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Gene: Nat8 MGI:1915646

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Gene Summary

Name:
N-acetyltransferase 8 (GCN5-related)
Synonyms:
0610037O16Rik,  Cml4

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

VIP of left eye

25 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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Eye Morphology

VIP of left eye

16 Images

View images
Eye Morphology

VIP of right eye

16 Images

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Eye Morphology

VIP of right eye

25 Images

View images
Eye Morphology

VIP of right fundus

25 Images

View images
Eye Morphology

VIP of left fundus

25 Images

View images
X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Forepaw

10 Images

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Eye Morphology

VIP of left fundus

16 Images

View images
X-ray

XRay Images Whole Body Lateral Orientation

10 Images

View images
X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

View images
Eye Morphology

VIP of right fundus

16 Images

View images

Human diseases caused by Nat8 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Nat8

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nat8.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy. Acta neuropathologica (November 2017) Nat8ltm1(KOMP)Vlcg PMC5756261
Suppressing N-Acetyl-l-Aspartate Synthesis Prevents Loss of Neurons in a Murine Model of Canavan Leukodystrophy. The Journal of neuroscience : the official journal of the Society for Neuroscience (January 2017) Nat8ltm1(KOMP)Vlcg PMC5242397
Ablating N-acetylaspartate prevents leukodystrophy in a Canavan disease model. Annals of neurology (March 2015) Nat8ltm1(KOMP)Vlcg 25712859
Do reductions in brain N-acetylaspartate levels contribute to the etiology of some neuropsychiatric disorders? Journal of neuroscience research (April 2013) Nat8ltm1(KOMP)Vlcg 23633398

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Nat8tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Nat8em1(IMPC)Bay Intra-exon deletion Mice

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