Cog6 - component of oligomeric golgi complex 6 | International Mouse Phenotyping Consortium

Genes Phenotypes

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Gene: Cog6

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Name

component of oligomeric golgi complex 6

MGI ID

MGI:1914792

Synonyms

N/A

Viability

Homozygous - Viable

Embryo viewer

N/A

Other links

MGI Ensembl

Significant phenotypes (41) Measurements chart (377) All data table (940)

Expression & images (0) Disease models (0) Order (2)

Significant

Not Significant

Not tested

View body weight measurements

Phenotype	Allele	Zyg	Life Stage	P Value
decreased CD8-positive, alpha-beta T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased monocyte cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
vertebral transformation	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	3.29×10^-10
decreased bone mineral content	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	2.16×10^-05
decreased memory-marker gamma-delta T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased B-2 B cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased granulocyte number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased KLRG1+ CD8 alpha beta T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased circulating amylase level	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	6.69×10^-07
increased follicular B cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
abnormal bone structure	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	2.60×10^-05
decreased CD4-positive, alpha beta T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased circulating alkaline phosphatase level	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	7.07×10^-09
increased KLRG1+ CD4 alpha beta T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	5.27×10^-05
decreased effector memory CD8-positive, alpha-beta T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased circulating total protein level	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	3.98×10^-05
decreased memory-marker CD4-negative NK T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased CD5-positive gamma-delta T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased red blood cell distribution width	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	1.46×10^-10
decreased T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased B cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	5.85×10^-05
increased KLRG1-positive T-helper cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased memory-marker gamma-delta T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
decreased CD8-positive, naive alpha-beta T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
decreased memory-marker NK cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased KLRG1-positive NK cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
abnormal coat/hair pigmentation	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	3.60×10^-05
decreased hemoglobin content	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	3.41×10^-07
increased Ly6C high monocyte number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	5.55×10^-05
decreased alpha-beta T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased eosinophil cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
decreased NK cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased mean platelet volume	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	6.11×10^-07
increased effector memory CD4-positive, alpha-beta T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	5.85×10^-05
increased CD4-positive, alpha beta T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
increased gamma-delta T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
decreased erythrocyte cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	1.69×10^-05
decreased memory-marker CD4-positive NK T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
decreased NK T cell number	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
abnormal cornea morphology	Cog6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	3.83×10^-05

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Expression

Expression data not available

Associated Images

DSS Histology
16 Images

Mesenteric Lymph Node Immunophenotyping: Images associated with FACS analysis
155 Images

Spleen Immunophenotyping: Images associated with FACS analysis
204 Images

X-ray: XRay Images Whole Body Lateral Orientation
27 Images

X-ray: XRay Images Whole Body Dorso Ventral
41 Images

X-ray: XRay Images Skull Dorso Ventral Orientation
13 Images

X-ray: XRay Images Forepaw
15 Images

X-ray: XRay Images Skull Lateral Orientation
14 Images

Eye Morphology: Images Ophthalmoscopy
2 Images

Eye Morphology: Images Slit Lamp
7 Images

Legacy Phenotype Associated Images

Cog6^{tm1a(EUCOMM)Wtsi}
HOM, Female, WTSI

View all 68 images

Cog6^{tm1a(EUCOMM)Wtsi}
abnormal cornea morphology, HOM, Male, WTSI

Cog6^{tm1a(EUCOMM)Wtsi}
abnormal cornea morphology, HOM, Female, WTSI

View all 9 images

Cog6^{tm1a(EUCOMM)Wtsi}
abnormal tail morphology, kinked tail, HOM, Female, WTSI

Cog6^{tm1a(EUCOMM)Wtsi}
abnormal coat/hair pigmentation, HOM, Female, WTSI

Cog6^{tm1a(EUCOMM)Wtsi}
abnormal tail morphology, kinked tail, HOM, Female, WTSI

Cog6^{tm1a(EUCOMM)Wtsi}
abnormal coat/hair pigmentation, HOM, Female, WTSI

View all 6 images

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Order Mouse and ES Cells

MGI Allele	Allele Type	Produced
Cog6^{tm1a(EUCOMM)Wtsi}	KO first allele (reporter-tagged insertion with conditional potential)	Mice, Targeting vectors, ES Cells
Cog6^{tm1(KOMP)Vlcg}	Reporter-tagged deletion allele (with selection cassette)	Targeting vectors, ES Cells

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