Pold3 | polymerase (DNA-directed), delta 3, accessory subunit

GeneMGI:1915217Synonyms: C85233, P68, +3 more

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Mortality/aging

16 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

1Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased circulating insulin level	1 supporting dataset	Pold3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.64x10^-47
preweaning lethality, complete penetrance	1 supporting dataset	Pold3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Pold3^{tm1b(EUCOMM)Wtsi}	homozygote	E9.5	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Pold3^{tm1b(EUCOMM)Wtsi}	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pold3.

Associated images

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Histopathology

There is no histopathology data found for Pold3.

IMPC related publications

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External links

No external links available for Pold3.

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*Pold3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pold3^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pold3^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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