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Gene: Plgrkt MGI:1915009

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
plasminogen receptor, C-terminal lysine transmembrane protein
Synonyms:
5033414D02Rik,  Plg-RKT,  1110007H22Rik

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Plgrkt mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Plgrkt by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Lymphoblastic Transformation, Intrinsic Defect In
Chronic mucocutaneous candidiasis OMIM:247450
Lymphoblastic Transformation, Inhibition Of
Chronic mucocutaneous candidiasis OMIM:247430
Lymphokine Deficiency
Chronic mucocutaneous candidiasis OMIM:247650
Candidiasis, Familial, 6
Chronic mucocutaneous candidiasis OMIM:613956
Acne Inversa, Familial, 3
Chronic furunculosis, Recurrent cutaneous abscess formation, Perifolliculitis, Acne inversa OMIM:613737
Acne Inversa, Familial, 1
Acne inversa OMIM:142690
Chilblain Lupus 2
Chilblains OMIM:614415
Linear Atrophoderma Of Moulin
Pruritus, Inflammatory abnormality of the skin ORPHA:140933
Benign Cephalic Histiocytosis
Inflammatory abnormality of the skin, Skin rash ORPHA:157997
Immunodeficiency 51
Recurrent skin infections, Eczema, Pneumonia, Pustule, Chronic mucocutaneous candidiasis, Recurre... OMIM:613953
Paget Disease, Extramammary
Eczematoid dermatitis OMIM:167300
Dissecting Cellulitis Of The Scalp
Pruritus, Recurrent skin infections ORPHA:345
Immunodeficiency 107, Susceptibility To Invasive Staphylococcus Aureus Infection
Chronic furunculosis, Cutaneous abscess OMIM:619986
Kerion Celsi
Recurrent cutaneous abscess formation, Inflammatory abnormality of the skin, Recurrent skin infec... ORPHA:499
Erythema Nodosum, Familial
Erythema nodosum OMIM:132990
Intellectual Developmental Disorder, Fra12A Type
Erythroderma OMIM:136630
Erythroderma, Lethal Congenital
Congenital exfoliative erythroderma OMIM:227090
Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease
Chronic furunculosis, Recurrent cutaneous abscess formation, Perifolliculitis, Acne inversa OMIM:613736
Erythroderma Desquamativum
Seborrheic dermatitis ORPHA:314
Chronic Actinic Dermatitis
Late onset atopic dermatitis, Eczema, Allergic rhinitis, Pruritus, Erythroderma ORPHA:330064
Perifolliculitis Capitis Abscedens Et Suffodiens, Familial
Perifolliculitis OMIM:260910
Bullous Diffuse Cutaneous Mastocytosis
Pruritus, Erythroderma ORPHA:280785
Seborrhea-Like Dermatitis With Psoriasiform Elements
Seborrheic dermatitis OMIM:610227
Candidiasis, Familial, 8
Chronic oral candidiasis, Blepharitis, Cheilitis, Seborrheic dermatitis OMIM:615527
Ichthyosis, Congenital, Autosomal Recessive 7
Erythroderma OMIM:615022
Pityriasis Rubra Pilaris
Pruritus, Pustule, Eczema, Erythroderma ORPHA:2897
Erythrokeratodermia Variabilis Et Progressiva 1
Erythroderma OMIM:133200
Agammaglobulinemia 9, Autosomal Recessive
Agammaglobulinemia, Failure to thrive, Eczematoid dermatitis, Seborrheic dermatitis OMIM:619693
Epidermolytic Hyperkeratosis 1
Erythroderma OMIM:113800
Lymphatic Malformation 3
Recurrent skin infections OMIM:613480
Inflammatory Skin And Bowel Disease, Neonatal, 1
Pustule, Increased circulating IgE level, Erythroderma, Failure to thrive, Blepharitis OMIM:614328
Familial Reactive Perforating Collagenosis
Perifolliculitis, Inflammatory abnormality of the skin, Maculopapular exanthema, Pruritus, Crusti... ORPHA:79147
T-B+ Severe Combined Immunodeficiency Due To Cd3Delta/Cd3Epsilon/Cd3Zeta
Chronic oral candidiasis, Pneumonia, Recurrent pneumonia, Hepatitis, Increased circulating antibo... ORPHA:169160
Verrucous Hemangioma
Inflammatory abnormality of the skin ORPHA:464318
Erythrokeratodermia Variabilis Et Progressiva 6
Pruritus, Superficial dermal perivascular inflammatory infiltrate OMIM:618531
Immunodeficiency 25
Increased circulating IgA level, Increased circulating IgE level, Recurrent pneumonia, Increased ... OMIM:610163
Peeling Skin Syndrome 1
Pruritus, Increased circulating IgE level, Palmoplantar hyperhidrosis, Erythroderma OMIM:270300
Immunodeficiency 85 And Autoimmunity
Failure to thrive in infancy, Eczema, Oligoarthritis, Decreased circulating total IgM, Decreased ... OMIM:619510
Immunodeficiency 15A
Chronic mucocutaneous candidiasis, Recurrent sinusitis, Recurrent otitis media, Acne inversa, Cut... OMIM:618204
Mental Retardation And Psoriasis
Psoriasiform dermatitis OMIM:309480
Congenital Ichthyosiform Erythroderma
Keratitis, Pruritus, Hypohidrosis, Erythroderma, Failure to thrive ORPHA:79394
Ige Responsiveness, Atopic
Eczema, Allergic rhinitis OMIM:147050
Keratolytic Winter Erythema
Pustule ORPHA:50943
Hyper-Ige Syndrome 5, Autosomal Recessive, With Recurrent Infections
Recurrent skin infections, Increased circulating IgE level, Atopic dermatitis, Decreased circulat... OMIM:618944
Severe Combined Immunodeficiency, X-Linked
Failure to thrive, Skin rash, Pneumonia, Reduced natural killer cell activity, Recurrent pneumoni... OMIM:300400
Netherton Syndrome
Failure to thrive, Recurrent skin infections, Allergic rhinitis, Eczema, Increased circulating Ig... OMIM:256500
Inflammatory Bowel Disease 28, Autosomal Recessive
Perianal abscess, Enterocolitis, Folliculitis, Pyoderma, Colitis, Crohn's disease OMIM:613148
Immunodeficiency 50
Eczema, Decreased circulating antibody level OMIM:300988
Immunodeficiency 66
Pustule, Defective T cell proliferation, Recurrent skin infections OMIM:618847
Epidermodysplasia Verruciformis
Pustule, Recurrent skin infections, Seborrheic dermatitis ORPHA:302
Ichthyosis, Congenital, Autosomal Recessive 10
Erythroderma OMIM:615024
Epidermolytic Hyperkeratosis 2
Erythroderma OMIM:620150
Quinquaud Folliculitis Decalvans
Pustule, Recurrent skin infections ORPHA:346
Caspase 8 Deficiency
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vacc... OMIM:607271
Wiskott-Aldrich Syndrome 2
Defective T cell proliferation, Eczema, Reduced natural killer cell activity OMIM:614493
Immunodeficiency 58
Recurrent cutaneous abscess formation, Eczema, Allergic rhinitis, Seborrheic dermatitis, Recurren... OMIM:618131
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Glomerulonephritis, Eczema, Increased circulating IgE level, Hepatitis, Arthritis, Erythroderma, ... OMIM:304790
Complement Component 5 Deficiency
Generalized seborrheic dermatitis OMIM:609536
Bullous Impetigo
Pustule, Recurrent bacterial skin infections, Septic arthritis ORPHA:36237
Erosive Pustular Dermatosis Of The Scalp
Pustule ORPHA:222
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Psoriasiform dermatitis, Failure to thrive in infancy, Eczema, Increased circulating IgE level, D... OMIM:606367
Immunodeficiency Due To Selective Anti-Polysaccharide Antibody Deficiency
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vacc... ORPHA:70593
Ichthyosis Prematurity Syndrome
Pruritus, Allergic rhinitis, Erythroderma OMIM:608649
Congenital Lethal Erythroderma
Congenital exfoliative erythroderma, Failure to thrive ORPHA:1954
Chilblain Lupus
Inflammatory abnormality of the skin, Skin rash, Discoid lupus rash, Increased circulating antibo... ORPHA:90280
Deafness, Neural, With Atypical Atopic Dermatitis
Late onset atopic dermatitis OMIM:221700
Psoriasis 15, Pustular, Susceptibility To
Psoriasiform dermatitis OMIM:616106
Autosomal Dominant Epidermolytic Ichthyosis
Weight loss, Erythroderma ORPHA:312
Pemphigus Foliaceus
Psoriasiform dermatitis, Pruritus, Pustule, Crusting erythematous dermatitis, Erythroderma ORPHA:79481
Alopecia-Intellectual Disability Syndrome 4
Erythroderma OMIM:618840
Dermatitis, Atopic
Recurrent skin infections, Allergic rhinitis, Eczema, Pruritus, Atopic dermatitis, Conjunctivitis OMIM:603165
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Increased circulating IgA level, Increased circulating IgE level, Increased circulating IgG level... ORPHA:169154
Panniculitis-Induced Localized Lipodystrophy
Inflammatory abnormality of the skin, Abnormal immunoglobulin level ORPHA:90159
Erythroderma, Congenital, With Palmoplantar Keratoderma, Hypotrichosis, And Hyper-Ige
Psoriasiform dermatitis, Recurrent skin infections, Eosinophilic infiltration of the esophagus, I... OMIM:615508
Immunodeficiency 57 With Autoinflammation
Skin rash, Gastritis, Perianal abscess, Bronchiectasis, Decreased circulating antibody level, Inf... OMIM:618108
Elastoderma
Erysipelas, Eczema ORPHA:228240
Immunodeficiency 11B With Atopic Dermatitis
Pneumonia, Increased circulating IgE level, Atopic dermatitis, Bronchiectasis, Ulcerative colitis... OMIM:617638
Drug Reaction With Eosinophilia And Systemic Symptoms
Skin rash, Pustule, Myocarditis, Hepatitis, Thyroiditis, Weight loss, Tubulointerstitial nephriti... ORPHA:139402
Agammaglobulinemia 7, Autosomal Recessive
Erythema nodosum, Agammaglobulinemia, Panhypogammaglobulinemia OMIM:615214
Netherton Syndrome
Skin rash, Eczema, Increased circulating IgE level, Decreased circulating antibody level, Erythro... ORPHA:634
Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome
Small for gestational age, Eczema, Failure to thrive in infancy, Increased circulating IgE level,... OMIM:617241
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Inflammatory abnormality of the skin, Sinusitis, Recurrent pneumonia, Increased circulating IgE l... ORPHA:277
Sézary Syndrome
Pruritus, Abnormal immunoglobulin level, Erythroderma ORPHA:3162
Ichthyosis With Confetti
Pruritus, Decreased body weight, Erythroderma OMIM:609165
Lymphoproliferative Syndrome, X-Linked, 2
Acne, Recurrent skin infections, Erythema nodosum, Hepatitis, Decreased circulating antibody leve... OMIM:300635
Hypohidrotic Ectodermal Dysplasia With Immunodeficiency
Failure to thrive, Eczema, Abnormal immunoglobulin level, Increased circulating IgE level, Chroni... ORPHA:98813
Copper Deficiency, Familial Benign
Seborrheic dermatitis OMIM:121270
Mycosis Fungoides
Pruritus, Psoriasiform dermatitis, Eczema OMIM:254400
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 2
Acne, Seborrheic dermatitis OMIM:614441
Pressure-Induced Localized Lipoatrophy
Inflammatory abnormality of the skin ORPHA:90160
Interstitial Granulomatous Dermatitis With Arthritis
Pruritus, Inflammatory abnormality of the skin, Rheumatoid arthritis ORPHA:79099
Inflammatory Bowel Disease 25, Autosomal Recessive
Perianal abscess, Pancolitis, Folliculitis, Enterocolitis OMIM:612567
Familial Hemophagocytic Lymphohistiocytosis
Skin rash, Maculopapular exanthema, Reduced natural killer cell activity, Decreased circulating a... ORPHA:540
Hyper-Ige Syndrome 3, Autosomal Recessive, With Recurrent Infections
Osteomyelitis, Recurrent skin infections, Eczema, Pruritus, Recurrent pneumonia, Increased circul... OMIM:618282
Ichthyosis, Hystrix-Like, With Deafness
Punctate keratitis, Erythroderma OMIM:602540
Omenn Syndrome
Pneumonia, Pruritus, Thyroiditis, Erythroderma, Failure to thrive, Hypothyroidism ORPHA:39041
Immunodeficiency, Common Variable, 14
Psoriasiform dermatitis, Decreased circulating total IgM, Recurrent sinusitis, Decreased specific... OMIM:617765
Zinc Deficiency, Transient Neonatal
Eczema OMIM:608118
Pellagra-Like Syndrome
Skin rash OMIM:260650
Immunodeficiency 81
Recurrent cutaneous abscess formation, Skin rash, Reduced natural killer cell activity, Reduced a... OMIM:619374
Mal De Meleda
Inflammatory abnormality of the skin, Superficial dermal perivascular inflammatory infiltrate ORPHA:87503
Severe Combined Immunodeficiency Due To Dclre1C Deficiency
Failure to thrive, Skin rash, Recurrent aphthous stomatitis, Otitis media, Chronic oral candidias... ORPHA:275
Ichthyosis, Congenital, Autosomal Recessive 5
Erythroderma OMIM:604777
Ameloonychohypohidrotic Syndrome
Seborrheic dermatitis OMIM:104570
Lamellar Ichthyosis
Chronic otitis media, Pruritus, Erythroderma ORPHA:313
Generalized Pustular Psoriasis
Pustule, Overweight, Cheilitis, Uveitis, Obesity, Arthritis, Palmoplantar pustulosis, Erythroderma ORPHA:247353
Ichthyosis, Congenital, Autosomal Recessive 9
Hypohidrosis, Erythroderma OMIM:615023
Papa Syndrome
Increased inflammatory response, Myositis, Acne, Pustule, Arthritis, Increased circulating antibo... ORPHA:69126
Erythema Elevatum Diutinum
Skin rash, Increased circulating antibody level ORPHA:90000
Subcorneal Pustular Dermatosis
Hyperthyroidism, Pruritus, Pustule, Increased circulating antibody level, Rheumatoid arthritis, H... ORPHA:48377
Hypertrophic Osteoarthropathy, Primary, Autosomal Dominant
Acne, Seborrheic dermatitis OMIM:167100
Ichthyosis, Congenital, Autosomal Recessive 1
Erythroderma OMIM:242300
Spinocerebellar Ataxia 34
Erythroderma OMIM:133190
Bathing Suit Ichthyosis
Hypohidrosis, Erythroderma ORPHA:100976
Immunodeficiency, Common Variable, 12, With Autoimmunity
Atrophic gastritis, Recurrent skin infections, Recurrent pneumonia, Bronchiectasis, Decreased cir... OMIM:616576
Ichthyosis, Congenital, Autosomal Recessive 6
Hypohidrosis, Erythroderma OMIM:612281
Keratitis-Ichthyosis-Deafness Syndrome, Autosomal Recessive
Failure to thrive, Conjunctivitis, Erythroderma OMIM:242150
Harlequin Ichthyosis
Erythroderma ORPHA:457
Congenital Disorder Of Glycosylation, Type If
Failure to thrive, Erythroderma OMIM:609180
Trichothiodystrophy 1, Photosensitive
Keratoconjunctivitis sicca, Decreased circulating IgG level, Small for gestational age, Erythroderma OMIM:601675
Autoimmune Lymphoproliferative Syndrome Due To Ctla4 Haploinsuffiency
Atrophic gastritis, Psoriasiform dermatitis, Eczema, Pneumonia, Bronchiectasis, Atopic dermatitis... ORPHA:436159
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation
Atrophic gastritis, Psoriasiform dermatitis, Eczema, Bronchiectasis, Decreased circulating antibo... OMIM:616100
Diffuse Cutaneous Mastocytosis
Pruritus, Erythroderma ORPHA:79456
Idiopathic Localized Lipodystrophy
Pruritus, Inflammatory abnormality of the skin ORPHA:90158
Immunoskeletal Dysplasia With Neurodevelopmental Abnormalities
Decreased circulating antibody level, Erythroderma OMIM:617425
Yao Syndrome
Inflammatory abnormality of the skin, Pericarditis, Skin rash, Xerostomia, Weight loss, Arthritis... OMIM:617321
Immunodeficiency 96
Eczema, Decreased circulating total IgM, Defective T cell proliferation, Recurrent otitis media, ... OMIM:619774
Iga Pemphigus
Neutrophilic infiltration of the skin, Monoclonal elevation of circulating IgA, Increased circula... ORPHA:555905
Biotinidase Deficiency
Skin rash, Conjunctivitis, Recurrent skin infections, Seborrheic dermatitis OMIM:253260
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Eczema, Lymphadenitis, Inflammation of the large intestine, Erythroderma, Failure to thrive OMIM:615895
Letterer-Siwe Disease
Stomatitis, Seborrheic dermatitis OMIM:246400
Omenn Syndrome
Failure to thrive, Pneumonia, Erythroderma OMIM:603554
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1
Hyperhidrosis, Arthritis, Eczematoid dermatitis, Seborrheic dermatitis OMIM:259100
Pachydermoperiostosis
Osteomyelitis, Acne, Elevated circulating growth hormone concentration, Seborrheic dermatitis, Hy... ORPHA:2796
Majeed Syndrome
Failure to thrive, Inflammatory abnormality of the skin, Osteomyelitis, Skin rash OMIM:609628
Chondrodysplasia Punctata 2, X-Linked Dominant
Failure to thrive, Erythroderma OMIM:302960
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Myositis, Tubulointerstitial nephritis, Colitis, Hypothyroidism, Psoriasiform dermatitis, Hyperth... ORPHA:37042
X-Linked Dominant Chondrodysplasia Punctata
Erythroderma ORPHA:35173
Majeed Syndrome
Inflammatory abnormality of the skin, Osteomyelitis, Acne, Cachexia, Pustule, Synovitis, Weight l... ORPHA:77297
Idiopathic Hypereosinophilic Syndrome
Inflammatory abnormality of the skin, Eczema, Cholangitis, Pruritus, Chronic hepatitis, Arthritis... ORPHA:3260
T-B+ Severe Combined Immunodeficiency Due To Jak3 Deficiency
Skin rash, Failure to thrive in infancy, Partial IgA deficiency, Pustule, Acute otitis media, Rec... ORPHA:35078
Transketolase Deficiency
Conjunctivitis, Uveitis, Seborrheic dermatitis ORPHA:488618
3-Methylcrotonyl-Coa Carboxylase 2 Deficiency
Failure to thrive, Seborrheic dermatitis OMIM:210210
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency
Absent specific antibody response, Inflammatory abnormality of the skin, Sinusitis, Skin rash, Pn... OMIM:102700
Trichothiodystrophy
Congenital exfoliative erythroderma, Eczema, Keratoconjunctivitis sicca, Conjunctivitis, Panhypog... ORPHA:33364
Vexas Syndrome
Inflammatory abnormality of the skin, Neutrophilic infiltration of the skin, Chondritis of pinna,... OMIM:301054
Centrifugal Lipodystrophy
Lymphadenitis, Inflammatory abnormality of the skin ORPHA:90156
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Superficial dermal perivascular inflammatory infiltrate, Eczema, Seborrheic dermatitis, Pruritus,... ORPHA:83617
Intellectual Disability-Seizures-Macrocephaly-Obesity Syndrome
Obesity, Failure to thrive, Eczema, Seborrheic dermatitis ORPHA:369950
22Q11.2 Deletion Syndrome
Hypoparathyroidism, Hyperthyroidism, Acne, Impaired T cell function, Seborrheic dermatitis, Obesi... ORPHA:567
Neurodevelopmental Disorder With Epilepsy And Hemochromatosis
Truncal obesity, Aspiration pneumonia, Seborrheic dermatitis OMIM:301072
Monosomy 22
Hyperhidrosis, Seborrheic dermatitis ORPHA:96123
Thrombocytopenia-Absent Radius Syndrome
Decreased circulating antibody level, Seborrheic dermatitis OMIM:274000
Uremic Pruritus
Pruritus, Inflammatory abnormality of the skin, Recurrent skin infections ORPHA:94059
Hemihyperplasia-Multiple Lipomatosis Syndrome
Seborrheic dermatitis ORPHA:276280
Digeorge Syndrome
Acne, Impaired T cell function, Seborrheic dermatitis, Recurrent pneumonia, Obesity, Recurrent si... OMIM:188400
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2
Large for gestational age, Seborrheic dermatitis OMIM:300868
Igg4-Related Kidney Disease
Pericarditis, Inflammatory abnormality of the skin, Increased circulating IgG4 level, Lymphadenit... ORPHA:449395
Ifap Syndrome 1, With Or Without Bresheck Syndrome
Recurrent skin infections, Eczema, Keratitis, Hypohidrosis, Erythroderma OMIM:308205

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Plgrkt

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Plgrkt.

No publications found that use IMPC mice or data for Plgrkt.

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MGI Allele Allele Type Produced
Plgrkttm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Plgrkttm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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