Gene Summary

Name:
NADH:ubiquinone oxidoreductase subunit A6
Synonyms:
14kDa,  B230217P19Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to organogenesis Ndufa6em1(IMPC)Bay HOM   E9.5 0.00
preweaning lethality, complete penetrance Ndufa6em1(IMPC)Bay HOM   Early adult 0.00
increased heart left ventricle size Ndufa6em1(IMPC)Bay HET   Early adult 8.09×10-05
thick ventricular wall Ndufa6em1(IMPC)Bay HET Early adult 3.60×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

8 Images

X-ray

XRay Images Forepaw

8 Images

X-ray

XRay Images Whole Body Lateral Orientation

7 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

8 Images

X-ray

XRay Images Whole Body Dorso Ventral

8 Images

Human diseases caused by Ndufa6 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ndufa6 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Isolated Complex I Deficiency
Hypertrophic cardiomyopathy ORPHA:2609
Mitochondrial Complex I Deficiency, Nuclear Type 33
OMIM:618253

The table below shows human diseases predicted to be associated to Ndufa6 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Subaortic Stenosis, Membranous
Subvalvular aortic stenosis OMIM:271950
Isolated Complex I Deficiency
Hypertrophic cardiomyopathy ORPHA:2609
Mitochondrial Complex I Deficiency, Nuclear Type 33
OMIM:618253

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ndufa6

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ndufa6.

No publications found that use IMPC mice or data for Ndufa6.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Ndufa6tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ndufa6tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Ndufa6em1(IMPC)Bay Exon Deletion Mice

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter