Gene Summary

Name:
asparagine-linked glycosylation 13
Synonyms:
Glt28d1,  4833435D08Rik,  MDS031,  2810046O15Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased leukocyte cell number Alg13tm1a(KOMP)Wtsi HOM Early adult 2.53×10-06
decreased lean body mass Alg13tm1a(KOMP)Wtsi HOM Early adult 1.25×10-08
decreased bone mineral density Alg13tm1a(KOMP)Wtsi HOM Early adult 1.11×10-15
decreased bone mineral content Alg13tm1a(KOMP)Wtsi HOM Early adult 2.66×10-11
increased total body fat amount Alg13tm1a(KOMP)Wtsi HOM Early adult 3.29×10-09

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

14 Images

X-ray

XRay Images Whole Body Lateral Orientation

14 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

12 Images

X-ray

XRay Images Forepaw

13 Images

X-ray

XRay Images Skull Lateral Orientation

14 Images

Histopathology

Images

5 Images

Legacy Phenotype Associated Images

View all 67 images

Human diseases caused by Alg13 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Alg13 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Developmental And Epileptic Encephalopathy 36
Seizure, Infantile spasms, Tonic seizure, Myoclonic seizure, Atonic seizure OMIM:300884
Alg13-Cdg
Abnormal lateral ventricle morphology, Infantile spasms ORPHA:324422

The table below shows human diseases predicted to be associated to Alg13 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Focal Cortical Dysplasia, Type Ii
Astrocytosis, Focal impaired awareness seizure OMIM:607341
Dysplasia Of Head Of Femur, Meyer Type
Limited hip movement, Multicentric femoral head ossification, Leukocytosis, Delayed femoral head ... ORPHA:168621
Progressive Non-Fluent Aphasia
Astrocytosis, Abnormal lower motor neuron morphology ORPHA:100070
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7
Astrocytosis, Myoclonus OMIM:600795
Sporadic Creutzfeldt-Jakob Disease
Astrocytosis, Gliosis, Myoclonus ORPHA:204
Behavioral Variant Of Frontotemporal Dementia
Astrocytosis, Bilateral tonic-clonic seizure ORPHA:275864
Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy
Seizure, Astrocytosis OMIM:611087
Familial Infantile Bilateral Striatal Necrosis
Basal ganglia gliosis, Astrocytosis, Myoclonus ORPHA:225154
Myeloproliferative Syndrome, Transient
Leukocytosis, Transient myeloproliferative syndrome OMIM:159595
Inherited Creutzfeldt-Jakob Disease
Seizure, Astrocytosis, Myoclonus ORPHA:282166
Neutrophil Immunodeficiency Syndrome
Leukocytosis, Abnormality of neutrophil physiology ORPHA:183707
Acute Myelomonocytic Leukemia
Anemia, Leukocytosis, Thrombocytopenia, Weight loss, Eosinophilia ORPHA:517
Eosinophilia, Familial
Eosinophilia, Thrombocytopenia, Anemia, Leukocytosis OMIM:131400
Immunodeficiency 69
Anemia, Hemophagocytosis, Pancytopenia, Leukocytosis, Failure to thrive, Hepatosplenomegaly, Sple... OMIM:618963
Ghosal Hematodiaphyseal Dysplasia
Increased bone mineral density, Refractory anemia, Myelofibrosis, Thrombocytopenia, Leukopenia, H... OMIM:231095
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Epilepsia partialis continua, Focal myoclonic seizure, Astrocytosis, Gliosis, Generalized non-con... OMIM:203700
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
Generalized non-motor (absence) seizure, Astrocytosis, Focal-onset seizure, Seizure ORPHA:258
Acquired Idiopathic Sideroblastic Anemia
Normocytic anemia, Acute myeloid leukemia, Normochromic anemia, Pancytopenia, Anemia of inadequat... ORPHA:75564
Aggressive Systemic Mastocytosis
Anemia, Increased proportion of CD25+ mast cells, Pancytopenia, Leukemia, Leukocytosis, Osteoporo... ORPHA:98850
Majeed Syndrome
Hypochromic microcytic anemia, Increased bone mineral density, Cachexia, Leukocytosis, Synovitis,... ORPHA:77297
Leukocyte Adhesion Deficiency, Type Iii
Osteopetrosis, Anemia, Leukocytosis, Hepatosplenomegaly, Splenomegaly, Extramedullary hematopoiesis OMIM:612840
Chronic Myeloid Leukemia
Myeloproliferative disorder, Leukocytosis, Abnormal granulocyte morphology, Thrombocytopenia, Spl... ORPHA:521
Polycythemia Vera
Increased red blood cell mass, Leukocytosis, Increased circulating hemoglobin concentration, Thro... OMIM:263300
Cockayne Syndrome Type 3
Seizure, Astrocytosis ORPHA:90324
Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Astrocytosis ORPHA:309854
Immunodeficiency 73A With Defective Neutrophil Chemotaxis And Leukocytosis
Macrocytic anemia, Rectal abscess, Reduction of neutrophil motility, Leukocytosis, Neutrophilia, ... OMIM:608203
Supranuclear Palsy, Progressive, 1
Astrocytosis, Gliosis OMIM:601104
Sickle Cell Anemia
Chronic hemolytic anemia, Iron deficiency anemia, Increased mean corpuscular volume, Leukocytosis... ORPHA:232
Thrombocytopenia 2
Abnormal platelet shape, Thrombocytopenia, Leukocytosis, Abnormal platelet volume OMIM:188000
Developmental And Epileptic Encephalopathy 36
Seizure, Infantile spasms, Tonic seizure, Myoclonic seizure, Atonic seizure OMIM:300884
Alg13-Cdg
Abnormal lateral ventricle morphology, Infantile spasms ORPHA:324422

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

Phenotype Allele Zygosity Sex Life Stage
Ovary - hypoplasia Alg13tm1a(KOMP)Wtsi HOM Early adult
Testes - process of degenerative change Alg13tm1a(KOMP)Wtsi HEM Early adult
Uterus - hypoplasia Alg13tm1a(KOMP)Wtsi HOM Early adult

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Alg13.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Alg13tm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Alg13tm1a(KOMP)Wtsi Alg13tm1a(KOMP)Wtsi PMC6459510

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Alg13tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Alg13tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Alg13tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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