Chd8 | chromodomain helicase DNA binding protein 8

GeneMGI:1915022Synonyms: Duplin, 5830451P18Rik

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological Mortality/aging

15 No significant impact

4 Not tested

Gene metrics:9Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

impaired glucose tolerance1 supporting datasetChd8em1(IMPC)MbpheterozygoteEarly adult1.93x10-5 
preweaning lethality, complete penetrance3 supporting datasetsChd8em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal spleen morphology1 supporting datasetChd8em1(IMPC)MbpheterozygoteEarly adultN/A * 
decreased locomotor activity2 supporting datasetsChd8em1(IMPC)MbpheterozygoteEarly adult9.86x10-7 
embryonic lethality prior to organogenesis1 supporting datasetChd8em1(IMPC)MbphomozygoteE9.5N/A * 
enlarged lymph nodes1 supporting datasetChd8em1(IMPC)MbpheterozygoteEarly adultN/A * 
increased lymphocyte cell number1 supporting datasetChd8em1(IMPC)MbpheterozygoteEarly adult7.96x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  

lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Chd8em1(IMPC)MbpExon Deletionmouse
Chd8tm49072(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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