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Gene: Paics MGI:1914304

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Gene Summary

Name:
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
Synonyms:
PAIS,  AIRC,  2610511I09Rik,  ADE2H1

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Paicsem1(IMPC)Mbp HOM   Early adult 0.00
embryonic growth retardation Paicsem1(IMPC)Mbp HET E9.5 0.00
prenatal lethality prior to heart atrial septation Paicsem1(IMPC)Mbp HOM   E15.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

27 Images

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X-ray

XRay Images Whole Body Lateral Orientation

9 Images

View images

Human diseases caused by Paics mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Paics by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Phosphoribosylaminoimidazole Carboxylase Deficiency
Neonatal death OMIM:619859

The table below shows human diseases predicted to be associated to Paics by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Finger Locking, Recurrent, With Intrauterine Growth Retardation And Proportionate Short Stature
Intrauterine growth retardation, Short stature OMIM:135950
Phosphoribosylaminoimidazole Carboxylase Deficiency
Neonatal death OMIM:619859

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Paics

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Paics.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer. Cancer research (December 2015) Paicsem1(IMPC)Mbp 26637667

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MGI Allele Allele Type Produced
Paicsem1(IMPC)Mbp Exon Deletion Mice, Tissue

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