Gene: Rpa1

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Name
replication protein A1
MGI ID
MGI:1915525
Synonyms
5031405K23Rik RP-A RF-A Rpa 70kDa
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Rpa1tm1b(KOMP)Wtsi HOM   Early adult 0.00
increased mean corpuscular volume Rpa1tm1b(KOMP)Wtsi HET   Early adult 2.37×10-05
increased body length Rpa1tm1b(KOMP)Wtsi HET   Early adult 9.18×10-05
increased heart weight Rpa1tm1b(KOMP)Wtsi HET   Early adult 1.75×10-06
embryonic lethality prior to tooth bud stage Rpa1tm1b(KOMP)Wtsi HOM   E12.5 0.00
embryonic lethality prior to organogenesis Rpa1tm1b(KOMP)Wtsi HOM   E9.5 0.00
decreased circulating glucose level Rpa1tm1b(KOMP)Wtsi HET Early adult 3.01×10-05

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590) N/A
Aorta 2 No  (1/590) N/A
Bone marrow 2 No N/A
Brain 2 No  (3/590) N/A
Brainstem 2 No  (2/590) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (3/590) N/A
Cerebral cortex 2 No  (2/590) N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No  (1/590) N/A
Hippocampus 2 No  (3/590) N/A
Hypothalamus 2 No  (2/590) N/A
Kidney 2 No  (20/590)  (1/2) N/A
Large intestine 2 No  (10/590) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/590) N/A
Lung 2 No  (1/590)  (1/2)  Section images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No  (2/590) N/A
Ovary 2 No  (1/590) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/590) N/A
Peripheral nervous system 2 No  (1/590) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/590) N/A
Prostate gland 2 No  (12/590) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/590) N/A
Spinal cord 2 No  (2/590) N/A
Spleen 2 No  (2/590) N/A
Stomach 2 No  (13/590) N/A
Striatum 2 No  (3/590) N/A
Submandibular gland 2 No  (2/132)  (1/2)  Section images
Testis 2 No  (5/590)  (1/2)  Section images
Thalamus 2 No N/A
Thymus 2 No N/A
Thyroid gland 2 No  (16/590) N/A
Trachea 2 No  (2/590)  (2/2)  Section images
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/506) N/A
Ear 1  (1/506) N/A
Embryo 1  (1/507) N/A
Eye 1  (1/506) N/A
Foot 1  (1/506) N/A
Forebrain 1  (1/506) N/A
Forelimb 1  (1/506) N/A
Hand 1  (1/506) N/A
Head 1  (5/506) N/A
Heart 1  (1/506) N/A
Hindbrain 1  (6/506) N/A
Hindlimb 1  (1/506) N/A
Liver 1  (1/504) N/A
Lung 1  (1/504) N/A
Mandibular process 1  (1/506) N/A
Maxillary process 1  (1/506) N/A
Midbrain 1  (1/506) N/A
Oral cavity 1  (1/504) N/A
Skin 1  (1/506) N/A
Tail 1  (1/506) N/A
Tail somite 1  (1/506) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
15 Images
X-ray: XRay Images Whole Body Lateral Orientation
15 Images
Original Image
Adult LacZ: LacZ Images Section
5 Images
Eye Morphology: Images Ophthalmoscopy
4 Images
X-ray: XRay Images Skull Lateral Orientation
15 Images
X-ray: XRay Images Forepaw
15 Images
X-ray: XRay Images Whole Body Dorso Ventral
15 Images
Sleep Wake: Wake state (bmp file)
1 Images
Eye Morphology: Images Slit Lamp
3 Images
Combined SHIRPA and Dysmorphology
1 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Rpa1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Rpa1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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