Gene: Sfr1 MGI:1915038
Log in to followPhenotypes
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
preweaning lethality, complete penetrance | Sfr1em1(IMPC)Mbp | HOM | Early adult | 0.00 | ||
abnormal embryo size | Sfr1em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
embryonic growth retardation | Sfr1em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
increased circulating aspartate transaminase level | Sfr1em1(IMPC)Mbp | HET | Early adult | 1.13×10-07 | ||
abnormal somite shape | Sfr1em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
abnormal neural tube morphology | Sfr1em1(IMPC)Mbp | HOM | E9.5 | 0.00 |
Human diseases caused by Sfr1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Sfr1 by phenotypic similarity.
Histopathology
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Sfr1
Order Mouse and ES Cells
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
This service may be affected by the Covid-19 pandemic. See how
MGI Allele | Allele Type | Produced |
---|---|---|
Sfr1tm119361(L1L2_Pgk_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Sfr1em1(IMPC)Mbp | Exon Deletion | Mice, Tissue |
Sfr1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
Sfr1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
The IMPC Newsletter
Get highlights of the most important data releases, news and events, delivered straight to your email inbox
Subscribe to newsletter