Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

cyclin Y
4631402G10Rik,  3110050L10Rik,  1700025H17Rik,  5730405I09Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ccny mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ccny by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Lipodystrophy, Familial Partial, Type 7
Decreased adipose tissue around neck, Lack of facial subcutaneous fat, Loss of subcutaneous adipo... OMIM:606721
Mental Retardation, Autosomal Dominant 33
Hyperactivity, Decreased body weight OMIM:616311
Chylomicron Retention Disease
Failure to thrive, Hypocholesterolemia, Hypotriglyceridemia, Steatorrhea, Hypoalbuminemia, Decrea... OMIM:246700
Lipodystrophy, Congenital Generalized, Type 3
Hepatomegaly, Lipodystrophy, Reduced subcutaneous adipose tissue, Generalized lipodystrophy, Sple... OMIM:612526
Lipodystrophy, Familial Partial, Type 5
Hepatomegaly, Abnormal circulating lipid concentration, Lipodystrophy, Hepatic steatosis, Hypertr... OMIM:615238
Obesity, Decreased resting energy expenditure, Increased waist to hip ratio OMIM:601665
Gaucher Disease, Atypical, Due To Saposin C Deficiency
Hypocholesterolemia, Hepatomegaly, Hypersplenism, Splenomegaly OMIM:610539
Severe Neurodegenerative Syndrome With Lipodystrophy
Hepatomegaly, Reduced subcutaneous adipose tissue, Reduced intraabdominal adipose tissue, General... ORPHA:363400
Mental Retardation, Autosomal Dominant 45
Hyperactivity, Attention deficit hyperactivity disorder OMIM:617600
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Hyperactivity, Large for gestational age ORPHA:356996
Squalene Synthase Deficiency
Failure to thrive in infancy, Hypocholesterolemia, Increased circulating farnesol concentration, ... OMIM:618156
Bile Acid Synthesis Defect, Congenital, 1
Hepatomegaly, Giant cell hepatitis, Acholic stools, Failure to thrive, Hypocholesterolemia, Hyper... OMIM:607765
Lipase Deficiency, Combined
Pancreatitis, Lipodystrophy, Hypertriglyceridemia OMIM:246650
Congenital Disorder Of Glycosylation, Type Ia
Hepatomegaly, Hepatic fibrosis, Failure to thrive, Hypocholesterolemia, Abnormal subcutaneous fat... OMIM:212065
Microcephaly, Congenital Cataract, And Psoriasiform Dermatitis
Failure to thrive, Decreased LDL cholesterol concentration, Hypocholesterolemia OMIM:616834
Potocki-Lupski Syndrome
Failure to thrive, Hyperactivity, Hypocholesterolemia, Small for gestational age OMIM:610883
Insulin-Like Growth Factor I Deficiency
Hyperactivity, Decreased body weight OMIM:608747
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Intellectual Developmental Disorder, Autosomal Recessive 54
Hyperactivity OMIM:617028
Schizophrenia 15
Hyperactivity OMIM:613950
Elevated circulating transferrin concentration, Increased LDL cholesterol concentration, Lipodyst... OMIM:616000
Encephalopathy, Progressive, With Or Without Lipodystrophy
Dystonia, Hepatomegaly, Hyperactivity, Ataxia, Hypertriglyceridemia OMIM:615924
Peroxisome Biogenesis Disorder 3B
Failure to thrive, Hepatomegaly, Hypocholesterolemia, Steatorrhea OMIM:266510
Chylomicron Retention Disease
Failure to thrive, Hypocholesterolemia, Increased hepatocellular lipid droplets, Hepatic steatosi... ORPHA:71
X-Linked Intellectual Disability, Stocco Dos Santos Type
Hyperactivity, Small for gestational age ORPHA:85288
Mandibuloacral Dysplasia
Loss of subcutaneous adipose tissue in limbs, Reduced intrathoracic adipose tissue, Increased adi... ORPHA:2457
Developmental And Epileptic Encephalopathy 43
Hyperactivity, Ataxia OMIM:617113
Maternal Uniparental Disomy Of Chromosome 4
Hypocholesterolemia, Dysmetria, Spastic gait, Elevated circulating creatine kinase concentration,... ORPHA:96180
Hepatomegaly, Decreased HDL cholesterol concentration, Hepatic fibrosis, Failure to thrive, Hypoc... ORPHA:14
Autism Spectrum Disorder Due To Auts2 Deficiency
Small for gestational age, Joint contracture of the hand, Arthrogryposis multiplex congenita, Ing... ORPHA:352490
Lipodystrophy, Familial Partial, Type 2
Increased facial adipose tissue, Hepatomegaly, Decreased HDL cholesterol concentration, Loss of s... OMIM:151660
Hyponatremia, Hypoalbuminemia, Hypocholesterolemia, Failure to thrive, Abnormal adipose tissue mo... ORPHA:79324
8p23.1 deletion syndrome
Hyperactivity, Congenital diaphragmatic hernia DECIPHER:39
Congenital Analbuminemia
Hypoproteinemia, Hyperlipidemia, Small for gestational age, Lipodystrophy, Hypercholesterolemia, ... ORPHA:86816
Chromosome 3Q29 Deletion Syndrome
Failure to thrive, Hyperactivity, Gait ataxia, Small for gestational age OMIM:609425
Neurodevelopmental Disorder With Motor And Speech Delay And Behavioral Abnormalities
Hyperactivity, Broad-based gait, Elbow flexion contracture OMIM:619470
Juvenile Huntington Disease
Dystonia, Weight loss, Bradykinesia, Hyperactivity, Progressive cerebellar ataxia, Ataxia, Broad-... ORPHA:248111
Citrullinemia, Type Ii, Neonatal-Onset
Decreased HDL cholesterol concentration, Failure to thrive, Hyperbilirubinemia, Hypercholesterole... OMIM:605814
Dihydropyrimidine Dehydrogenase Deficiency
Failure to thrive, Hyperactivity, Lethargy OMIM:274270
Citrullinemia Type Ii
Hepatomegaly, Hypoproteinemia, Decreased HDL cholesterol concentration, Hepatic fibrosis, Hyperli... ORPHA:247585
Coffin-Siris Syndrome 8
Failure to thrive, Hyperactivity OMIM:618362
Hyperphosphatasia With Mental Retardation Syndrome 6
Hip contracture, Elevated circulating creatine kinase concentration, Knee flexion contracture, Hy... OMIM:616809
Morm Syndrome
Hyperactivity, Truncal obesity ORPHA:75858
Hyperprolinemia, Type I
Hyperprolinemia, Hyperactivity, Ataxia OMIM:239500
Intellectual Developmental Disorder With Abnormal Behavior, Microcephaly, And Short Stature
Hyperactivity, Decreased body weight OMIM:618342
Glycine Encephalopathy
Hyperactivity, Hyperglycinemia, Lethargy OMIM:605899
Pontocerebellar Hypoplasia, Hypotonia, And Respiratory Insufficiency Syndrome, Neonatal Lethal
Hypocholesterolemia, Hepatomegaly OMIM:618810
Neurodevelopmental Disorder With Epilepsy And Hypoplasia Of The Corpus Callosum
Dysmetria, Gait disturbance, Inability to walk, Hyperactivity OMIM:618090
Smith-Magenis Syndrome
Hypercholesterolemia, Hyperactivity, Hypertriglyceridemia, Increased body weight OMIM:182290
13Q12.3 Microdeletion Syndrome
Failure to thrive, Congenital diaphragmatic hernia, Hyperactivity, Camptodactyly, Obesity ORPHA:412035
Chromosome 15Q25 Deletion Syndrome
Hyperactivity, Attention deficit hyperactivity disorder, Inguinal hernia, Congenital diaphragmati... OMIM:614294
Language Delay And Attention Deficit-Hyperactivity Disorder/Cognitive Impairment With Or Without Cardiac Arrhythmia
Hyperactivity, Attention deficit hyperactivity disorder OMIM:617182
Neurodevelopmental Disorder With Movement Abnormalities, Abnormal Gait, And Autistic Features
Failure to thrive, Hyperactivity, Unsteady gait, Broad-based gait OMIM:617865
Kaufman Oculocerebrofacial Syndrome
Failure to thrive, Hypocholesterolemia OMIM:244450
Hyperactivity, Attention deficit hyperactivity disorder, Maternal hyperphenylalaninemia, Hyperphe... OMIM:261600
Clark-Baraitser Syndrome
Hyperactivity, Obesity OMIM:617752
Clcn4-Related X-Linked Intellectual Disability Syndrome
Progressive cerebellar ataxia, Hyperactivity, Unsteady gait, Inguinal hernia ORPHA:485350
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Hyperactivity, Obesity, Ataxia, Broad-based gait ORPHA:411515
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Failure to thrive, Hepatic necrosis, Abnormal circulating acetylcarnitine concentration, Mildly e... ORPHA:71212
19P13.12 Microdeletion Syndrome
Hyperlipidemia, Arthrogryposis multiplex congenita, Hyperactivity, Hepatic steatosis, Obesity ORPHA:254346
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome
Athetosis, Hepatomegaly, Microvesicular hepatic steatosis, Dystonia, Limb joint contracture, Ling... ORPHA:404454
X-Linked Cerebral Adrenoleukodystrophy
Gait disturbance, Dysmetria, Hamstring contractures, Abnormal circulating fatty-acid concentratio... ORPHA:139396
Mental Retardation, Autosomal Recessive 13
Hyperactivity, Truncal obesity OMIM:613192
Neurodevelopmental Disorder With Brain Abnormalities, Poor Growth, And Dysmorphic Facies
Failure to thrive, Hyperactivity OMIM:615286
Smith-Lemli-Opitz Syndrome
Elevated 7-dehydrocholesterol, Failure to thrive, Hypocholesterolemia, Cholestatic liver disease,... OMIM:270400
Secondary Intestinal Lymphangiectasia
Decreased prealbumin level, Hypocholesterolemia, Reduced circulating transferrin concentration, C... ORPHA:90363
Mucopolysaccharidosis, Type Iiic
Hyperactivity, Hepatomegaly, Hernia, Splenomegaly OMIM:252930
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Small for gestational age, Neonatal hyperbilirubinemia, Failure to thrive, Truncal obesity, Hyper... ORPHA:73272
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Hyperactivity, Obesity, Shuffling gait, Broad-based gait ORPHA:3077
Myopathy With Extrapyramidal Signs
Hepatomegaly, Dystonia, Elevated circulating creatine kinase concentration, Hypervalinemia, Extre... OMIM:615673
Inverted Duplicated Chromosome 15 Syndrome
Hyperactivity, Hernia ORPHA:3306
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency
Hyperactivity, Dystonia, Ataxia, Transient hyperphenylalaninemia OMIM:612716
Intellectual Disability-Obesity-Prognathism-Eye And Skin Anomalies Syndrome
Hyperactivity, Obesity ORPHA:397973
Legius Syndrome
Dystonia, Xanthelasma, Hyperactivity, Attention deficit hyperactivity disorder, Multiple lipomas ORPHA:137605
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Lethargy, Hepatomegaly, Hypoproteinemia, Small for gestational age, Elevated circulating creatine... ORPHA:26793
Intellectual Developmental Disorder, X-Linked, Syndromic, Snijders Blok Type
Hyperactivity, Decreased body weight, Broad-based gait OMIM:300958
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Hyperactivity, Attention deficit hyperactivity disorder OMIM:301008
Mental Retardation, Autosomal Dominant 7
Gait disturbance, Failure to thrive in infancy, Small for gestational age, Hyperactivity, Ataxia OMIM:614104
Intellectual Developmental Disorder, X-Linked, Syndromic, Claes-Jensen Type
Failure to thrive, Shuffling gait, Cholelithiasis, Hyperactivity, Flexion contracture, Decreased ... OMIM:300534
Tangier Disease
Hypocholesterolemia, Hepatosplenomegaly, Hypertriglyceridemia ORPHA:31150
Infantile Neuroaxonal Dystrophy
Dystonia, Gait disturbance, Hyperactivity, Ataxia, Flexion contracture, Unsteady gait ORPHA:35069
Cri-Du-Chat Syndrome
Hyperactivity, Difficulty walking, Small for gestational age, Inguinal hernia OMIM:123450
Intellectual Disability, Birk-Barel Type
Contractures involving the joints of the feet, Hyperactivity, Congenital finger flexion contractures ORPHA:166108
Spastic Paraplegia 29, Autosomal Dominant
Hyperactivity, Hiatus hernia, Neonatal hyperbilirubinemia OMIM:609727
Intellectual Developmental Disorder, X-Linked 107
Hyperactivity, Obesity, Attention deficit hyperactivity disorder OMIM:301013
Severe Motor And Intellectual Disabilities-Sensorineural Deafness-Dystonia Syndrome
Failure to thrive, Hyperactivity ORPHA:369939
Graves Disease, Susceptibility To, 1
Hyperactivity, Weight loss OMIM:275000
X-Linked Creatine Transporter Deficiency
Athetosis, Dystonia, Cachexia, Abnormal circulating creatine concentration, Hyperactivity, Ataxia ORPHA:52503
Bone Marrow Failure Syndrome 3
Failure to thrive, Hernia, Amelogenesis imperfecta, Hyperactivity, Enamel hypoplasia, Exocrine pa... OMIM:617052
X-Linked Intellectual Disability, Cabezas Type
Cachexia, Hyperactivity, Broad-based gait, Camptodactyly of finger, Obesity, Inguinal hernia ORPHA:85293
Intellectual Disability-Strabismus Syndrome
Gait disturbance, Congenital finger flexion contractures, Failure to thrive, Congenital diaphragm... ORPHA:363528
Mucopolysaccharidosis, Type Iiid
Hyperactivity, Hepatomegaly, Flexion contracture, Splenomegaly OMIM:252940
Cln5 Disease
Dysmetria, Hyperactivity, Inability to walk, Dysdiadochokinesis, Ataxia, Truncal ataxia, Unsteady... ORPHA:228360
Hyperlysinemia, Type I
Hyperactivity, Hyperlysinemia OMIM:238700
Glass Syndrome
Hyperactivity, Inguinal hernia, Broad-based gait, Camptodactyly OMIM:612313
16P12.1P12.3 Triplication Syndrome
Failure to thrive, Hyperactivity, Attention deficit hyperactivity disorder, Abnormality of the in... ORPHA:485405
Neurodevelopmental Disorder With Or Without Autism Or Seizures
Failure to thrive, Hyperactivity OMIM:619239
Mental Retardation, X-Linked 77
Hyperactivity OMIM:300454
Pediatric-Onset Graves Disease
Hepatomegaly, Failure to thrive, Splenomegaly, Hyperactivity, Elevated hepatic transaminase, Jaun... ORPHA:525731
Guanidinoacetate Methyltransferase Deficiency
Hyperactivity, Dystonia, Athetosis, Ataxia ORPHA:382
Intellectual Developmental Disorder, X-Linked, Syndromic, Lujan-Fryns Type
Hyperactivity, Flexion contracture OMIM:309520
White-Sutton Syndrome
Congenital diaphragmatic hernia, Hyperactivity, Ventral hernia, Obesity, Inguinal hernia ORPHA:468678
Hepatomegaly, Portal fibrosis, Spastic gait, Micronodular cirrhosis, Hyperammonemia, Hyperactivit... OMIM:207800
Insensitivity To Pain, Congenital, With Anhidrosis
Corneal scarring, Hyperactivity OMIM:256800
Cntnap2-Related Developmental And Epileptic Encephalopathy
Hyperactivity, Obesity, Hepatomegaly, Ataxia ORPHA:163681
Hypomagnesemia, Seizures, And Mental Retardation 2
Hypomagnesemia, Hyperactivity, Hypokalemia OMIM:618314
Noonan Syndrome-Like Disorder With Loose Anagen Hair 1
Failure to thrive, Large for gestational age, Hyperactivity, Attention deficit hyperactivity diso... OMIM:607721
Brooks-Wisniewski-Brown syndrome
Hyperactivity, Flexion contracture, Small for gestational age OMIM:300612
Hypoornithinemia, Failure to thrive, Dysmetria, Hyperammonemia, Hyperactivity, Tip-toe gait, Hype... ORPHA:2203
Monosomy 9Q22.3
Hyperactivity, Umbilical hernia, Large for gestational age ORPHA:77301
Dyrk1A-Related Intellectual Disability Syndrome
Gait disturbance, Small for gestational age, Failure to thrive, Hyperactivity, Multiple joint con... ORPHA:464306
Hyperthyroidism, Nonautoimmune
Hyperactivity, Small for gestational age OMIM:609152
Early Infantile Epileptic Encephalopathy
Dystonia, Failure to thrive, Hyperactivity, Episodic ataxia, Umbilical hernia ORPHA:1934
Distal Monosomy 12Q
Failure to thrive in infancy, Annular pancreas, Hyperactivity, Biliary atresia, Obesity, Elbow fl... ORPHA:96149
Familial Hyperthyroidism Due To Mutations In Tsh Receptor
Hyperactivity, Weight loss, Small for gestational age ORPHA:424
Neurodegeneration With Brain Iron Accumulation 2B
Dystonia, Dysmetria, Bradykinesia, Hyperactivity, Dysdiadochokinesis, Gait ataxia OMIM:610217
Familial Gestational Hyperthyroidism
Hyperactivity, Weight loss ORPHA:99819
Mend Syndrome
Failure to thrive, Hyperactivity, Elevated 8(9)-cholestenol, Elevated 8-dehydrocholesterol ORPHA:401973
Hepatomegaly, Lingual dystonia, Loss of ambulation, Elevated circulating creatine kinase concentr... ORPHA:2388
Microcephaly-Corpus Callosum Hypoplasia-Intellectual Disability-Facial Dysmorphism Syndrome
Hyperactivity, Inguinal hernia ORPHA:457284
Tuberous Sclerosis Complex
Attention deficit hyperactivity disorder, Hyperactivity, Hepatic cysts, Shagreen patch ORPHA:805
Monosomy 22Q13.3
Hyperactivity, Obesity, Umbilical hernia ORPHA:48652
Spastic Tetraplegia-Thin Corpus Callosum-Progressive Postnatal Microcephaly Syndrome
Multiple joint contractures, Hyperactivity ORPHA:447997
Neurodegeneration With Brain Iron Accumulation 1
Dystonia, Gait disturbance, Bradykinesia, Hyperactivity, Ataxia, Akinesia, Blepharospasm OMIM:234200
Hereditary Sensory And Autonomic Neuropathy Type 4
Corneal scarring, Fasciitis, Hyperactivity, Atypical scarring of skin, Difficulty walking ORPHA:642
Hyperhistidinemia, Hyperactivity ORPHA:2157


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ccny

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ccny.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex. The EMBO journal (August 2021) Ccnyl1tm1a(EUCOMM)Wtsi PMC8488556
Correction: CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse. PLoS genetics (March 2019) Ccnyl1tm1a(EUCOMM)Wtsi PMC6398826
Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells. PLoS genetics (May 2016) Ccnyl1tm1a(EUCOMM)Wtsi PMC4874687
Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation. Cell (November 2015) Ccnyl1tm1a(EUCOMM)Wtsi 26590424
CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse. PLoS genetics (August 2015) Ccnyl1tm1a(EUCOMM)Wtsi PMC4549061

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