Agpat2 | 1-acylglycerol-3-phosphate O-acyltransferase 2
Physiological systems
24 / 24 physiological systems tested
12 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Digestive/alimentary Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Mortality/aging Renal/urinary system
12 No significant impact
Data collections
Gene metrics:17Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged uterus | 1 supporting dataset | Agpat2em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Agpat2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged kidney | 1 supporting dataset | Agpat2em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| enlarged liver | 1 supporting dataset | Agpat2em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| enlarged spleen | 1 supporting dataset | Agpat2em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| abnormal liver morphology | 1 supporting dataset | Agpat2em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| increased circulating total protein level | 1 supporting dataset | Agpat2em1(IMPC)Ccpcz | heterozygote | Early adult | 5.27x10-7 | ||
| no spontaneous movement | 1 supporting dataset | Agpat2em1(IMPC)Ccpcz | homozygote | E18.5 | N/A * | ||
| abnormal stomach morphology | 1 supporting dataset | Agpat2em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| increased circulating serum albumin level | 1 supporting dataset | Agpat2em1(IMPC)Ccpcz | heterozygote | Early adult | 3.16x10-5 |
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Human diseases caused by Agpat2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Agpat2.
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| Agpat2em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Agpat2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Agpat2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |