Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
C1q and tumor necrosis factor related protein 4
Synonyms:
9430004J15Rik,  CTRP4,  0710001E10Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by C1qtnf4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to C1qtnf4 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Macrophage Activation Syndrome
Hemophagocytosis, Increased circulating interleukin 6, Neutropenia, Hepatitis, Anemia, Splenomega... ORPHA:158061
Familial Hemophagocytic Lymphohistiocytosis
Abnormality of serum cytokine level, Increased circulating interleukin 6, Neutropenia, Erythroder... ORPHA:540
Acute Lung Injury
Abnormality of serum cytokine level, Increased circulating surfactant protein level, Increased ci... ORPHA:178320
Sweet Syndrome
Leukocytosis, Chronic lymphatic leukemia, Increased circulating interleukin 6, Sterile abscess, I... ORPHA:3243
Adult Acute Respiratory Distress Syndrome
Increased circulating interleukin 6, Pneumonia, Pancreatitis, Abnormal serum interleukin level, A... ORPHA:70578
Neutropenia, Severe Congenital, 1, Autosomal Dominant
Thrombocytosis, Neutropenia, Monocytosis, Congenital agranulocytosis, Anemia, Increased circulati... OMIM:202700
Vulvovaginal Gingival Syndrome
Abnormality of tumor necrosis factor secretion ORPHA:83453
Immunodeficiency 89 And Autoimmunity
Hypochromic microcytic anemia, Bronchiectasis, Increased circulating IgA level, Increased circula... OMIM:619632
Eosinophil Peroxidase Deficiency
Abnormal eosinophil morphology OMIM:261500
Psoriasis-Related Juvenile Idiopathic Arthritis
Psoriasiform dermatitis, Oligoarthritis, Sacroiliac arthritis, Anterior uveitis, Iridocyclitis, U... ORPHA:85436
Eosinophilic Fasciitis
Myositis, Fasciitis, Arthritis, Abnormal eosinophil morphology, Eosinophilia ORPHA:3165
Idiopathic Acute Eosinophilic Pneumonia
Abnormal eosinophil morphology ORPHA:724
Allergic Bronchopulmonary Aspergillosis
Abnormal eosinophil morphology, Bronchiectasis ORPHA:1164
Wiskott-Aldrich Syndrome
Sinusitis, Eczema, Inflammation of the large intestine, Neutropenia, Acute leukemia, Chronic otit... ORPHA:906
Dermatomyositis
Myocarditis, Abnormal eosinophil morphology, Pericarditis, Arthritis ORPHA:221

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for C1qtnf4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to C1qtnf4.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
CTRP4 ablation impairs associative learning and memory. FASEB journal : official publication of the Federation of American Societies for Experimental Biology (November 2021) C1qtnf4tm1a(KOMP)Wtsi 34610176

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
C1qtnf4tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
C1qtnf4tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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