Gene Summary

NADH:ubiquinone oxidoreductase subunit A10

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral density Ndufa10tm1e.1(EUCOMM)Hmgu HET Early adult 3.37×10-07
abnormal gait Ndufa10tm1e.1(EUCOMM)Hmgu HET   Early adult 8.82×10-06
abnormal bone structure Ndufa10tm1e.1(EUCOMM)Hmgu HET Early adult 2.22×10-09
increased total body fat amount Ndufa10tm1e.1(EUCOMM)Hmgu HET Early adult 6.09×10-08
preweaning lethality, complete penetrance Ndufa10tm1e.1(EUCOMM)Hmgu HOM   Early adult 1.80×10-09

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Whole Body Lateral Orientation

7 Images


XRay Images Whole Body Dorso Ventral

10 Images

Human diseases caused by Ndufa10 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ndufa10 by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Mitochondrial Complex I Deficiency, Nuclear Type 22

The table below shows human diseases predicted to be associated to Ndufa10 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Melorheostosis, Isolated
Increased bone mineral density, Hyperostosis OMIM:155950
Hypophosphatemic Rickets, Autosomal Recessive, 1
Rickets, Craniosynostosis, Hypophosphatemic rickets, Increased bone mineral density OMIM:241520
Mitochondrial Complex I Deficiency, Nuclear Type 22


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ndufa10

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ndufa10.

No publications found that use IMPC mice or data for Ndufa10.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ndufa10tm1e.1(EUCOMM)Hmgu Promoter excision from Targeted, non-conditional allele Mice
Ndufa10tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Ndufa10tm55415(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ndufa10tm1e(EUCOMM)Hmgu Targeted, non-conditional allele Mice, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter