Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
kirre like nephrin family adhesion molecule 3
Synonyms:
Neph2,  2900036G11Rik,  1500010O20Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Kirrel3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Kirrel3 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Autosomal Dominant Non-Syndromic Intellectual Disability
Cerebral atrophy, Self-injurious behavior, Abnormal hippocampus morphology, Leukoencephalopathy, ... ORPHA:178469

The table below shows human diseases predicted to be associated to Kirrel3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Asperger Syndrome, Susceptibility To, 1
Impaired ability to form peer relationships OMIM:608638
Asperger Syndrome, X-Linked, Susceptibility To, 2
Impaired ability to form peer relationships OMIM:300497
Asperger Syndrome, X-Linked, Susceptibility To, 1
Impaired ability to form peer relationships OMIM:300494
Asperger Syndrome, Susceptibility To, 2
Impaired ability to form peer relationships OMIM:608631
Autism, Susceptibility To, 20
Impaired social interactions OMIM:618830
Intellectual Developmental Disorder With Autism And Speech Delay
Impaired social interactions, Pachygyria OMIM:606053
Hereditary Geniospasm
Abnormal social behavior ORPHA:53372
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Abnormal social behavior ORPHA:436151
Glycosylphosphatidylinositol Biosynthesis Defect 17
Overfriendliness, Dysplastic corpus callosum, Aggressive behavior, Primary microcephaly OMIM:618010
11Q22.2Q22.3 Microdeletion Syndrome
Abnormal social behavior, Anxiety, Poor eye contact, Depressed nasal bridge, Hypoplasia of the co... ORPHA:444002
Hsd10 Disease
Abnormal social behavior, Microcephaly, Frontotemporal cerebral atrophy, Optic atrophy, Focal whi... ORPHA:391417
Early-Onset Schizophrenia
Suicidal ideation, Lack of peer relationships, No social interaction, Unhappy demeanor, Anxiety, ... ORPHA:96369
Female Restricted Epilepsy With Intellectual Disability
Anxiety, Aggressive behavior, Abnormal social behavior ORPHA:101039
Dopa-Responsive Dystonia
Abnormal social behavior, Anxiety, Panic attack, Emotional lability, Irritability, Agoraphobia ORPHA:255
Lamb-Shaffer Syndrome
Microcephaly, Broad nasal tip, Optic atrophy, Abnormal social behavior ORPHA:530983
Early-Onset Autosomal Dominant Alzheimer Disease
Neurofibrillary tangles, Cerebral cortical atrophy, Abnormal social behavior ORPHA:1020
1P21.3 Microdeletion Syndrome
Broad nasal tip, Self-injurious behavior, Aggressive behavior, Shyness, Self-mutilation, Short nose ORPHA:293948
Metachromatic Leukodystrophy, Late Infantile Form
Abnormal social behavior, Decreased nerve conduction velocity, Emotional lability, Optic atrophy,... ORPHA:309256
Metachromatic Leukodystrophy, Juvenile Form
Abnormal social behavior, Decreased nerve conduction velocity, Emotional lability, Optic atrophy,... ORPHA:309263
Prader-Willi Syndrome Due To Translocation
Impaired social interactions, Broad nasal tip, Underdeveloped nasolabial fold, Anteverted nares, ... ORPHA:177907
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Abnormal cortical gyration, Bulbous nose, Abnormal social behavior, Hypoplastic hippocampus, Aggr... ORPHA:314647
Dihydropyrimidine Dehydrogenase Deficiency
Cerebral atrophy, Anteverted nares, Abnormal social behavior, Hyperintensity of cerebral white ma... ORPHA:1675
48,Xxxy Syndrome
Depressed nasal ridge, Abnormal social behavior, Abnormal aggressive, impulsive or violent behavi... ORPHA:96263
Metachromatic Leukodystrophy, Adult Form
Abnormal social behavior, Decreased nerve conduction velocity, Emotional lability, Orthostatic hy... ORPHA:309271
Childhood Absence Epilepsy
Anxiety, Abnormal social behavior ORPHA:64280
Fg Syndrome Type 1
Small pituitary gland, Abnormal social behavior, Aplasia/Hypoplasia of the corpus callosum, Optic... ORPHA:93932
Mend Syndrome
Abnormal social behavior, Aggressive behavior, Abnormal auditory evoked potentials, Abnormal nasa... ORPHA:401973
Koolen-De Vries Syndrome Due To A Point Mutation
Pineal cyst, Agenesis of corpus callosum, Underdeveloped nasal alae, Bulbous nose, Abnormal socia... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Pineal cyst, Agenesis of corpus callosum, Underdeveloped nasal alae, Bulbous nose, Abnormal socia... ORPHA:363958
Tuberous Sclerosis Complex
Cortical tubers, Abnormal social behavior, Self-injurious behavior, Anxiety, Aggressive behavior,... ORPHA:805
Niemann-Pick Disease Type C
Cerebral atrophy, Low frustration tolerance, Abnormal social behavior, Aggressive behavior, Apath... ORPHA:646
Williams Syndrome
Abnormality of the diencephalon, Abnormal social behavior, Anxiety, Wide nasal bridge, Microcepha... ORPHA:904
Autosomal Dominant Non-Syndromic Intellectual Disability
Cerebral atrophy, Self-injurious behavior, Abnormal hippocampus morphology, Leukoencephalopathy, ... ORPHA:178469

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Kirrel3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Kirrel3.

No publications found that use IMPC mice or data for Kirrel3.

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MGI Allele Allele Type Produced
Kirrel3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Kirrel3tm39576(L1L2_st1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Kirrel3tm39576(L1L2_gt1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Kirrel3tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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