Genes Phenotypes

Gene: Cog6

Name
component of oligomeric golgi complex 6
MGI ID
MGI:1914792
Synonyms
N/A
Viability
Homozygous - Viable
View
N/A
Other links
MGI   Ensembl  
Significant phenotypes (53) Measurements chart (418) All data table (559)
Expression & images (0) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
decreased CD8-positive, alpha-beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
abnormal cornea morphology Cog6tm1a(EUCOMM)Wtsi HOM postnatal 3.53×10-05
increased circulating amylase level Cog6tm1a(EUCOMM)Wtsi HOM postnatal 2.38×10-07
increased follicular B cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased memory-marker gamma-delta T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased plasma cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased memory-marker NK cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased KLRG1-positive T-helper cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased granulocyte number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased CD5-positive gamma-delta T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased red blood cell distribution width Cog6tm1a(EUCOMM)Wtsi HOM postnatal 1.98×10-10
increased circulating total protein level Cog6tm1a(EUCOMM)Wtsi HOM postnatal 4.01×10-05
decreased memory-marker NK cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased effector memory T-helper cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased CD8-positive, naive alpha-beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased KLRG1-positive NK cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
abnormal coat/hair pigmentation Cog6tm1a(EUCOMM)Wtsi HOM postnatal 2.62×10-05
increased CD4-negative NK T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased marginal zone B cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased NK cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased Ly6C-positive immature NK cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased gamma-delta T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased KLRG1+ CD4 alpha beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 5.71×10-05
decreased Ly6C-positive mature NK cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased B-2 B cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased monocyte cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased memory-marker gamma-delta T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
vertebral transformation Cog6tm1a(EUCOMM)Wtsi HOM postnatal 3.90×10-10
decreased memory-marker CD4-negative NK T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased KLRG1+ CD8 alpha beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased transitional stage T2 B cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased bone mineral content Cog6tm1a(EUCOMM)Wtsi HOM postnatal 2.96×10-05
decreased CD4-positive NK T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased effector memory CD8-positive, alpha-beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased T-helper cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased B cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 6.35×10-05
decreased alpha-beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased mean platelet volume Cog6tm1a(EUCOMM)Wtsi HOM postnatal 9.90×10-07
decreased hemoglobin content Cog6tm1a(EUCOMM)Wtsi HOM postnatal 3.97×10-07
increased Ly6C high monocyte number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 5.71×10-05
decreased memory-marker CD4-positive NK T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased CD4-positive, alpha beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased NK T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased CD4-positive, alpha beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
abnormal bone structure Cog6tm1a(EUCOMM)Wtsi HOM postnatal 8.54×10-05
increased circulating alkaline phosphatase level Cog6tm1a(EUCOMM)Wtsi HOM postnatal 7.06×10-09
increased effector memory CD4-positive, alpha-beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 5.41×10-05
increased eosinophil cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased erythrocyte cell number Cog6tm1a(EUCOMM)Wtsi HOM postnatal 3.91×10-05

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 Expression

Expression data not available

 Associated Images

Mesenteric Lymph Node Immunophenotyping: Images associated with FACS analysis
155 Images
Spleen Immunophenotyping: Images associated with FACS analysis
204 Images
DSS Histology
16 Images
Anti-nuclear antibody assay
14 Images
X-ray: XRay Images Lateral Orientation
27 Images
Eye Morphology: Images Slit Lamp
7 Images
X-ray: XRay Images Forepaw
15 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
13 Images
X-ray: XRay Images Dorso Ventral
41 Images
X-ray: XRay Images Skull Lateral Orientation
14 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Cog6tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Cog6tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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