductive system Adipose tissue Growth/size/body region Vision/eye Behavior/neurological Skeleton Craniofacial Cardiovascular system
12 No significant impact
4 Not tested
Data collections
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased body weight | 4 supporting datasets | Zc3hc1tm1a(KOMP)Wtsi | homozygote | Early adult | 2.65x10-9 | ||
| abnormal cornea morphology | 1 supporting dataset | Zc3hc1tm1a(KOMP)Wtsi | homozygote | Early adult | 2.91x10-5 | ||
| abnormal tooth morphology | 1 supporting dataset | Zc3hc1tm1a(KOMP)Wtsi | homozygote | Early adult | 6.52x10-5 | ||
| decreased lean body mass | 1 supporting dataset | Zc3hc1tm1a(KOMP)Wtsi | homozygote | Early adult | 4.63x10-7 | ||
| abnormal cranium morphology | 1 supporting dataset | Zc3hc1tm1a(KOMP)Wtsi | homozygote | Early adult | 6.83x10-5 | ||
| male infertility | 1 supporting dataset | Zc3hc1tm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal posture | 1 supporting dataset | Zc3hc1tm1a(KOMP)Wtsi | homozygote | Early adult | 1.53x10-5 | ||
| increased heart weight | 1 supporting dataset | Zc3hc1tm1a(KOMP)Wtsi | heterozygote | Early adult | 1.22x10-5 | ||
| increased total body fat amount | 1 supporting dataset | Zc3hc1tm1a(KOMP)Wtsi | homozygote | Early adult | 1.35x10-10 | ||
| abnormal snout morphology | 1 supporting dataset | Zc3hc1tm1a(KOMP)Wtsi | homozygote | Early adult | 1.72x10-8 |
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| adrenal gland | heterozygote | n/a | n/a | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Zc3hc1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Zc3hc1.
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| Zc3hc1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Zc3hc1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Zc3hc1tm295765(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Zc3hc1tm37311(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |