Gene: Dnajc19 MGI:1914963

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Gene Summary

Name:
DnaJ heat shock protein family (Hsp40) member C19
Synonyms:
1810055D05Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating alkaline phosphatase level Dnajc19tm1a(EUCOMM)Hmgu HOM   Early adult 3.96×10-06
increased circulating glucose level Dnajc19tm1a(EUCOMM)Hmgu HOM Early adult 9.57×10-07
decreased mean corpuscular hemoglobin concentration Dnajc19tm1a(EUCOMM)Hmgu HOM Early adult 3.81×10-05
trunk curl Dnajc19tm1a(EUCOMM)Hmgu HOM   Early adult 8.38×10-07

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dnajc19 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dnajc19 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Dilated Cardiomyopathy With Ataxia
ORPHA:66634
3-Methylglutaconic Aciduria, Type V
OMIM:610198

The table below shows human diseases predicted to be associated to Dnajc19 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Hemoglobin E-Beta-Thalassemia Syndrome
ORPHA:231249
Hemoglobin-Delta locus
OMIM:142000
Diabetes Mellitus, Permanent Neonatal, 4
OMIM:618858
Maturity-Onset Diabetes Of The Young, Type 3
OMIM:600496
Diabetes Mellitus, Transient Neonatal, 3
OMIM:610582
Maturity-Onset Diabetes Of The Young, Type 10
OMIM:613370
Pentosuria
ORPHA:2843
Thalassemia, Beta+, Silent Allele
OMIM:187550
Fetal Hemoglobin Quantitative Trait Locus 1
OMIM:141749
Hemoglobin H Disease
OMIM:613978
Diabetes Mellitus, Permanent Neonatal, 1
OMIM:606176
Delta-Beta-Thalassemia
ORPHA:231237
Acetophenetidin Sensitivity
OMIM:200300
Hemoglobin C-Beta-Thalassemia Syndrome
ORPHA:231242
Glycogen Storage Disease 0, Liver
OMIM:240600
Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome
ORPHA:231393
Hyperproinsulinemia
OMIM:616214
Methemoglobinemia, Beta Type
OMIM:617971
Methemoglobinemia, Alpha Type
OMIM:617973
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
ORPHA:46532
Alpha-Thalassemia Myelodysplasia Syndrome
OMIM:300448
Congenital Amegakaryocytic Thrombocytopenia
ORPHA:3319
Diabetes Mellitus, Transient Neonatal, 1
OMIM:601410
Cyanosis, Transient Neonatal
OMIM:613977
Hypogonadism, Male, With Mental Retardation And Skeletal Anomalies
OMIM:307500
Diabetes Mellitus, Permanent Neonatal, 2
OMIM:618856
Alpha-Thalassemia
ORPHA:846
Type 1 Diabetes Mellitus
OMIM:222100
Transient Neonatal Diabetes Mellitus
ORPHA:99886
Sickle Cell Anemia
ORPHA:232
Beta-Thalassemia
OMIM:613985
Alpha-Thalassemia
OMIM:604131
Diamond-Blackfan Anemia 3
OMIM:610629
Alpha-Thalassemia-Myelodysplastic Syndrome
ORPHA:231401
Mody
ORPHA:552
Methylmalonic Aciduria And Homocystinuria, Cblj Type
OMIM:614857
Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities
OMIM:262190
Beta-Thalassemia
ORPHA:848
Cone-Rod Synaptic Disorder Syndrome, Congenital Nonprogressive
OMIM:618970
Lipodystrophy, Familial Partial, Type 3
OMIM:604367
Lipodystrophy, Familial Partial, Type 1
OMIM:608600
Diabetes And Deafness, Maternally Inherited
OMIM:520000
Glycogen Storage Disease Due To Hepatic Glycogen Synthase Deficiency
ORPHA:2089
Mohr-Tranebjaerg Syndrome
OMIM:304700
Hypokalemic Periodic Paralysis
ORPHA:681
Insulin-Resistance Syndrome Type B
ORPHA:2298
Diabetes Mellitus, Permanent Neonatal, 3
OMIM:618857
Bone Marrow Failure Syndrome 6
OMIM:618849
Beta-Thalassemia Intermedia
ORPHA:231222
Hb Bart'S Hydrops Fetalis
ORPHA:163596
Primary Familial Polycythemia
ORPHA:90042
Methemoglobinemia Due To Deficiency Of Methemoglobin Reductase
OMIM:250800
Sandifer Syndrome
ORPHA:71272
Huntington Disease-Like 1
ORPHA:157941
Dominant Beta-Thalassemia
ORPHA:231226
Beta-Thalassemia Major
ORPHA:231214
Necrotizing Enterocolitis
ORPHA:391673
Dystonia 1, Torsion, Autosomal Dominant
OMIM:128100
Pancreatic And Cerebellar Agenesis
OMIM:609069
Mitochondrial Complex Iv Deficiency, Nuclear Type 5
OMIM:220111
Dend Syndrome
ORPHA:79134
Nephropathy With Pretibial Epidermolysis Bullosa And Deafness
OMIM:609057
Greig Cephalopolysyndactyly Syndrome
OMIM:175700
Classic Pantothenate Kinase-Associated Neurodegeneration
ORPHA:216866
Diamond-Blackfan Anemia 6
OMIM:612561
Donohue Syndrome
OMIM:246200
Methemoglobinemia And Ambiguous Genitalia
OMIM:250790
Mandibuloacral Dysplasia With Type B Lipodystrophy
OMIM:608612
Fanconi-Bickel Syndrome
ORPHA:2088
Beta-Ketothiolase Deficiency
ORPHA:134
Symptomatic Form Of Hemochromatosis Type 1
ORPHA:465508
Bardet-Biedl Syndrome 9
OMIM:615986
Sporadic Infantile Bilateral Striatal Necrosis
ORPHA:225147
Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16
ORPHA:98791
Pyruvate Carboxylase Deficiency
ORPHA:3008
Short Syndrome
OMIM:269880
Mandibuloacral Dysplasia With Type A Lipodystrophy
OMIM:248370
Acquired Aneurysmal Subarachnoid Hemorrhage
ORPHA:90065
Vici Syndrome
OMIM:242840
Mitchell-Riley Syndrome
OMIM:615710
Rabson-Mendenhall Syndrome
ORPHA:769
Isolated Sedoheptulokinase Deficiency
ORPHA:440713
Acth-Independent Macronodular Adrenal Hyperplasia 2
OMIM:615954
Lipodystrophy, Familial Partial, Type 2
OMIM:151660
Hereditary Methemoglobinemia
ORPHA:621
Shwachman-Diamond Syndrome 1
OMIM:260400
Alpha-Thalassemia/Mental Retardation Syndrome, Chromosome 16-Related
OMIM:141750
Acquired Methemoglobinemia
ORPHA:464453
Blackfan-Diamond Anemia
ORPHA:124
Lead Poisoning
ORPHA:330015
Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome
ORPHA:847
Alpha-Thalassemia/Mental Retardation Syndrome, X-Linked
OMIM:301040
Thyrotoxic Periodic Paralysis
ORPHA:79102
Leprechaunism
ORPHA:508
Scorpion Envenomation
ORPHA:466677
Isolated Permanent Neonatal Diabetes Mellitus
ORPHA:99885
Unilateral Polymicrogyria
ORPHA:268943
Atypical Werner Syndrome
ORPHA:79474
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
ORPHA:293987
Cognitive Impairment-Coarse Facies-Heart Defects-Obesity-Pulmonary Involvement-Short Stature-Skeletal Dysplasia Syndrome
ORPHA:444077
Heart Defects, Congenital, And Other Congenital Anomalies
OMIM:600001
Dilated Cardiomyopathy With Ataxia
ORPHA:66634
3-Methylglutaconic Aciduria, Type V
OMIM:610198

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dnajc19

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dnajc19.

No publications found that use IMPC mice or data for Dnajc19.

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MGI Allele Allele Type Produced
Dnajc19tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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