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Gene: Mpc1 MGI:1915240

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
mitochondrial pyruvate carrier 1
Synonyms:
3830411I18Rik,  Brp44l,  0610006G08Rik

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Mpc1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mpc1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mpc1.

There are 15 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation. Cell reports (June 2023) Mpc1tm1c(EUCOMM)Wtsi 37267106
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function. Cell metabolism (April 2022) Mpc1tm1a(EUCOMM)Wtsi PMC9116152
Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity. Nature immunology (May 2021) Mpc1tm1a(EUCOMM)Wtsi PMC7610876
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. Cell metabolism (December 2020) Mpc1tm1c(EUCOMM)Wtsi 33333007
Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Cells (April 2020) Mpc1tm1c(EUCOMM)Wtsi 32290105
T Cell-Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation. Journal of immunology (Baltimore, Md. : 1950) (March 2020) Mpc1tm1c(EUCOMM)Wtsi 32161096
Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development. Cell reports (March 2020) Mpc1tm1c(EUCOMM)Wtsi PMC7170217
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier. Cell metabolism (December 2019) Mpc1tm1c(EUCOMM)Wtsi 31813825
Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis. Cell reports (September 2019) Mpc1tm1c(EUCOMM)Wtsi Mpc1tm1a(EUCOMM)Wtsi PMC6746334
Loss of MPC1 reprograms retinal metabolism to impair visual function. Proceedings of the National Academy of Sciences of the United States of America (February 2019) Mpc1tm1c(EUCOMM)Wtsi PMC6397593
Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II-driven respiration. The Journal of biological chemistry (November 2018) Mpc1tm1c(EUCOMM)Wtsi 30385511
Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. Cell reports (October 2018) Mpc1tm1a(EUCOMM)Wtsi PMC6349418
The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity. Molecular metabolism (September 2017) Mpc1tm1c(EUCOMM)Wtsi PMC5681281
Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. Nature cell biology (August 2017) Mpc1tm1c(EUCOMM)Wtsi 28812582
Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis. Cell metabolism (September 2015) Mpc1tm1c(EUCOMM)Wtsi Mpc1tm1a(EUCOMM)Wtsi PMC4754674

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Mpc1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Mpc1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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