Gene Summary

Name:
glutaminyl-tRNA synthetase
Synonyms:
1200016L19Rik,  1110018N24Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Qarsem1(IMPC)Mbp HOM   Early adult 0.00
anophthalmia Qarsem1(IMPC)Mbp HET Early adult 0.00
abnormal eye morphology Qarsem1(IMPC)Mbp HET Early adult 0.00
embryonic lethality prior to organogenesis Qarsem1(IMPC)Mbp HOM   E9.5 0.00
abnormal skeletal muscle morphology Qarsem1(IMPC)Mbp HET Early adult 0.00
abnormal skin morphology Qarsem1(IMPC)Mbp HET Early adult 0.00
abnormal brain morphology Qarsem1(IMPC)Mbp HET Early adult 0.00
persistence of hyaloid vascular system Qarsem1(IMPC)Mbp HET Early adult 3.61×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

39 Images

X-ray

XRay Images Whole Body Lateral Orientation

13 Images

Human diseases caused by Qars mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Qars by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Microcephaly, Progressive, With Seizures And Cerebral And Cerebellar Atrophy
OMIM:615760

The table below shows human diseases predicted to be associated to Qars by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Microphthalmia, Isolated, With Coloboma 10
Iris coloboma, Anophthalmia, Chorioretinal coloboma, Microphthalmia OMIM:616428
Microphthalmia, Isolated, With Coloboma 5
Anophthalmia, Iris coloboma, Bilateral microphthalmos, Microphthalmia, Chorioretinal coloboma OMIM:611638
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome
Anophthalmia, Microphthalmia ORPHA:85275
Microphthalmia, Isolated 1
Anophthalmia, Microphthalmia OMIM:251600
Microphthalmia, Isolated 8
Retinal coloboma, Optic nerve hypoplasia, Retinal detachment, Anophthalmia, True anophthalmia, Mi... OMIM:615113
Microphthalmia, Syndromic 12
Anophthalmia, Congenital diaphragmatic hernia, Microphthalmia OMIM:615524
Dextrocardia With Unusual Facies And Microphthalmia
Anophthalmia, Microphthalmia OMIM:221950
Microcornea-Posterior Megalolenticonus-Persistent Fetal Vasculature-Coloboma Syndrome
Remnants of the hyaloid vascular system, Posterior lenticonus, Iris coloboma, Microphthalmia, Cho... ORPHA:231736
Microphthalmia, Isolated 3
Anophthalmia, Microphthalmia OMIM:611038
Fryns Microphthalmia Syndrome
Anophthalmia, Microphthalmia OMIM:600776
Meckel Syndrome, Type 8
Anophthalmia, Microphthalmia OMIM:613885
Anencephaly 2
Anophthalmia OMIM:619452
Oculocerebrocutaneous Syndrome
Anophthalmia, Microphthalmia OMIM:164180
Solitary Median Maxillary Central Incisor
Coloboma, Cyclopia, Anophthalmia, Microphthalmia OMIM:147250
Walker-Warburg Syndrome
Muscular dystrophy, Retinal detachment, Anophthalmia, Optic atrophy, Iris coloboma, Aplasia/Hypop... ORPHA:899
Anophthalmia Plus Syndrome
Iris coloboma, Anophthalmia ORPHA:1104
Microphthalmia With Brain And Digit Anomalies
Iris coloboma, Anophthalmia, Chorioretinal coloboma, Microphthalmia ORPHA:139471
Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Anophthalmia ORPHA:411986
Trisomy 13
Anophthalmia, Optic atrophy, Iris coloboma, Microphthalmia, Aplasia/Hypoplasia of the iris ORPHA:3378
Manitoba Oculotrichoanal Syndrome
Anophthalmia, Microphthalmia OMIM:248450
Microphthalmia, Syndromic 5
Coloboma, Optic nerve hypoplasia, Anophthalmia, Microphthalmia OMIM:610125
Reese Retinal Dysplasia
Remnants of the hyaloid vascular system, Retinal dysplasia OMIM:266400
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Iris coloboma, Anophthalmia, Microphthalmia ORPHA:77298
Matthew-Wood Syndrome
Anophthalmia, Congenital diaphragmatic hernia, Microphthalmia ORPHA:2470
Microphthalmia With Limb Anomalies
Camptodactyly of 2nd-5th fingers, Anophthalmia, Microphthalmia OMIM:206920
Coloboma, Ocular, Autosomal Dominant
Remnants of the hyaloid vascular system, Optic disc coloboma, Microphthalmia, Optic nerve aplasia... OMIM:120200
Cockayne Syndrome Type 2
Limb hypertonia, Anophthalmia, Flexion contracture ORPHA:90322
Trisomy 1Q
Camptodactyly of finger, Anophthalmia, Congenital diaphragmatic hernia ORPHA:261344
Hydrolethalus
Anophthalmia, Microphthalmia ORPHA:2189
Cerebrooculonasal Syndrome
Anophthalmia ORPHA:66625
Oculopalatocerebral Syndrome
Remnants of the hyaloid vascular system, Microphthalmia OMIM:257910
Optic Nerve Hypoplasia, Bilateral
Optic nerve hypoplasia, Optic nerve aplasia, Remnants of the hyaloid vascular system OMIM:165550
Oculotrichoanal Syndrome
Anophthalmia, Microphthalmia ORPHA:2717
Microphthalmia/Coloboma And Skeletal Dysplasia Syndrome
Coloboma, Anophthalmia, Microphthalmia OMIM:615877
Anophthalmia-Megalocornea-Cardiopathy-Skeletal Anomalies Syndrome
Camptodactyly of finger, Hypoplasia of the musculature, Anophthalmia, Aniridia ORPHA:1101
Microphthalmia, Syndromic 9
Congenital diaphragmatic hernia, Diaphragmatic eventration, Anophthalmia, Bilateral microphthalmos OMIM:601186
Cockayne Syndrome Type 1
Optic atrophy, Foot joint contracture, Anophthalmia, Pigmentary retinopathy ORPHA:90321
Holoprosencephaly
Congenital diaphragmatic hernia, Anophthalmia, Optic atrophy, Iris coloboma, Cyclopia, Microphtha... ORPHA:2162
Microphthalmia, Syndromic 3
Optic nerve hypoplasia, Anophthalmia, Coloboma, Microphthalmia, Optic nerve aplasia OMIM:206900
Persistent Hyperplastic Primary Vitreous
Remnants of the hyaloid vascular system, Microphthalmia, Buphthalmos, Hyaloid vascular remnant an... ORPHA:91495
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Iris coloboma, Anophthalmia, Microphthalmia ORPHA:2250
Pierson Syndrome
Remnants of the hyaloid vascular system, Microphthalmia, Retinal detachment, Posterior lenticonus... OMIM:609049
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 7
Remnants of the hyaloid vascular system, Optic nerve hypoplasia, Muscular dystrophy, Retinal deta... OMIM:614643
Cerebrooculonasal Syndrome
Optic nerve hypoplasia, Iris coloboma, Anophthalmia OMIM:605627
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Abnormality of retinal pigmentation, Retinal detachment, Anophthalmia, Optic atrophy, Microphthal... ORPHA:2526
Proboscis Lateralis
Optic nerve hypoplasia, Anophthalmia, Optic disc coloboma, Iris coloboma, Cyclopia, Microphthalmi... ORPHA:141099
Fibular Hemimelia
Anophthalmia ORPHA:93323
Microphthalmia, Syndromic 2
Contracture of the proximal interphalangeal joint of the 3rd toe, Remnants of the hyaloid vascula... OMIM:300166
Microphthalmia With Linear Skin Defects Syndrome
Abnormality of retinal pigmentation, Congenital diaphragmatic hernia, Anophthalmia, Microphthalmi... ORPHA:2556
Vacterl With Hydrocephalus
Anophthalmia, Microphthalmia ORPHA:3412
Persistent Hyperplastic Primary Vitreous, Autosomal Recessive
Remnants of the hyaloid vascular system, Buphthalmos, Retinal nonattachment, Iris coloboma, Micro... OMIM:221900
Microgastria-Limb Reduction Defect Syndrome
Anophthalmia, Congenital muscular torticollis, Microphthalmia ORPHA:2538
14Q22Q23 Microdeletion Syndrome
Optic nerve aplasia, Anophthalmia ORPHA:264200
Meckel Syndrome
Optic atrophy, Aplasia/Hypoplasia of the iris, Anophthalmia, Microphthalmia ORPHA:564
Focal Dermal Hypoplasia
Diastasis recti, Congenital diaphragmatic hernia, Anophthalmia, Optic atrophy, Iris coloboma, Mic... OMIM:305600
Microgastria-Limb Reduction Defects Association
Anophthalmia OMIM:156810
Joubert Syndrome 21
Anophthalmia OMIM:615636
Charge Syndrome
Anophthalmia, Optic atrophy, Iris coloboma, Microphthalmia, Facial palsy, Chorioretinal coloboma ORPHA:138
Holoprosencephaly 9
Optic nerve hypoplasia, Anophthalmia, Microphthalmia OMIM:610829
Oculo-Palato-Cerebral Syndrome
Remnants of the hyaloid vascular system, Retinal detachment, Microphthalmia ORPHA:2714
Charge Syndrome
Retinal coloboma, Anophthalmia, Unilateral microphthalmos, Coloboma, Iris coloboma, Microphthalmi... OMIM:214800
Microphthalmia With Limb Anomalies
Optic atrophy, Camptodactyly of 2nd-5th fingers, True anophthalmia, Microphthalmia ORPHA:1106
Fraser Syndrome 1
Anophthalmia, Bilateral microphthalmos OMIM:219000
Branchiooculofacial Syndrome
Retinal coloboma, Anophthalmia, Iris coloboma, Elbow flexion contracture, Microphthalmia, Facial ... OMIM:113620
Microphthalmia, Syndromic 6
Flexion contracture of thumb, Coloboma, Anophthalmia, Microphthalmia OMIM:607932
Fraser Syndrome
Anophthalmia, Microphthalmia ORPHA:2052
Microphthalmia, Syndromic 1
Joint contracture of the hand, Anophthalmia, Optic disc coloboma, Camptodactyly, Iris coloboma, M... OMIM:309800
Neurofibromatosis Type 2
Remnants of the hyaloid vascular system, Wrist drop, Foot dorsiflexor weakness, Facial palsy ORPHA:637
Holoprosencephaly 2
Remnants of the hyaloid vascular system, Iris coloboma, Cyclopia, Microphthalmia, Chorioretinal c... OMIM:157170
Neuroocular Syndrome
Remnants of the hyaloid vascular system, Hypoplasia of the fovea, Iris coloboma, Microphthalmia, ... OMIM:619539
Norrie Disease
Remnants of the hyaloid vascular system, Retinal detachment, Aplasia/Hypoplasia of the lens, Opti... ORPHA:649
Craniofacial Microsomia
Anophthalmia, Hypoplasia of facial musculature, Microphthalmia OMIM:164210
Microcephaly, Progressive, With Seizures And Cerebral And Cerebellar Atrophy
OMIM:615760

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Qars

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Qars.

No publications found that use IMPC mice or data for Qars.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Qarstm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Qarstm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Qarsem1(IMPC)Mbp Inter-exon deletion Mice, Tissue
Qarstm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Qarstm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter