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Gene: Ndufa10 MGI:1914523

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Gene Summary

Name:
NADH:ubiquinone oxidoreductase subunit A10
Synonyms:
2900053E13Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral density Ndufa10tm1e.1(EUCOMM)Hmgu HET Early adult 3.37×10-07
abnormal gait Ndufa10tm1e.1(EUCOMM)Hmgu HET   Early adult 8.82×10-06
preweaning lethality, complete penetrance Ndufa10tm1e.1(EUCOMM)Hmgu HOM   Early adult 1.80×10-09
abnormal bone structure Ndufa10tm1e.1(EUCOMM)Hmgu HET Early adult 2.22×10-09
increased total body fat amount Ndufa10tm1e.1(EUCOMM)Hmgu HET Early adult 6.09×10-08

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

7 Images

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Human diseases caused by Ndufa10 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ndufa10 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Leigh Syndrome With Leukodystrophy
Progressive cerebellar ataxia ORPHA:255241
Mitochondrial Complex I Deficiency, Nuclear Type 22
OMIM:618243

The table below shows human diseases predicted to be associated to Ndufa10 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Melorheostosis, Isolated
Increased bone mineral density, Hyperostosis OMIM:155950
Hypophosphatemic Rickets, Autosomal Recessive, 1
Hypophosphatemic rickets, Increased bone mineral density, Rickets, Craniosynostosis OMIM:241520
Dacryocystitis-Osteopoikilosis Syndrome
Increased bone mineral density, Osteopoikilosis ORPHA:1562
Leigh Syndrome With Leukodystrophy
Progressive cerebellar ataxia ORPHA:255241
Mitochondrial Complex I Deficiency, Nuclear Type 22
OMIM:618243

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ndufa10

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ndufa10.

No publications found that use IMPC mice or data for Ndufa10.

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MGI Allele Allele Type Produced
Ndufa10tm1e.1(EUCOMM)Hmgu Promoter excision from Targeted, non-conditional allele Mice
Ndufa10tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Ndufa10tm55415(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ndufa10tm1e(EUCOMM)Hmgu Targeted, non-conditional allele Mice, ES Cells

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