Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
autophagy related 101
Synonyms:
9430023L20Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Atg101 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Atg101 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Pulmonary Hypoplasia, Primary
Neonatal death, Pulmonary hypoplasia OMIM:265430
Lethal Congenital Contracture Syndrome 11
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:617194
Renal Hypodysplasia/Aplasia 4
Pulmonary hypoplasia OMIM:619887
Renal Hypodysplasia/Aplasia 2
Pulmonary hypoplasia OMIM:615721
Mitochondrial Complex I Deficiency, Nuclear Type 35
Neonatal death, Intrauterine growth retardation, Pulmonary hypoplasia OMIM:619003
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 4B
Neonatal death, Pulmonary hypoplasia OMIM:615228
Coenzyme Q10 Deficiency, Primary, 8
Postnatal growth retardation, Intrauterine growth retardation, Pulmonary hypoplasia OMIM:616733
Hydrops Fetalis, Nonimmune, With Gracile Bones And Dysmorphism
Pulmonary hypoplasia OMIM:613124
Larsen-Like Syndrome, Lethal Type
Neonatal death, Pulmonary hypoplasia OMIM:245650
Combined Oxidative Phosphorylation Deficiency 8
Neonatal death, Pulmonary hypoplasia OMIM:614096
Mesomelic Dwarfism-Cleft Palate-Camptodactyly Syndrome
Abnormal lung lobation, Pulmonary hypoplasia ORPHA:2631
Microphthalmia, Syndromic 12
Neonatal death, Pulmonary hypoplasia OMIM:615524
Cortical Dysplasia, Complex, With Other Brain Malformations 9
Short stature, Pulmonary hypoplasia OMIM:618174
Nphp3-Related Meckel-Like Syndrome
Pulmonary hypoplasia ORPHA:3032
Neurodevelopmental Disorder With Spasticity, Hypomyelinating Leukodystrophy, And Brain Abnormalities
Pulmonary hypoplasia OMIM:616531
Renal Tubular Dysgenesis
Pulmonary hypoplasia ORPHA:3033
Spondylospinal Thoracic Dysostosis
Pulmonary hypoplasia OMIM:601809
Arthrogryposis Multiplex Congenita 1, Neurogenic, With Myelin Defect
Stillbirth, Pulmonary hypoplasia OMIM:617468
Lethal Congenital Contracture Syndrome 1
Neonatal death, Pulmonary hypoplasia OMIM:253310
Diaphragmatic Defect-Limb Deficiency-Skull Defect Syndrome
Pulmonary hypoplasia ORPHA:2141
Primary Pulmonary Hypoplasia
Recurrent respiratory infections, Pneumothorax, Abnormal pulmonary artery morphology, Pulmonary h... ORPHA:2257
46,Xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs
Pulmonary artery stenosis, Bilateral lung agenesis, Congenital pulmonary airway malformation, Pul... OMIM:611812
Thanatophoric Dysplasia
Disproportionate short-limb short stature, Pulmonary hypoplasia, Intrauterine growth retardation ORPHA:2655
Growth Delay-Hydrocephaly-Lung Hypoplasia Syndrome
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:3035
Achondrogenesis Type 2
Short stature, Pulmonary hypoplasia ORPHA:93296
Congenital Diaphragmatic Hernia
Pulmonary hypoplasia ORPHA:2140
Lethal Congenital Contracture Syndrome Type 1
Short stature, Pulmonary hypoplasia ORPHA:1486
Matthew-Wood Syndrome
Intrauterine growth retardation, Abnormal lung morphology, Pulmonary hypoplasia ORPHA:2470
Atelosteogenesis, Type Ii
Stillbirth, Pulmonary hypoplasia OMIM:256050
Tonne-Kalscheuer Syndrome
Growth delay, Short stature, Pulmonary hypoplasia OMIM:300978
Spinal Muscular Atrophy With Congenital Bone Fractures 2
Pulmonary hypoplasia OMIM:616867
Multiple Pterygium Syndrome, X-Linked
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:312150
Pallister-Hall-Like Syndrome
Short stature, Pulmonary hypoplasia OMIM:241800
Fetal Akinesia Deformation Sequence
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:994
Dyssegmental Dysplasia, Silverman-Handmaker Type
Neonatal death, Disproportionate short-limb short stature, Severe short stature, Pulmonary hypopl... OMIM:224410
Congenital Myopathy 1B, Autosomal Recessive
Recurrent respiratory infections, Pulmonary hypoplasia OMIM:255320
Serkal Syndrome
Growth delay, Pulmonary hypoplasia ORPHA:139466
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly
Neonatal death, Stillbirth, Pulmonary hypoplasia OMIM:236500
Multiple Pterygium Syndrome, Lethal Type
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:253290
Diaphragmatic Defects, Limb Deficiencies, And Ossification Defects Of Skull
Pulmonary hypoplasia OMIM:601163
Maternal Uniparental Disomy Of Chromosome 2
Postnatal growth retardation, Intrauterine growth retardation, Respiratory infections in early li... ORPHA:96179
Microphthalmia, Syndromic 9
Severe short stature, Short stature, Agenesis of pulmonary vessels, Alveolar capillary dysplasia,... OMIM:601186
Osteochondrodysplasia, Complex Lethal, Symoens-Barnes-Gistelinck Type
Intrauterine growth retardation, Pleural effusion, Pulmonary hypoplasia OMIM:616897
Lissencephaly Type 3-Metacarpal Bone Dysplasia Syndrome
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:86822
Odontochondrodysplasia 1
Recurrent respiratory infections, Mesomelic short stature, Short stature, Pulmonary hypoplasia OMIM:184260
1Q41Q42 Microdeletion Syndrome
Growth delay, Short stature, Pulmonary hypoplasia ORPHA:250999
Thanatophoric Dysplasia, Type I
Neonatal death, Disproportionate short-limb short stature, Lethal short-limbed short stature, Pul... OMIM:187600
Microcephaly-Micromelia Syndrome
Neonatal death, Intrauterine growth retardation, Pulmonary hypoplasia OMIM:251230
Renal-Hepatic-Pancreatic Dysplasia 2
Stillbirth, Abnormal lung lobation, Pulmonary hypoplasia OMIM:615415
Gillessen-Kaesbach-Nishimura Syndrome
Abnormal lung lobation, Pulmonary hypoplasia OMIM:263210
Marden-Walker Syndrome
Postnatal growth retardation, Intrauterine growth retardation, Pulmonary hypoplasia OMIM:248700
Intellectual Developmental Disorder With Cardiac Defects And Dysmorphic Facies
Pulmonary artery atresia, Recurrent respiratory infections, Pulmonary hypoplasia OMIM:618316
Platyspondylic Dysplasia, Torrance Type
Disproportionate short-limb short stature, Pulmonary hypoplasia ORPHA:85166
Platyspondylic Lethal Skeletal Dysplasia, Torrance Type
Stillbirth, Neonatal short-limb short stature, Rhizomelia, Pulmonary hypoplasia OMIM:151210
Diaphanospondylodysostosis
Intrauterine growth retardation, Disproportionate short-trunk short stature, Pulmonary hypoplasia OMIM:608022
Acro-Renal-Mandibular Syndrome
Intrauterine growth retardation, Abnormal lung lobation, Pulmonary hypoplasia ORPHA:958
Alg3-Cdg
Pulmonary hypoplasia ORPHA:79321
Renal Tubular Dysgenesis
Pulmonary hypoplasia OMIM:267430
Nephronophthisis 2
Pulmonary hypoplasia OMIM:602088
Lethal Congenital Contracture Syndrome 10
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:617022
Vacterl Association, X-Linked, With Or Without Hydrocephalus
Neonatal death, Pulmonary hypoplasia OMIM:314390
Gaucher Disease, Perinatal Lethal
Neonatal death, Intrauterine growth retardation, Pulmonary hypoplasia OMIM:608013
Renal Hypodysplasia/Aplasia 1
Pulmonary hypoplasia OMIM:191830
Distal Triplication 15Q
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:314588
Short-Rib Thoracic Dysplasia 19 With Or Without Polydactyly
Pulmonary hypoplasia OMIM:617895
Agnathia-Otocephaly Complex
Pulmonary hypoplasia OMIM:202650
Tetrasomy 5P
Postnatal growth retardation, Recurrent respiratory infections, Pulmonary hypoplasia ORPHA:3309
Teebi Hypertelorism Syndrome 1
Short stature, Pulmonary hypoplasia OMIM:145420
Short-Rib Thoracic Dysplasia 12
Neonatal death, Atelectasis, Pulmonary hypoplasia, Intrauterine growth retardation OMIM:269860
Multiple Acyl-Coa Dehydrogenase Deficiency
Neonatal death, Pulmonary hypoplasia OMIM:231680
Chromosome 1Q41-Q42 Deletion Syndrome
Short stature, Pulmonary hypoplasia OMIM:612530
Pericardial And Diaphragmatic Defect
Pulmonary hypoplasia, Pulmonary sequestration ORPHA:2847
Scimitar Syndrome
Recurrent respiratory infections, Abnormal lung morphology, Partial anomalous pulmonary venous re... ORPHA:185
Severe Congenital Nemaline Myopathy
Pulmonary hypoplasia ORPHA:171430
Short-Rib Thoracic Dysplasia 7 With Or Without Polydactyly
Short stature, Pulmonary hypoplasia OMIM:614091
Atelosteogenesis Type I
Neonatal short-trunk short stature, Rhizomelia, Pulmonary hypoplasia ORPHA:1190
Spinal Muscular Atrophy With Congenital Bone Fractures 1
Pulmonary hypoplasia OMIM:616866
Meacham Syndrome
Partial anomalous pulmonary venous return, Cardiac total anomalous pulmonary venous connection, S... OMIM:608978
Autosomal Recessive Multiple Pterygium Syndrome
Intrauterine growth retardation, Short stature, Pulmonary hypoplasia ORPHA:2990
Short-Rib Thoracic Dysplasia 8 With Or Without Polydactyly
Short stature, Pulmonary hypoplasia OMIM:615503
Dyssegmental Dysplasia, Silverman-Handmaker Type
Severe short stature, Pulmonary hypoplasia ORPHA:1865
Cutis Laxa, Autosomal Recessive, Type Ic
Atelectasis, Recurrent pneumonia, Growth delay, Pulmonary hypoplasia, Emphysema, Peripheral pulmo... OMIM:613177
Neurodegeneration And Seizures Due To Copper Transport Defect
Pneumothorax, Pulmonary hypoplasia OMIM:620306
Congenital Hemidysplasia With Ichthyosiform Erythroderma And Limb Defects
Mild intrauterine growth retardation, Stillbirth, Short stature, Pulmonary hypoplasia OMIM:308050
Achondrogenesis, Type Ia
Stillbirth, Disproportionate short-trunk short stature, Pulmonary hypoplasia OMIM:200600
Gastrointestinal Defects And Immunodeficiency Syndrome 2
Pulmonary hypoplasia, Interstitial emphysema, Bronchiectasis OMIM:619708
Kagami-Ogata Syndrome
Pulmonary hypoplasia OMIM:608149
Mosaic Trisomy 16
Intrauterine growth retardation, Abnormal lung morphology, Pulmonary hypoplasia ORPHA:1708
Vacterl With Hydrocephalus
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:3412
Chromosome 13Q33-Q34 Deletion Syndrome
Short stature, Pulmonary hypoplasia OMIM:619148
Genitopatellar Syndrome
Short stature, Pulmonary hypoplasia ORPHA:85201
Congenital Tracheomalacia
Pneumonia, Pneumothorax, Partial anomalous pulmonary venous return, Bronchiectasis, Recurrent upp... ORPHA:95430
Czeizel-Losonci Syndrome
Pulmonary hypoplasia ORPHA:2437
Achondroplasia
Neonatal short-limb short stature, Rhizomelia, Pulmonary hypoplasia OMIM:100800
Caudal Regression Syndrome
Pulmonary hypoplasia ORPHA:3027
Meckel Syndrome, Type 6
Bilobed right lung, Pulmonary hypoplasia OMIM:612284
Neu-Laxova Syndrome
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:2671
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease
Neonatal death, Pulmonary hypoplasia OMIM:263200
Truncus Arteriosus
Anomalous origin of one pulmonary artery from ascending aorta, Pulmonary artery stenosis, Abnorma... ORPHA:3384
Raine Syndrome
Neonatal death, Short stature, Pulmonary hypoplasia OMIM:259775
Greenberg Dysplasia
Rhizomelia, Abnormal lung lobation, Severe short-limb dwarfism, Stillbirth, Disproportionate shor... OMIM:215140
Short-Rib Thoracic Dysplasia 13 With Or Without Polydactyly
Stillbirth, Rhizomelia, Pulmonary hypoplasia OMIM:616300
B3Galt6-Related Spondylodysplastic Ehlers-Danlos Syndrome
Postnatal growth retardation, Atelectasis, Pulmonary hypoplasia, Repeated pneumothoraces ORPHA:536467
Meckel Syndrome 14
Pneumothorax, Pulmonary hypoplasia OMIM:619879
Tarp Syndrome
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:2886
Congenital Myopathy 17
Respiratory tract infection, Pulmonary hypoplasia OMIM:618975
Mosaic Trisomy 1
Pulmonary artery atresia, Pulmonary hypoplasia ORPHA:1692
Acrocephalopolydactylous Dysplasia
Pulmonary hypoplasia, Extrapulmonary sequestrum OMIM:200995
Atelosteogenesis Type Ii
Rhizomelic arm shortening, Rhizomelia, Pulmonary hypoplasia ORPHA:56304
Lethal Congenital Contracture Syndrome 9
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:616503
Abnormal Origin Of Right Or Left Pulmonary Artery From The Aorta
Recurrent respiratory infections, Aortopulmonary window, Pulmonary hypoplasia, Pulmonary artery a... ORPHA:99050
Stuve-Wiedemann Syndrome 1
Pulmonary arterial medial hypertrophy, Pulmonary hypoplasia, Short stature OMIM:601559
Distal Deletion 15Q
Short stature, Postnatal growth retardation, Growth delay, Pulmonary hypoplasia, Intrauterine gro... ORPHA:1596
Acrorenal-Mandibular Syndrome
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:200980
Oligomeganephronia
Pulmonary venous occlusion, Pulmonary hypoplasia ORPHA:2260
Absence Of The Pulmonary Artery
Recurrent respiratory infections, Recurrent pneumonia, Bronchiectasis, Growth delay, Pulmonary hy... ORPHA:980
Peroxisome Biogenesis Disorder 1A (Zellweger)
Pulmonary hypoplasia OMIM:214100
Short-Rib Thoracic Dysplasia 1 With Or Without Polydactyly
Recurrent respiratory infections, Short stature, Pulmonary hypoplasia OMIM:208500
Congenital Myopathy 22B, Severe Fetal
Pleural effusion, Pulmonary hypoplasia OMIM:620369
Renal Agenesis, Bilateral
Pulmonary hypoplasia ORPHA:1848
Orofaciodigital Syndrome Type 4
Recurrent respiratory infections, Severe short stature, Growth delay, Bilateral lung agenesis, Pu... ORPHA:2753
Pagod Syndrome
Pulmonary artery hypoplasia, Abnormality of the pulmonary artery, Short stature, Pulmonary hypopl... ORPHA:991
Renal Agenesis
Pulmonary hypoplasia ORPHA:411709
Renal-Hepatic-Pancreatic Dysplasia 1
Neonatal death, Pulmonary hypoplasia OMIM:208540
Blomstrand Lethal Chondrodysplasia
Neonatal short-limb short stature, Rhizomelia, Pulmonary hypoplasia ORPHA:50945
Fryns Syndrome
Pulmonary hypoplasia ORPHA:2059
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 1
Pulmonary hypoplasia OMIM:614080
Esophageal Atresia
Growth delay, Recurrent respiratory infections, Pulmonary hypoplasia, Bronchitis ORPHA:1199
Pentalogy Of Cantrell
Pulmonary hypoplasia ORPHA:1335
Smith-Lemli-Opitz Syndrome
Rhizomelia, Short stature, Abnormal lung lobation, Growth delay, Pulmonary hypoplasia, Intrauteri... ORPHA:818
Meier-Gorlin Syndrome 7
Growth delay, Short stature, Pulmonary hypoplasia OMIM:617063
Fetal Akinesia Deformation Sequence 1
Intrauterine growth retardation, Stillbirth, Pulmonary hypoplasia OMIM:208150
Multiple Pterygium Syndrome, Escobar Variant
Short stature, Pulmonary hypoplasia OMIM:265000
Ogden Syndrome
Short stature, Postnatal growth retardation, Pulmonary artery stenosis, Growth delay, Pulmonary h... OMIM:300855
Thoracoabdominal Syndrome
Pulmonary hypoplasia OMIM:313850
Alg9-Cdg
Rhizomelia, Abnormal lung lobation, Pulmonary hypoplasia ORPHA:79328
Fontaine Progeroid Syndrome
Short stature, Pneumothorax, Pulmonary hypoplasia, Neonatal death, Intrauterine growth retardatio... OMIM:612289
Short-Rib Thoracic Dysplasia 20 With Polydactyly
Neonatal death, Pulmonary hypoplasia OMIM:617925
Restrictive Dermopathy 1
Neonatal death, Intrauterine growth retardation, Stillbirth, Pulmonary hypoplasia OMIM:275210
Smith-Lemli-Opitz Syndrome
Short stature, Abnormal lung lobation, Growth delay, Pulmonary hypoplasia, Hypocholesterolemia, I... OMIM:270400
Otopalatodigital Syndrome Type 2
Pulmonary hypoplasia ORPHA:90652
Spondylodysplastic Ehlers-Danlos Syndrome
Short stature, Pulmonary hypoplasia ORPHA:536471
Neu-Laxova Syndrome 1
Neonatal death, Intrauterine growth retardation, Stillbirth, Pulmonary hypoplasia OMIM:256520
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Postnatal growth retardation, Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:83617
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Pulmonary hypoplasia OMIM:616546
Spondylocostal Dysostosis With Anal Atresia And Urogenital Anomalies
Pulmonary hypoplasia OMIM:271520
Fryns Syndrome
Chylothorax, Stillbirth, Pulmonary hypoplasia OMIM:229850
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 2
Pulmonary hypoplasia OMIM:619351
Ulbright-Hodes Syndrome
Postnatal growth retardation, Pneumothorax, Birth length less than 3rd percentile, Severe intraut... ORPHA:3404
Meckel Syndrome, Type 1
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:249000
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Short stature, Postnatal growth retardation, Pulmonary artery stenosis, Growth delay, Pulmonary h... ORPHA:96334
Short-Rib Thoracic Dysplasia 6 With Or Without Polydactyly
Pulmonary hypoplasia OMIM:263520
Osteogenesis Imperfecta
Rhizomelia, Short stature, Growth delay, Pulmonary hypoplasia, Intrauterine growth retardation ORPHA:666
Diaphragmatic Hernia 4, With Cardiovascular Defects
Pulmonary artery hypoplasia, Pulmonary hypoplasia, Aortopulmonary window OMIM:620025
Autosomal Recessive Polycystic Kidney Disease
Growth delay, Recurrent pneumonia, Spontaneous pneumothorax, Pulmonary hypoplasia ORPHA:731
Joubert Syndrome 21
Pulmonary hypoplasia OMIM:615636
Mckusick-Kaufman Syndrome
Pulmonary hypoplasia OMIM:236700
Aphalangy-Hemivertebrae-Urogenital-Intestinal Dysgenesis Syndrome
Pulmonary hypoplasia ORPHA:1112
Tetraamelia Syndrome 1
Peripheral pulmonary vessel aplasia, Pulmonary hypoplasia OMIM:273395
Restrictive Dermopathy
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:1662
Tetrasomy 9P
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:3310
Dpagt1-Cdg
Pulmonary hypoplasia ORPHA:86309
Schinzel-Giedion Syndrome
Recurrent pneumonia, Pulmonary hypoplasia ORPHA:798
Fraser Syndrome 1
Pulmonary hypoplasia OMIM:219000
Penile Agenesis
Bilateral lung agenesis, Pulmonary hypoplasia ORPHA:49
Cardiac-Urogenital Syndrome
Scimitar anomaly, Partial anomalous pulmonary venous return, Pulmonary hypoplasia OMIM:618280
Fraser Syndrome
Abnormal lung lobation, Pulmonary hypoplasia ORPHA:2052
Congenital Total Pulmonary Venous Return Anomaly
Recurrent respiratory infections, Pulmonary artery stenosis, Supracardiac total anomalous pulmona... ORPHA:99125
Short Rib-Polydactyly Syndrome, Verma-Naumoff Type
Disproportionate short-limb short stature, Pulmonary hypoplasia ORPHA:93271
Genitopatellar Syndrome
Pulmonary hypoplasia OMIM:606170
Pallister-Killian Syndrome
Rhizomelia, Mesomelic/rhizomelic limb shortening, Growth delay, Stillbirth, Pulmonary hypoplasia OMIM:601803
Microphthalmia, Syndromic 1
Growth delay, Pulmonary hypoplasia OMIM:309800
Craniofacial Microsomia 1
Pulmonary hypoplasia OMIM:164210

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Atg101

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Atg101.

No publications found that use IMPC mice or data for Atg101.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Atg101tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Atg101tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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