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Gene: Arl13b MGI:1915396

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
ADP-ribosylation factor-like 13B
Synonyms:
Arl2l1,  C530009C10Rik,  A930014M17Rik,  A530097K21Rik,  hnn

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Arl13b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Arl13b by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Joubert Syndrome
Encephalocele, Hydrocephalus ORPHA:475
Joubert Syndrome 8
Occipital encephalocele OMIM:612291

The table below shows human diseases predicted to be associated to Arl13b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Frontal Encephalocele
Encephalocele, Hydrocephalus, Spina bifida ORPHA:1931
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Acalvaria
Hydrocephalus, Holoprosencephaly, Spina bifida ORPHA:945
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Anencephaly, Spina bifida ORPHA:2476
Craniorachischisis
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Caudal Duplication
Myelomeningocele, Spinal cord lesion, Spina bifida ORPHA:1756
Chiari Malformation Type Ii
Spina bifida, Myelomeningocele, Hydrocephalus, Cervical myelopathy, Syringomyelia OMIM:207950
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Schisis Association
Encephalocele, Anencephaly, Spina bifida ORPHA:63862
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Aplasia Cutis Congenita
Spinal dysraphism ORPHA:1114
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Isolated Klippel-Feil Syndrome
Spina bifida ORPHA:2345
Sirenomelia
Spina bifida, Sirenomelia ORPHA:3169
Camptodactyly Syndrome, Guadalajara Type 1
Spina bifida ORPHA:1327
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Czeizel-Losonci Syndrome
Myelomeningocele, Spina bifida occulta, Hydrocephalus, Spina bifida ORPHA:2437
Aminopterin/Methotrexate Embryofetopathy
Encephalocele, Hydrocephalus, Meningocele, Anencephaly, Spinal dysraphism, Holoprosencephaly ORPHA:1908
Waardenburg Syndrome Type 1
Meningocele, Spina bifida ORPHA:894
Iniencephaly
Encephalocele, Spina bifida, Hydrocephalus, Myelomeningocele, Anencephaly, Spinal dysraphism, Syr... ORPHA:63259
Fountain Syndrome
Spina bifida occulta, Spina bifida ORPHA:3219
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida ORPHA:1120
Pelvis-Shoulder Dysplasia
Hydranencephaly, Hydrocephalus, Spina bifida ORPHA:2839
Sacral Defect With Anterior Meningocele
Myeloschisis, Tethered cord, Myelomeningocele, Hydrocephalus, Meningocele, Dermal sinus tract, Hy... OMIM:600145
Cerebrocostomandibular Syndrome
Hydranencephaly, Myelomeningocele, Meningocele, Spina bifida ORPHA:1393
Amish Lethal Microcephaly
Spina bifida ORPHA:99742
Trisomy 20P
Umbilical hernia, Spina bifida ORPHA:261318
Diabetic Embryopathy
Hydrocephalus, Spinal dysraphism ORPHA:1926
Chromosome 17P13.1 Deletion Syndrome
Umbilical hernia, Hydrocephalus, Spina bifida OMIM:613776
Lumbar Syndrome
Myelomeningocele, Spina bifida ORPHA:83628
Neu-Laxova Syndrome 2
Spina bifida OMIM:616038
Limb Body Wall Complex
Encephalocele, Spina bifida, Myelomeningocele, Hydrocephalus, Abnormal spinal cord morphology, An... ORPHA:2369
Mosaic Trisomy 9
Spina bifida ORPHA:99776
Vertebral, Cardiac, Renal, And Limb Defects Syndrome 1
Tethered cord, Spinal dysraphism OMIM:617660
Trisomy 18
Anencephaly, Holoprosencephaly, Spina bifida ORPHA:3380
Vacterl With Hydrocephalus
Aqueductal stenosis, Hydrocephalus, Spina bifida ORPHA:3412
Isolated Posterior Meningocele
Tethered cord, Hydrocephalus, Lipomyelomeningocele, Meningocele, Neural tube defect, Hydromyelia,... ORPHA:268810
Phakomatosis Pigmentokeratotica
Spina bifida ORPHA:2874
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida OMIM:193500
Cloacal Exstrophy
Myelomeningocele, Spina bifida ORPHA:93929
Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi
Tethered cord, Spinal dysraphism OMIM:612918
Nail-Patella Syndrome
Spina bifida OMIM:161200
Neu-Laxova Syndrome
Spina bifida ORPHA:2671
Focal Dermal Hypoplasia
Umbilical hernia, Spina bifida ORPHA:2092
Fibular Hemimelia
Spina bifida ORPHA:93323
Hallermann-Streiff Syndrome
Spina bifida OMIM:234100
Pagod Syndrome
Encephalocele, Meningocele, Spina bifida ORPHA:991
Split Cord Malformation
Tethered cord, Cervical spina bifida, Myelomeningocele, Lipomyelomeningocele, Hydrocephalus, Meni... ORPHA:573278
Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 2
Spinal dysraphism OMIM:603546
Basal Cell Nevus Syndrome 1
Hydrocephalus, Spina bifida OMIM:109400
Ulnar Hemimelia
Spinal dysraphism ORPHA:93320
22Q11.2 Deletion Syndrome
Spina bifida, Hydrocephalus, Meningocele, Occipital myelomeningocele, Umbilical hernia ORPHA:567
Koolen-De Vries Syndrome Due To A Point Mutation
Hydrocephalus, Spina bifida, Dural ectasia ORPHA:363965
17Q21.31 Microdeletion Syndrome
Hydrocephalus, Spina bifida, Dural ectasia ORPHA:363958
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Spina bifida ORPHA:508498
Thrombocytopenia-Absent Radius Syndrome
Syringomyelia, Spina bifida OMIM:274000
Neurofibromatosis, Type I
Aqueductal stenosis, Hydrocephalus, Spina bifida OMIM:162200
Campomelic Dysplasia
Hydrocephalus, Spina bifida, Spinal dysraphism OMIM:114290
Jacobsen Syndrome
Spina bifida ORPHA:2308
Holoprosencephaly
Encephalocele, Hydrocephalus, Spinal cord tumor, Spinal dysraphism, Branchial anomaly, Holoprosen... ORPHA:2162
Fanconi Anemia
Umbilical hernia, Hydrocephalus, Spina bifida ORPHA:84
Aicardi Syndrome
Spina bifida OMIM:304050
Rubinstein-Taybi Syndrome 1
Spina bifida occulta, Spina bifida OMIM:180849
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Tethered cord, Spina bifida OMIM:619480
Neu-Laxova Syndrome 1
Hydranencephaly, Small placenta, Short umbilical cord, Spina bifida OMIM:256520
Vater/Vacterl Association
Occipital encephalocele, Tethered cord, Spina bifida, Patent urachus OMIM:192350
Cartilage-Hair Hypoplasia
Spinal dysraphism ORPHA:175
Otopalatodigital Syndrome, Type Ii
Umbilical hernia, Hydrocephalus, Spina bifida OMIM:304120
Exstrophy-Epispadias Complex
Hydrocephalus, Spina bifida ORPHA:322
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Large placenta, Spinal dysraphism ORPHA:96334
Joubert Syndrome
Encephalocele, Hydrocephalus ORPHA:475
Joubert Syndrome 8
Occipital encephalocele OMIM:612291

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Arl13b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Arl13b.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
ARL13B regulates Sonic hedgehog signaling from outside primary cilia. eLife (March 2020) Arl13btm1c(EUCOMM)Wtsi PMC7075693
Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts. Journal of the American Society of Nephrology : JASN (May 2016) Arl13btm1c(EUCOMM)Wtsi Arl13btm1a(EUCOMM)Wtsi PMC5118478

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Arl13btm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Arl13btm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Arl13btm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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