Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal bone structure | Ndufa10tm1e.1(EUCOMM)Hmgu | HET | Early adult | 2.22×10-09 | ||
preweaning lethality, complete penetrance | Ndufa10tm1e.1(EUCOMM)Hmgu | HOM | Early adult | 1.80×10-09 | ||
increased total body fat amount | Ndufa10tm1e.1(EUCOMM)Hmgu | HET | Early adult | 6.09×10-08 | ||
decreased bone mineral density | Ndufa10tm1e.1(EUCOMM)Hmgu | HET | Early adult | 3.37×10-07 | ||
abnormal gait | Ndufa10tm1e.1(EUCOMM)Hmgu | HET | Early adult | 8.82×10-06 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Ndufa10 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Mitochondrial Complex I Deficiency, Nuclear Type 22 | OMIM:618243 |
The table below shows human diseases predicted to be associated to Ndufa10 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Melorheostosis, Isolated | Hyperostosis, Increased bone mineral density | OMIM:155950 | |
Hypophosphatemic Rickets, Autosomal Recessive, 1 | Hypophosphatemic rickets, Increased bone mineral density, Rickets, Craniosynostosis | OMIM:241520 | |
Mitochondrial Complex I Deficiency, Nuclear Type 22 | OMIM:618243 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Ndufa10tm1e.1(EUCOMM)Hmgu | Promoter excision from Targeted, non-conditional allele | Mice |
Ndufa10tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
Ndufa10tm55415(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Ndufa10tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | Mice, ES Cells |
Get highlights of the most important data releases, news and events, delivered straight to your email inbox
Subscribe to newsletter