The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nat8.
There are 2 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy.||Acta neuropathologica (November 2017)||Nat8ltm1(KOMP)Vlcg||PMC5756261|
|Suppressing N-Acetyl-l-Aspartate Synthesis Prevents Loss of Neurons in a Murine Model of Canavan Leukodystrophy.||The Journal of neuroscience : the official journal of the Society for Neuroscience (January 2017)||Nat8ltm1(KOMP)Vlcg||PMC5242397|
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
This service may be affected by the Covid-19 pandemic. See how
|MGI Allele||Allele Type||Produced|
|Nat8tm1(NCOM)Mfgc||Reporter-tagged deletion allele (with selection cassette)||Targeting vectors, ES Cells|