Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Wholemount images | heterozygote | 100% (2 of 2) |
Brain | Wholemount images | heterozygote | 100% (2 of 2) |
Brainstem | Wholemount images | heterozygote | 100% (2 of 2) |
Cartilage tissue | Wholemount images | heterozygote | 100% (2 of 2) |
Cerebellum | Wholemount images | heterozygote | 100% (2 of 2) |
Cerebral cortex | Wholemount images | heterozygote | 100% (2 of 2) |
Gall bladder | Wholemount images | heterozygote | 100% (2 of 2) |
Heart | Wholemount images | heterozygote | 100% (2 of 2) |
Hippocampus | Wholemount images | heterozygote | 100% (2 of 2) |
Hypothalamus | Wholemount images | heterozygote | 100% (2 of 2) |
Kidney | Wholemount images | heterozygote | 100% (2 of 2) |
Large intestine | Wholemount images | heterozygote | 100% (2 of 2) |
Lower urinary tract | Wholemount images | heterozygote | 100% (2 of 2) |
Lung | Wholemount images | heterozygote | 50% (1 of 2) |
Mammary gland | Wholemount images | heterozygote | 50% (1 of 2) |
Olfactory lobe | Wholemount images | heterozygote | 100% (2 of 2) |
Oviduct | Wholemount images | heterozygote | 50% (1 of 2) |
Parathyroid gland | Wholemount images | heterozygote | 100% (2 of 2) |
Peripheral nervous system | Wholemount images | heterozygote | 100% (2 of 2) |
Pituitary gland | Wholemount images | heterozygote | 100% (2 of 2) |
Skin | Wholemount images | heterozygote | 50% (1 of 2) |
Small intestine | Wholemount images | heterozygote | 100% (2 of 2) |
Spinal cord | Wholemount images | heterozygote | 100% (2 of 2) |
Stomach | Wholemount images | heterozygote | 100% (2 of 2) |
Striatum | Wholemount images | heterozygote | 100% (2 of 2) |
Testis | Wholemount images | heterozygote | 50% (1 of 2) |
Thyroid gland | Wholemount images | heterozygote | 50% (1 of 2) |
Trachea | Wholemount images | heterozygote | 100% (2 of 2) |
Vascular system | Wholemount images | heterozygote | 100% (2 of 2) |
Aorta | N/A | heterozygote | 0.0% (0 of 2) |
Bone | N/A | heterozygote | 0.0% (0 of 2) |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
Esophagus | N/A | heterozygote | 0.0% (0 of 2) |
Eye | N/A | heterozygote | 0.0% (0 of 2) |
Liver | N/A | heterozygote | 0.0% (0 of 2) |
Lymph node | N/A | heterozygote | 0.0% (0 of 2) |
Oral epithelium | N/A | heterozygote | 0.0% (0 of 2) |
Ovary | N/A | heterozygote | 0.0% (0 of 2) |
Pancreas | N/A | heterozygote | 0.0% (0 of 2) |
Peyer's patch | N/A | heterozygote | 0.0% (0 of 2) |
Prostate gland | N/A | heterozygote | 0.0% (0 of 2) |
Skeletal muscle | N/A | heterozygote | 0.0% (0 of 2) |
Spleen | N/A | heterozygote | 0.0% (0 of 2) |
Thymus | N/A | heterozygote | 0.0% (0 of 2) |
Uterus | N/A | heterozygote | 0.0% (0 of 2) |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Brain | N/A | heterozygote | 0.0% (0 of 2) |
Brain | N/A | homozygote | 100% (3 of 3) |
Ear | N/A | heterozygote | 0.0% (0 of 2) |
Ear | N/A | homozygote | 33.33% (1 of 3) |
Embryo | N/A | heterozygote | 100% (2 of 2) |
Embryo | N/A | homozygote | 100% (3 of 3) |
Eye | N/A | heterozygote | 0.0% (0 of 2) |
Eye | N/A | homozygote | 33.33% (1 of 3) |
Footplate | N/A | heterozygote | 0.0% (0 of 2) |
Footplate | N/A | homozygote | 33.33% (1 of 3) |
Forebrain | N/A | heterozygote | 0.0% (0 of 2) |
Forebrain | N/A | homozygote | 100% (3 of 3) |
Forelimb | N/A | heterozygote | 0.0% (0 of 2) |
Forelimb | N/A | homozygote | 66.67% (2 of 3) |
Handplate | N/A | heterozygote | 0.0% (0 of 2) |
Handplate | N/A | homozygote | 100% (3 of 3) |
Head | N/A | heterozygote | 0.0% (0 of 2) |
Head | N/A | homozygote | 100% (3 of 3) |
Heart | N/A | heterozygote | 100% (2 of 2) |
Heart | N/A | homozygote | 100% (3 of 3) |
Hindbrain | N/A | heterozygote | 0.0% (0 of 2) |
Hindbrain | N/A | homozygote | 100% (3 of 3) |
Hindlimb | N/A | heterozygote | 0.0% (0 of 2) |
Hindlimb | N/A | homozygote | 66.67% (2 of 3) |
Liver | N/A | heterozygote | 0.0% (0 of 2) |
Liver | N/A | homozygote | 33.33% (1 of 3) |
Lung | N/A | heterozygote | 0.0% (0 of 2) |
Lung | N/A | homozygote | 0.0% (0 of 3) |
Mandibular process | N/A | heterozygote | 0.0% (0 of 2) |
Mandibular process | N/A | homozygote | 33.33% (1 of 3) |
Maxillary process | N/A | heterozygote | 0.0% (0 of 2) |
Maxillary process | N/A | homozygote | 33.33% (1 of 3) |
Midbrain | N/A | heterozygote | 0.0% (0 of 2) |
Midbrain | N/A | homozygote | 66.67% (2 of 3) |
Oral cavity | N/A | heterozygote | 0.0% (0 of 2) |
Oral cavity | N/A | homozygote | 33.33% (1 of 3) |
Skin | N/A | heterozygote | 0.0% (0 of 2) |
Skin | N/A | homozygote | 33.33% (1 of 3) |
Tail somite | N/A | heterozygote | 0.0% (0 of 2) |
Tail somite | N/A | homozygote | 0.0% (0 of 3) |
Tail | N/A | heterozygote | 0.0% (0 of 2) |
Tail | N/A | homozygote | 0.0% (0 of 3) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
bone | 0.0% |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
esophagus | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
heart | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
olfactory lobe | 0.0% |
oral epithelium | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
striatum | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
trachea | 0.0% |
uterus | 0.0% |
vascular system | 0.0% |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
brain | 0.0% |
ear | 0.0% |
embryo | 0.0% |
eye | 0.0% |
footplate | 0.0% |
forebrain | 0.0% |
forelimb | 0.0% |
handplate | 0.0% |
head | 0.0% |
heart | 0.0% |
hindbrain | 0.0% |
hindlimb | 0.0% |
liver | 0.0% |
lung | 0.0% |
mandibular process | 0.0% |
maxillary process | 0.0% |
midbrain | 0.0% |
oral cavity | 0.0% |
skin | 0.0% |
tail | 0.0% |
tail somite group | 0.0% |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Dmac2l by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
22q11 duplication syndrome | Telecanthus | DECIPHER:32 | |
Oculomotor-Levator Synkinesis | Ptosis, Eyelid retraction, Abnormal eyelid morphology | OMIM:151610 | |
Ptosis, Hereditary Congenital 1 | Congenital ptosis | OMIM:178300 | |
Marcus Gunn Phenomenon | Unilateral ptosis, Congenital ptosis | OMIM:154600 | |
Orbital Margin, Hypoplasia Of | Lacrimal duct atresia, Lower eyelid coloboma, Congenital extraocular muscle anomaly | OMIM:165600 | |
Short Tarsus With Absence Of Lower Eyelashes | Absent lower eyelashes, Hypoplasia of the lower eyelids | OMIM:600269 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Dmac2ltm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Dmac2ltm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Dmac2ltm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | Mice |
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