Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
preweaning lethality, complete penetrance | Chd8em1(IMPC)Mbp | HOM | Early adult | 0.00 | ||
impaired glucose tolerance | Chd8em1(IMPC)Mbp | HET | Early adult | 8.05×10-05 | ||
embryonic lethality prior to organogenesis | Chd8em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
decreased locomotor activity | Chd8em1(IMPC)Mbp | HET | Early adult | 2.60×10-07 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Chd8 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Intellectual Developmental Disorder With Autism And Macrocephaly | Pronoun reversal, Echolalia, Delayed speech and language development, Constipation, Anxiety | OMIM:615032 |
The table below shows human diseases predicted to be associated to Chd8 by phenotypic similarity.
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
Phenotype | Allele | Zygosity | Sex | Life Stage |
---|---|---|---|---|
Spleen - MPATH pathological process term hyperplasia | Chd8em1(IMPC)Mbp | HET | Early adult | |
Spleen - MPATH pathological entity term lymphoid hyperplasia | Chd8em1(IMPC)Mbp | HET | Early adult | |
Lymph node - MPATH pathological entity term lymphoid hyperplasia | Chd8em1(IMPC)Mbp | HET | Early adult | |
Lymph node - MPATH pathological process term hyperplasia | Chd8em1(IMPC)Mbp | HET | Early adult |
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MGI Allele | Allele Type | Produced |
---|---|---|
Chd8em1(IMPC)Mbp | Exon Deletion | Mice, Tissue |
Chd8tm49072(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
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