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Gene: Alg13 MGI:1914824

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Gene Summary

Name:
asparagine-linked glycosylation 13
Synonyms:
Glt28d1,  4833435D08Rik,  MDS031,  2810046O15Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral density Alg13tm1a(KOMP)Wtsi HOM   Early adult 1.11×10-15
decreased bone mineral content Alg13tm1a(KOMP)Wtsi HOM   Early adult 3.22×10-11
decreased lean body mass Alg13tm1a(KOMP)Wtsi HOM   Early adult 1.28×10-08
increased total body fat amount Alg13tm1a(KOMP)Wtsi HOM   Early adult 3.29×10-09
increased leukocyte cell number Alg13tm1a(KOMP)Wtsi HOM   Early adult 2.53×10-06

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

14 Images

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X-ray

XRay Images Skull Lateral Orientation

14 Images

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X-ray

XRay Images Forepaw

13 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

12 Images

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X-ray

XRay Images Whole Body Dorso Ventral

14 Images

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Histopathology

Images

5 Images

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Legacy Phenotype Associated Images
Alg13tm1a(KOMP)Wtsi
HOM, Female, WTSI
Alg13tm1a(KOMP)Wtsi
HOM, Female, WTSI
Alg13tm1a(KOMP)Wtsi
HOM, Female, WTSI
Alg13tm1a(KOMP)Wtsi
HOM, Female, WTSI
Alg13tm1a(KOMP)Wtsi
HOM, Female, WTSI

View all 67 images

Alg13tm1a(KOMP)Wtsi
back skin, HOM, Female, WTSI
Alg13tm1a(KOMP)Wtsi
back skin, HOM, Female, WTSI

Human diseases caused by Alg13 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Alg13 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Developmental And Epileptic Encephalopathy 36
Myoclonic seizure, Seizure, Tonic seizure, Atonic seizure, Infantile spasms OMIM:300884
Alg13-Cdg
Infantile spasms, Abnormal lateral ventricle morphology ORPHA:324422

The table below shows human diseases predicted to be associated to Alg13 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Focal Cortical Dysplasia, Type Ii
Astrocytosis, Focal impaired awareness seizure OMIM:607341
Dysplasia Of Head Of Femur, Meyer Type
Leukocytosis, Multicentric femoral head ossification, Delayed femoral head ossification, Limited ... ORPHA:168621
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7
Myoclonus, Astrocytosis OMIM:600795
Sporadic Creutzfeldt-Jakob Disease
Astrocytosis, Myoclonus, Gliosis ORPHA:204
Behavioral Variant Of Frontotemporal Dementia
Bilateral tonic-clonic seizure, Astrocytosis ORPHA:275864
Familial Infantile Bilateral Striatal Necrosis
Myoclonus, Basal ganglia gliosis, Astrocytosis ORPHA:225154
Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy
Astrocytosis, Seizure OMIM:611087
Myeloproliferative Syndrome, Transient
Transient myeloproliferative syndrome, Leukocytosis OMIM:159595
Inherited Creutzfeldt-Jakob Disease
Astrocytosis, Myoclonus, Seizure ORPHA:282166
Neutrophil Immunodeficiency Syndrome
Leukocytosis, Abnormality of neutrophil physiology ORPHA:183707
Acute Myelomonocytic Leukemia
Anemia, Weight loss, Leukocytosis, Eosinophilia, Thrombocytopenia ORPHA:517
Eosinophilia, Familial
Anemia, Thrombocytopenia, Leukocytosis, Eosinophilia OMIM:131400
Immunodeficiency 69
Anemia, Pancytopenia, Hepatosplenomegaly, Failure to thrive, Thrombocytosis, Leukocytosis, Spleno... OMIM:618963
Ghosal Hematodiaphyseal Dysplasia
Leukopenia, Hyperostosis cranialis interna, Increased bone mineral density, Myelofibrosis, Refrac... OMIM:231095
Sickle Cell Anemia
Osteomyelitis, Hemolytic anemia, Reticulocytosis, Persistence of hemoglobin F, Chronic hemolytic ... ORPHA:232
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Epilepsia partialis continua, Myoclonus, Status epilepticus, Generalized non-convulsive status ep... OMIM:203700
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
Focal-onset seizure, Astrocytosis, Seizure, Generalized non-motor (absence) seizure ORPHA:258
Progressive Non-Fluent Aphasia
Abnormal lower motor neuron morphology, Astrocytosis ORPHA:100070
Acquired Idiopathic Sideroblastic Anemia
Acute myeloid leukemia, Neutropenia, Megaloblastic erythroid hyperplasia, Normocytic anemia, Eryt... ORPHA:75564
Aggressive Systemic Mastocytosis
Anemia, Neutropenia, Weight loss, Leukemia, Hypersplenism, Pancytopenia, Hepatosplenomegaly, Oste... ORPHA:98850
Majeed Syndrome
Increased susceptibility to fractures, Flexion contracture, Osteomyelitis, Weight loss, Increased... ORPHA:77297
Leukocyte Adhesion Deficiency, Type Iii
Anemia, Hepatosplenomegaly, Leukocytosis, Extramedullary hematopoiesis, Osteopetrosis, Splenomegaly OMIM:612840
Chronic Myeloid Leukemia
Abnormal granulocyte morphology, Abnormal basophil morphology, Thrombocytosis, Leukocytosis, Myel... ORPHA:521
Polycythemia Vera
Increased red blood cell mass, Increased hematocrit, Thrombocytosis, Leukocytosis, Thrombocytopen... OMIM:263300
Cockayne Syndrome Type 3
Astrocytosis, Seizure ORPHA:90324
Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Astrocytosis ORPHA:309854
Immunodeficiency 73A With Defective Neutrophil Chemotaxis And Leukocytosis
Impaired neutrophil chemotaxis, Neutrophilia, Abnormally low T cell receptor excision circle leve... OMIM:608203
Supranuclear Palsy, Progressive, 1
Astrocytosis, Gliosis OMIM:601104
Developmental And Epileptic Encephalopathy 36
Myoclonic seizure, Seizure, Tonic seizure, Atonic seizure, Infantile spasms OMIM:300884
Alg13-Cdg
Infantile spasms, Abnormal lateral ventricle morphology ORPHA:324422

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

Phenotype Allele Zygosity Sex Life Stage
Ovary - hypoplasia Alg13tm1a(KOMP)Wtsi HOM Early adult
Testes - process of degenerative change Alg13tm1a(KOMP)Wtsi HEM Early adult
Uterus - hypoplasia Alg13tm1a(KOMP)Wtsi HOM Early adult

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Alg13.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Alg13tm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Alg13tm1a(KOMP)Wtsi Alg13tm1a(KOMP)Wtsi PMC6459510

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MGI Allele Allele Type Produced
Alg13tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Alg13tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Alg13tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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