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Gene: Ino80 MGI:1915392

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Gene Summary

Name:
INO80 complex subunit
Synonyms:
Inoc1,  2310079N15Rik,  INO80,  4632409L19Rik

Order Alleles

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Ino80tm1b(EUCOMM)Hmgu HOM   Early adult 0.00
decreased locomotor activity Ino80tm1a(EUCOMM)Hmgu HET Early adult 3.34×10-09
decreased exploration in new environment Ino80tm1a(EUCOMM)Hmgu HET Early adult 2.48×10-08
abnormal seminal vesicle morphology Ino80tm1a(EUCOMM)Hmgu HET Early adult 0.00
increased aggression Ino80tm1a(EUCOMM)Hmgu HET   Early adult 3.90×10-06
prolonged QRS complex duration Ino80tm1a(EUCOMM)Hmgu HET Early adult 4.42×10-05
preweaning lethality, complete penetrance Ino80tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
abnormal vocalization Ino80tm1a(EUCOMM)Hmgu HET Early adult 1.61×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

No Adult expression data was found for this gene.

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Brain N/A heterozygote 100% (2 of 2)
Brain N/A homozygote Not available
Ear N/A heterozygote 100% (2 of 2)
Ear N/A homozygote Not available
Embryo N/A heterozygote 100% (2 of 2)
Embryo N/A homozygote Not available
Eye N/A heterozygote 100% (2 of 2)
Eye N/A homozygote Not available
Footplate N/A heterozygote Ambiguous
Footplate N/A homozygote Not available
Forebrain N/A heterozygote 100% (2 of 2)
Forebrain N/A homozygote Not available
Forelimb N/A heterozygote 100% (2 of 2)
Forelimb N/A homozygote Not available
Handplate N/A heterozygote Ambiguous
Handplate N/A homozygote Not available
Head N/A heterozygote 100% (2 of 2)
Head N/A homozygote Not available
Heart N/A heterozygote 100% (2 of 2)
Heart N/A homozygote Not available
Hindbrain N/A heterozygote 100% (2 of 2)
Hindbrain N/A homozygote Not available
Hindlimb N/A heterozygote 100% (2 of 2)
Hindlimb N/A homozygote Not available
Liver N/A heterozygote 100% (2 of 2)
Liver N/A homozygote Not available
Lung N/A heterozygote 100% (2 of 2)
Lung N/A homozygote Not available
Mandibular process N/A heterozygote 100% (2 of 2)
Mandibular process N/A homozygote Not available
Maxillary process N/A heterozygote 100% (2 of 2)
Maxillary process N/A homozygote Not available
Midbrain N/A heterozygote 100% (2 of 2)
Midbrain N/A homozygote Not available
Oral cavity N/A heterozygote 100% (2 of 2)
Oral cavity N/A homozygote Not available
Chorioallantoic placenta N/A heterozygote 100% (1 of 1)
Chorioallantoic placenta N/A homozygote 100% (1 of 1)
Skin N/A heterozygote 100% (2 of 2)
Skin N/A homozygote Not available
Tail somite N/A heterozygote 100% (2 of 2)
Tail somite N/A homozygote Not available
Tail N/A heterozygote 100% (2 of 2)
Tail N/A homozygote Not available

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
brain 1.09% (5 of 460)
ear 0.22% (1 of 462)
embryo 0.22% (1 of 460)
eye 0.22% (1 of 448)
footplate 0.22% (1 of 464)
forebrain 0.22% (1 of 450)
forelimb 0.22% (1 of 453)
handplate 0.22% (1 of 449)
head 1.08% (5 of 461)
heart 0.23% (1 of 443)
hindbrain 1.1% (5 of 454)
hindlimb 0.22% (1 of 464)
liver 0.22% (1 of 448)
lung 0.22% (1 of 448)
mandibular process 0.22% (1 of 463)
maxillary process 0.22% (1 of 450)
midbrain 0.22% (1 of 453)
oral cavity 0.22% (1 of 455)
placenta 14.29% (5 of 35)
skin 0.21% (1 of 469)
tail 0.22% (1 of 445)
tail somite group 0.22% (1 of 457)

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

20 Images

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Embryo LacZ

LacZ images wholemount

2 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Echo

M-Mode Images

14 Images

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Gross Pathology and Tissue Collection

Images

1 Images

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Embryo LacZ

LacZ images section

1 Images

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Human diseases caused by Ino80 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ino80 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Progressive Familial Heart Block, Type Ia
Complete heart block with broad QRS complexes, Left anterior fascicular block, Sudden cardiac dea... OMIM:113900
Brugada Syndrome
ST segment elevation, Ventricular fibrillation, Cardiac arrest, Paroxysmal ventricular tachycardi... ORPHA:130
Incessant Infant Ventricular Tachycardia
Cardiac arrest, Ventricular tachycardia, Histiocytoid cardiomyopathy, Congestive heart failure, W... ORPHA:45453
Familial Progressive Cardiac Conduction Defect
Arrhythmia, Congestive heart failure, Bundle branch block, Syncope, Heart block ORPHA:871
Cardiomyopathy, Dilated, 1E
Atrial standstill, Dilated cardiomyopathy, Reduced systolic function, Atrial flutter, Premature v... OMIM:601154
Progressive Familial Heart Block, Type Ib
Shortened PR interval, Arrhythmia, Left anterior fascicular block, Right bundle branch block, Syn... OMIM:604559
Brugada Syndrome 1
Ventricular fibrillation, Cardiac arrest, Atrial flutter, Sudden cardiac death, Right bundle bran... OMIM:601144
Cardiac Conduction Disease With Or Without Dilated Cardiomyopathy
Dilated cardiomyopathy, Sinus bradycardia, Atrial flutter, Cardiac arrest, Premature ventricular ... OMIM:616117
Pomt2-Related Limb-Girdle Muscular Dystrophy R14
Left ventricular systolic dysfunction, Dilated cardiomyopathy, Cognitive impairment, Inability to... ORPHA:206559
Atrial Septal Defect-Atrioventricular Conduction Defects Syndrome
Bundle branch block, Arrhythmia ORPHA:1479
Brugada Syndrome 2
Prolonged PR interval, Ventricular fibrillation, First degree atrioventricular block, Sudden card... OMIM:611777
Ventricular Tachycardia, Familial
Right bundle branch block, Sudden cardiac death, Paroxysmal ventricular tachycardia OMIM:192605
Atrial Standstill
Atrial standstill, Ventricular tachycardia, Arrhythmia, Congestive heart failure, Reduced ejectio... ORPHA:1344
Glycogen Storage Disease Xv
Ventricular arrhythmia, Right bundle branch block OMIM:613507
Cardiomyopathy, Familial Hypertrophic, 13
Ventricular fibrillation, Left anterior fascicular block, Hypertrophic cardiomyopathy, Right bund... OMIM:613243
Congenital Heart Defects, Multiple Types, 3
Right bundle branch block, Atrial fibrillation, Atrioventricular block, Tachycardia, Atrioventric... OMIM:614954
Atrial Septal Defect, Sinus Venosus Type
Automatic atrial tachycardia, Atrial flutter, Systolic heart murmur, Congestive heart failure, Le... ORPHA:99105
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Recessive 2
Right bundle branch block, Cognitive impairment, Ataxia, Unsteady gait OMIM:616479
Bundle Branch Block, Familial Isolated Complete Right
Right bundle branch block OMIM:113950
Cardiomyopathy, Familial Hypertrophic, 10
Ventricular fibrillation, Ventricular tachycardia, T-wave inversion, Hypertrophic cardiomyopathy,... OMIM:608758
Cardiomyopathy, Familial Hypertrophic, 6
Ventricular preexcitation, Sinus bradycardia, Wolff-Parkinson-White syndrome, Hypertrophic cardio... OMIM:600858
Brugada Syndrome 5
ST segment elevation, Ventricular fibrillation, Bundle branch block OMIM:612838
Familial Dilated Cardiomyopathy
Left ventricular systolic dysfunction, Reduced ejection fraction, Arrhythmia, Congestive heart fa... ORPHA:217607
Arrhythmogenic Right Ventricular Dysplasia, Familial, 13
Bundle branch block, Ventricular tachycardia OMIM:615616
Arrhythmogenic Right Ventricular Dysplasia, Familial, 14
Ventricular tachycardia, Premature ventricular contraction, Left bundle branch block, Presyncope,... OMIM:618920
Brugada Syndrome 8
Ventricular tachycardia, ST segment elevation, Right bundle branch block OMIM:613123
Cardiomyopathy, Familial Hypertrophic, 16
Asymmetric septal hypertrophy, Atrial fibrillation, Ventricular tachycardia, Left bundle branch b... OMIM:613838
Muscular Dystrophy-Dystroglycanopathy (Limb-Girdle), Type C, 2
Right bundle branch block OMIM:613158
Sick Sinus Syndrome 4
Abnormal QT interval, Sinus bradycardia, Paroxysmal atrial fibrillation, Chronotropic incompetenc... OMIM:619464
Idiopathic Neonatal Atrial Flutter
Reduced ejection fraction, Arrhythmia, Abnormal left ventricular function, Abnormal EKG, Abnormal... ORPHA:45452
Cardiomyopathy, Familial Hypertrophic, 4
Ventricular fibrillation, Cardiac arrest, Hypertrophic cardiomyopathy, Right bundle branch block,... OMIM:115197
Glycogen Storage Disease With Severe Cardiomyopathy Due To Glycogenin Deficiency
ST segment elevation, Ventricular fibrillation, Ventricular tachycardia, Arrhythmia, T-wave inver... ORPHA:263297
Loeffler Endocarditis
Left ventricular diastolic dysfunction, Aortic regurgitation, Arrhythmia, Congestive heart failur... ORPHA:75566
Pulmonary Hypertension, Primary, 4
Atrial flutter, First degree atrioventricular block, Increased pulmonary vascular resistance, Rig... OMIM:615344
Wolff-Parkinson-White Syndrome
Ventricular preexcitation, Paroxysmal atrial fibrillation, Atrial flutter, Shortened PR interval,... OMIM:194200
Peripartum Cardiomyopathy
Left ventricular systolic dysfunction, Dilated cardiomyopathy, Abnormal T-wave, Sinus tachycardia... ORPHA:563
Atrial Septal Defect, Ostium Secundum Type
Atrial flutter, Systolic heart murmur, Abnormal left ventricular function, Congestive heart failu... ORPHA:99103
Complete Atrioventricular Septal Defect
Abnormal atrioventricular valve physiology, Elevated jugular venous pressure, Systolic heart murm... ORPHA:1329
Ebstein Anomaly
Ventricular preexcitation, Atrial standstill, Sudden cardiac death, Right bundle branch block, At... OMIM:224700
Long Qt Syndrome 14
Sinus bradycardia, Ventricular fibrillation, Cardiac arrest, T-wave alternans, Prolonged QT inter... OMIM:616247
Naxos Disease
Dilated cardiomyopathy, Paroxysmal ventricular tachycardia, Premature ventricular contraction, Co... OMIM:601214
Sick Sinus Syndrome 1
Sinus bradycardia, Sick sinus syndrome, Absent P wave, Prolonged QT interval, Atrioventricular bl... OMIM:608567
Atrial Septal Defect, Ostium Primum Type
Prolonged PR interval, Atrial flutter, Systolic heart murmur, Congestive heart failure, Abnormall... ORPHA:99106
Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation
Dilated cardiomyopathy, Atrial flutter, Abnormal left ventricular function, Congestive heart fail... ORPHA:300751
Tropical Endomyocardial Fibrosis
Abnormal ST segment, Right bundle branch block, Left bundle branch block, Atrial fibrillation, Pu... ORPHA:75565
Brugada Syndrome 3
Sudden cardiac death, Ventricular arrhythmia, Atrial fibrillation, J wave, Syncope, Shortened QT ... OMIM:611875
Plectin-Related Limb-Girdle Muscular Dystrophy R17
Loss of ability to walk, Right bundle branch block ORPHA:254361
Aapoaiv Amyloidosis
Sinus bradycardia, Atrial flutter, Hypertrophic cardiomyopathy, Supravalvular aortic stenosis, Le... ORPHA:439232
Atrial Septal Defect, Coronary Sinus Type
Systolic heart murmur, Arrhythmia, Abnormally loud pulmonic component of the second heart sound, ... ORPHA:99104
Isolated Right Ventricular Hypoplasia
Systolic heart murmur, Congestive heart failure, Abnormal atrioventricular conduction, Right bund... ORPHA:439
Myh7-Related Late-Onset Scapuloperoneal Muscular Dystrophy
Abnormal left ventricular function, Arrhythmia, Left anterior fascicular block, Steppage gait, Hy... ORPHA:437572
Cerebellar Ataxia, Brain Abnormalities, And Cardiac Conduction Defects
Dysmetria, Inability to walk, Ataxia, Right bundle branch block, Mitral regurgitation, Tricuspid ... OMIM:619576
Histiocytoid Cardiomyopathy
Shortened PR interval, Atrial flutter, Polycystic ovaries, Congestive heart failure, Ventricular ... ORPHA:137675
Dysferlin-Related Limb-Girdle Muscular Dystrophy R2
Reduced ejection fraction, Abnormal EKG, Inability to walk, Right bundle branch block, Tip-toe gait ORPHA:268
Ebstein Malformation Of The Tricuspid Valve
Arrhythmia, Congestive heart failure, Sudden cardiac death, Right bundle branch block, Atrial fib... ORPHA:1880
Scorpion Envenomation
Increased circulating troponin I concentration, Premature ventricular contraction, Arrhythmia, Co... ORPHA:466677
Noonan Syndrome With Multiple Lentigines
Arrhythmia, Cryptorchidism, Hypertrophic cardiomyopathy, Bundle branch block, Myocardial infarcti... ORPHA:500
Fabry Disease
Cognitive impairment, Mucosal telangiectasiae, Arrhythmia, Congestive heart failure, Anxiety, Bun... ORPHA:324
Crimean-Congo Hemorrhagic Fever
Subconjunctival hemorrhage, Bundle branch block, Epididymitis, Hypertension, Hematemesis, Subdura... ORPHA:99827
Leopard Syndrome 1
Cryptorchidism, Micropenis, Third degree atrioventricular block, Bundle branch block, Hypertrophi... OMIM:151100
Cutis Laxa, Autosomal Recessive, Type Iid
Congestive heart failure, Micropenis, Hypertrophic cardiomyopathy, Right bundle branch block, Bil... OMIM:617403
Juvenile Dermatomyositis
Gastrointestinal hemorrhage, Arrhythmia, Mucosal telangiectasiae, Bundle branch block, Telangiect... ORPHA:93672
Chronic Thromboembolic Pulmonary Hypertension
Abnormal T-wave, Abnormal left ventricular function, Congestive heart failure, Pulmonary embolism... ORPHA:70591
Eisenmenger Syndrome
Right-to-left shunt, Elevated jugular venous pressure, Ventricular tachycardia, Left-to-right shu... ORPHA:97214
Noonan Syndrome-Like Disorder With Loose Anagen Hair 2
Cryptorchidism, Anxiety, Right bundle branch block, Pulmonic stenosis, Mitral regurgitation, Tric... OMIM:617506
Marbach-Rustad Progeroid Syndrome
Right bundle branch block, Pulmonary insufficiency OMIM:619322
Aortic Arch Interruption
Systolic heart murmur, Aortic regurgitation, Congestive heart failure, Shock, Absent pulse, Right... ORPHA:2299
Neurodevelopmental Disorder With Brain Anomalies, Seizures, And Scoliosis
Right bundle branch block OMIM:618590
Simpson-Golabi-Behmel Syndrome
Cryptorchidism, Supernumerary nipple, Bundle branch block, Hypoplasia of penis, Prolonged QT inte... ORPHA:373
Nestor-Guillermo Progeria Syndrome
Sinus tachycardia, Right bundle branch block, Pulmonary arterial hypertension, Hypertension, Mitr... OMIM:614008
Congenitally Corrected Transposition Of The Great Arteries
Third degree atrioventricular block, Premature atrial contractions, Mobitz I atrioventricular blo... ORPHA:216694
Cutis Laxa, Autosomal Recessive, Type Iic
Tricuspid regurgitation, Right bundle branch block, Bilateral cryptorchidism, Aortic regurgitation OMIM:617402

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ino80

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ino80.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
INO80 requires a polycomb subunit to regulate the establishment of poised chromatin in murine spermatocytes. Development (Cambridge, England) (January 2022) Ino80tm1c(EUCOMM)Hmgu 35006254
Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease. Nature communications (January 2018) Ino80tm1c(EUCOMM)Hmgu Ino80tm1a(EUCOMM)Hmgu PMC5785521
The Mouse INO80 Chromatin-Remodeling Complex Is an Essential Meiotic Factor for Spermatogenesis. Biology of reproduction (November 2015) Ino80tm1c(EUCOMM)Hmgu Ino80tm1a(EUCOMM)Hmgu PMC4809561

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MGI Allele Allele Type Produced
Ino80tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ino80tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Ino80tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice

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