Gene Summary

zinc finger, MYM-type 4
Zfp262,  6330503C17Rik

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating amylase level Zmym4em1(IMPC)Wtsi HET Early adult 8.92×10-05
increased circulating cholesterol level Zmym4em1(IMPC)Wtsi HET   Early adult 1.35×10-06
increased circulating calcium level Zmym4em1(IMPC)Wtsi HET Early adult 7.83×10-06
increased circulating HDL cholesterol level Zmym4em1(IMPC)Wtsi HET   Early adult 1.32×10-05
increased circulating glycerol level Zmym4em1(IMPC)Wtsi HET Early adult 3.20×10-06
decreased body length Zmym4em1(IMPC)Wtsi HET   Early adult 1.45×10-06
decreased circulating fructosamine level Zmym4em1(IMPC)Wtsi HET Early adult 2.23×10-06
decreased bone mineral content Zmym4em1(IMPC)Wtsi HET   Early adult 3.76×10-05

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Zmym4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Zmym4 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Hypertriglyceridemia 2
Hypertriglyceridemia, Decreased HDL cholesterol concentration, Hypercholesterolemia OMIM:619324
Xanthomatosis, Susceptibility To
Hypercholesterolemia OMIM:602247
Thyroid Hormone Metabolism, Abnormal, 2
Hypercholesterolemia OMIM:619855
Sitosterolemia 2
Elevated circulating sitosterol concentration, Hypercholesterolemia OMIM:618666
Cholesterol-Ester Transfer Protein Deficiency
Increased HDL cholesterol concentration, Hyperlipoproteinemia, Hyperlipidemia, Hypercholesterolem... ORPHA:79506
Hyperlipoproteinemia, Type Ii, And Deafness
Increased LDL cholesterol concentration, Hypertriglyceridemia, Hypercholesterolemia OMIM:144300
Glycogen Storage Disease Vi
Hypertriglyceridemia, Hyperlipidemia, Hypercholesterolemia OMIM:232700
Hypercholesterolemia, Familial, 4
Hypertriglyceridemia, Decreased LDL cholesterol concentration, Hypercholesterolemia OMIM:603813
Ulna Metaphyseal Dysplasia Syndrome
Hypercalcemia OMIM:191420
Coronary Artery Disease, Autosomal Dominant, 1
Hypercholesterolemia OMIM:608320
Hyperlipidemia, Familial Combined, 3
Hypercholesterolemia, Increased VLDL cholesterol concentration, Elevated circulating apolipoprote... OMIM:144250
Congenital Disorder Of Glycosylation, Type Iip
Decreased circulating ceruloplasmin concentration, Increased LDL cholesterol concentration, Hyper... OMIM:616829
Blue Diaper Syndrome
Abnormal circulating tryptophan concentration, Hypercalcemia OMIM:211000
Hypercalcemia ORPHA:55881
Hyperparathyroidism 4
Osteopenia, Hypercalcemia OMIM:617343
Elevated circulating transferrin concentration, Increased LDL cholesterol concentration, Hypercho... OMIM:616000
Diarrhea 7, Protein-Losing Enteropathy Type
Hypoalbuminemia, Hyperlipidemia, Hypercholesterolemia OMIM:615863
Hypothyroidism, Congenital, Nongoitrous, 8
Hypercholesterolemia OMIM:301033
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 1
Hypoalbuminemia, Hypercholesterolemia OMIM:607250
Morbid Obesity And Spermatogenic Failure
Increased LDL cholesterol concentration, Hypertriglyceridemia, Decreased HDL cholesterol concentr... OMIM:615703
Hypocalcemia, Autosomal Dominant 2
Abnormal blood phosphate concentration, Hypocalcemia OMIM:615361
Hyperparathyroidism 1
Hypercalcemia OMIM:145000
Nephropathy-Deafness-Hyperparathyroidism Syndrome
Hypercalcemia, Bone cyst ORPHA:2668
Familial Apolipoprotein Gene Cluster Deletion Syndrome
Hypocholesterolemia, Decreased circulating apolipoprotein A-I concentration, Decreased HDL choles... OMIM:620058
Distal Myopathy, Tateyama Type
Abnormal circulating creatine kinase concentration, Hypercholesterolemia ORPHA:488650
Cholestasis, Progressive Familial Intrahepatic, 10
Increased total bilirubin, Increased serum bile acid concentration, Hypercholesterolemia, Conjuga... OMIM:619868
Hepatic Lipase Deficiency
Hypercholesterolemia, Hypertriglyceridemia, Increased HDL cholesterol concentration OMIM:614025
Spinocerebellar Ataxia With Axonal Neuropathy Type 1
Hypoalbuminemia, Hypercholesterolemia ORPHA:94124
Hypoparathyroidism, Familial Isolated, 2
Hyperphosphatemia, Hypocalcemia, Hypocalcemic seizures OMIM:618883
Parathyroid Carcinoma
Hypercalcemia OMIM:608266
Hypercalcemia, Infantile, 2
Hypophosphatemia, Hypercalcemia OMIM:616963
Granulomatous Slack Skin
Hypercalcemia ORPHA:33111
Tumoral Calcinosis, Hyperphosphatemic, Familial, 3
Hyperphosphatemia, Metacarpal periosteal thickening, Calvarial osteosclerosis, Osteopenia, Hyperc... OMIM:617994
Lipodystrophy, Congenital Generalized, Type 3
Hypocalcemia, Hypertriglyceridemia, Hypercholesterolemia OMIM:612526
Familial Isolated Hyperparathyroidism
Osteopenia, Hypophosphatemia, Generalized osteoporosis, Hypercalcemia ORPHA:99879
Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies
Osteopenia, Craniosynostosis, Hypercalcemia OMIM:614732
22q11 deletion syndrome (Velocardiofacial / DiGeorge syndrome)
Hypocalcemia DECIPHER:16
Congenital Disorder Of Glycosylation, Type Iio
Hypercholesterolemia, Decreased circulating ceruloplasmin concentration, Increased LDL cholestero... OMIM:616828
Glycogen Storage Disease Ixa1
Hypertriglyceridemia, Hyperuricemia, Hypercholesterolemia OMIM:306000
Myopathy, Tubular Aggregate, 2
Hypocalcemia, Elevated circulating creatine kinase concentration OMIM:615883
Hypercholesterolemia, Familial, 3
Hypercholesterolemia, Abnormal LDL cholesterol concentration, Xanthelasma OMIM:603776
Hypercholesterolemia, Familial, 2
Hypercholesterolemia, Increased LDL cholesterol concentration, Xanthelasma OMIM:144010
Cholesteryl Ester Storage Disease
Hypertriglyceridemia, Hypercholesterolemia ORPHA:75234
Vitamin D-Dependent Rickets, Type 3
Hypophosphatemia, Hypocalcemia, Osteopenia OMIM:619073
Craniosynostosis, Hypercalcemia ORPHA:436
Hypomagnesemia 1, Intestinal
Hypocalcemia, Hypomagnesemia OMIM:602014
Small Cell Carcinoma Of The Bladder
Hypercalcemia ORPHA:284400
Diffuse Neonatal Hemangiomatosis
Hypercalcemia ORPHA:2123
Blue Diaper Syndrome
Hyperphosphatemia, Hypercalcemia ORPHA:94086
Growth Hormone Insensitivity Syndrome
Hypercholesterolemia ORPHA:181393
Hyperparathyroidism, Neonatal Self-Limited Primary, With Hypercalciuria
Hypercalcemia OMIM:239199
Infantile Myofibromatosis
Osteolysis, Hypercalcemia, Bone cyst ORPHA:2591
Apolipoprotein C-Ii Deficiency
Hypercholesterolemia, Increased circulating chylomicron concentration, Hypertriglyceridemia, Decr... OMIM:207750
Pseudohypoparathyroidism, Type Ii
Hyperphosphatemia, Hypocalcemia OMIM:203330
Hypophosphatemic Rickets And Hyperparathyroidism
Rickets, Hypophosphatemia, Hypophosphatemic rickets, Hypercalcemia OMIM:612089
Hypercalcemia, Infantile, 1
Hypercalcemia OMIM:143880
Progressive Familial Intrahepatic Cholestasis
Hypocalcemia, Reduced bone mineral density ORPHA:172
Ataxia-Oculomotor Apraxia 4
Hypoalbuminemia, Elevated circulating alpha-fetoprotein concentration, Hypercholesterolemia OMIM:616267
Rhabdoid Tumor
Hypercalcemia ORPHA:69077
Thymic Neuroendocrine Tumor
Osteopenia, Hypercalcemia, Increased circulating cortisol level ORPHA:97289
Glycogen Storage Disease Due To Lactate Dehydrogenase M-Subunit Deficiency
Hypercalcemia, Elevated creatine kinase after exercise ORPHA:284426
Hypophosphatasia, Infantile
Elevated plasma pyrophosphate, Unossified vertebral bodies, Decreased calvarial ossification, Hyp... OMIM:241500
Paget Disease Of Bone 2, Early-Onset
Osteolysis, Osteosclerosis of the ulna, Sclerosis of skull base, Hypercalcemia OMIM:602080
Morgagni-Stewart-Morel Syndrome
Hyperostosis frontalis interna, Hyperuricemia, Osteoporosis, Hypercholesterolemia ORPHA:77296
Oculoskeletodental Syndrome
Hypocalcemia, Hypercalcemia ORPHA:557003
Familial Isolated Hypoparathyroidism Due To Agenesis Of Parathyroid Gland
Hyperphosphatemia, Hypocalcemia, Hypomagnesemia, Hypocalcemic seizures ORPHA:2239
Autosomal Recessive Kenny-Caffey Syndrome
Hypocalcemic tetany, Calvarial osteosclerosis, Cortical thickening of long bone diaphyses, Decrea... ORPHA:93324
Hyperparathyroidism 2 With Jaw Tumors
Hypercalcemia OMIM:145001
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia
Hypercholesterolemia, Hypoalbuminemia, Elevated circulating creatine kinase concentration OMIM:208920
Fibrous Dysplasia Of Bone
Thin bony cortex, Increased circulating cortisol level, Osteomalacia, Hypophosphatemia, Rickets, ... ORPHA:249
Uremic Pruritus
Increased blood urea nitrogen, Renal hypophosphatemia, Hypercalcemia, Hypermagnesemia ORPHA:94059
Spinocerebellar Ataxia With Axonal Neuropathy Type 2
Hypercholesterolemia, Hypoalbuminemia, Elevated circulating alpha-fetoprotein concentration, Elev... ORPHA:64753
Renal Tubular Acidosis, Distal, 1
Elevated circulating creatinine concentration, Hypokalemia, Hypocalcemia, Osteomalacia OMIM:179800
Citrullinemia, Type Ii, Neonatal-Onset
Hyperlysinemia, Hyperthreoninemia, Hypermethioninemia, Hyperbilirubinemia, Hypertyrosinemia, Decr... OMIM:605814
Temple Syndrome Due To Paternal 14Q32.2 Hypomethylation
Hypercholesterolemia ORPHA:254531
Hypocalciuric Hypercalcemia, Familial, Type Iii
Hypophosphatemia, Osteomalacia, Hypercalcemia, Hypermagnesemia OMIM:600740
Non-Functioning Paraganglioma
Hypercalcemia ORPHA:94080
Hypocalcemia, Autosomal Dominant 1
Hyperphosphatemia, Hypokalemia, Increased circulating renin level, Hypocalcemia, Hypomagnesemia OMIM:601198
Hypoparathyroidism, Familial Isolated, 1
Hyperphosphatemia, Hypocalcemia, Hypocalcemic seizures OMIM:146200
Hypocalciuric Hypercalcemia, Familial, Type I
Hypercalcemia, Hypermagnesemia OMIM:145980
Chylomicron Retention Disease
Decreased LDL cholesterol concentration, Steatorrhea, Hypotriglyceridemia, Hypocholesterolemia, H... OMIM:246700
Intermediate Osteopetrosis
Hypocalcemia, Generalized osteosclerosis, Osteosclerosis of the base of the skull, Abnormality of... ORPHA:210110
Cholestasis, Progressive Familial Intrahepatic, 7, With Or Without Hearing Loss
Hypocalcemia, Elevated circulating gamma-aminobutyric acid concentration OMIM:619658
Glucose-Galactose Malabsorption
Hypernatremia, Hypercalcemia ORPHA:35710
Congenital Analbuminemia
Increased alpha-globulin, Hypoproteinemia, Hyperlipidemia, Hypercholesterolemia, Hypoalbuminemia ORPHA:86816
Hypocalciuric Hypercalcemia, Familial, Type Ii
Hypercalcemia, Hypermagnesemia OMIM:145981
Metaphyseal Chondrodysplasia, Jansen Type
Osteopenia, Hypophosphatemia, Hypercalcemia OMIM:156400
Late-Onset Isolated Acth Deficiency
Generalized bone demineralization, Hyperuricemia, Decreased circulating cortisol level, Hyperkale... ORPHA:199299
Pseudohypoparathyroidism, Type Ib
Hyperphosphatemia, Hypocalcemia OMIM:603233
Pseudohypoparathyroidism Type 2
Hyperphosphatemia, Hypocalcemic tetany, Calcinosis, Hypocalcemic seizures, Hypocalcemia ORPHA:94090
Autosomal Dominant Hypophosphatemic Rickets
Rickets, Hypophosphatemia, Hypocalcemia, Osteomalacia ORPHA:89937
Idiopathic Steroid-Resistant Nephrotic Syndrome
Abnormal circulating lipid concentration, Hypertriglyceridemia, Hypoalbuminemia, Hypercholesterol... ORPHA:567548
Pheochromocytoma--Islet Cell Tumor Syndrome
Hypercalcemia OMIM:171420
Laron Syndrome
Hypercholesterolemia ORPHA:633
Paternal Uniparental Disomy Of Chromosome 1
Increased blood urea nitrogen, Craniosynostosis, Hypercalcemia ORPHA:251004
Hypocalcemic Vitamin D-Resistant Rickets
Osteomalacia, Hypophosphatemia, Coarse metaphyseal trabecularization, Osteolysis, Abnormal bone s... ORPHA:93160
Hyperlipoproteinemia, Type I
Hypercholesterolemia, Increased circulating chylomicron concentration, Hyperlipidemia, Lactescent... OMIM:238600
Congenital Generalized Lipodystrophy
Increased C-peptide level, Hypertriglyceridemia, Bone cyst, Hypercholesterolemia ORPHA:528
Hyperphosphatemia, Hypocalcemia, Ectopic ossification ORPHA:79445
Temple Syndrome
Hypertriglyceridemia, Hypercholesterolemia OMIM:616222
Nephrotic Syndrome, Type 11
Hypoalbuminemia, Hypercholesterolemia OMIM:616730
Galactokinase Deficiency
Hypergalactosemia, Increased level of galactitol in plasma, Hypercholesterolemia ORPHA:79237
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency
Hyperlysinemia, Abnormal circulating lipid concentration, Hyperthreoninemia, Hypergalactosemia, H... ORPHA:247598
Vitamin D Hydroxylation-Deficient Rickets, Type 1B
Thin bony cortex, Hypophosphatemia, Sparse bone trabeculae, Rickets, Hypocalcemia, Delayed epiphy... OMIM:600081
Autoimmune Hypoparathyroidism
Hypocalcemic tetany, Hyperphosphatemia, Increased bone mineral density, Hypocalcemic seizures, Hy... ORPHA:36913
Alpha-Heavy Chain Disease
Hypocalcemia ORPHA:100025
Abdominal Obesity-Metabolic Syndrome 3
Increased LDL cholesterol concentration, Hypertriglyceridemia, Hypercholesterolemia OMIM:615812
Hyperparathyroidism, Neonatal Severe
Hypophosphatemia, Hypercalcemia, Calcinosis OMIM:239200
Oculoskeletodental Syndrome
Hypocalcemia, Hypercalcemia OMIM:618440
Bartter Syndrome, Type 1, Antenatal
Increased serum prostaglandin E2, Hyperaldosteronism, Hypokalemia, Increased circulating renin le... OMIM:601678
Cholestasis, Progressive Familial Intrahepatic, 8
Hypercholesterolemia, Increased serum bile acid concentration, Conjugated hyperbilirubinemia, Ele... OMIM:619662
2P21 Microdeletion Syndrome
Hypocalcemia ORPHA:163693
Citrullinemia Type Ii
Acute hyperammonemia, Hypoproteinemia, Decreased HDL cholesterol concentration, Hyperlipidemia, H... ORPHA:247585
Hypercholesterolemia ORPHA:263501
Familial Hypocalciuric Hypercalcemia
Osteomalacia, Hypermagnesemia, Hypercalcemia, Hypocalcemic seizures, Renal hypophosphatemia ORPHA:405
Ataxia With Vitamin E Deficiency
Increased LDL cholesterol concentration, Hypertriglyceridemia, Xanthelasma, Hypercholesterolemia OMIM:277460
Smith-Magenis Syndrome
Hypertriglyceridemia, Hypercholesterolemia OMIM:182290
Acute Adrenal Insufficiency
Hyperuricemia, Decreased circulating cortisol level, Hyperkalemia, Increased circulating renin le... ORPHA:95409
Osteoporosis, Hypercalcemia ORPHA:98292
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency
Increased LDL cholesterol concentration, Hypertriglyceridemia, Hypercholesterolemia ORPHA:209902
Refractory Celiac Disease
Hypophosphatemia, Hypoproteinemia, Hypocalcemia, Hypomagnesemia, Osteoporosis, Hypoalbuminemia ORPHA:398063
Mandibuloacral Dysplasia
Increased circulating free fatty acid level, Acroosteolysis of distal phalanges (feet), Osteolyti... ORPHA:2457
Vitamin D Hydroxylation-Deficient Rickets, Type 1A
Thin bony cortex, Hypophosphatemia, Sparse bone trabeculae, Rickets, Hypocalcemic seizures, Hypoc... OMIM:264700
Addison Disease
Generalized bone demineralization, Hyperuricemia, Decreased circulating cortisol level, Hyperkale... ORPHA:85138
Multiple Myeloma
Osteopenia, Elevated circulating creatinine concentration, Hyperproteinemia, Hypercalcemia ORPHA:29073
Hypophosphatemic Rickets
Osteomalacia, Hypophosphatemia, Rickets, Craniofacial osteosclerosis, Hyperostosis, Hypercalcemia... ORPHA:437
Intellectual Disability-Seizures-Hypophosphatasia-Ophthalmic-Skeletal Anomalies Syndrome
Osteopenia, Hypertriglyceridemia, Craniosynostosis, Hypercalcemia ORPHA:369837
9Q31.1Q31.3 Microdeletion Syndrome
Hypercholesterolemia ORPHA:401923
Pseudohypoparathyroidism, Type Ic
Hypocalcemic tetany, Hypocalcemia, Osteoporosis, Hyperphosphatemia OMIM:612462
Kenny-Caffey Syndrome, Type 1
Hypocalcemia, Hypomagnesemia, Decreased skull ossification, Calvarial osteosclerosis OMIM:244460
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14
Hypercholesterolemia ORPHA:96184
Hypercholesterolemia, Increased LDL cholesterol concentration, Decreased HDL cholesterol concentr... ORPHA:412
Monosomy 13Q34
Hypercalcemia ORPHA:96168
Sitosterolemia 1
Reduced haptoglobin level, Hypercholesterolemia, Elevated circulating sitosterol concentration, X... OMIM:210250
Lysosomal Acid Lipase Deficiency
Steatorrhea, Increased LDL cholesterol concentration, Decreased HDL cholesterol concentration, Hy... OMIM:278000
Hypocalcemic Vitamin D-Dependent Rickets
Thin bony cortex, Osteomalacia, Hypophosphatemia, Sparse bone trabeculae, Rickets, Hypocalcemic s... ORPHA:289157
Sporadic Pheochromocytoma/Secreting Paraganglioma
Hypercalcemia ORPHA:276621
Multiple Endocrine Neoplasia, Type I
Hypercalcemia, Increased circulating cortisol level OMIM:131100
Micrognathia-Recurrent Infections-Behavioral Abnormalities-Mild Intellectual Disability Syndrome
Hypercalcemia ORPHA:476126
Megalocornea-Mental Retardation Syndrome
Osteopenia, Hypercholesterolemia OMIM:249310
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Hypercholesterolemia, Hypertriglyceridemia, Osteoporosis, Elevated circulating creatine kinase co... ORPHA:79240
Albers-Schönberg Osteopetrosis
Hypocalcemia, Generalized osteosclerosis ORPHA:53
Pseudohypoparathyroidism Type 1B
Hypocalcemic tetany, Hyperphosphatemia, Calcinosis, Increased bone density with cystic changes, I... ORPHA:94089
Megalocornea-Intellectual Disability Syndrome
Osteopenia, Hypercholesterolemia ORPHA:2479
Mandibuloacral Dysplasia With Type A Lipodystrophy
Acroosteolysis of distal phalanges (feet), Calcinosis, Osteopenia, Hyperlipidemia, Hypercholester... OMIM:248370
Hypercalcemia OMIM:171300
Galloway-Mowat Syndrome 7
Hypercholesterolemia OMIM:618348
Osteopetrosis, Autosomal Recessive 1
Calvarial osteosclerosis, Increased bone mineral density, Hypocalcemia, Osteopetrosis, Craniosyno... OMIM:259700
Hypoparathyroidism-Retardation-Dysmorphism Syndrome
Hypocalcemia, Patchy osteosclerosis, Hyperphosphatemia, Hypocalcemic seizures OMIM:241410
Timothy Syndrome
Hypocalcemia OMIM:601005
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Hypercholesterolemia, Hypertriglyceridemia, Osteoporosis, Elevated circulating creatine kinase co... ORPHA:264580
Smith-Magenis Syndrome
Hypertriglyceridemia, Hypercholesterolemia ORPHA:819
Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal
Hypertriglyceridemia, Hypercholesterolemia OMIM:610644
Ring Chromosome 10 Syndrome
Hypocalcemia ORPHA:1438
Genetic Recurrent Myoglobinuria
Highly elevated creatine kinase, Hypocalcemia, Hyperkalemia, Hyperphosphatemia ORPHA:99845
Hepatocellular Carcinoma
Hypokalemia, Hyperbilirubinemia, Hypercalcemia, Hyponatremia, Hypoalbuminemia ORPHA:88673
Familial Isolated Hypoparathyroidism
Hypocalcemia ORPHA:2238
Hereditary Pheochromocytoma-Paraganglioma
Hypercalcemia ORPHA:29072
Hypercalcemia, Steatorrhea, Increased circulating cortisol level ORPHA:97283
Hypercalcemia, Increased circulating cortisol level ORPHA:97278
Hypotonia-Cystinuria Syndrome
Hypocalcemia OMIM:606407
Glycogen Storage Disease Due To Phosphorylase Kinase Deficiency
Hypercholesterolemia, Hypertriglyceridemia, Elevated circulating creatine kinase concentration ORPHA:370
Acquired Aneurysmal Subarachnoid Hemorrhage
Hypercholesterolemia ORPHA:90065
Diarrhea 10, Protein-Losing Enteropathy Type
Hyponatremia, Hypocalcemia, Hypertriglyceridemia, Hypomagnesemia, Hypoalbuminemia OMIM:618183
Hypokalemia, Hypercalcemia, Increased circulating cortisol level ORPHA:97282
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Increased circulating free fatty acid level, Elevated circulating creatine kinase concentration, ... ORPHA:26793
Hyperparathyroidism-Jaw Tumor Syndrome
Osteoporosis, Hypophosphatemia, Hypercalcemia ORPHA:99880
Lysinuric Protein Intolerance
Hyperalaninemia, Hyperglycinemia, Intraalveolar phospholipid accumulation, Hyperglutaminemia, Ste... ORPHA:470
Parathyroid Carcinoma
Osteoporosis, Hypophosphatemia, Hypercalcemia ORPHA:143
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis
Increased skull ossification, Craniofacial osteosclerosis, Diaphyseal sclerosis, Hypocalcemia, Os... OMIM:618476
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes
Hypokalemia, Hypocalcemia, Hypomagnesemia OMIM:175500
Oncogenic Osteomalacia
Fibrous dysplasia of the bones, Hypophosphatemia, Hypocalcemia ORPHA:352540
Hypercalcemia, Steatorrhea, Increased circulating cortisol level ORPHA:97280
Kenny-Caffey Syndrome, Type 2
Hyperphosphatemia, Transient hypophosphatemia, Increased bone mineral density, Thickened cortex o... OMIM:127000
Isolated Thyroid-Stimulating Hormone Deficiency
Abnormal circulating thyroglobulin level, Delayed proximal femoral epiphyseal ossification, Neona... ORPHA:90674
Zollinger-Ellison Syndrome
Hypercalcemia, Increased circulating cortisol level ORPHA:913
Hypercalcemia, Increased circulating cortisol level ORPHA:97261
Colchicine Poisoning
Hypophosphatemia, Hypokalemia, Abnormal blood ion concentration, Hyponatremia, Hypocalcemia, Hypo... ORPHA:31824
Gracile Bone Dysplasia
Hypocalcemia, Decreased skull ossification OMIM:602361
Primary Intestinal Lymphangiectasia
Hypocalcemia, Hypoproteinemia, Hypomagnesemia, Hypoalbuminemia ORPHA:90362
Low Phospholipid-Associated Cholelithiasis
Hypercholesterolemia ORPHA:69663
Multiple Endocrine Neoplasia Type 4
Hypercalcemia, Increased circulating cortisol level ORPHA:276152
Sanjad-Sakati Syndrome
Hypocalcemia, Patchy osteosclerosis, Hyperphosphatemia ORPHA:2323
Dahlberg-Borer-Newcomer Syndrome
Hypocalcemia ORPHA:1563
X-Linked Agammaglobulinemia
Hypocalcemia ORPHA:47
Multiple Endocrine Neoplasia Type 1
Increased circulating cortisol level, Primary hypercortisolism, Osteolysis, Hypercalcemia, Reduce... ORPHA:652
Celiac Disease, Susceptibility To, 1
Rickets, Hypocalcemia, Osteoporosis, Steatorrhea OMIM:212750
Gaisböck Syndrome
Hyperuricemia, Increased circulating renin level, Hypercholesterolemia, Hyperproteinemia, Hypertr... ORPHA:90041
Pseudohypoparathyroidism Type 1C
Hypocalcemic tetany, Hyperphosphatemia, Ectopic ossification, Calcinosis, Increased bone mineral ... ORPHA:79444
Lipodystrophy, Familial Partial, Type 2
Hypertriglyceridemia, Decreased HDL cholesterol concentration, Hypercholesterolemia OMIM:151660
Pseudohypoparathyroidism, Type Ia
Hypocalcemic tetany, Subcutaneous ossification, Osteoporosis, Hyperphosphatemia OMIM:103580
Osteopetrosis, Autosomal Recessive 5
Increased bone mineral density, Hyperbilirubinemia, Decreased osteoclast count, Cranial hyperosto... OMIM:259720
Autosomal Dominant Hypocalcemia
Hypocalcemia, Hypomagnesemia, Hyperphosphatemia, Reduced bone mineral density ORPHA:428
Hypokalemia, Hypocalcemia, Abnormal blood ion concentration, Hyponatremia ORPHA:173
Lysosomal Acid Lipase Deficiency
Hypercholesterolemia, Hyperkalemia, Steatorrhea, Xanthelasma, Hyponatremia, Hypertriglyceridemia ORPHA:275761
Congenital Disorder Of Glycosylation, Type Ig
Hypocalcemia OMIM:607143
Kidney Tubulopathy-Dilated Cardiomyopathy Syndrome
Hyperaldosteronism, Hypocalcemia, Hypomagnesemia, Hypocalcemic tetany ORPHA:73224
Neuroleptic Malignant Syndrome
Hyperphosphatemia, Hyperuricemia, Hyperkalemia, Elevated circulating creatine kinase concentratio... ORPHA:94093
Pseudohypoparathyroidism Type 1A
Hypocalcemic tetany, Hyperphosphatemia, Ectopic ossification, Calcinosis, Increased bone mineral ... ORPHA:79443
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib
Hyperuricemia, Xanthelasma, Osteopenia, Hyperlipidemia, Hypercholesterolemia, Hypertriglyceridemi... ORPHA:79259
Neurodevelopmental Disorder With Microcephaly, Cataracts, And Renal Abnormalities
Calcinosis, Hypokalemia, Osteopenia, Hyponatremia, Hypocalcemia OMIM:617913
Multiple Endocrine Neoplasia Type 2
Hypercalcemia ORPHA:653
Lowe Oculocerebrorenal Syndrome
Elevated maternal serum alpha-fetoprotein, Osteomalacia, Elevated amniotic fluid alpha-fetoprotei... OMIM:309000
Immunodeficiency 47
Decreased circulating copper concentration, Hypercholesterolemia OMIM:300972
Lmna-Related Cardiocutaneous Progeria Syndrome
Hypertriglyceridemia, Hypercholesterolemia ORPHA:363618
Bardet-Biedl Syndrome 20
Hypercholesterolemia OMIM:619471
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Hypocalcemia, Hypoproteinemia OMIM:235255
Juvenile Nephropathic Cystinosis
Hypocalcemic tetany, Hypophosphatemia, Hypokalemia, Hyponatremia, Elevated circulating creatinine... ORPHA:411634
Bacterial Toxic-Shock Syndrome
Elevated circulating creatinine concentration, Hypocalcemia, Hypoalbuminemia, Elevated circulatin... ORPHA:36234
Williams Syndrome
Abnormal circulating lipid concentration, Increased bone mineral density, Elevated circulating cr... ORPHA:904
Double Outlet Right Ventricle
Hypocalcemia ORPHA:3426
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
Hypocalcemia, Hypoproteinemia ORPHA:1655
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Decreased prealbumin level, Abnormal blood ion concentration, Hypocalcemia, Hypomagnesemia, Hypoa... ORPHA:37042
Mitochondrial Trifunctional Protein Deficiency
Hypocalcemia ORPHA:746
Autosomal Recessive Hypophosphatemic Rickets
Hypocalcemic tetany, Rickets of the lower limbs, Abnormal trabecular bone morphology, Increased b... ORPHA:289176
Oculocerebrorenal Syndrome Of Lowe
Hyperaldosteronism, Hyponatremia, Osteomalacia, Hypophosphatemia, Hypokalemia, Hypercholesterolem... ORPHA:534
Hypercalcemia, Bone cyst ORPHA:797
Rajab Interstitial Lung Disease With Brain Calcifications 1
Thin bony cortex, Unconjugated hyperbilirubinemia, Rickets, Osteopenia, Hypocalcemia, Hypoalbumin... OMIM:613658
Williams-Beuren Syndrome
Osteopenia, Osteoporosis, Hypercalcemia OMIM:194050
Autosomal Recessive Malignant Osteopetrosis
Hypophosphatemia, Hypocalcemia, Osteopetrosis, Craniosynostosis, Reduced bone mineral density ORPHA:667
Cartilage-Hair Hypoplasia
Hypocalcemia, Abnormal bone ossification, Abnormally ossified vertebrae ORPHA:175
Autosomal Dominant Kenny-Caffey Syndrome
Hypocalcemic tetany, Hyperphosphatemia, Calvarial osteosclerosis, Cortical thickening of long bon... ORPHA:93325
Ethylene Glycol Poisoning
Hypocalcemia, Hyperkalemia ORPHA:31826
Igg4-Related Thyroid Disease
Hypocalcemia ORPHA:64744
Pearson Syndrome
Hyperalaninemia, Hypokalemia, Hypophosphatemia, Steatorrhea, Hypocalcemia, Hypomagnesemia ORPHA:699
Alagille Syndrome 1
Hypertriglyceridemia, Hypercholesterolemia OMIM:118450
Osteopetrosis With Renal Tubular Acidosis
Hypocalcemia, Osteopetrosis, Elevated circulating creatine kinase concentration ORPHA:2785
Isotretinoin-Like Syndrome
Hypocalcemia ORPHA:2306
Gitelman Syndrome
Hypokalemia, Primary hyperaldosteronism, Hypermagnesemia, Hypocalcemia, Hypomagnesemia ORPHA:358
Exercise-Induced Malignant Hyperthermia
Hypocalcemia, Hyperkalemia, Hyperphosphatemia, Elevated circulating creatine kinase concentration ORPHA:466650
Velocardiofacial Syndrome
Hypocalcemia OMIM:192430
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Hypocalcemia, Hypocalcemic seizures ORPHA:2237
Sotos Syndrome
Craniosynostosis, Hypercalcemia ORPHA:821
X-Linked Intellectual Disability-Craniofacioskeletal Syndrome
Hypocalcemia, Hyperbilirubinemia ORPHA:163979
Craniofacioskeletal Syndrome
Hypocalcemia OMIM:300712
Homozygous Familial Hypercholesterolemia
Increased LDL cholesterol concentration, Hyperlipidemia, Hypercholesterolemia ORPHA:391665
Cranioectodermal Dysplasia 1
Sagittal craniosynostosis, Hypocalcemia, Osteoporosis OMIM:218330
Hennekam Syndrome
Hypocalcemia, Craniosynostosis ORPHA:2136
Lipodystrophy, Familial Partial, Type 7
Hypertriglyceridemia, Hypercholesterolemia OMIM:606721
Steinert Myotonic Dystrophy
Hypercholesterolemia ORPHA:273
Infection-Related Hemolytic Uremic Syndrome
Hypocalcemia, Hyperkalemia, Hyponatremia ORPHA:544482
Visceral Steatosis, Congenital
Hypocalcemia OMIM:228100
Biliary, Renal, Neurologic, And Skeletal Syndrome
Hyperbilirubinemia, Increased circulating ferritin concentration, Osteopenia, Hypercholesterolemi... OMIM:619534
Liver Disease, Severe Congenital
Hyperalaninemia, Elevated hepatic iron concentration, Hyperbilirubinemia, Elevated circulating al... OMIM:619991
22Q11.2 Deletion Syndrome
Multiple suture craniosynostosis, Hypocalcemia ORPHA:567
Acrodysostosis With Multiple Hormone Resistance
Hypocalcemia, Hyperphosphatemia ORPHA:280651
Thymic Aplasia
Hypocalcemic tetany ORPHA:83471
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Hypocalcemia, Hypomagnesemia OMIM:619503
Digeorge Syndrome
Hypocalcemia OMIM:188400
Johanson-Blizzard Syndrome
Hypocalcemia, Increased VLDL cholesterol concentration OMIM:243800
Charge Syndrome
Hypocalcemia OMIM:214800


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zmym4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zmym4.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Zmym4em1(IMPC)Wtsi PMC7263671
Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription. Cell metabolism (June 2020) Zmym4em1(IMPC)Wtsi PMC7267775
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Zmym4em1(IMPC)Wtsi PMC6671969

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MGI Allele Allele Type Produced
Zmym4tm36782(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Zmym4em1(IMPC)Wtsi Deletion Mice

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