Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Mcoln2 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mcoln2.
There are 2 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells. | eLife (November 2018) | Mcoln2tm1e.1(KOMP)Wtsi | PMC6257821 |
Novel Role of TRPML2 in the Regulation of the Innate Immune Response. | Journal of immunology (Baltimore, Md. : 1950) (October 2015) | Mcoln2tm1e(KOMP)Wtsi Mcoln2tm1e.1(KOMP)Wtsi | PMC4637233 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Mcoln2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Mcoln2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
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