The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|decreased circulating thyroxine level||Cand2tm1a(EUCOMM)Wtsi||HOM||Early adult||6.82×10-05|
|decreased circulating iron level||Cand2tm1a(EUCOMM)Wtsi||HOM||Early adult||9.28×10-05|
|increased red blood cell distribution width||Cand2tm1a(EUCOMM)Wtsi||HOM||Early adult||8.25×10-05|
|decreased total body fat amount||Cand2tm1a(EUCOMM)Wtsi||HOM||Early adult||1.66×10-05|
|increased lean body mass||Cand2tm1a(EUCOMM)Wtsi||HOM||Early adult||1.69×10-08|
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
Legacy Phenotype Associated Images
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Cand2 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cand2.
There are 3 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.||Nature communications (August 2019)||Cand2tm1a(EUCOMM)Wtsi||PMC6671969|
|Mouse screen reveals multiple new genes underlying mouse and human hearing loss.||PLoS biology (April 2019)||Cand2tm1a(EUCOMM)Wtsi||PMC6459510|
|Detecting epistasis within chromatin regulatory circuitry reveals CAND2 as a novel susceptibility gene for obesity.||International journal of obesity (2005) (May 2018)||Cand2tm1a(EUCOMM)Wtsi||29717274|
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|MGI Allele||Allele Type||Produced|
|Cand2tm1a(EUCOMM)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|
|Cand2tm1e(EUCOMM)Wtsi||Targeted, non-conditional allele||ES Cells|