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Gene: Zmym4 MGI:1915035

Gene Summary

Name:

zinc finger, MYM-type 4

Synonyms:

Zfp262, 6330503C17Rik

Order Alleles

IMPC Data Collections

Body Weight Measurements
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype	Allele	Zyg	Life Stage	P Value
increased circulating glycerol level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	3.20×10^-06
decreased circulating fructosamine level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	2.23×10^-06
increased circulating HDL cholesterol level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	1.32×10^-05
increased circulating calcium level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	7.83×10^-06
increased circulating amylase level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	8.92×10^-05
decreased body length	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	1.45×10^-06
increased circulating cholesterol level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	1.35×10^-06

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Zmym4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Zmym4 (0 diseases)
Human diseases predicted to be associated with Zmym4 (240 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Zmym4 by phenotypic similarity.

Disease	Matching phenotypes	Source
Cholesterol-Ester Transfer Protein Deficiency	Hyperlipidemia, Hyperlipoproteinemia, Hypercholesterolemia, Hypotriglyceridemia, Increased HDL ch...	ORPHA:79506
Hypertriglyceridemia 2	Hypercholesterolemia, Decreased HDL cholesterol concentration, Hypertriglyceridemia	OMIM:619324
Xanthomatosis, Susceptibility To	Hypercholesterolemia	OMIM:602247
Coronary Artery Disease, Autosomal Dominant, 1	Hypercholesterolemia	OMIM:608320
Sitosterolemia 2	Hypercholesterolemia, Elevated circulating sitosterol concentration	OMIM:618666
Glycogen Storage Disease Ixa1	Hypercholesterolemia, Hypertriglyceridemia	OMIM:306000
Hyperlipoproteinemia, Type Ii, And Deafness	Increased LDL cholesterol concentration, Hypercholesterolemia, Hypertriglyceridemia	OMIM:144300
Glycogen Storage Disease Vi	Hypercholesterolemia, Hypertriglyceridemia, Hyperlipidemia	OMIM:232700
Ulna Metaphyseal Dysplasia Syndrome	Hypercalcemia	OMIM:191420
Hypercholesterolemia, Familial, 4	Hypercholesterolemia, Increased VLDL cholesterol concentration, Hypertriglyceridemia	OMIM:603813
Hyperlipidemia, Familial Combined, 3	Hyperlipidemia, Increased LDL cholesterol concentration, Increased VLDL cholesterol concentration...	OMIM:144250
Pentosuria	Abnormality of circulating enzyme level, Abnormal circulating carbohydrate concentration	ORPHA:2843
Blue Diaper Syndrome	Hypercalcemia, Abnormal circulating tryptophan concentration	OMIM:211000
Adamantinoma	Hypercalcemia	ORPHA:55881
Coronary Artery Disease, Autosomal Dominant 2	Hypercholesterolemia, Hypertriglyceridemia, Hyperlipidemia	OMIM:610947
Congenital Disorder Of Glycosylation, Type Iip	Increased LDL cholesterol concentration, Hypercholesterolemia, Decreased circulating ceruloplasmi...	OMIM:616829
Diarrhea 7, Protein-Losing Enteropathy Type	Hypercholesterolemia, Hyperlipidemia, Hypoalbuminemia	OMIM:615863
Hypothyroidism, Congenital, Nongoitrous, 8	Hypercholesterolemia	OMIM:301033
Hyperparathyroidism 1	Hypercalcemia	OMIM:145000
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 1	Hypercholesterolemia, Hypoalbuminemia	OMIM:607250
Morbid Obesity And Spermatogenic Failure	Increased LDL cholesterol concentration, Decreased HDL cholesterol concentration, Hypercholestero...	OMIM:615703
Citrullinemia, Type Ii, Neonatal-Onset	Decreased HDL cholesterol concentration, Hyperbilirubinemia, Hypercholesterolemia, Hypertriglycer...	OMIM:605814
Distal Myopathy, Tateyama Type	Hypercholesterolemia, Abnormal circulating creatine kinase concentration	ORPHA:488650
Analbuminemia	Increased LDL cholesterol concentration, Hypercholesterolemia, Elevated circulating transferrin c...	OMIM:616000
Hypoparathyroidism, Familial Isolated, 2	Hyperphosphatemia, Hypocalcemic seizures, Hypocalcemia	OMIM:618883
Hypocalcemia, Autosomal Dominant 2	Hypocalcemia	OMIM:615361
Hepatic Lipase Deficiency	Hypercholesterolemia, Hypertriglyceridemia, Increased HDL cholesterol concentration	OMIM:614025
Parathyroid Carcinoma	Hypercalcemia	OMIM:608266
Hyperparathyroidism 4	Hypercalcemia	OMIM:617343
Hypervitaminosis A, Susceptibility To	Hypercalcemia	OMIM:240150
22q11 deletion syndrome (Velocardiofacial / DiGeorge syndrome)	Hypocalcemia	DECIPHER:16
Hypercalcemia, Infantile, 2	Hypercalcemia, Hypophosphatemia	OMIM:616963
Granulomatous Slack Skin	Hypercalcemia	ORPHA:33111
Spinocerebellar Ataxia With Axonal Neuropathy Type 1	Hypercholesterolemia, Hypoalbuminemia	ORPHA:94124
Lipodystrophy, Congenital Generalized, Type 3	Hypercholesterolemia, Hypertriglyceridemia, Hypocalcemia	OMIM:612526
Hypercholesterolemia, Familial, 3	Hypercholesterolemia, Xanthelasma, Abnormal LDL cholesterol concentration	OMIM:603776
Ataxia With Vitamin E Deficiency	Increased LDL cholesterol concentration, Xanthelasma, Hypercholesterolemia, Hypertriglyceridemia	OMIM:277460
Congenital Disorder Of Glycosylation, Type Iio	Increased LDL cholesterol concentration, Hypercholesterolemia, Decreased circulating ceruloplasmi...	OMIM:616828
Hypomagnesemia 1, Intestinal	Hypomagnesemia, Hypocalcemia	OMIM:602014
Myopathy, Tubular Aggregate, 2	Elevated circulating creatine kinase concentration, Hypocalcemia	OMIM:615883
Hypercholesterolemia, Familial, 2	Increased LDL cholesterol concentration, Xanthelasma, Hypercholesterolemia	OMIM:144010
Small Cell Carcinoma Of The Bladder	Hypercalcemia	ORPHA:284400
Nephropathy-Deafness-Hyperparathyroidism Syndrome	Hypercalcemia	ORPHA:2668
Pseudohypoparathyroidism, Type Ii	Hyperphosphatemia, Hypocalcemia	OMIM:203330
Cholesteryl Ester Storage Disease	Hypercholesterolemia, Hypertriglyceridemia	ORPHA:75234
Pseudohypoparathyroidism Type 2	Hypocalcemic tetany, Hyperphosphatemia, Hypocalcemic seizures, Hypocalcemia	ORPHA:94090
Diffuse Neonatal Hemangiomatosis	Hypercalcemia	ORPHA:2123
Familial Isolated Hyperparathyroidism	Hypercalcemia, Infantile hypercalcemia, Hypophosphatemia	ORPHA:99879
Blue Diaper Syndrome	Hypercalcemia, Hyperphosphatemia	ORPHA:94086
Apolipoprotein C-Ii Deficiency	Hypercholesterolemia, Decreased circulating apolipoprotein C-II concentration, Hypertriglyceridem...	OMIM:207750
Hyperparathyroidism, Neonatal Self-Limited Primary, With Hypercalciuria	Hypercalcemia	OMIM:239199
Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies	Hypercalcemia	OMIM:614732
Growth Hormone Insensitivity Syndrome	Hypercholesterolemia	ORPHA:181393
Familial Isolated Hypoparathyroidism Due To Agenesis Of Parathyroid Gland	Hypomagnesemia, Hyperphosphatemia, Hypocalcemic seizures, Hypocalcemia	ORPHA:2239
Temple Syndrome	Hypercholesterolemia, Hypertriglyceridemia	OMIM:616222
Rhabdoid Tumor	Hypercalcemia	ORPHA:69077
Hypophosphatasia	Hypercalcemia	ORPHA:436
Glycogen Storage Disease Due To Lactate Dehydrogenase M-Subunit Deficiency	Hypercalcemia, Elevated creatine kinase after exercise	ORPHA:284426
Lipodystrophy, Familial Partial, Type 7	Hypercholesterolemia, Hypertriglyceridemia	OMIM:606721
Vitamin D-Dependent Rickets, Type 3	Hypophosphatemia, Hypocalcemia	OMIM:619073
Hyperparathyroidism 2 With Jaw Tumors	Hypercalcemia	OMIM:145001
Oculocerebrodental Syndrome	Hypercalcemia, Hypocalcemia	ORPHA:557003
Hypoparathyroidism, Familial Isolated, 1	Hyperphosphatemia, Hypocalcemia	OMIM:146200
Uremic Pruritus	Hypermagnesemia, Hypercalcemia, Increased blood urea nitrogen, Renal hypophosphatemia	ORPHA:94059
Hypophosphatemic Rickets And Hyperparathyroidism	Hypercalcemia, Hypophosphatemia, Hypophosphatemic rickets	OMIM:612089
Hypocalcemia, Autosomal Dominant 1	Hypokalemia, Hypomagnesemia, Hypocalcemia, Increased circulating renin level, Hyperphosphatemia	OMIM:601198
Chylomicron Retention Disease	Hypocholesterolemia, Hypotriglyceridemia, Steatorrhea, Hypoalbuminemia, Decreased LDL cholesterol...	OMIM:246700
Tumoral Calcinosis, Hyperphosphatemic, Familial, 3	Hypercalcemia, Hyperphosphatemia	OMIM:617994
Hypocalciuric Hypercalcemia, Familial, Type I	Hypermagnesemia, Hypercalcemia	OMIM:145980
Temple Syndrome Due To Paternal 14Q32.2 Hypomethylation	Hypercholesterolemia	ORPHA:254531
Hypercalcemia, Infantile, 1	Infantile hypercalcemia	OMIM:143880
Pseudohypoparathyroidism, Type Ib	Hyperphosphatemia, Hypocalcemia	OMIM:603233
Cholestasis, Progressive Familial Intrahepatic, 7, With Or Without Hearing Loss	Elevated circulating gamma-aminobutyric acid concentration, Hypocalcemia	OMIM:619658
Spinocerebellar Ataxia With Axonal Neuropathy Type 2	Elevated circulating creatine kinase concentration, Elevated alpha-fetoprotein, Hypercholesterole...	ORPHA:64753
Thymic Neuroendocrine Tumor	Hypercalcemia, Increased circulating cortisol level	ORPHA:97289
Hypocalciuric Hypercalcemia, Familial, Type Ii	Hypermagnesemia, Hypercalcemia	OMIM:145981
Non-Functioning Paraganglioma	Hypercalcemia	ORPHA:94080
Glucose-Galactose Malabsorption	Hypercalcemia, Hypernatremia	ORPHA:35710
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia	Hypercholesterolemia, Hypoalbuminemia	OMIM:208920
Congenital Analbuminemia	Hypoproteinemia, Hyperlipidemia, Hypercholesterolemia, Hypoalbuminemia, Increased alpha-globulin	ORPHA:86816
Infantile Myofibromatosis	Hypercalcemia	ORPHA:2591
Pheochromocytoma--Islet Cell Tumor Syndrome	Hypercalcemia	OMIM:171420
Progressive Familial Intrahepatic Cholestasis	Hypocalcemia	ORPHA:172
Idiopathic Steroid-Resistant Nephrotic Syndrome	Abnormal circulating lipid concentration, Hypercholesterolemia, Hypertriglyceridemia, Hypoalbumin...	ORPHA:567548
Hypophosphatasia, Infantile	Hypercalcemia, Elevated plasma pyrophosphate	OMIM:241500
Hyperlipoproteinemia, Type I	Hypercholesterolemia, Lactescent serum, Hyperlipidemia, Increased circulating chylomicron concent...	OMIM:238600
Laron Syndrome	Hypercholesterolemia	ORPHA:633
Nephrotic Syndrome, Type 11	Hypercholesterolemia, Hypoalbuminemia	OMIM:616730
Abdominal Obesity-Metabolic Syndrome 3	Hypercholesterolemia	OMIM:615812
Alpha-Heavy Chain Disease	Hypocalcemia	ORPHA:100025
Morgagni-Stewart-Morel Syndrome	Hypercholesterolemia, Hyperuricemia	ORPHA:77296
Galactokinase Deficiency	Hypercholesterolemia, Hypergalactosemia, Increased level of galactitol in plasma	ORPHA:79237
Hypocalciuric Hypercalcemia, Familial, Type Iii	Hypermagnesemia, Hypercalcemia, Hypophosphatemia	OMIM:600740
2P21 Microdeletion Syndrome	Hypocalcemia	ORPHA:163693
Familial Hypocalciuric Hypercalcemia	Hypercalcemia, Hypocalcemic seizures, Infantile hypercalcemia, Renal hypophosphatemia, Hypermagne...	ORPHA:405
Citrullinemia Type Ii	Hypoproteinemia, Decreased HDL cholesterol concentration, Hyperlipidemia, Hypercholesterolemia, A...	ORPHA:247585
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency	Abnormal circulating glutamine concentration, Abnormal circulating serine concentration, Abnormal...	ORPHA:247598
Hyperparathyroidism, Neonatal Severe	Hypercalcemia, Calcinosis, Hypophosphatemia	OMIM:239200
Smith-Magenis Syndrome	Hypercholesterolemia, Hypertriglyceridemia	OMIM:182290
Oculoskeletodental Syndrome	Hypercalcemia, Hypocalcemia	OMIM:618440
Metaphyseal Chondrodysplasia, Jansen Type	Hypercalcemia, Hypophosphatemia	OMIM:156400
Acute Adrenal Insufficiency	Hyperkalemia, Hypercalcemia, Hyponatremia, Hyperuricemia, Increased circulating renin level, Decr...	ORPHA:95409
Cholestasis, Progressive Familial Intrahepatic, 8	Hypercholesterolemia, Elevated alpha-fetoprotein, Conjugated hyperbilirubinemia, Increased serum ...	OMIM:619662
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency	Increased LDL cholesterol concentration, Hypercholesterolemia, Hypertriglyceridemia	ORPHA:209902
Paternal Uniparental Disomy Of Chromosome 1	Hypercalcemia, Increased blood urea nitrogen	ORPHA:251004
Sitosterolemia 1	Hypercholesterolemia, Elevated circulating sitosterol concentration, Hyperapobetalipoproteinemia	OMIM:210250
Late-Onset Isolated Acth Deficiency	Hyponatremia, Hypercalcemia, Decreased circulating cortisol level, Hyperuricemia	ORPHA:199299
Autosomal Recessive Kenny-Caffey Syndrome	Hypocalcemic tetany, Hypocalcemic seizures, Hypocalcemia	ORPHA:93324
Congenital Generalized Lipodystrophy	Hypercholesterolemia, Increased C-peptide level, Hypertriglyceridemia	ORPHA:528
Cog4-Cdg	Hypercholesterolemia	ORPHA:263501
Bartter Syndrome, Type 1, Antenatal	Hypercalcemia, Hypokalemia, Increased serum prostaglandin E2, Hypochloremia, Hypomagnesemia, Hype...	OMIM:601678
Autoimmune Hypoparathyroidism	Hypocalcemic tetany, Hyperphosphatemia, Hypocalcemic seizures, Hypocalcemia	ORPHA:36913
9Q31.1Q31.3 Microdeletion Syndrome	Hypercholesterolemia	ORPHA:401923
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14	Hypercholesterolemia	ORPHA:96184
Dysbetalipoproteinemia	Decreased HDL cholesterol concentration, Increased LDL cholesterol concentration, Hypercholestero...	ORPHA:412
Sporadic Pheochromocytoma/Secreting Paraganglioma	Hypercalcemia	ORPHA:276621
Multiple Endocrine Neoplasia, Type I	Hypercalcemia, Increased circulating cortisol level	OMIM:131100
Diarrhea 10, Protein-Losing Enteropathy Type	Hyponatremia, Hypoalbuminemia, Hypomagnesemia, Hypertriglyceridemia, Hypocalcemia	OMIM:618183
Lysosomal Acid Lipase Deficiency	Decreased HDL cholesterol concentration, Increased LDL cholesterol concentration, Hypercholestero...	OMIM:278000
Refractory Celiac Disease	Hypoproteinemia, Hypoalbuminemia, Hypophosphatemia, Hypomagnesemia, Hypocalcemia	ORPHA:398063
Addison Disease	Hyperkalemia, Hypercalcemia, Hyponatremia, Hyperuricemia, Increased circulating renin level, Decr...	ORPHA:85138
Mastocytosis	Hypercalcemia	ORPHA:98292
Fibrous Dysplasia Of Bone	Hypercalcemia, Increased circulating cortisol level, Hypophosphatemia	ORPHA:249
Renal Tubular Acidosis, Distal, 1	Hypocalcemia	OMIM:179800
Autosomal Dominant Hypophosphatemic Rickets	Hypophosphatemia, Hypocalcemia	ORPHA:89937
Galloway-Mowat Syndrome 7	Hypercholesterolemia	OMIM:618348
Micrognathia-Recurrent Infections-Behavioral Abnormalities-Mild Intellectual Disability Syndrome	Hypercalcemia	ORPHA:476126
Intellectual Disability-Seizures-Hypophosphatasia-Ophthalmic-Skeletal Anomalies Syndrome	Hypercalcemia, Hypertriglyceridemia	ORPHA:369837
Mandibuloacral Dysplasia	Hypercholesterolemia, Hypertriglyceridemia, Increased circulating free fatty acid level	ORPHA:2457
Ring Chromosome 10 Syndrome	Hypocalcemia	ORPHA:1438
Pseudohypoparathyroidism Type 1B	Hypocalcemic tetany, Hyperphosphatemia, Hypocalcemic seizures, Hypocalcemia	ORPHA:94089
Pheochromocytoma	Hypercalcemia	OMIM:171300
Familial Isolated Hypoparathyroidism	Hypocalcemia	ORPHA:2238
Multiple Myeloma	Hyperproteinemia, Elevated circulating creatinine concentration, Hypercalcemia	ORPHA:29073
Timothy Syndrome	Hypocalcemia	OMIM:601005
Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal	Hypercholesterolemia, Hypertriglyceridemia	OMIM:610644
Genetic Recurrent Myoglobinuria	Hyperkalemia, Highly elevated creatine kinase, Hyperphosphatemia, Hypocalcemia	ORPHA:99845
Monosomy 13Q34	Infantile hypercalcemia	ORPHA:96168
Hypotonia-Cystinuria Syndrome	Hypocalcemia	OMIM:606407
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency	Elevated circulating creatine kinase concentration, Hypercholesterolemia, Hypertriglyceridemia	ORPHA:79240
Vipoma	Hypercalcemia, Increased circulating cortisol level, Hypokalemia	ORPHA:97282
Somatostatinoma	Hypercalcemia, Increased circulating cortisol level, Steatorrhea	ORPHA:97283
Hypoparathyroidism-Retardation-Dysmorphism Syndrome	Hyperphosphatemia, Hypocalcemic seizures, Hypocalcemia	OMIM:241410
Ppoma	Hypercalcemia, Increased circulating cortisol level	ORPHA:97278
Glycogen Storage Disease Due To Phosphorylase Kinase Deficiency	Elevated circulating creatine kinase concentration, Hypercholesterolemia, Hypertriglyceridemia	ORPHA:370
Hereditary Pheochromocytoma-Paraganglioma	Hypercalcemia	ORPHA:29072
Megalocornea-Mental Retardation Syndrome	Hypercholesterolemia	OMIM:249310
Smith-Magenis Syndrome	Hypercholesterolemia, Hypertriglyceridemia	ORPHA:819
Hepatocellular Carcinoma	Hyponatremia, Hypercalcemia, Hypokalemia, Hyperbilirubinemia, Hypoalbuminemia	ORPHA:88673
Megalocornea-Intellectual Disability Syndrome	Hypercholesterolemia	ORPHA:2479
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes	Hypomagnesemia, Hypokalemia, Hypocalcemia	OMIM:175500
Hyperparathyroidism-Jaw Tumor Syndrome	Hypercalcemia, Infantile hypercalcemia, Hypophosphatemia	ORPHA:99880
Very Long Chain Acyl-Coa Dehydrogenase Deficiency	Hypoproteinemia, Elevated circulating creatine kinase concentration, Increased circulating free f...	ORPHA:26793
Acquired Aneurysmal Subarachnoid Hemorrhage	Hypercholesterolemia	ORPHA:90065
Colchicine Poisoning	Hyponatremia, Hypokalemia, Hypophosphatemia, Hypomagnesemia, Hypocalcemia, Abnormal blood ion con...	ORPHA:31824
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency	Elevated circulating creatine kinase concentration, Hypercholesterolemia, Hypertriglyceridemia	ORPHA:264580
Kenny-Caffey Syndrome, Type 1	Hypomagnesemia, Hypocalcemia	OMIM:244460
Parathyroid Carcinoma	Hypercalcemia, Infantile hypercalcemia, Hypophosphatemia	ORPHA:143
Albers-Schönberg Osteopetrosis	Hypocalcemia	ORPHA:53
Glucagonoma	Hypercalcemia, Increased circulating cortisol level, Steatorrhea	ORPHA:97280
Zollinger-Ellison Syndrome	Hypercalcemia, Increased circulating cortisol level	ORPHA:913
Low Phospholipid-Associated Cholelithiasis	Hypercholesterolemia	ORPHA:69663
Grfoma	Hypercalcemia, Increased circulating cortisol level	ORPHA:97261
Multiple Endocrine Neoplasia Type 4	Hypercalcemia, Increased circulating cortisol level	ORPHA:276152
Primary Intestinal Lymphangiectasia	Hypomagnesemia, Hypoproteinemia, Hypocalcemia, Hypoalbuminemia	ORPHA:90362
Isolated Thyroid-Stimulating Hormone Deficiency	Hypercholesterolemia, Abnormal circulating thyroglobulin level, Neonatal hyperbilirubinemia	ORPHA:90674
Dahlberg-Borer-Newcomer Syndrome	Hypocalcemia	ORPHA:1563
Gaisböck Syndrome	Hyperproteinemia, Hyperuricemia, Hypercholesterolemia, Hypertriglyceridemia, Increased circulatin...	ORPHA:90041
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis	Hypocalcemia	OMIM:618476
Hypocalcemic Vitamin D-Resistant Rickets	Hypophosphatemia, Hypocalcemia	ORPHA:93160
X-Linked Agammaglobulinemia	Hypocalcemia	ORPHA:47
Lysinuric Protein Intolerance	Abnormal circulating serine concentration, Decreased HDL cholesterol concentration, Increased LDL...	ORPHA:470
Lipodystrophy, Familial Partial, Type 2	Hypercholesterolemia, Decreased HDL cholesterol concentration, Hypertriglyceridemia	OMIM:151660
Tubular Renal Disease-Cardiomyopathy Syndrome	Hypomagnesemia, Hypocalcemic tetany, Hyperaldosteronism, Hypocalcemia	ORPHA:73224
Congenital Disorder Of Glycosylation, Type Ig	Hypocalcemia	OMIM:607143
Osteopetrosis, Autosomal Recessive 5	Hyperbilirubinemia, Hypocalcemia	OMIM:259720
Neuroleptic Malignant Syndrome	Hyperkalemia, Hyponatremia, Hypernatremia, Elevated circulating creatine kinase concentration, Hy...	ORPHA:94093
Hypocalcemic Vitamin D-Dependent Rickets	Hypophosphatemia, Hypocalcemic seizures, Hypocalcemia	ORPHA:289157
Cholera	Hyponatremia, Hypocalcemia, Hypokalemia, Abnormal blood ion concentration	ORPHA:173
Lysosomal Acid Lipase Deficiency	Hyperkalemia, Hyponatremia, Hypercholesterolemia, Xanthelasma, Steatorrhea, Hypertriglyceridemia	ORPHA:275761
Oncogenic Osteomalacia	Hypophosphatemia, Hypocalcemia	ORPHA:352540
Sanjad-Sakati Syndrome	Hyperphosphatemia, Hypocalcemia	ORPHA:2323
Multiple Endocrine Neoplasia Type 2	Hypercalcemia	ORPHA:653
Hypophosphatemic Rickets	Hypercalcemia, Hypophosphatemia	ORPHA:437
Lmna-Related Cardiocutaneous Progeria Syndrome	Hypercholesterolemia, Hypertriglyceridemia	ORPHA:363618
Bardet-Biedl Syndrome 20	Hypercholesterolemia	OMIM:619471
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly	Hypoproteinemia, Hypocalcemia	OMIM:235255
Osteopetrosis, Autosomal Recessive 1	Hypocalcemia	OMIM:259700
Juvenile Nephropathic Cystinosis	Hypouricemia, Hyponatremia, Hypocalcemic tetany, Hypokalemia, Elevated circulating creatinine con...	ORPHA:411634
Multiple Endocrine Neoplasia Type 1	Hypercalcemia, Increased circulating cortisol level, Primary hypercortisolism	ORPHA:652
Bacterial Toxic-Shock Syndrome	Elevated circulating creatine kinase concentration, Elevated circulating creatinine concentration...	ORPHA:36234
Gracile Bone Dysplasia	Hypocalcemia	OMIM:602361
Double Outlet Right Ventricle	Hypocalcemia	ORPHA:3426
Immunodeficiency 47	Hypercholesterolemia, Decreased circulating copper concentration	OMIM:300972
Autosomal Dominant Hypocalcemia	Hypomagnesemia, Hyperphosphatemia, Hypocalcemia	ORPHA:428
Pseudohypoparathyroidism Type 1C	Calcinosis, Hypocalcemic tetany, Hypocalcemic seizures, Hypocalcemia, Hyperphosphatemia	ORPHA:79444
Kenny-Caffey Syndrome, Type 2	Transient hypophosphatemia, Hyperphosphatemia, Hypocalcemia	OMIM:127000
Celiac Disease, Susceptibility To, 1	Steatorrhea, Hypocalcemia	OMIM:212750
Mitochondrial Trifunctional Protein Deficiency	Hypocalcemia	ORPHA:746
Pseudohypoparathyroidism, Type Ic	Hypocalcemic tetany, Hyperphosphatemia	OMIM:612462
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome	Hypoproteinemia, Hypocalcemia	ORPHA:1655
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome	Decreased prealbumin level, Hypocalcemia, Hypomagnesemia, Hypoalbuminemia, Abnormal blood ion con...	ORPHA:37042
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib	Hyperlipidemia, Hyperuricemia, Hypercholesterolemia, Xanthelasma, Hypertriglyceridemia	ORPHA:79259
Pseudohypoparathyroidism, Type Ia	Hypocalcemic tetany, Hyperphosphatemia	OMIM:103580
Williams Syndrome	Abnormal circulating lipid concentration, Hypercalcemia, Elevated circulating creatine kinase con...	ORPHA:904
Pseudohypoparathyroidism Type 1A	Calcinosis, Hypocalcemic tetany, Hypocalcemic seizures, Hypocalcemia, Hyperphosphatemia	ORPHA:79443
Oculocerebrorenal Syndrome Of Lowe	Hyponatremia, Hypokalemia, Hypophosphatemia, Hypercholesterolemia, Hyperaldosteronism, Hypoammonemia	ORPHA:534
Lowe Oculocerebrorenal Syndrome	Hypercholesterolemia, Elevated maternal serum alpha-fetoprotein, Elevated amniotic fluid alpha-fe...	OMIM:309000
Ethylene Glycol Poisoning	Hyperkalemia, Hypocalcemia	ORPHA:31826
Igg4-Related Thyroid Disease	Hypocalcemia	ORPHA:64744
Pearson Syndrome	Hypokalemia, Hypophosphatemia, Hyperalaninemia, Hypomagnesemia, Steatorrhea, Hypocalcemia	ORPHA:699
Alagille Syndrome 1	Hypercholesterolemia, Hypertriglyceridemia	OMIM:118450
Sarcoidosis	Hypercalcemia	ORPHA:797
Gitelman Syndrome	Primary hyperaldosteronism, Hypokalemia, Hypomagnesemia, Hypocalcemia, Hypermagnesemia	ORPHA:358
Exercise-Induced Malignant Hyperthermia	Elevated circulating creatine kinase concentration, Hyperkalemia, Hyperphosphatemia, Hypocalcemia	ORPHA:466650
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome	Hypocalcemic seizures, Hypocalcemia	ORPHA:2237
Williams-Beuren Syndrome	Hypercalcemia	OMIM:194050
X-Linked Intellectual Disability-Craniofacioskeletal Syndrome	Hyperbilirubinemia, Hypocalcemia	ORPHA:163979
Craniofacioskeletal Syndrome	Hypocalcemia	OMIM:300712
Velocardiofacial Syndrome	Hypocalcemia	OMIM:192430
Homozygous Familial Hypercholesterolemia	Increased LDL cholesterol concentration, Hypercholesterolemia, Hyperlipidemia	ORPHA:391665
Cartilage-Hair Hypoplasia	Hypocalcemia	ORPHA:175
Osteopetrosis With Renal Tubular Acidosis	Elevated circulating creatine kinase concentration, Hypocalcemia	ORPHA:2785
Visceral Steatosis, Congenital	Hypocalcemia	OMIM:228100
Infection-Related Hemolytic Uremic Syndrome	Hyperkalemia, Hyponatremia, Hypocalcemia	ORPHA:544482
Sotos Syndrome	Hypercalcemia	ORPHA:821
Steinert Myotonic Dystrophy	Hypercholesterolemia	ORPHA:273
Rajab Interstitial Lung Disease With Brain Calcifications 1	Unconjugated hyperbilirubinemia, Hypocalcemia, Hypoalbuminemia	OMIM:613658
Acrodysostosis With Multiple Hormone Resistance	Hyperphosphatemia, Hypocalcemia	ORPHA:280651
Cranioectodermal Dysplasia 1	Hypocalcemia	OMIM:218330
Autosomal Recessive Malignant Osteopetrosis	Hypophosphatemia, Hypocalcemia	ORPHA:667
Hennekam Syndrome	Hypocalcemia	ORPHA:2136
Biliary, Renal, Neurologic, And Skeletal Syndrome	Elevated circulating creatinine concentration, Hyperbilirubinemia, Hypercholesterolemia, Increase...	OMIM:619534
22Q11.2 Deletion Syndrome	Hypocalcemia	ORPHA:567
Autosomal Dominant Kenny-Caffey Syndrome	Hypocalcemic tetany, Hyperphosphatemia, Hypocalcemic seizures	ORPHA:93325
Thymic Aplasia	Hypocalcemic tetany	ORPHA:83471
Digeorge Syndrome	Hypocalcemia	OMIM:188400
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies	Hypomagnesemia, Hypocalcemia	OMIM:619503
Johanson-Blizzard Syndrome	Increased VLDL cholesterol concentration, Hypocalcemia	OMIM:243800
Charge Syndrome	Hypocalcemia	OMIM:214800

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zmym4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zmym4.

There are 3 publications which use IMPC produced mice or data.

Title	Journal	IMPC Allele	PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.	G3 (Bethesda, Md.) (June 2020)	Zmym4^{em1(IMPC)Wtsi}	PMC7263671
Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription.	Cell metabolism (June 2020)	Zmym4^{em1(IMPC)Wtsi}	PMC7267775
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.	Nature communications (August 2019)	Zmym4^{em1(IMPC)Wtsi}	PMC6671969

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MGI Allele	Allele Type	Produced
Zmym4^{tm36782(L1L2_gt0)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors
Zmym4^{em1(IMPC)Wtsi}	Deletion	Mice

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