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Gene: Zmym4 MGI:1915035

Gene Summary

Name:

zinc finger, MYM-type 4

Synonyms:

Zfp262, 6330503C17Rik

Order Alleles

IMPC Data Collections

Body Weight Measurements
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype	Allele	Zyg	Life Stage	P Value
decreased circulating fructosamine level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	2.23×10^-06
increased circulating amylase level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	8.92×10^-05
decreased body length	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	1.45×10^-06
increased circulating HDL cholesterol level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	1.32×10^-05
increased circulating calcium level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	7.83×10^-06
decreased bone mineral content	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	3.76×10^-05
increased circulating glycerol level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	3.20×10^-06
increased circulating cholesterol level	Zmym4^{em1(IMPC)Wtsi}	HET	Early adult	1.35×10^-06

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Zmym4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Zmym4 (0 diseases)
Human diseases predicted to be associated with Zmym4 (259 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Zmym4 by phenotypic similarity.

Disease	Matching phenotypes	Source
Cholesterol-Ester Transfer Protein Deficiency	Hypotriglyceridemia, Increased HDL cholesterol concentration, Hyperlipidemia, Hyperlipoproteinemi...	ORPHA:79506
Hypertriglyceridemia 2	Hypercholesterolemia, Hypertriglyceridemia, Decreased HDL cholesterol concentration	OMIM:619324
Xanthomatosis, Susceptibility To	Hypercholesterolemia	OMIM:602247
Thyroid Hormone Metabolism, Abnormal, 2	Hypercholesterolemia	OMIM:619855
Sitosterolemia 2	Hypercholesterolemia, Elevated circulating sitosterol concentration	OMIM:618666
Glycogen Storage Disease Vi	Hyperlipidemia, Hypertriglyceridemia, Hypercholesterolemia	OMIM:232700
Hyperlipoproteinemia, Type Ii, And Deafness	Increased LDL cholesterol concentration, Hypercholesterolemia, Hypertriglyceridemia	OMIM:144300
Hypercholesterolemia, Familial, 4	Decreased LDL cholesterol concentration, Hypercholesterolemia, Hypertriglyceridemia	OMIM:603813
Ulna Metaphyseal Dysplasia Syndrome	Hypercalcemia	OMIM:191420
Coronary Artery Disease, Autosomal Dominant, 1	Hypercholesterolemia	OMIM:608320
Hyperlipidemia, Familial Combined, 3	Xanthelasma, Increased LDL cholesterol concentration, Hyperlipidemia, Increased VLDL cholesterol ...	OMIM:144250
Blue Diaper Syndrome	Abnormal circulating tryptophan concentration, Hypercalcemia	OMIM:211000
Congenital Disorder Of Glycosylation, Type Iip	Increased LDL cholesterol concentration, Hypercholesterolemia, Decreased circulating ceruloplasmi...	OMIM:616829
Adamantinoma	Hypercalcemia	ORPHA:55881
Hyperparathyroidism 4	Osteopenia, Hypercalcemia	OMIM:617343
Diarrhea 7, Protein-Losing Enteropathy Type	Hypoalbuminemia, Hyperlipidemia, Hypercholesterolemia	OMIM:615863
Analbuminemia	Hypoalbuminemia, Increased LDL cholesterol concentration, Elevated circulating transferrin concen...	OMIM:616000
Hypothyroidism, Congenital, Nongoitrous, 8	Hypercholesterolemia	OMIM:301033
Morbid Obesity And Spermatogenic Failure	Increased LDL cholesterol concentration, Hypercholesterolemia, Hypertriglyceridemia, Decreased HD...	OMIM:615703
Hypocalcemia, Autosomal Dominant 2	Abnormal blood phosphate concentration, Hypocalcemia	OMIM:615361
Hyperparathyroidism 1	Hypercalcemia	OMIM:145000
Nephropathy-Deafness-Hyperparathyroidism Syndrome	Hypercalcemia, Bone cyst	ORPHA:2668
Distal Myopathy, Tateyama Type	Abnormal circulating creatine kinase concentration, Hypercholesterolemia	ORPHA:488650
Cholestasis, Progressive Familial Intrahepatic, 10	Hypoalbuminemia, Increased total bilirubin, Increased serum bile acid concentration, Hypercholest...	OMIM:619868
Hepatic Lipase Deficiency	Increased HDL cholesterol concentration, Hypertriglyceridemia, Hypercholesterolemia	OMIM:614025
Spinocerebellar Ataxia With Axonal Neuropathy Type 1	Hypoalbuminemia, Hypercholesterolemia	ORPHA:94124
Parathyroid Carcinoma	Hypercalcemia	OMIM:608266
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 1	Hypoalbuminemia, Hypercholesterolemia	OMIM:607250
Hypoparathyroidism, Familial Isolated, 2	Hypocalcemic seizures, Hyperphosphatemia, Hypocalcemia	OMIM:618883
Hyperinsulinemic Hypoglycemia, Familial, 8	Increased C-peptide level, Hypercholesterolemia, Hyperammonemia	OMIM:620211
Hypercalcemia, Infantile, 2	Hypophosphatemia, Hypercalcemia	OMIM:616963
Familial Apolipoprotein Gene Cluster Deletion Syndrome	Hypocholesterolemia, Hypotriglyceridemia, Decreased circulating apolipoprotein A-I concentration,...	OMIM:620058
Lipodystrophy, Congenital Generalized, Type 3	Hypercholesterolemia, Hypocalcemia, Hypertriglyceridemia	OMIM:612526
Granulomatous Slack Skin	Hypercalcemia	ORPHA:33111
Familial Isolated Hyperparathyroidism	Generalized osteoporosis, Osteopenia, Hypophosphatemia, Hypercalcemia	ORPHA:99879
Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies	Osteopenia, Hypercalcemia, Craniosynostosis	OMIM:614732
22q11 deletion syndrome (Velocardiofacial / DiGeorge syndrome)	Hypocalcemia	DECIPHER:16
Congenital Disorder Of Glycosylation, Type Iio	Increased LDL cholesterol concentration, Hypercholesterolemia, Elevated circulating creatine kina...	OMIM:616828
Hypercholesterolemia, Familial, 3	Xanthelasma, Hypercholesterolemia, Abnormal LDL cholesterol concentration	OMIM:603776
Glycogen Storage Disease Ixa1	Hypercholesterolemia, Hyperuricemia, Hypertriglyceridemia	OMIM:306000
Myopathy, Tubular Aggregate, 2	Hypocalcemia, Elevated circulating creatine kinase concentration	OMIM:615883
Hypercholesterolemia, Familial, 2	Xanthelasma, Increased LDL cholesterol concentration, Hypercholesterolemia	OMIM:144010
Cholesteryl Ester Storage Disease	Hypercholesterolemia, Hypertriglyceridemia	ORPHA:75234
Hypomagnesemia 1, Intestinal	Hypocalcemia, Hypomagnesemia	OMIM:602014
Hypophosphatasia	Craniosynostosis, Hypercalcemia	ORPHA:436
Vitamin D-Dependent Rickets, Type 3	Osteopenia, Hypophosphatemia, Hypocalcemia	OMIM:619073
Small Cell Carcinoma Of The Bladder	Hypercalcemia	ORPHA:284400
Diffuse Neonatal Hemangiomatosis	Hypercalcemia	ORPHA:2123
Blue Diaper Syndrome	Hypercalcemia, Hyperphosphatemia	ORPHA:94086
Hyperparathyroidism, Neonatal Self-Limited Primary, With Hypercalciuria	Hypercalcemia	OMIM:239199
Pseudohypoparathyroidism Type 2	Hypocalcemic tetany, Hypocalcemic seizures, Hyperphosphatemia, Hypocalcemia	ORPHA:94090
Apolipoprotein C-Ii Deficiency	Hypercholesterolemia, Decreased circulating apolipoprotein C-II concentration, Increased circulat...	OMIM:207750
Infantile Myofibromatosis	Hypercalcemia, Osteolysis, Bone cyst	ORPHA:2591
Progressive Familial Intrahepatic Cholestasis	Reduced bone mineral density, Hypocalcemia	ORPHA:172
Tumoral Calcinosis, Hyperphosphatemic, Familial, 3	Osteopenia, Hyperphosphatemia, Metacarpal periosteal thickening, Calvarial osteosclerosis, Hyperc...	OMIM:617994
Pseudohypoparathyroidism, Type Ii	Hyperphosphatemia, Hypocalcemia	OMIM:203330
Hypercalcemia, Infantile, 1	Hypercalcemia	OMIM:143880
Hypophosphatemic Rickets And Hyperparathyroidism	Hypophosphatemia, Hypophosphatemic rickets, Hypercalcemia, Rickets	OMIM:612089
Thymic Neuroendocrine Tumor	Osteopenia, Hypercalcemia, Increased circulating cortisol level	ORPHA:97289
Tumoral Calcinosis, Hyperphosphatemic, Familial, 1	Hyperphosphatemia, Hyperostosis, Subperiosteal bone formation, Calcinosis, Hypercalcemia	OMIM:211900
Rhabdoid Tumor	Hypercalcemia	ORPHA:69077
Morgagni-Stewart-Morel Syndrome	Osteoporosis, Hypercholesterolemia, Hyperuricemia, Hyperostosis frontalis interna	ORPHA:77296
Glycogen Storage Disease Due To Lactate Dehydrogenase M-Subunit Deficiency	Hypercalcemia, Elevated creatine kinase after exercise	ORPHA:284426
Ataxia-Oculomotor Apraxia 4	Hypoalbuminemia, Hypercholesterolemia, Elevated circulating alpha-fetoprotein concentration	OMIM:616267
Hypophosphatasia, Infantile	Unossified vertebral bodies, Elevated plasma pyrophosphate, Decreased calvarial ossification, Cra...	OMIM:241500
Paget Disease Of Bone 2, Early-Onset	Sclerosis of skull base, Hypercalcemia, Osteolysis, Osteosclerosis of the ulna	OMIM:602080
Oculoskeletodental Syndrome	Hypercalcemia, Hypocalcemia	ORPHA:557003
Familial Isolated Hypoparathyroidism Due To Agenesis Of Parathyroid Gland	Hypocalcemic seizures, Hyperphosphatemia, Hypocalcemia, Hypomagnesemia	ORPHA:2239
Uremic Pruritus	Renal hypophosphatemia, Hypermagnesemia, Hypercalcemia, Increased blood urea nitrogen	ORPHA:94059
Spondyloepiphyseal Dysplasia, Nishimura Type	Delayed epiphyseal ossification, Hyperphosphatemia, Hypocalcemia	OMIM:618618
Hyperparathyroidism 2 With Jaw Tumors	Hypercalcemia	OMIM:145001
Renal Tubular Acidosis, Distal, 1	Hypokalemia, Elevated circulating creatinine concentration, Hypocalcemia, Osteomalacia	OMIM:179800
Autosomal Recessive Kenny-Caffey Syndrome	Hypocalcemic tetany, Hypocalcemia, Decreased skull ossification, Calvarial osteosclerosis, Cortic...	ORPHA:93324
Citrullinemia, Type Ii, Neonatal-Onset	Hypermethioninemia, Decreased HDL cholesterol concentration, Hyperbilirubinemia, Hyperthreoninemi...	OMIM:605814
Fibrous Dysplasia Of Bone	Rickets, Increased circulating cortisol level, Osteomalacia, Cortical irregularity, Fibrous dyspl...	ORPHA:249
Hypocalcemia, Autosomal Dominant 1	Hyperphosphatemia, Hypomagnesemia, Hypocalcemia, Hypokalemia, Increased circulating renin level	OMIM:601198
Temple Syndrome Due To Paternal 14Q32.2 Hypomethylation	Hypercholesterolemia	ORPHA:254531
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia	Hypoalbuminemia, Hypercholesterolemia, Elevated circulating creatine kinase concentration	OMIM:208920
Non-Functioning Paraganglioma	Hypercalcemia	ORPHA:94080
Hypocalciuric Hypercalcemia, Familial, Type Iii	Hypermagnesemia, Hypophosphatemia, Hypercalcemia, Osteomalacia	OMIM:600740
Hypomagnesemia 7, Renal, With Or Without Dilated Cardiomyopathy	Hypokalemia, Hyponatremia, Hypocalcemia, Hypomagnesemia	OMIM:620152
Cholestasis, Progressive Familial Intrahepatic, 7, With Or Without Hearing Loss	Hypocalcemia, Elevated circulating gamma-aminobutyric acid concentration	OMIM:619658
Spinocerebellar Ataxia With Axonal Neuropathy Type 2	Hypoalbuminemia, Elevated circulating creatine kinase concentration, Hypercholesterolemia, Elevat...	ORPHA:64753
Hypocalciuric Hypercalcemia, Familial, Type I	Hypermagnesemia, Hypercalcemia	OMIM:145980
Hypoparathyroidism, Familial Isolated, 1	Hypocalcemic seizures, Hyperphosphatemia, Hypocalcemia	OMIM:146200
Hypocalciuric Hypercalcemia, Familial, Type Ii	Hypermagnesemia, Hypercalcemia	OMIM:145981
Congenital Analbuminemia	Hypoalbuminemia, Hyperlipidemia, Hypercholesterolemia, Hypoproteinemia, Increased alpha-globulin	ORPHA:86816
Metaphyseal Chondrodysplasia, Jansen Type	Osteopenia, Hypophosphatemia, Hypercalcemia	OMIM:156400
Glucose-Galactose Malabsorption	Hypercalcemia, Hypernatremia	ORPHA:35710
Pseudohypoparathyroidism, Type Ib	Hyperphosphatemia, Hypocalcemia	OMIM:603233
Paternal Uniparental Disomy Of Chromosome 1	Craniosynostosis, Hypercalcemia, Increased blood urea nitrogen	ORPHA:251004
Idiopathic Steroid-Resistant Nephrotic Syndrome	Hypoalbuminemia, Hypercholesterolemia, Abnormal circulating lipid concentration, Hypertriglycerid...	ORPHA:567548
Pheochromocytoma--Islet Cell Tumor Syndrome	Hypercalcemia	OMIM:171420
Late-Onset Isolated Acth Deficiency	Hyperuricemia, Hyponatremia, Decreased circulating cortisol level, Generalized bone demineralizat...	ORPHA:199299
Autosomal Dominant Hypophosphatemic Rickets	Hypophosphatemia, Rickets, Hypocalcemia, Osteomalacia	ORPHA:89937
Laron Syndrome	Hypercholesterolemia	ORPHA:633
Temple Syndrome	Hypercholesterolemia, Hypertriglyceridemia	OMIM:616222
Alpha-Heavy Chain Disease	Hypocalcemia	ORPHA:100025
Congenital Generalized Lipodystrophy	Hypercholesterolemia, Increased C-peptide level, Bone cyst, Hypertriglyceridemia	ORPHA:528
Hypocalcemic Vitamin D-Resistant Rickets	Coarse metaphyseal trabecularization, Osteomalacia, Hypocalcemia, Hypophosphatemia, Bone cyst, Os...	ORPHA:93160
Galactokinase Deficiency	Hypercholesterolemia, Hypergalactosemia, Increased level of galactitol in plasma	ORPHA:79237
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency	Hypoalbuminemia, Elevated circulating alpha-fetoprotein concentration, Hypermethioninemia, Abnorm...	ORPHA:247598
Nephrotic Syndrome, Type 11	Hypoalbuminemia, Hypercholesterolemia	OMIM:616730
Autoimmune Hypoparathyroidism	Hyperphosphatemia, Hypocalcemic tetany, Hypocalcemia, Increased bone mineral density, Hypocalcemi...	ORPHA:36913
Familial Hypocalciuric Hypercalcemia	Renal hypophosphatemia, Hypermagnesemia, Osteomalacia, Hypocalcemic seizures, Hypercalcemia	ORPHA:405
Oculoskeletodental Syndrome	Hypercalcemia, Hypocalcemia	OMIM:618440
Vitamin D Hydroxylation-Deficient Rickets, Type 1B	Delayed epiphyseal ossification, Rickets, Hypocalcemia, Sparse bone trabeculae, Hypophosphatemia,...	OMIM:600081
Pseudohypoparathyroidism Type 1B	Hyperphosphatemia, Hypocalcemic tetany, Increased bone density with cystic changes, Hypocalcemia,...	ORPHA:94089
Bartter Syndrome, Type 1, Antenatal	Osteopenia, Hyperchloriduria, Increased serum prostaglandin E2, Hypomagnesemia, Hyperaldosteronis...	OMIM:601678
Corticosterone Methyloxidase Type Ii Deficiency	Increased circulating 18-hydroxycortisone level, Hyponatremia, Increased circulating corticostero...	OMIM:610600
Cog4-Cdg	Hypercholesterolemia	ORPHA:263501
Citrullinemia Type Ii	Hypoalbuminemia, Decreased HDL cholesterol concentration, Hyperlipidemia, Acute hyperammonemia, H...	ORPHA:247585
Hyperlipoproteinemia, Type I	Lactescent serum, Hyperlipidemia, Increased circulating chylomicron concentration, Hypercholester...	OMIM:238600
Acute Adrenal Insufficiency	Hyperuricemia, Hyponatremia, Decreased circulating cortisol level, Hyperkalemia, Hypercalcemia, I...	ORPHA:95409
2P21 Microdeletion Syndrome	Hypocalcemia	ORPHA:163693
Ataxia With Vitamin E Deficiency	Xanthelasma, Increased LDL cholesterol concentration, Hypercholesterolemia, Hypertriglyceridemia	OMIM:277460
Abdominal Obesity-Metabolic Syndrome 3	Increased LDL cholesterol concentration, Hypercholesterolemia, Hypertriglyceridemia	OMIM:615812
Smith-Magenis Syndrome	Hypercholesterolemia, Hypertriglyceridemia	OMIM:182290
Cholestasis, Progressive Familial Intrahepatic, 8	Hypercholesterolemia, Elevated circulating alpha-fetoprotein concentration, Conjugated hyperbilir...	OMIM:619662
Hyperparathyroidism, Neonatal Severe	Hypophosphatemia, Hypercalcemia, Calcinosis	OMIM:239200
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency	Increased LDL cholesterol concentration, Hypercholesterolemia, Hypertriglyceridemia	ORPHA:209902
Refractory Celiac Disease	Hypoalbuminemia, Hypomagnesemia, Hypocalcemia, Hypophosphatemia, Osteoporosis, Hypoproteinemia	ORPHA:398063
Pseudohypoaldosteronism, Type Ib3, Autosomal Recessive	Hyperaldosteronism, Hyperkalemia, Hyponatremia, Increased circulating renin level	OMIM:620126
Multiple Myeloma	Elevated circulating creatinine concentration, Hyperproteinemia, Osteopenia, Hypercalcemia	ORPHA:29073
Mandibuloacral Dysplasia	Increased circulating free fatty acid level, Acroosteolysis of distal phalanges (feet), Hyperchol...	ORPHA:2457
Spinal Cord Injury	Hypercalcemia	ORPHA:90058
Addison Disease	Hyperuricemia, Hyponatremia, Decreased circulating cortisol level, Generalized bone demineralizat...	ORPHA:85138
Pseudohypoaldosteronism, Type Ib2, Autosomal Recessive	Hyperaldosteronism, Hyperkalemia, Hyponatremia, Increased circulating renin level	OMIM:620125
Vitamin D Hydroxylation-Deficient Rickets, Type 1A	Delayed epiphyseal ossification, Rickets, Hypocalcemia, Sparse bone trabeculae, Hypophosphatemia,...	OMIM:264700
Intellectual Disability-Seizures-Hypophosphatasia-Ophthalmic-Skeletal Anomalies Syndrome	Osteopenia, Hypercalcemia, Craniosynostosis, Hypertriglyceridemia	ORPHA:369837
Kenny-Caffey Syndrome, Type 1	Decreased skull ossification, Hypocalcemia, Calvarial osteosclerosis, Hypomagnesemia	OMIM:244460
Pseudohypoparathyroidism, Type Ic	Osteoporosis, Hypocalcemic tetany, Hyperphosphatemia, Hypocalcemia	OMIM:612462
9Q31.1Q31.3 Microdeletion Syndrome	Hypercholesterolemia	ORPHA:401923
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14	Hypercholesterolemia	ORPHA:96184
Dysbetalipoproteinemia	Xanthelasma, Increased LDL cholesterol concentration, Hypertriglyceridemia, Hypercholesterolemia,...	ORPHA:412
Monosomy 13Q34	Hypercalcemia	ORPHA:96168
Cholesteryl Ester Storage Disease	Increased LDL cholesterol concentration, Hypertriglyceridemia, Hypercholesterolemia, Decreased HD...	OMIM:278000
Sitosterolemia 1	Hyperapobetalipoproteinemia, Xanthelasma, Reduced haptoglobin level, Elevated circulating sitoste...	OMIM:210250
Sporadic Pheochromocytoma/Secreting Paraganglioma	Hypercalcemia	ORPHA:276621
Multiple Endocrine Neoplasia, Type I	Hypercalcemia, Increased circulating cortisol level	OMIM:131100
Micrognathia-Recurrent Infections-Behavioral Abnormalities-Mild Intellectual Disability Syndrome	Hypercalcemia	ORPHA:476126
Late-Onset Familial Hypoaldosteronism	Hyponatremia, Elevated serum 11-deoxycortisol, Abnormal circulating corticosterone level, Hyperka...	ORPHA:556037
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency	Osteoporosis, Elevated circulating creatine kinase concentration, Hypercholesterolemia, Hypertrig...	ORPHA:79240
Hypokalemic Alkalosis, Familial, With Specific Renal Tubulopathy	Hypokalemia, Abnormal magnesium concentration, Increased serum prostaglandin E2, Increased circul...	OMIM:241150
Albers-Schönberg Osteopetrosis	Generalized osteosclerosis, Hypocalcemia	ORPHA:53
Megalocornea-Intellectual Disability Syndrome	Osteopenia, Hypercholesterolemia	ORPHA:2479
Galloway-Mowat Syndrome 7	Hypercholesterolemia	OMIM:618348
Pheochromocytoma	Hypercalcemia	OMIM:171300
Smith-Magenis Syndrome	Hypercholesterolemia, Hypertriglyceridemia	ORPHA:819
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency	Osteoporosis, Elevated circulating creatine kinase concentration, Hypercholesterolemia, Hypertrig...	ORPHA:264580
Hypoparathyroidism-Retardation-Dysmorphism Syndrome	Patchy osteosclerosis, Hypocalcemic seizures, Hyperphosphatemia, Hypocalcemia	OMIM:241410
Early-Onset Familial Hypoaldosteronism	Hyponatremia, Elevated serum 11-deoxycortisol, Abnormal circulating corticosterone level, Hyperka...	ORPHA:556030
Mandibuloacral Dysplasia With Type A Lipodystrophy	Osteopenia, Hyperlipidemia, Acroosteolysis of distal phalanges (feet), Hypercholesterolemia, Calc...	OMIM:248370
Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal	Hypercholesterolemia, Hypertriglyceridemia	OMIM:610644
Ring Chromosome 10 Syndrome	Hypocalcemia	ORPHA:1438
Hypocalcemic Vitamin D-Dependent Rickets	Delayed epiphyseal ossification, Rickets, Osteomalacia, Hypocalcemia, Sparse bone trabeculae, Hyp...	ORPHA:289157
Hereditary Pheochromocytoma-Paraganglioma	Hypercalcemia	ORPHA:29072
Neuhauser Syndrome	Osteopenia, Hypercholesterolemia	OMIM:249310
Osteopetrosis, Autosomal Recessive 1	Hypocalcemia, Osteopetrosis, Calvarial osteosclerosis, Craniosynostosis, Increased bone mineral d...	OMIM:259700
Genetic Recurrent Myoglobinuria	Hyperkalemia, Hyperphosphatemia, Hypocalcemia, Highly elevated creatine kinase	ORPHA:99845
Diarrhea 10, Protein-Losing Enteropathy Type	Hypoalbuminemia, Hypomagnesemia, Hypocalcemia, Hyponatremia, Hypertriglyceridemia	OMIM:618183
Lysinuric Protein Intolerance	Osteopenia, Intraalveolar phospholipid accumulation, Increased circulating ferritin concentration...	ORPHA:470
Familial Isolated Hypoparathyroidism	Hypocalcemia	ORPHA:2238
Very Long Chain Acyl-Coa Dehydrogenase Deficiency	Increased circulating free fatty acid level, Hyperammonemia, Hypocalcemia, Elevated circulating c...	ORPHA:26793
Hypotonia-Cystinuria Syndrome	Hypocalcemia	OMIM:606407
Hypokalemic Tubulopathy And Deafness	Hyperaldosteronism, Increased circulating renin level	OMIM:619406
Congenital Disorder Of Glycosylation, Type Iiaa	Hypercholesterolemia, Hyperammonemia	OMIM:620454
Hyperparathyroidism-Jaw Tumor Syndrome	Osteoporosis, Hypophosphatemia, Hypercalcemia	ORPHA:99880
Isolated Thyroid-Stimulating Hormone Deficiency	Abnormal circulating thyroglobulin concentration, Neonatal hyperbilirubinemia, Hypercholesterolem...	ORPHA:90674
Kenny-Caffey Syndrome, Type 2	Hyperphosphatemia, Hypocalcemia, Thickened cortex of long bones, Transient hypophosphatemia, Incr...	OMIM:127000
Somatostatinoma	Steatorrhea, Hypercalcemia, Increased circulating cortisol level	ORPHA:97283
Vipoma	Hypokalemia, Hypercalcemia, Increased circulating cortisol level	ORPHA:97282
Pseudohypoaldosteronism, Type I, Autosomal Dominant	Hyperaldosteronism, Hyperkalemia, Hyponatremia, Increased circulating renin level	OMIM:177735
Parathyroid Carcinoma	Osteoporosis, Hypophosphatemia, Hypercalcemia	ORPHA:143
Acquired Aneurysmal Subarachnoid Hemorrhage	Hypercholesterolemia	ORPHA:90065
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes	Hypokalemia, Hypocalcemia, Hypomagnesemia	OMIM:175500
Ppoma	Hypercalcemia, Increased circulating cortisol level	ORPHA:97278
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis	Craniofacial osteosclerosis, Increased skull ossification, Hypocalcemia, Osteopetrosis, Diaphysea...	OMIM:618476
Oncogenic Osteomalacia	Hypophosphatemia, Fibrous dysplasia of the bones, Hypocalcemia	ORPHA:352540
Primary Biliary Cholangitis	Hypoalbuminemia, Abnormal circulating lipid concentration, Xanthelasma, Hypercholesterolemia, Ste...	ORPHA:186
Gracile Bone Dysplasia	Hypocalcemia, Decreased skull ossification	OMIM:602361
Gaisböck Syndrome	Hyperuricemia, Hypercholesterolemia, Hypertriglyceridemia, Hyperproteinemia, Increased circulatin...	ORPHA:90041
Colchicine Poisoning	Hypomagnesemia, Hypocalcemia, Hypokalemia, Hyponatremia, Hypophosphatemia, Abnormal blood ion con...	ORPHA:31824
Glucagonoma	Steatorrhea, Hypercalcemia, Increased circulating cortisol level	ORPHA:97280
Low Phospholipid-Associated Cholelithiasis	Hypercholesterolemia	ORPHA:69663
Primary Intestinal Lymphangiectasia	Hypoalbuminemia, Hypoproteinemia, Hypocalcemia, Hypomagnesemia	ORPHA:90362
Timothy Syndrome	Hypocalcemia	OMIM:601005
Zollinger-Ellison Syndrome	Hypercalcemia, Increased circulating cortisol level	ORPHA:913
Grfoma	Hypercalcemia, Increased circulating cortisol level	ORPHA:97261
Generalized Pustular Psoriasis	Elevated circulating C-reactive protein concentration, Hyponatremia, Hypocalcemia, Hypoalbuminemia	ORPHA:247353
Celiac Disease, Susceptibility To, 1	Steatorrhea, Osteoporosis, Rickets, Hypocalcemia	OMIM:212750
Sanjad-Sakati Syndrome	Patchy osteosclerosis, Hyperphosphatemia, Hypocalcemia	ORPHA:2323
Multiple Endocrine Neoplasia Type 4	Hypercalcemia, Increased circulating cortisol level	ORPHA:276152
Prader-Willi Syndrome	Osteopenia, Decreased HDL cholesterol concentration, Hypercholesterolemia, Hypertriglyceridemia, ...	OMIM:176270
X-Linked Agammaglobulinemia	Hypocalcemia	ORPHA:47
Multiple Endocrine Neoplasia Type 1	Increased circulating cortisol level, Hypercalcemia, Primary hypercortisolism, Reduced bone miner...	ORPHA:652
Dahlberg-Borer-Newcomer Syndrome	Hypocalcemia	ORPHA:1563
Autosomal Dominant Hypocalcemia	Reduced bone mineral density, Hyperphosphatemia, Hypocalcemia, Hypomagnesemia	ORPHA:428
Osteopetrosis, Autosomal Recessive 5	Cranial hyperostosis, Hyperbilirubinemia, Hypocalcemia, Osteopetrosis, Decreased osteoclast count...	OMIM:259720
Lipodystrophy, Familial Partial, Type 2	Hypercholesterolemia, Decreased HDL cholesterol concentration, Hypertriglyceridemia	OMIM:151660
Pseudohypoparathyroidism Type 1C	Ectopic ossification, Hyperphosphatemia, Hypocalcemic tetany, Hypocalcemia, Calcinosis, Increased...	ORPHA:79444
Neuroleptic Malignant Syndrome	Hyperphosphatemia, Hypomagnesemia, Hypocalcemia, Hyperuricemia, Elevated circulating creatine kin...	ORPHA:94093
Lysosomal Acid Lipase Deficiency	Xanthelasma, Hyponatremia, Hypercholesterolemia, Hypertriglyceridemia, Steatorrhea, Hyperkalemia	ORPHA:275761
Pseudohypoparathyroidism, Type Ia	Osteoporosis, Hypocalcemic tetany, Subcutaneous ossification, Hyperphosphatemia	OMIM:103580
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib	Osteopenia, Xanthelasma, Hyperlipidemia, Hyperuricemia, Hypercholesterolemia, Hypertriglyceridemi...	ORPHA:79259
Cholera	Hypokalemia, Abnormal blood ion concentration, Hyponatremia, Hypocalcemia	ORPHA:173
Kidney Tubulopathy-Dilated Cardiomyopathy Syndrome	Hyperaldosteronism, Hypocalcemic tetany, Hypocalcemia, Hypomagnesemia	ORPHA:73224
Neurodevelopmental Disorder With Microcephaly, Cataracts, And Renal Abnormalities	Osteopenia, Hypocalcemia, Hypokalemia, Hyponatremia, Calcinosis	OMIM:617913
Pseudohypoparathyroidism Type 1A	Ectopic ossification, Hyperphosphatemia, Hypocalcemic tetany, Hypocalcemia, Calcinosis, Increased...	ORPHA:79443
Bardet-Biedl Syndrome 20	Hypercholesterolemia	OMIM:619471
Multiple Endocrine Neoplasia Type 2	Hypercalcemia	ORPHA:653
Immunodeficiency 47	Decreased circulating copper concentration, Hypercholesterolemia	OMIM:300972
Lmna-Related Cardiocutaneous Progeria Syndrome	Hypercholesterolemia, Hypertriglyceridemia	ORPHA:363618
Juvenile Nephropathic Cystinosis	Hypouricemia, Elevated circulating creatinine concentration, Hypocalcemic tetany, Hypocalcemia, H...	ORPHA:411634
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly	Hypoproteinemia, Hypocalcemia	OMIM:235255
Congenital Disorder Of Glycosylation, Type Ig	Hypocalcemia	OMIM:607143
Bartter Syndrome, Type 5, Antenatal, Transient	Hypokalemia, Hyponatremia, Hypochloremia, Increased circulating renin level	OMIM:300971
Bacterial Toxic-Shock Syndrome	Hypoalbuminemia, Elevated circulating creatinine concentration, Hypocalcemia, Elevated circulatin...	ORPHA:36234
Williams Syndrome	Osteopenia, Abnormal circulating lipid concentration, Elevated circulating creatine kinase concen...	ORPHA:904
Lowe Oculocerebrorenal Syndrome	Elevated amniotic fluid alpha-fetoprotein, Rickets, Osteomalacia, Elevated circulating creatine k...	OMIM:309000
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome	Hypoalbuminemia, Hypomagnesemia, Hypocalcemia, Decreased circulating prealbumin concentration, Ab...	ORPHA:37042
Double Outlet Right Ventricle	Hypocalcemia	ORPHA:3426
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome	Hypoproteinemia, Hypocalcemia	ORPHA:1655
Mitochondrial Trifunctional Protein Deficiency	Hypocalcemia	ORPHA:746
Oculocerebrorenal Syndrome Of Lowe	Osteomalacia, Hyperaldosteronism, Hyponatremia, Hypokalemia, Hypophosphatemia, Hypercholesterolem...	ORPHA:534
Rajab Interstitial Lung Disease With Brain Calcifications 1	Hypoalbuminemia, Osteopenia, Rickets, Hypocalcemia, Thin bony cortex, Unconjugated hyperbilirubin...	OMIM:613658
Sarcoidosis	Hypercalcemia, Bone cyst	ORPHA:797
Hypomagnesemia 3, Renal	Increased circulating beta-C-terminal telopeptide concentration, Hyperphosphatemia, Rickets, Hypo...	OMIM:248250
Cartilage-Hair Hypoplasia	Abnormally ossified vertebrae, Hypocalcemia, Abnormal bone ossification	ORPHA:175
Williams-Beuren Syndrome	Osteoporosis, Osteopenia, Hypercalcemia	OMIM:194050
Autosomal Recessive Malignant Osteopetrosis	Hypocalcemia, Hypophosphatemia, Osteopetrosis, Craniosynostosis, Reduced bone mineral density	ORPHA:667
Autosomal Dominant Kenny-Caffey Syndrome	Hyperphosphatemia, Hypocalcemic tetany, Decreased skull ossification, Calvarial osteosclerosis, C...	ORPHA:93325
Ethylene Glycol Poisoning	Hyperkalemia, Hypocalcemia	ORPHA:31826
Pearson Syndrome	Hypomagnesemia, Hypocalcemia, Hypokalemia, Hypophosphatemia, Hyperalaninemia, Steatorrhea	ORPHA:699
Igg4-Related Thyroid Disease	Hypocalcemia	ORPHA:64744
Alagille Syndrome 1	Hypercholesterolemia, Hypertriglyceridemia	OMIM:118450
Gitelman Syndrome	Hypermagnesemia, Hypomagnesemia, Hypocalcemia, Hypokalemia, Primary hyperaldosteronism	ORPHA:358
Velocardiofacial Syndrome	Hypocalcemia	OMIM:192430
Exercise-Induced Malignant Hyperthermia	Hyperkalemia, Hyperphosphatemia, Hypocalcemia, Elevated circulating creatine kinase concentration	ORPHA:466650
Osteopetrosis With Renal Tubular Acidosis	Osteopetrosis, Hypocalcemia, Elevated circulating creatine kinase concentration	ORPHA:2785
Sotos Syndrome	Craniosynostosis, Hypercalcemia	ORPHA:821
X-Linked Intellectual Disability-Craniofacioskeletal Syndrome	Hyperbilirubinemia, Hypocalcemia	ORPHA:163979
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome	Hypocalcemic seizures, Hypocalcemia	ORPHA:2237
Lipodystrophy, Familial Partial, Type 7	Hypercholesterolemia, Hypertriglyceridemia	OMIM:606721
Cranioectodermal Dysplasia 1	Osteoporosis, Sagittal craniosynostosis, Hypocalcemia	OMIM:218330
Craniofacioskeletal Syndrome	Hypocalcemia	OMIM:300712
Hennekam Syndrome	Craniosynostosis, Hypocalcemia	ORPHA:2136
Infection-Related Hemolytic Uremic Syndrome	Hyponatremia, Hyperkalemia, Hypocalcemia	ORPHA:544482
Steinert Myotonic Dystrophy	Hypercholesterolemia	ORPHA:273
Biliary, Renal, Neurologic, And Skeletal Syndrome	Hypoalbuminemia, Osteopenia, Increased circulating ferritin concentration, Elevated circulating c...	OMIM:619534
Liver Disease, Severe Congenital	Increased circulating ferritin concentration, Hyperbilirubinemia, Hypocalcemia, Hyperammonemia, H...	OMIM:619991
Homozygous Familial Hypercholesterolemia	Hyperlipidemia, Increased LDL cholesterol concentration, Hypercholesterolemia	ORPHA:391665
22Q11.2 Deletion Syndrome	Hypocalcemia, Multiple suture craniosynostosis	ORPHA:567
T-Cell Immunodeficiency With Thymic Aplasia	Hypocalcemic tetany	ORPHA:83471
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies	Hypocalcemia, Hypomagnesemia	OMIM:619503
Intellectual Developmental Disorder, Autosomal Dominant 71, With Behavioral Abnormalities	Hypocalcemia	OMIM:620330
Digeorge Syndrome	Hypocalcemia	OMIM:188400
Charge Syndrome	Hypocalcemia	OMIM:214800
Johanson-Blizzard Syndrome	Conjugated hyperbilirubinemia, Hypocalcemia, Increased VLDL cholesterol concentration	OMIM:243800

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zmym4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zmym4.

There are 3 publications which use IMPC produced mice or data.

Title	Journal	IMPC Allele	PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.	G3 (Bethesda, Md.) (June 2020)	Zmym4^{em1(IMPC)Wtsi}	PMC7263671
Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription.	Cell metabolism (June 2020)	Zmym4^{em1(IMPC)Wtsi}	PMC7267775
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.	Nature communications (August 2019)	Zmym4^{em1(IMPC)Wtsi}	PMC6671969

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Zmym4^{tm36782(L1L2_gt0)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors
Zmym4^{em1(IMPC)Wtsi}	Deletion	Mice

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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