banner
Genes Phenotypes Help, News, Blog

Gene: Kirrel3 MGI:1914953

Log in to follow
Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
kirre like nephrin family adhesion molecule 3
Synonyms:
Neph2,  2900036G11Rik,  1500010O20Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Kirrel3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Kirrel3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Autism, Susceptibility To, 20
Impaired social interactions OMIM:618830
Hereditary Geniospasm
Abnormal social behavior ORPHA:53372
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Abnormal social behavior ORPHA:436151
11Q22.2Q22.3 Microdeletion Syndrome
Abnormal social behavior, Depressed nasal bridge ORPHA:444002
Hsd10 Disease
Abnormal social behavior, Optic atrophy ORPHA:391417
Female Restricted Epilepsy With Intellectual Disability
Abnormal social behavior ORPHA:101039
Lamb-Shaffer Syndrome
Abnormal social behavior, Optic atrophy, Broad nasal tip ORPHA:530983
Childhood Absence Epilepsy
Abnormal social behavior, Depression ORPHA:64280
Metachromatic Leukodystrophy, Late Infantile Form
Decreased nerve conduction velocity, Emotional lability, Abnormal social behavior, Optic atrophy ORPHA:309256
48,Xxxy Syndrome
Irritability, Abnormal social behavior, Depressed nasal ridge, Abnormal aggressive, impulsive or ... ORPHA:96263
Metachromatic Leukodystrophy, Juvenile Form
Decreased nerve conduction velocity, Emotional lability, Abnormal social behavior, Optic atrophy ORPHA:309263
Metachromatic Leukodystrophy, Adult Form
Decreased nerve conduction velocity, Optic atrophy, Depression, Emotional lability, Abnormal soci... ORPHA:309271
Prader-Willi Syndrome Due To Translocation
Narrow nasal bridge, Anteverted nares, Prominent nose, Broad nasal tip, Lateral ventricle dilatat... ORPHA:177907
Fg Syndrome Type 1
Optic nerve hypoplasia, Abnormal social behavior, Choanal atresia, Prominent nose ORPHA:93932
Dihydropyrimidine Dehydrogenase Deficiency
Depressed nasal bridge, Anteverted nares, Irritability, Prominent nasal tip, Abnormal social beha... ORPHA:1675
Early-Onset Autosomal Dominant Alzheimer Disease
Abnormal social behavior ORPHA:1020
Koolen-De Vries Syndrome Due To A Point Mutation
Thick nasal alae, Prominent nasal bridge, Underdeveloped nasal alae, Bulbous nose, Optic atrophy,... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Thick nasal alae, Prominent nasal bridge, Underdeveloped nasal alae, Bulbous nose, Optic atrophy,... ORPHA:363958
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Bulbous nose, Wide nose, Abnormal social behavior, Anteverted nares ORPHA:314647
Mend Syndrome
Abnormal nasal bridge morphology, Abnormal social behavior, Prominent nasal bridge, Abnormal audi... ORPHA:401973
Niemann-Pick Disease Type C
Abnormal social behavior, Low frustration tolerance, Depression ORPHA:646
Tuberous Sclerosis Complex
Abnormal social behavior, Depression ORPHA:805
Williams Syndrome
Wide nasal bridge, Depression, Short nose, Abnormal social behavior, Overfriendliness ORPHA:904

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Kirrel3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Kirrel3.

No publications found that use IMPC mice or data for Kirrel3.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Kirrel3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Kirrel3tm39576(L1L2_st1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Kirrel3tm39576(L1L2_gt1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Kirrel3tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter