Gene Summary

Name:
divergent protein kinase domain 1A
Synonyms:
2900024C23Rik,  Fam69a

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating alkaline phosphatase level Dipk1atm1a(EUCOMM)Wtsi HOM Early adult 6.44×10-11
decreased total body fat amount Dipk1atm1a(EUCOMM)Wtsi HOM Early adult 2.27×10-05
increased heart weight Dipk1atm1a(EUCOMM)Wtsi HOM Early adult 2.84×10-08
increased circulating sodium level Dipk1atm1a(EUCOMM)Wtsi HOM Early adult 1.03×10-07
increased lean body mass Dipk1atm1a(EUCOMM)Wtsi HOM Early adult 2.29×10-06

Download data as:  TSV  XLS

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Dorso Ventral Orientation

14 Images

X-ray

XRay Images Forepaw

14 Images

X-ray

XRay Images Skull Lateral Orientation

14 Images

X-ray

XRay Images Whole Body Lateral Orientation

14 Images

X-ray

XRay Images Whole Body Dorso Ventral

14 Images

Eye Morphology

Images Ophthalmoscopy

4 Images

Human diseases caused by Dipk1a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Dipk1a by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Pentosuria
Abnormality of circulating enzyme level, Abnormal circulating carbohydrate concentration ORPHA:2843
Hyperchlorhidrosis, Isolated
Hyperkalemia, Hyponatremia, Failure to thrive OMIM:143860
Glucose-Galactose Malabsorption
Hypernatremia, Failure to thrive, Hypercalcemia, Weight loss ORPHA:35710
Hearing Loss-Familial Salivary Gland Insensitivity To Aldosterone Syndrome
Hyponatremia ORPHA:3225
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Hypernatremia, Failure to thrive OMIM:125800
Diabetes Insipidus, Nephrogenic, X-Linked
Hypernatremia, Failure to thrive OMIM:304800
Ethanolaminosis
Cardiomegaly OMIM:227150
Corticosterone Methyloxidase Type Ii Deficiency
Hyperkalemia, Failure to thrive, Hyponatremia, Increased circulating renin level OMIM:610600
Erythroderma, Congenital, With Palmoplantar Keratoderma, Hypotrichosis, And Hyper-Ige
Hypernatremia, Pulmonic stenosis, Ventricular septal defect OMIM:615508
Corticosterone Methyloxidase Type I Deficiency
Hyperkalemia, Failure to thrive, Hyponatremia, Increased circulating renin level OMIM:203400
Nephrogenic Syndrome Of Inappropriate Antidiuresis
Decreased circulating renin level, Hyponatremia, Decreased serum creatinine OMIM:300539
Chronic Bilirubin Encephalopathy
Hypernatremia, Neonatal hyperbilirubinemia, Hypoalbuminemia ORPHA:529808
Acute Bilirubin Encephalopathy
Hypernatremia, Neonatal hyperbilirubinemia, Hypoalbuminemia ORPHA:529799
Glucocorticoid Deficiency 4 With Or Without Mineralocorticoid Deficiency
Hyperkalemia, Hyponatremia, Failure to thrive OMIM:614736
Pyruvate Carboxylase Deficiency
Hypernatremia, Hypoglutaminemia, Increased serum pyruvate, Increased level of L-glutamic acid in ... ORPHA:3008
Pseudohypoaldosteronism, Type I, Autosomal Dominant
Hyperkalemia, Failure to thrive, Hyponatremia, Increased circulating renin level OMIM:177735
Late-Onset Familial Hypoaldosteronism
Hyperkalemia, Failure to thrive, Hyponatremia, Increased circulating renin level ORPHA:556037
Spinocerebellar Ataxia, Autosomal Recessive 23
Hyponatremia OMIM:616949
Neuroleptic Malignant Syndrome
Hypocalcemia, Hypernatremia, Hyponatremia, Elevated circulating creatine kinase concentration, Hy... ORPHA:94093
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Cardiomegaly, Hypoalbuminemia, Obesity ORPHA:88643
Nephrogenic Diabetes Insipidus
Hypernatremia, Failure to thrive ORPHA:223
Early-Onset Familial Hypoaldosteronism
Hyperkalemia, Failure to thrive, Hyponatremia, Increased circulating renin level ORPHA:556030
Bartter Syndrome, Type 5, Antenatal, Transient
Hypokalemia, Hyponatremia, Increased circulating renin level, Hypochloremia OMIM:300971
Webb-Dattani Syndrome
Hypernatremia OMIM:615926
Encephalopathy, Acute, Infection-Induced, Susceptibility To, 9
Hyponatremia, Failure to thrive OMIM:618426
Central Diabetes Insipidus
Failure to thrive, Hyponatremia, Weight loss ORPHA:178029
Pseudohypoaldosteronism, Type I, Autosomal Recessive
Hyperkalemia, Hyponatremia, Failure to thrive OMIM:264350
Hypoadrenocorticism, Familial
Hyperkalemia, Hyponatremia OMIM:240200
Hyperkalemic Periodic Paralysis
Flexion contracture, Hyponatremia, Hypokalemia, Elevated circulating creatine kinase concentratio... ORPHA:682
Generalized Pseudohypoaldosteronism Type 1
Hyponatremia, Weight loss, Increased circulating renin level, Failure to thrive in infancy, Hyper... ORPHA:171876
Hemophagocytic Lymphohistiocytosis, Familial, 1
Increased circulating ferritin concentration, Increased total bilirubin, Hypoproteinemia, Increas... OMIM:267700
Diarrhea 1, Secretory Chloride, Congenital
Hypokalemia, Hyponatremia, Failure to thrive, Hypochloremia OMIM:214700
Hereditary Coproporphyria
Atypical scarring of skin, Hyponatremia, Abnormal circulating porphyrin concentration ORPHA:79273
Hyperuricemia, Pulmonary Hypertension, Renal Failure, And Alkalosis Syndrome
Hypomagnesemia, Hyponatremia, Hyperuricemia, Failure to thrive OMIM:613845
Familial Hypoaldosteronism
Hyperkalemia, Failure to thrive, Hyponatremia, Increased circulating renin level ORPHA:427
Wolcott-Rallison Syndrome
Atrial septal defect, Hyperbilirubinemia, Hyponatremia, Decreased body weight, Hepatomegaly, Doub... ORPHA:1667
Porphyria Due To Ala Dehydratase Deficiency
Hyponatremia, Abnormal circulating porphyrin concentration, Ankle flexion contracture, Increased ... ORPHA:100924
Hemophagocytic Lymphohistiocytosis, Familial, 2
Increased circulating ferritin concentration, Increased total bilirubin, Hypoproteinemia, Hyponat... OMIM:603553
Colchicine Poisoning
Hypophosphatemia, Hypocalcemia, Hyponatremia, Abnormal blood ion concentration, Hypokalemia, Myoc... ORPHA:31824
Pituitary Deficiency Due To Empty Sella Turcica Syndrome
Hyponatremia ORPHA:91354
Legionnaires Disease
Endocarditis, Pericarditis, Cellulitis, Hyponatremia, Splenomegaly, Myocarditis ORPHA:549
Steroid-Responsive Encephalopathy Associated With Autoimmune Thyroiditis
Hyponatremia ORPHA:83601
Diarrhea 10, Protein-Losing Enteropathy Type
Hypocalcemia, Pericardial effusion, Hyponatremia, Hypertriglyceridemia, Hypoalbuminemia, Hypomagn... OMIM:618183
Congenital Isolated Acth Deficiency
Hyponatremia ORPHA:199296
Hartsfield Syndrome
Hypernatremia OMIM:615465
Bartter Syndrome, Type 4B, Neonatal, With Sensorineural Deafness
Hyponatremia, Hypokalemia, Failure to thrive, Hypochloremia, Hyperchloriduria OMIM:613090
Herpes Simplex Virus Encephalitis
Hyponatremia, Elevated circulating C-reactive protein concentration ORPHA:1930
Combined Oxidative Phosphorylation Deficiency 33
Hepatomegaly, Left ventricular hypertrophy, Cardiomegaly, Elevated circulating creatine kinase co... OMIM:617713
Necrotizing Enterocolitis
Hyponatremia, Small for gestational age, Abnormal heart morphology ORPHA:391673
Whipple Disease
Pericarditis, Hyponatremia, Hepatomegaly, Cachexia, Splenomegaly, Myocarditis ORPHA:3452
Carnitine Palmitoyltransferase Ii Deficiency, Infantile
Dilated cardiomyopathy, Hepatomegaly, Cardiomegaly, Elevated circulating creatine kinase concentr... OMIM:600649
Snakebite Envenomation
Hyponatremia ORPHA:449285
Adrenal Hypoplasia, Congenital
Hyponatremia, Failure to thrive OMIM:300200
Familial Glucocorticoid Deficiency
Hyponatremia, Weight loss, Failure to thrive, Hyperkalemia, Hypertrophic cardiomyopathy ORPHA:361
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Hyponatremia, Hypokalemia, Failure to thrive, Hypochloremia, Hyperchloriduria OMIM:602522
Congenital Adrenal Hyperplasia Due To 3-Beta-Hydroxysteroid Dehydrogenase Deficiency
Hyperkalemia, Failure to thrive, Hyponatremia, Increased circulating renin level ORPHA:90791
Porphyria Variegata
Scarring, Hyponatremia, Abnormal circulating porphyrin concentration ORPHA:79473
Acute Adrenal Insufficiency
Hyponatremia, Hyperuricemia, Increased circulating renin level, Weight loss, Hypercalcemia, Failu... ORPHA:95409
Danon Disease
Myocardial fibrosis, Dilated cardiomyopathy, Cardiomegaly, Elevated circulating creatine kinase c... OMIM:300257
Mitochondrial Complex Iv Deficiency, Nuclear Type 20
Failure to thrive in infancy, Hepatomegaly, Hyperalaninemia, Cardiomegaly, Hyperprolinemia OMIM:619064
Cholera
Hypocalcemia, Hypokalemia, Hyponatremia, Abnormal blood ion concentration ORPHA:173
Mirage Syndrome
Hyperkalemia, Hyponatremia, Decreased body weight OMIM:617053
Juvenile Nephropathic Cystinosis
Hypophosphatemia, Hypocalcemia, Hypouricemia, Elevated circulating creatinine concentration, Hypo... ORPHA:411634
Late-Onset Isolated Acth Deficiency
Hyponatremia, Hyperuricemia, Weight loss, Hypercalcemia, Failure to thrive ORPHA:199299
Carnitine Palmitoyltransferase I Deficiency
Hepatomegaly, Cardiomegaly, Elevated circulating creatine kinase concentration, Hyperammonemia, T... OMIM:255120
Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency
Hyperkalemia, Hyponatremia, Failure to thrive ORPHA:90790
Infant Botulism
Hyponatremia ORPHA:178478
Combined Oxidative Phosphorylation Deficiency 41
Elevated circulating creatine kinase concentration, Cardiomegaly OMIM:618838
Shigellosis
Hyponatremia, Failure to thrive in infancy, Abnormal blood ion concentration, Myocarditis ORPHA:810
Addison Disease
Hyponatremia, Hyperuricemia, Increased circulating renin level, Weight loss, Hypercalcemia, Failu... ORPHA:85138
Infantile Bartter Syndrome With Sensorineural Deafness
Hyponatremia, Increased circulating renin level, Hypokalemia, Small for gestational age, Failure ... ORPHA:89938
Ch├ędiak-Higashi Syndrome
Increased circulating ferritin concentration, Hypoproteinemia, Pericardial effusion, Hyponatremia... ORPHA:167
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
Hyponatremia, Failure to thrive ORPHA:293978
Lysosomal Acid Lipase Deficiency
Hypercholesterolemia, Hyponatremia, Weight loss, Hypertriglyceridemia, Cachexia, Failure to thriv... ORPHA:275761
Holoprosencephaly
Ventricular septal defect, Hyponatremia, Omphalocele, Failure to thrive in infancy, Abnormal pulm... ORPHA:2162
46,Xy Disorder Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Hyponatremia, Increased circulating renin level, Failure to thrive, Hyperkalemia, Abnormal circul... ORPHA:168558
Hepatocellular Carcinoma
Hyperbilirubinemia, Hyponatremia, Weight loss, Hepatomegaly, Hypokalemia, Hypercalcemia, Hypoalbu... ORPHA:88673
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Hyponatremia, Increased circulating renin level, Failure to thrive, Hyperkalemia, Abnormal circul... ORPHA:289548
Adenohypophysitis
Hyponatremia ORPHA:95512
Shiga Toxin-Associated Hemolytic Uremic Syndrome
Elevated circulating creatinine concentration, Hypokalemia, Hyponatremia, Unconjugated hyperbilir... ORPHA:90038
Pituitary Apoplexy
Hyponatremia ORPHA:95613
Sheehan Syndrome
Hyponatremia, Obesity ORPHA:91355
Japanese Encephalitis
Elbow flexion contracture, Hyponatremia ORPHA:79139
Panhypophysitis
Hyponatremia ORPHA:95513
Familial Dysautonomia
Hyponatremia ORPHA:1764
Acute Intermittent Porphyria
Hyponatremia ORPHA:79276
Oculocerebrorenal Syndrome Of Lowe
Hypophosphatemia, Hypoammonemia, Hypercholesterolemia, Abnormal dental enamel morphology, Atypica... ORPHA:534
Congenital Tricuspid Valve Dysplasia
Anomalous pulmonary venous return, Abnormal tricuspid valve leaflet morphology, Pericardial effus... ORPHA:555874
Cystinosis, Nephropathic
Decreased plasma carnitine, Hypophosphatemic rickets, Hyponatremia, Failure to thrive in infancy,... OMIM:219800
Infection-Related Hemolytic Uremic Syndrome
Hyperkalemia, Hypocalcemia, Hyponatremia, Myocarditis ORPHA:544482
Autosomal Recessive Polycystic Kidney Disease
Enlarged kidney, Hyponatremia, Splenomegaly, Hepatosplenomegaly, Increased serum bile acid concen... ORPHA:731
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Hyponatremia, Hyperlipidemia, Obesity ORPHA:293987
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Hyponatremia, Weight loss, Failure to thrive, Hypochloremia, Hyperkalemia ORPHA:90794
Heterotaxy, Visceral, 1, X-Linked
Atrial septal defect, Single ventricle, Ventricular septal defect, Mitral atresia, Omphalocele, D... OMIM:306955
Aorta Coarctation
Abnormal left ventricular outflow tract morphology, Aortic valve atresia, Perimembranous ventricu... ORPHA:1457

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dipk1a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dipk1a.

No publications found that use IMPC mice or data for Dipk1a.

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MGI Allele Allele Type Produced
Dipk1atm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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