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Gene: Abcg8

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Name
ATP binding cassette subfamily G member 8
MGI ID
MGI:1914720
Synonyms
1300003C16Rik Sterolin-2
Viability
Data available
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (39) Measurements chart (270) All data table (579)
Expression & images (113) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
decreased eosinophil cell number Abcg8tm1b(KOMP)Wtsi HOM   Early adult 5.09×10-05
decreased CD8-positive, alpha-beta T cell number Abcg8tm1b(KOMP)Wtsi HOM   Early adult 1.63×10-06
increased memory-marker CD4-negative NK T cell number Abcg8tm1b(KOMP)Wtsi HOM Early adult 4.00×10-07
increased spleen weight Abcg8tm1b(KOMP)Wtsi HOM Early adult 3.22×10-05
decreased B-2 B cell number Abcg8tm1b(KOMP)Wtsi HOM Early adult 3.71×10-12
decreased memory-marker CD4-negative NK T cell number Abcg8tm1b(KOMP)Wtsi HOM Early adult 8.19×10-05
decreased CD8-positive, CD25-positive alpha-beta T cell number Abcg8tm1b(KOMP)Wtsi HOM Early adult 1.86×10-18
thick ventricular wall Abcg8tm1b(KOMP)Wtsi HOM Early adult 3.60×10-07
increased circulating creatinine level Abcg8tm1b(KOMP)Wtsi HOM   Early adult 7.77×10-06
increased circulating alkaline phosphatase level Abcg8tm1b(KOMP)Wtsi HOM Early adult 7.89×10-23
decreased mean corpuscular volume Abcg8tm1b(KOMP)Wtsi HOM Early adult 7.09×10-12
decreased CD4-negative NK T cell number Abcg8tm1b(KOMP)Wtsi HOM Early adult 1.89×10-08
abnormal cholesterol homeostasis Abcg8tm1b(KOMP)Wtsi HOM Early adult 6.12×10-13
decreased circulating serum albumin level Abcg8tm1b(KOMP)Wtsi HOM Early adult 2.80×10-05
decreased circulating iron level Abcg8tm1b(KOMP)Wtsi HOM Early adult 3.69×10-05
decreased CD4-positive, alpha beta T cell number Abcg8tm1b(KOMP)Wtsi HOM Early adult 8.06×10-06
abnormal liver morphology Abcg8tm1b(KOMP)Wtsi HOM Early adult 0.00
increased circulating potassium level Abcg8tm1b(KOMP)Wtsi HOM Early adult 9.65×10-10
increased effector memory T-helper cell number Abcg8tm1b(KOMP)Wtsi HOM Early adult 1.50×10-06
decreased mean corpuscular hemoglobin Abcg8tm1b(KOMP)Wtsi HOM Early adult 5.52×10-24
immune system phenotype Abcg8tm1b(KOMP)Wtsi HOM Early adult 4.95×10-06
decreased CD8-positive, naive alpha-beta T cell number Abcg8tm1b(KOMP)Wtsi HOM   Early adult 6.42×10-06
decreased mean corpuscular hemoglobin concentration Abcg8tm1b(KOMP)Wtsi HOM Early adult 3.52×10-05
decreased CD5-positive Ly6C-positive T cell number Abcg8tm1b(KOMP)Wtsi HOM   Early adult 1.17×10-05
impaired righting response Abcg8tm1b(KOMP)Wtsi HOM Early adult 2.91×10-09
increased mean platelet volume Abcg8tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal spleen morphology Abcg8tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased Ly6C-positive immature NK cell number Abcg8tm1b(KOMP)Wtsi HOM   Early adult 1.88×10-05
increased circulating cholesterol level Abcg8tm1b(KOMP)Wtsi HOM Early adult 8.60×10-10
decreased hematocrit Abcg8tm1b(KOMP)Wtsi HOM   Early adult 9.37×10-05
decreased T cell number Abcg8tm1b(KOMP)Wtsi HOM Early adult 1.50×10-05
decreased hemoglobin content Abcg8tm1b(KOMP)Wtsi HOM Early adult 1.85×10-07
decreased effector memory T-helper cell number Abcg8tm1b(KOMP)Wtsi HOM Early adult 6.15×10-05
enlarged liver Abcg8tm1b(KOMP)Wtsi HOM Early adult 0.00
increased circulating triglyceride level Abcg8tm1b(KOMP)Wtsi HOM Early adult 6.41×10-12
increased body weight Abcg8tm1b(KOMP)Wtsi HOM   Early adult 3.14×10-05
enlarged spleen Abcg8tm1b(KOMP)Wtsi HOM Early adult 0.00
increased red blood cell distribution width Abcg8tm1b(KOMP)Wtsi HOM Early adult 3.98×10-13
cataract Abcg8tm1b(KOMP)Wtsi HOM   Early adult 4.79×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (4/583)  Section images
Aorta 4 No  (1/583)  Section images
Blood 4 No N/A
Bone 4 No  Section images
Bone marrow 4 No N/A
Brain 4 No  (4/583)  (1/4)  Section images
Brainstem 4 No  (2/583)  Section images
Brown adipose tissue 4 No  Section images
Cartilage tissue 4 No  (1/583)  (1/4)  Section images
Cecum 4 No  (12/371)  (1/4)  Section images
Cerebellum 4 No  (3/583)  Section images
Cerebral cortex 4 No  (2/583)  Section images
Chest bone 4 No  Section images
Colon 4 No  (12/127)  Section images
Cranium 4 No  Section images
Diaphragm 4 No  Section images
Duodenum 4 No  (2/127)  (1/4)  Section images
Epididymis 4 No  (18/132) N/A
Esophagus 4 No  (7/407)  Section images
Eye 4 No  Section images
Gall bladder 4 No  (1/4)  Section images
Gonadal fat pad 4 No N/A
Harderian gland 4 No  Section images
Heart 4 No  (2/583)  Section images
Hindlimb 4 No  Section images
Hippocampus 4 No  (3/583)  Section images
Hypothalamus 4 No  (2/583)  Section images
Ileum 4 No  (14/127)  (2/4)  Section images
Jejunum 4 No  (6/127)  (2/4)  Section images
Kidney 4 No  (21/583)  Section images
Large intestine 4 No  (10/583)  Section images
Liver 4 No  (2/4)  Section images
Lower urinary tract 4 No  (1/583)  Section images
Lung 4 No  (2/583)  Section images
Lymph node 4 No  (1/583)  Section images
Main olfactory bulb 4 No N/A
Mammary gland 4 No  Section images
Mesenteric adipose tissue 4 No N/A
Mesenteric lymph node 4 No N/A
Midbrain 4 No N/A
Olfactory lobe 4 No  (2/583)  Section images
Oral epithelium 4 No  Section images
Ovary 4 No  (1/583)  Section images
Oviduct 4 No  Section images
Pancreas 4 No  (5/583)  (1/4)  Section images
Parathyroid gland 4 No  (1/563)  (1/4)  Section images
Parotid gland 4 No N/A
Penis 4 No  Section images
Peripheral nervous system 4 No  (2/583)  Section images
Peyer's patch 4 No  (1/4)  Section images
Pituitary gland 4 No  (1/583)  Section images
Prostate gland 4 No  (12/583)  Section images
Quadriceps 4 No  Section images
Sciatic nerve 4 No N/A
Skeletal muscle 4 No  Section images
Skin 4 No  (1/583)  Section images
Small intestine 4 No  (9/583)  (2/4)  Section images
Spinal cord 4 No  (3/583)  Section images
Spleen 4 No  (3/583)  Section images
Stomach 4 No  (13/583)  Section images
Stomach pyloric region 4 No N/A
Striatum 4 No  (3/583)  (1/4)  Section images
Sublingual gland 4 No N/A
Submandibular gland 4 No  (2/130)  (1/4)  Section images
Testis 4 No  (6/583)  (1/4)  Section images
Thalamus 4 No N/A
Thymus 4 No  (1/583)  (1/4)  Section images
Thyroid gland 4 No  (17/583)  Section images
Tongue 4 No  (5/127)  (1/4)  Section images
Trachea 4 No  (3/583)  Section images
Trigeminal V nerve 4 No N/A
Urinary bladder 4 No  Section images
Uterus 4 No  Section images
Vagina 4 No  Section images
Vas deferens 4 No  (15/382) N/A
Vascular system 4 No  Section images
Vesicular gland 4 No N/A
White adipose tissue 4 No  Section images
LacZ Wholemount Images
LacZ Section Images
Unassigned Top Level MA (6)
adipose tissue (4)
Brown adipose tissue no expression
MA:0000057
cardiovascular system (7)
Aorta ambiguous
MA:0000062
digestive system (30)
Cecum expression
MA:0000334
endocrine system (6)
Adrenal gland no expression
MA:0000116
exocrine system (4)
Mammary gland no expression
MA:0000145
immune system (9)
Lymph Node no expression
MA:0000139
integumental system (4)
Mammary gland no expression
MA:0000145
limb (2)
Hindlimb no expression
MA:0000026
musculoskeletal system (13)
Bone no expression
MA:0001459
nervous system (22)
Brain expression
MA:0000168
postnatal mouse (122)
Adrenal gland no expression
MA:0000116
reproductive system (8)
Ovary no expression
MA:0000384
respiratory system (12)
Diaphragm no expression
MA:0001904
sensory organ (6)
Eye no expression
MA:0000261
set of connective tissues (6)
Brown adipose tissue no expression
MA:0000057
trunk (57)
Adrenal gland no expression
MA:0000116
urinary system (7)
Kidney no expression
MA:0000368
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
2  (6/505) Image Only N/A
2  (1/73) Image Only N/A
2  (1/64) Image Only N/A
2  (1/505) Image Only N/A
2  (1/506)  (2/2) N/A
2  (1/71) Image Only N/A
2  (1/505) Image Only N/A
2  (1/505) Image Only N/A
2  (1/302) Image Only N/A
2  (1/505) Image Only N/A
2  (1/505) Image Only N/A
2  (1/505) Image Only N/A
2  (5/505) Image Only N/A
2  (1/505) Image Only N/A
2  (6/505) Image Only N/A
2  (1/505) Image Only N/A
2  (1/64) Image Only N/A
2  (1/64) Image Only N/A
2  (1/503) Image Only N/A
2  (1/302) Image Only N/A
2  (1/503) Image Only N/A
2  (1/505) Image Only N/A
2  (1/505) Image Only N/A
2  (1/505) Image Only N/A
2  (1/75) Image Only N/A
2  (1/503) Image Only N/A
2  (1/64) Image Only N/A
2  (1/75) Image Only N/A
2  (1/505) Image Only N/A
2  (1/72) Image Only N/A
2  (1/505) Image Only N/A
2  (1/505) Image Only N/A
2  (1/302) Image Only N/A
2  (1/302) Image Only N/A
2  (1/71) Image Only N/A

 Associated Images

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Adult LacZ: LacZ Images Section
128 Images
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X-ray: XRay Images Whole Body Dorso Ventral
26 Images
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X-ray: XRay Images Hind Leg and Hip
29 Images
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Embryo LacZ: LacZ images wholemount
8 Images
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X-ray: XRay Images Skull Dorso Ventral Orientation
13 Images
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X-ray: XRay Images Forepaw
13 Images
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X-ray: XRay Images Skull Lateral Orientation
13 Images
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X-ray: XRay Images Whole Body Lateral Orientation
13 Images

 Disease Models

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MGI Allele Allele Type Produced
Abcg8tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Abcg8tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Abcg8tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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