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Gene: Zmym4 MGI:1915035

Gene Summary

Name:

zinc finger, MYM-type 4

Synonyms:

Zfp262, 6330503C17Rik

Order Alleles

IMPC Data Collections

Body Weight Measurements
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype	Allele	Zyg	Life Stage	P Value
increased circulating amylase level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	8.92×10^-05
increased circulating cholesterol level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	1.35×10^-06
increased circulating calcium level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	7.83×10^-06
increased circulating HDL cholesterol level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	1.32×10^-05
increased circulating glycerol level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	3.20×10^-06
decreased body length	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	1.45×10^-06
decreased circulating fructosamine level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	2.23×10^-06
decreased bone mineral content	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	3.76×10^-05

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Zmym4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Zmym4 (0 diseases)
Human diseases predicted to be associated with Zmym4 (251 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Zmym4 by phenotypic similarity.

Disease	Matching phenotypes	Source
Hypertriglyceridemia 2	Hypertriglyceridemia, Decreased HDL cholesterol concentration, Hypercholesterolemia	OMIM:619324
Xanthomatosis, Susceptibility To	Hypercholesterolemia	OMIM:602247
Thyroid Hormone Metabolism, Abnormal, 2	Hypercholesterolemia	OMIM:619855
Sitosterolemia 2	Elevated circulating sitosterol concentration, Hypercholesterolemia	OMIM:618666
Cholesterol-Ester Transfer Protein Deficiency	Increased HDL cholesterol concentration, Hyperlipoproteinemia, Hyperlipidemia, Hypercholesterolem...	ORPHA:79506
Hyperlipoproteinemia, Type Ii, And Deafness	Increased LDL cholesterol concentration, Hypertriglyceridemia, Hypercholesterolemia	OMIM:144300
Glycogen Storage Disease Vi	Hypertriglyceridemia, Hyperlipidemia, Hypercholesterolemia	OMIM:232700
Hypercholesterolemia, Familial, 4	Hypertriglyceridemia, Decreased LDL cholesterol concentration, Hypercholesterolemia	OMIM:603813
Ulna Metaphyseal Dysplasia Syndrome	Hypercalcemia	OMIM:191420
Coronary Artery Disease, Autosomal Dominant, 1	Hypercholesterolemia	OMIM:608320
Hyperlipidemia, Familial Combined, 3	Hypercholesterolemia, Increased VLDL cholesterol concentration, Elevated circulating apolipoprote...	OMIM:144250
Congenital Disorder Of Glycosylation, Type Iip	Decreased circulating ceruloplasmin concentration, Increased LDL cholesterol concentration, Hyper...	OMIM:616829
Blue Diaper Syndrome	Abnormal circulating tryptophan concentration, Hypercalcemia	OMIM:211000
Adamantinoma	Hypercalcemia	ORPHA:55881
Hyperparathyroidism 4	Osteopenia, Hypercalcemia	OMIM:617343
Analbuminemia	Elevated circulating transferrin concentration, Increased LDL cholesterol concentration, Hypercho...	OMIM:616000
Diarrhea 7, Protein-Losing Enteropathy Type	Hypoalbuminemia, Hyperlipidemia, Hypercholesterolemia	OMIM:615863
Hypothyroidism, Congenital, Nongoitrous, 8	Hypercholesterolemia	OMIM:301033
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 1	Hypoalbuminemia, Hypercholesterolemia	OMIM:607250
Morbid Obesity And Spermatogenic Failure	Increased LDL cholesterol concentration, Hypertriglyceridemia, Decreased HDL cholesterol concentr...	OMIM:615703
Hypocalcemia, Autosomal Dominant 2	Abnormal blood phosphate concentration, Hypocalcemia	OMIM:615361
Hyperparathyroidism 1	Hypercalcemia	OMIM:145000
Nephropathy-Deafness-Hyperparathyroidism Syndrome	Hypercalcemia, Bone cyst	ORPHA:2668
Familial Apolipoprotein Gene Cluster Deletion Syndrome	Hypocholesterolemia, Decreased circulating apolipoprotein A-I concentration, Decreased HDL choles...	OMIM:620058
Distal Myopathy, Tateyama Type	Abnormal circulating creatine kinase concentration, Hypercholesterolemia	ORPHA:488650
Cholestasis, Progressive Familial Intrahepatic, 10	Increased total bilirubin, Increased serum bile acid concentration, Hypercholesterolemia, Conjuga...	OMIM:619868
Hepatic Lipase Deficiency	Hypercholesterolemia, Hypertriglyceridemia, Increased HDL cholesterol concentration	OMIM:614025
Spinocerebellar Ataxia With Axonal Neuropathy Type 1	Hypoalbuminemia, Hypercholesterolemia	ORPHA:94124
Hypoparathyroidism, Familial Isolated, 2	Hyperphosphatemia, Hypocalcemia, Hypocalcemic seizures	OMIM:618883
Parathyroid Carcinoma	Hypercalcemia	OMIM:608266
Hypercalcemia, Infantile, 2	Hypophosphatemia, Hypercalcemia	OMIM:616963
Granulomatous Slack Skin	Hypercalcemia	ORPHA:33111
Tumoral Calcinosis, Hyperphosphatemic, Familial, 3	Hyperphosphatemia, Metacarpal periosteal thickening, Calvarial osteosclerosis, Osteopenia, Hyperc...	OMIM:617994
Lipodystrophy, Congenital Generalized, Type 3	Hypocalcemia, Hypertriglyceridemia, Hypercholesterolemia	OMIM:612526
Familial Isolated Hyperparathyroidism	Osteopenia, Hypophosphatemia, Generalized osteoporosis, Hypercalcemia	ORPHA:99879
Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies	Osteopenia, Craniosynostosis, Hypercalcemia	OMIM:614732
22q11 deletion syndrome (Velocardiofacial / DiGeorge syndrome)	Hypocalcemia	DECIPHER:16
Congenital Disorder Of Glycosylation, Type Iio	Hypercholesterolemia, Decreased circulating ceruloplasmin concentration, Increased LDL cholestero...	OMIM:616828
Glycogen Storage Disease Ixa1	Hypertriglyceridemia, Hyperuricemia, Hypercholesterolemia	OMIM:306000
Myopathy, Tubular Aggregate, 2	Hypocalcemia, Elevated circulating creatine kinase concentration	OMIM:615883
Hypercholesterolemia, Familial, 3	Hypercholesterolemia, Abnormal LDL cholesterol concentration, Xanthelasma	OMIM:603776
Hypercholesterolemia, Familial, 2	Hypercholesterolemia, Increased LDL cholesterol concentration, Xanthelasma	OMIM:144010
Cholesteryl Ester Storage Disease	Hypertriglyceridemia, Hypercholesterolemia	ORPHA:75234
Vitamin D-Dependent Rickets, Type 3	Hypophosphatemia, Hypocalcemia, Osteopenia	OMIM:619073
Hypophosphatasia	Craniosynostosis, Hypercalcemia	ORPHA:436
Hypomagnesemia 1, Intestinal	Hypocalcemia, Hypomagnesemia	OMIM:602014
Small Cell Carcinoma Of The Bladder	Hypercalcemia	ORPHA:284400
Diffuse Neonatal Hemangiomatosis	Hypercalcemia	ORPHA:2123
Blue Diaper Syndrome	Hyperphosphatemia, Hypercalcemia	ORPHA:94086
Growth Hormone Insensitivity Syndrome	Hypercholesterolemia	ORPHA:181393
Hyperparathyroidism, Neonatal Self-Limited Primary, With Hypercalciuria	Hypercalcemia	OMIM:239199
Infantile Myofibromatosis	Osteolysis, Hypercalcemia, Bone cyst	ORPHA:2591
Apolipoprotein C-Ii Deficiency	Hypercholesterolemia, Increased circulating chylomicron concentration, Hypertriglyceridemia, Decr...	OMIM:207750
Pseudohypoparathyroidism, Type Ii	Hyperphosphatemia, Hypocalcemia	OMIM:203330
Hypophosphatemic Rickets And Hyperparathyroidism	Rickets, Hypophosphatemia, Hypophosphatemic rickets, Hypercalcemia	OMIM:612089
Hypercalcemia, Infantile, 1	Hypercalcemia	OMIM:143880
Progressive Familial Intrahepatic Cholestasis	Hypocalcemia, Reduced bone mineral density	ORPHA:172
Ataxia-Oculomotor Apraxia 4	Hypoalbuminemia, Elevated circulating alpha-fetoprotein concentration, Hypercholesterolemia	OMIM:616267
Rhabdoid Tumor	Hypercalcemia	ORPHA:69077
Thymic Neuroendocrine Tumor	Osteopenia, Hypercalcemia, Increased circulating cortisol level	ORPHA:97289
Glycogen Storage Disease Due To Lactate Dehydrogenase M-Subunit Deficiency	Hypercalcemia, Elevated creatine kinase after exercise	ORPHA:284426
Hypophosphatasia, Infantile	Elevated plasma pyrophosphate, Unossified vertebral bodies, Decreased calvarial ossification, Hyp...	OMIM:241500
Paget Disease Of Bone 2, Early-Onset	Osteolysis, Osteosclerosis of the ulna, Sclerosis of skull base, Hypercalcemia	OMIM:602080
Morgagni-Stewart-Morel Syndrome	Hyperostosis frontalis interna, Hyperuricemia, Osteoporosis, Hypercholesterolemia	ORPHA:77296
Oculoskeletodental Syndrome	Hypocalcemia, Hypercalcemia	ORPHA:557003
Familial Isolated Hypoparathyroidism Due To Agenesis Of Parathyroid Gland	Hyperphosphatemia, Hypocalcemia, Hypomagnesemia, Hypocalcemic seizures	ORPHA:2239
Autosomal Recessive Kenny-Caffey Syndrome	Hypocalcemic tetany, Calvarial osteosclerosis, Cortical thickening of long bone diaphyses, Decrea...	ORPHA:93324
Hyperparathyroidism 2 With Jaw Tumors	Hypercalcemia	OMIM:145001
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia	Hypercholesterolemia, Hypoalbuminemia, Elevated circulating creatine kinase concentration	OMIM:208920
Fibrous Dysplasia Of Bone	Thin bony cortex, Increased circulating cortisol level, Osteomalacia, Hypophosphatemia, Rickets, ...	ORPHA:249
Uremic Pruritus	Increased blood urea nitrogen, Renal hypophosphatemia, Hypercalcemia, Hypermagnesemia	ORPHA:94059
Spinocerebellar Ataxia With Axonal Neuropathy Type 2	Hypercholesterolemia, Hypoalbuminemia, Elevated circulating alpha-fetoprotein concentration, Elev...	ORPHA:64753
Renal Tubular Acidosis, Distal, 1	Elevated circulating creatinine concentration, Hypokalemia, Hypocalcemia, Osteomalacia	OMIM:179800
Citrullinemia, Type Ii, Neonatal-Onset	Hyperlysinemia, Hyperthreoninemia, Hypermethioninemia, Hyperbilirubinemia, Hypertyrosinemia, Decr...	OMIM:605814
Temple Syndrome Due To Paternal 14Q32.2 Hypomethylation	Hypercholesterolemia	ORPHA:254531
Hypocalciuric Hypercalcemia, Familial, Type Iii	Hypophosphatemia, Osteomalacia, Hypercalcemia, Hypermagnesemia	OMIM:600740
Non-Functioning Paraganglioma	Hypercalcemia	ORPHA:94080
Hypocalcemia, Autosomal Dominant 1	Hyperphosphatemia, Hypokalemia, Increased circulating renin level, Hypocalcemia, Hypomagnesemia	OMIM:601198
Hypoparathyroidism, Familial Isolated, 1	Hyperphosphatemia, Hypocalcemia, Hypocalcemic seizures	OMIM:146200
Hypocalciuric Hypercalcemia, Familial, Type I	Hypercalcemia, Hypermagnesemia	OMIM:145980
Chylomicron Retention Disease	Decreased LDL cholesterol concentration, Steatorrhea, Hypotriglyceridemia, Hypocholesterolemia, H...	OMIM:246700
Intermediate Osteopetrosis	Hypocalcemia, Generalized osteosclerosis, Osteosclerosis of the base of the skull, Abnormality of...	ORPHA:210110
Cholestasis, Progressive Familial Intrahepatic, 7, With Or Without Hearing Loss	Hypocalcemia, Elevated circulating gamma-aminobutyric acid concentration	OMIM:619658
Glucose-Galactose Malabsorption	Hypernatremia, Hypercalcemia	ORPHA:35710
Congenital Analbuminemia	Increased alpha-globulin, Hypoproteinemia, Hyperlipidemia, Hypercholesterolemia, Hypoalbuminemia	ORPHA:86816
Hypocalciuric Hypercalcemia, Familial, Type Ii	Hypercalcemia, Hypermagnesemia	OMIM:145981
Metaphyseal Chondrodysplasia, Jansen Type	Osteopenia, Hypophosphatemia, Hypercalcemia	OMIM:156400
Late-Onset Isolated Acth Deficiency	Generalized bone demineralization, Hyperuricemia, Decreased circulating cortisol level, Hyperkale...	ORPHA:199299
Pseudohypoparathyroidism, Type Ib	Hyperphosphatemia, Hypocalcemia	OMIM:603233
Pseudohypoparathyroidism Type 2	Hyperphosphatemia, Hypocalcemic tetany, Calcinosis, Hypocalcemic seizures, Hypocalcemia	ORPHA:94090
Autosomal Dominant Hypophosphatemic Rickets	Rickets, Hypophosphatemia, Hypocalcemia, Osteomalacia	ORPHA:89937
Idiopathic Steroid-Resistant Nephrotic Syndrome	Abnormal circulating lipid concentration, Hypertriglyceridemia, Hypoalbuminemia, Hypercholesterol...	ORPHA:567548
Pheochromocytoma--Islet Cell Tumor Syndrome	Hypercalcemia	OMIM:171420
Laron Syndrome	Hypercholesterolemia	ORPHA:633
Paternal Uniparental Disomy Of Chromosome 1	Increased blood urea nitrogen, Craniosynostosis, Hypercalcemia	ORPHA:251004
Hypocalcemic Vitamin D-Resistant Rickets	Osteomalacia, Hypophosphatemia, Coarse metaphyseal trabecularization, Osteolysis, Abnormal bone s...	ORPHA:93160
Hyperlipoproteinemia, Type I	Hypercholesterolemia, Increased circulating chylomicron concentration, Hyperlipidemia, Lactescent...	OMIM:238600
Congenital Generalized Lipodystrophy	Increased C-peptide level, Hypertriglyceridemia, Bone cyst, Hypercholesterolemia	ORPHA:528
Pseudopseudohypoparathyroidism	Hyperphosphatemia, Hypocalcemia, Ectopic ossification	ORPHA:79445
Temple Syndrome	Hypertriglyceridemia, Hypercholesterolemia	OMIM:616222
Nephrotic Syndrome, Type 11	Hypoalbuminemia, Hypercholesterolemia	OMIM:616730
Galactokinase Deficiency	Hypergalactosemia, Increased level of galactitol in plasma, Hypercholesterolemia	ORPHA:79237
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency	Hyperlysinemia, Abnormal circulating lipid concentration, Hyperthreoninemia, Hypergalactosemia, H...	ORPHA:247598
Vitamin D Hydroxylation-Deficient Rickets, Type 1B	Thin bony cortex, Hypophosphatemia, Sparse bone trabeculae, Rickets, Hypocalcemia, Delayed epiphy...	OMIM:600081
Autoimmune Hypoparathyroidism	Hypocalcemic tetany, Hyperphosphatemia, Increased bone mineral density, Hypocalcemic seizures, Hy...	ORPHA:36913
Alpha-Heavy Chain Disease	Hypocalcemia	ORPHA:100025
Abdominal Obesity-Metabolic Syndrome 3	Increased LDL cholesterol concentration, Hypertriglyceridemia, Hypercholesterolemia	OMIM:615812
Hyperparathyroidism, Neonatal Severe	Hypophosphatemia, Hypercalcemia, Calcinosis	OMIM:239200
Oculoskeletodental Syndrome	Hypocalcemia, Hypercalcemia	OMIM:618440
Bartter Syndrome, Type 1, Antenatal	Increased serum prostaglandin E2, Hyperaldosteronism, Hypokalemia, Increased circulating renin le...	OMIM:601678
Cholestasis, Progressive Familial Intrahepatic, 8	Hypercholesterolemia, Increased serum bile acid concentration, Conjugated hyperbilirubinemia, Ele...	OMIM:619662
2P21 Microdeletion Syndrome	Hypocalcemia	ORPHA:163693
Citrullinemia Type Ii	Acute hyperammonemia, Hypoproteinemia, Decreased HDL cholesterol concentration, Hyperlipidemia, H...	ORPHA:247585
Cog4-Cdg	Hypercholesterolemia	ORPHA:263501
Familial Hypocalciuric Hypercalcemia	Osteomalacia, Hypermagnesemia, Hypercalcemia, Hypocalcemic seizures, Renal hypophosphatemia	ORPHA:405
Ataxia With Vitamin E Deficiency	Increased LDL cholesterol concentration, Hypertriglyceridemia, Xanthelasma, Hypercholesterolemia	OMIM:277460
Smith-Magenis Syndrome	Hypertriglyceridemia, Hypercholesterolemia	OMIM:182290
Acute Adrenal Insufficiency	Hyperuricemia, Decreased circulating cortisol level, Hyperkalemia, Increased circulating renin le...	ORPHA:95409
Mastocytosis	Osteoporosis, Hypercalcemia	ORPHA:98292
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency	Increased LDL cholesterol concentration, Hypertriglyceridemia, Hypercholesterolemia	ORPHA:209902
Refractory Celiac Disease	Hypophosphatemia, Hypoproteinemia, Hypocalcemia, Hypomagnesemia, Osteoporosis, Hypoalbuminemia	ORPHA:398063
Mandibuloacral Dysplasia	Increased circulating free fatty acid level, Acroosteolysis of distal phalanges (feet), Osteolyti...	ORPHA:2457
Vitamin D Hydroxylation-Deficient Rickets, Type 1A	Thin bony cortex, Hypophosphatemia, Sparse bone trabeculae, Rickets, Hypocalcemic seizures, Hypoc...	OMIM:264700
Addison Disease	Generalized bone demineralization, Hyperuricemia, Decreased circulating cortisol level, Hyperkale...	ORPHA:85138
Multiple Myeloma	Osteopenia, Elevated circulating creatinine concentration, Hyperproteinemia, Hypercalcemia	ORPHA:29073
Hypophosphatemic Rickets	Osteomalacia, Hypophosphatemia, Rickets, Craniofacial osteosclerosis, Hyperostosis, Hypercalcemia...	ORPHA:437
Intellectual Disability-Seizures-Hypophosphatasia-Ophthalmic-Skeletal Anomalies Syndrome	Osteopenia, Hypertriglyceridemia, Craniosynostosis, Hypercalcemia	ORPHA:369837
9Q31.1Q31.3 Microdeletion Syndrome	Hypercholesterolemia	ORPHA:401923
Pseudohypoparathyroidism, Type Ic	Hypocalcemic tetany, Hypocalcemia, Osteoporosis, Hyperphosphatemia	OMIM:612462
Kenny-Caffey Syndrome, Type 1	Hypocalcemia, Hypomagnesemia, Decreased skull ossification, Calvarial osteosclerosis	OMIM:244460
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14	Hypercholesterolemia	ORPHA:96184
Dysbetalipoproteinemia	Hypercholesterolemia, Increased LDL cholesterol concentration, Decreased HDL cholesterol concentr...	ORPHA:412
Monosomy 13Q34	Hypercalcemia	ORPHA:96168
Sitosterolemia 1	Reduced haptoglobin level, Hypercholesterolemia, Elevated circulating sitosterol concentration, X...	OMIM:210250
Lysosomal Acid Lipase Deficiency	Steatorrhea, Increased LDL cholesterol concentration, Decreased HDL cholesterol concentration, Hy...	OMIM:278000
Hypocalcemic Vitamin D-Dependent Rickets	Thin bony cortex, Osteomalacia, Hypophosphatemia, Sparse bone trabeculae, Rickets, Hypocalcemic s...	ORPHA:289157
Sporadic Pheochromocytoma/Secreting Paraganglioma	Hypercalcemia	ORPHA:276621
Multiple Endocrine Neoplasia, Type I	Hypercalcemia, Increased circulating cortisol level	OMIM:131100
Micrognathia-Recurrent Infections-Behavioral Abnormalities-Mild Intellectual Disability Syndrome	Hypercalcemia	ORPHA:476126
Megalocornea-Mental Retardation Syndrome	Osteopenia, Hypercholesterolemia	OMIM:249310
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency	Hypercholesterolemia, Hypertriglyceridemia, Osteoporosis, Elevated circulating creatine kinase co...	ORPHA:79240
Albers-Schönberg Osteopetrosis	Hypocalcemia, Generalized osteosclerosis	ORPHA:53
Pseudohypoparathyroidism Type 1B	Hypocalcemic tetany, Hyperphosphatemia, Calcinosis, Increased bone density with cystic changes, I...	ORPHA:94089
Megalocornea-Intellectual Disability Syndrome	Osteopenia, Hypercholesterolemia	ORPHA:2479
Mandibuloacral Dysplasia With Type A Lipodystrophy	Acroosteolysis of distal phalanges (feet), Calcinosis, Osteopenia, Hyperlipidemia, Hypercholester...	OMIM:248370
Pheochromocytoma	Hypercalcemia	OMIM:171300
Galloway-Mowat Syndrome 7	Hypercholesterolemia	OMIM:618348
Osteopetrosis, Autosomal Recessive 1	Calvarial osteosclerosis, Increased bone mineral density, Hypocalcemia, Osteopetrosis, Craniosyno...	OMIM:259700
Hypoparathyroidism-Retardation-Dysmorphism Syndrome	Hypocalcemia, Patchy osteosclerosis, Hyperphosphatemia, Hypocalcemic seizures	OMIM:241410
Timothy Syndrome	Hypocalcemia	OMIM:601005
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency	Hypercholesterolemia, Hypertriglyceridemia, Osteoporosis, Elevated circulating creatine kinase co...	ORPHA:264580
Smith-Magenis Syndrome	Hypertriglyceridemia, Hypercholesterolemia	ORPHA:819
Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal	Hypertriglyceridemia, Hypercholesterolemia	OMIM:610644
Ring Chromosome 10 Syndrome	Hypocalcemia	ORPHA:1438
Genetic Recurrent Myoglobinuria	Highly elevated creatine kinase, Hypocalcemia, Hyperkalemia, Hyperphosphatemia	ORPHA:99845
Hepatocellular Carcinoma	Hypokalemia, Hyperbilirubinemia, Hypercalcemia, Hyponatremia, Hypoalbuminemia	ORPHA:88673
Familial Isolated Hypoparathyroidism	Hypocalcemia	ORPHA:2238
Hereditary Pheochromocytoma-Paraganglioma	Hypercalcemia	ORPHA:29072
Somatostatinoma	Hypercalcemia, Steatorrhea, Increased circulating cortisol level	ORPHA:97283
Ppoma	Hypercalcemia, Increased circulating cortisol level	ORPHA:97278
Hypotonia-Cystinuria Syndrome	Hypocalcemia	OMIM:606407
Glycogen Storage Disease Due To Phosphorylase Kinase Deficiency	Hypercholesterolemia, Hypertriglyceridemia, Elevated circulating creatine kinase concentration	ORPHA:370
Acquired Aneurysmal Subarachnoid Hemorrhage	Hypercholesterolemia	ORPHA:90065
Diarrhea 10, Protein-Losing Enteropathy Type	Hyponatremia, Hypocalcemia, Hypertriglyceridemia, Hypomagnesemia, Hypoalbuminemia	OMIM:618183
Vipoma	Hypokalemia, Hypercalcemia, Increased circulating cortisol level	ORPHA:97282
Very Long Chain Acyl-Coa Dehydrogenase Deficiency	Increased circulating free fatty acid level, Elevated circulating creatine kinase concentration, ...	ORPHA:26793
Hyperparathyroidism-Jaw Tumor Syndrome	Osteoporosis, Hypophosphatemia, Hypercalcemia	ORPHA:99880
Lysinuric Protein Intolerance	Hyperalaninemia, Hyperglycinemia, Intraalveolar phospholipid accumulation, Hyperglutaminemia, Ste...	ORPHA:470
Parathyroid Carcinoma	Osteoporosis, Hypophosphatemia, Hypercalcemia	ORPHA:143
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis	Increased skull ossification, Craniofacial osteosclerosis, Diaphyseal sclerosis, Hypocalcemia, Os...	OMIM:618476
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes	Hypokalemia, Hypocalcemia, Hypomagnesemia	OMIM:175500
Oncogenic Osteomalacia	Fibrous dysplasia of the bones, Hypophosphatemia, Hypocalcemia	ORPHA:352540
Glucagonoma	Hypercalcemia, Steatorrhea, Increased circulating cortisol level	ORPHA:97280
Kenny-Caffey Syndrome, Type 2	Hyperphosphatemia, Transient hypophosphatemia, Increased bone mineral density, Thickened cortex o...	OMIM:127000
Isolated Thyroid-Stimulating Hormone Deficiency	Abnormal circulating thyroglobulin level, Delayed proximal femoral epiphyseal ossification, Neona...	ORPHA:90674
Zollinger-Ellison Syndrome	Hypercalcemia, Increased circulating cortisol level	ORPHA:913
Grfoma	Hypercalcemia, Increased circulating cortisol level	ORPHA:97261
Colchicine Poisoning	Hypophosphatemia, Hypokalemia, Abnormal blood ion concentration, Hyponatremia, Hypocalcemia, Hypo...	ORPHA:31824
Gracile Bone Dysplasia	Hypocalcemia, Decreased skull ossification	OMIM:602361
Primary Intestinal Lymphangiectasia	Hypocalcemia, Hypoproteinemia, Hypomagnesemia, Hypoalbuminemia	ORPHA:90362
Low Phospholipid-Associated Cholelithiasis	Hypercholesterolemia	ORPHA:69663
Multiple Endocrine Neoplasia Type 4	Hypercalcemia, Increased circulating cortisol level	ORPHA:276152
Sanjad-Sakati Syndrome	Hypocalcemia, Patchy osteosclerosis, Hyperphosphatemia	ORPHA:2323
Dahlberg-Borer-Newcomer Syndrome	Hypocalcemia	ORPHA:1563
X-Linked Agammaglobulinemia	Hypocalcemia	ORPHA:47
Multiple Endocrine Neoplasia Type 1	Increased circulating cortisol level, Primary hypercortisolism, Osteolysis, Hypercalcemia, Reduce...	ORPHA:652
Celiac Disease, Susceptibility To, 1	Rickets, Hypocalcemia, Osteoporosis, Steatorrhea	OMIM:212750
Gaisböck Syndrome	Hyperuricemia, Increased circulating renin level, Hypercholesterolemia, Hyperproteinemia, Hypertr...	ORPHA:90041
Pseudohypoparathyroidism Type 1C	Hypocalcemic tetany, Hyperphosphatemia, Ectopic ossification, Calcinosis, Increased bone mineral ...	ORPHA:79444
Lipodystrophy, Familial Partial, Type 2	Hypertriglyceridemia, Decreased HDL cholesterol concentration, Hypercholesterolemia	OMIM:151660
Pseudohypoparathyroidism, Type Ia	Hypocalcemic tetany, Subcutaneous ossification, Osteoporosis, Hyperphosphatemia	OMIM:103580
Osteopetrosis, Autosomal Recessive 5	Increased bone mineral density, Hyperbilirubinemia, Decreased osteoclast count, Cranial hyperosto...	OMIM:259720
Autosomal Dominant Hypocalcemia	Hypocalcemia, Hypomagnesemia, Hyperphosphatemia, Reduced bone mineral density	ORPHA:428
Cholera	Hypokalemia, Hypocalcemia, Abnormal blood ion concentration, Hyponatremia	ORPHA:173
Lysosomal Acid Lipase Deficiency	Hypercholesterolemia, Hyperkalemia, Steatorrhea, Xanthelasma, Hyponatremia, Hypertriglyceridemia	ORPHA:275761
Congenital Disorder Of Glycosylation, Type Ig	Hypocalcemia	OMIM:607143
Kidney Tubulopathy-Dilated Cardiomyopathy Syndrome	Hyperaldosteronism, Hypocalcemia, Hypomagnesemia, Hypocalcemic tetany	ORPHA:73224
Neuroleptic Malignant Syndrome	Hyperphosphatemia, Hyperuricemia, Hyperkalemia, Elevated circulating creatine kinase concentratio...	ORPHA:94093
Pseudohypoparathyroidism Type 1A	Hypocalcemic tetany, Hyperphosphatemia, Ectopic ossification, Calcinosis, Increased bone mineral ...	ORPHA:79443
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib	Hyperuricemia, Xanthelasma, Osteopenia, Hyperlipidemia, Hypercholesterolemia, Hypertriglyceridemi...	ORPHA:79259
Neurodevelopmental Disorder With Microcephaly, Cataracts, And Renal Abnormalities	Calcinosis, Hypokalemia, Osteopenia, Hyponatremia, Hypocalcemia	OMIM:617913
Multiple Endocrine Neoplasia Type 2	Hypercalcemia	ORPHA:653
Lowe Oculocerebrorenal Syndrome	Elevated maternal serum alpha-fetoprotein, Osteomalacia, Elevated amniotic fluid alpha-fetoprotei...	OMIM:309000
Immunodeficiency 47	Decreased circulating copper concentration, Hypercholesterolemia	OMIM:300972
Lmna-Related Cardiocutaneous Progeria Syndrome	Hypertriglyceridemia, Hypercholesterolemia	ORPHA:363618
Bardet-Biedl Syndrome 20	Hypercholesterolemia	OMIM:619471
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly	Hypocalcemia, Hypoproteinemia	OMIM:235255
Juvenile Nephropathic Cystinosis	Hypocalcemic tetany, Hypophosphatemia, Hypokalemia, Hyponatremia, Elevated circulating creatinine...	ORPHA:411634
Bacterial Toxic-Shock Syndrome	Elevated circulating creatinine concentration, Hypocalcemia, Hypoalbuminemia, Elevated circulatin...	ORPHA:36234
Williams Syndrome	Abnormal circulating lipid concentration, Increased bone mineral density, Elevated circulating cr...	ORPHA:904
Double Outlet Right Ventricle	Hypocalcemia	ORPHA:3426
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome	Hypocalcemia, Hypoproteinemia	ORPHA:1655
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome	Decreased prealbumin level, Abnormal blood ion concentration, Hypocalcemia, Hypomagnesemia, Hypoa...	ORPHA:37042
Mitochondrial Trifunctional Protein Deficiency	Hypocalcemia	ORPHA:746
Autosomal Recessive Hypophosphatemic Rickets	Hypocalcemic tetany, Rickets of the lower limbs, Abnormal trabecular bone morphology, Increased b...	ORPHA:289176
Oculocerebrorenal Syndrome Of Lowe	Hyperaldosteronism, Hyponatremia, Osteomalacia, Hypophosphatemia, Hypokalemia, Hypercholesterolem...	ORPHA:534
Sarcoidosis	Hypercalcemia, Bone cyst	ORPHA:797
Rajab Interstitial Lung Disease With Brain Calcifications 1	Thin bony cortex, Unconjugated hyperbilirubinemia, Rickets, Osteopenia, Hypocalcemia, Hypoalbumin...	OMIM:613658
Williams-Beuren Syndrome	Osteopenia, Osteoporosis, Hypercalcemia	OMIM:194050
Autosomal Recessive Malignant Osteopetrosis	Hypophosphatemia, Hypocalcemia, Osteopetrosis, Craniosynostosis, Reduced bone mineral density	ORPHA:667
Cartilage-Hair Hypoplasia	Hypocalcemia, Abnormal bone ossification, Abnormally ossified vertebrae	ORPHA:175
Autosomal Dominant Kenny-Caffey Syndrome	Hypocalcemic tetany, Hyperphosphatemia, Calvarial osteosclerosis, Cortical thickening of long bon...	ORPHA:93325
Ethylene Glycol Poisoning	Hypocalcemia, Hyperkalemia	ORPHA:31826
Igg4-Related Thyroid Disease	Hypocalcemia	ORPHA:64744
Pearson Syndrome	Hyperalaninemia, Hypokalemia, Hypophosphatemia, Steatorrhea, Hypocalcemia, Hypomagnesemia	ORPHA:699
Alagille Syndrome 1	Hypertriglyceridemia, Hypercholesterolemia	OMIM:118450
Osteopetrosis With Renal Tubular Acidosis	Hypocalcemia, Osteopetrosis, Elevated circulating creatine kinase concentration	ORPHA:2785
Isotretinoin-Like Syndrome	Hypocalcemia	ORPHA:2306
Gitelman Syndrome	Hypokalemia, Primary hyperaldosteronism, Hypermagnesemia, Hypocalcemia, Hypomagnesemia	ORPHA:358
Exercise-Induced Malignant Hyperthermia	Hypocalcemia, Hyperkalemia, Hyperphosphatemia, Elevated circulating creatine kinase concentration	ORPHA:466650
Velocardiofacial Syndrome	Hypocalcemia	OMIM:192430
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome	Hypocalcemia, Hypocalcemic seizures	ORPHA:2237
Sotos Syndrome	Craniosynostosis, Hypercalcemia	ORPHA:821
X-Linked Intellectual Disability-Craniofacioskeletal Syndrome	Hypocalcemia, Hyperbilirubinemia	ORPHA:163979
Craniofacioskeletal Syndrome	Hypocalcemia	OMIM:300712
Homozygous Familial Hypercholesterolemia	Increased LDL cholesterol concentration, Hyperlipidemia, Hypercholesterolemia	ORPHA:391665
Cranioectodermal Dysplasia 1	Sagittal craniosynostosis, Hypocalcemia, Osteoporosis	OMIM:218330
Hennekam Syndrome	Hypocalcemia, Craniosynostosis	ORPHA:2136
Lipodystrophy, Familial Partial, Type 7	Hypertriglyceridemia, Hypercholesterolemia	OMIM:606721
Steinert Myotonic Dystrophy	Hypercholesterolemia	ORPHA:273
Infection-Related Hemolytic Uremic Syndrome	Hypocalcemia, Hyperkalemia, Hyponatremia	ORPHA:544482
Visceral Steatosis, Congenital	Hypocalcemia	OMIM:228100
Biliary, Renal, Neurologic, And Skeletal Syndrome	Hyperbilirubinemia, Increased circulating ferritin concentration, Osteopenia, Hypercholesterolemi...	OMIM:619534
Liver Disease, Severe Congenital	Hyperalaninemia, Elevated hepatic iron concentration, Hyperbilirubinemia, Elevated circulating al...	OMIM:619991
22Q11.2 Deletion Syndrome	Multiple suture craniosynostosis, Hypocalcemia	ORPHA:567
Acrodysostosis With Multiple Hormone Resistance	Hypocalcemia, Hyperphosphatemia	ORPHA:280651
Thymic Aplasia	Hypocalcemic tetany	ORPHA:83471
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies	Hypocalcemia, Hypomagnesemia	OMIM:619503
Digeorge Syndrome	Hypocalcemia	OMIM:188400
Johanson-Blizzard Syndrome	Hypocalcemia, Increased VLDL cholesterol concentration	OMIM:243800
Charge Syndrome	Hypocalcemia	OMIM:214800

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zmym4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zmym4.

There are 3 publications which use IMPC produced mice or data.

Title	Journal	IMPC Allele	PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.	G3 (Bethesda, Md.) (June 2020)	Zmym4^{em1(IMPC)Wtsi}	PMC7263671
Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription.	Cell metabolism (June 2020)	Zmym4^{em1(IMPC)Wtsi}	PMC7267775
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.	Nature communications (August 2019)	Zmym4^{em1(IMPC)Wtsi}	PMC6671969

Order Mouse and ES Cells

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MGI Allele	Allele Type	Produced
Zmym4^{tm36782(L1L2_gt0)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors
Zmym4^{em1(IMPC)Wtsi}	Deletion	Mice

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