Ppp6c | protein phosphatase 6, catalytic subunit
Physiological systems
19 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Limbs/digits/tail Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton Mortality/aging
12 No significant impact
5 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Ppp6ctm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal auditory brainstem response | 1 supporting dataset | Ppp6ctm1b(EUCOMM)Hmgu | heterozygote | Early adult | 8.6x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Ppp6ctm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.02x10-6 | ||
| short tibia | 1 supporting dataset | Ppp6ctm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.88x10-5 | ||
| abnormal locomotor behavior | 1 supporting dataset | Ppp6ctm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.32x10-5 | ||
| increased mean corpuscular volume | 1 supporting dataset | Ppp6ctm1b(EUCOMM)Hmgu | heterozygote | Early adult | 8.5x10-5 | ||
| decreased blood urea nitrogen level | 1 supporting dataset | Ppp6ctm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.65x10-5 | ||
| abnormal vocalization | 1 supporting dataset | Ppp6ctm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.04x10-5 |
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Human diseases caused by Ppp6c mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ppp6c.
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| Ppp6ctm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ppp6ctm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ppp6ctm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |