Gene Summary

Name:
DnaJ heat shock protein family (Hsp40) member B4
Synonyms:
1700029A20Rik,  5730460G06Rik,  2010306G19Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

Human diseases caused by Dnajb4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Dnajb4 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Triglyceride Storage Disease, Type Ii
Obesity OMIM:190430
Bardet-Biedl Syndrome 14
Obesity OMIM:615991
Maturity-Onset Diabetes Of The Young, Type 11
Obesity, Overweight OMIM:613375
Obesity
Obesity, Increased waist to hip ratio OMIM:601665
Hypoinsulinemic Hypoglycemia With Hemihypertrophy
Truncal obesity, Large for gestational age OMIM:240900
Ethanolaminosis
Cardiomegaly OMIM:227150
Spermatogenic Failure, X-Linked, 1
Obesity OMIM:305700
Intellectual Developmental Disorder, Autosomal Dominant 39
Obesity OMIM:616521
Macrosomia With Microphthalmia, Lethal
Large for gestational age OMIM:248110
Abdominal Obesity-Metabolic Syndrome 1
Abdominal obesity OMIM:605552
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2
Abdominal obesity OMIM:605572
Acromegaloid Facial Appearance Syndrome
Large for gestational age OMIM:102150
Bardet-Biedl Syndrome 11
Obesity OMIM:615988
Thumb Stiffness-Brachydactyly-Intellectual Disability Syndrome
Obesity ORPHA:1078
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Obesity, Cardiomegaly ORPHA:88643
Prader-Willi Habitus, Osteopenia, And Camptodactyly
Obesity, Joint contracture of the hand, Camptodactyly OMIM:264010
Bardet-Biedl Syndrome 13
Obesity OMIM:615990
Bardet-Biedl Syndrome 12
Obesity OMIM:615989
Obesity Due To Melanocortin 4 Receptor Deficiency
Increased adipose tissue, Obesity, Childhood-onset truncal obesity ORPHA:71529
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy
Truncal obesity, Large for gestational age ORPHA:293964
Hyperinsulinemic Hypoglycemia, Familial, 2
Large for gestational age OMIM:601820
Intellectual Developmental Disorder, X-Linked 97
Obesity OMIM:300803
Macrosomia Adiposa Congenita
Obesity, Large for gestational age OMIM:248100
Hyperinsulinemic Hypoglycemia, Familial, 1
Large for gestational age OMIM:256450
Summitt Syndrome
Obesity OMIM:272350
Macrosomia-Microphthalmia-Cleft Palate Syndrome
Hepatomegaly, Large for gestational age ORPHA:2432
Bardet-Biedl Syndrome 18
Obesity OMIM:615995
Mitochondrial Complex Iv Deficiency, Nuclear Type 14
Obesity OMIM:619058
Adiposis Dolorosa
Obesity, Painful subcutaneous lipomas OMIM:103200
Body Mass Index Quantitative Trait Locus 20
Obesity, Tall stature OMIM:618406
Carcinoma Of Esophagus
Obesity, Weight loss ORPHA:70482
Polycystic Ovary Syndrome 1
Obesity, Enlarged polycystic ovaries OMIM:184700
Cortisone Reductase Deficiency 2
Obesity OMIM:614662
Ankylosing Vertebral Hyperostosis With Tylosis
Obesity ORPHA:2206
Bardet-Biedl Syndrome 2
Dilated cardiomyopathy, Bicuspid aortic valve, Atrial septal defect, Obesity OMIM:615981
Obesity Due To Prohormone Convertase I Deficiency
Failure to thrive, Obesity, Increased adipose tissue, Childhood-onset truncal obesity ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Failure to thrive, Obesity, Increased adipose tissue, Childhood-onset truncal obesity ORPHA:71526
Hepatic Veno-Occlusive Disease
Hepatomegaly, Increased body weight ORPHA:890
Central Precocious Puberty
Obesity, Overgrowth, Increased body weight ORPHA:759
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Omphalocele, Ventricular septal defect, Overgrowth, Small for gestational age, Abnormal heart mor... ORPHA:254534
Autism, Susceptibility To, 18
Overweight, Tall stature OMIM:615032
Microduplication Xp11.22P11.23 Syndrome
Obesity ORPHA:217377
Bardet-Biedl Syndrome 8
Situs inversus totalis, Obesity OMIM:615985
Bardet-Biedl Syndrome 19
Obesity OMIM:615996
Bardet-Biedl Syndrome 22
Obesity, Large for gestational age OMIM:617119
Prolactin Deficiency With Obesity And Enlarged Testes
Obesity OMIM:264120
Hyperostosis Frontalis Interna
Obesity OMIM:144800
Hypothyroidism, Congenital, Nongoitrous, 6
Omphalocele, Increased body mass index, Increased body weight OMIM:614450
Cortisone Reductase Deficiency 1
Obesity OMIM:604931
Abcd Syndrome
Large for gestational age OMIM:600501
Obesity, Hyperphagia, And Developmental Delay
Obesity OMIM:613886
Attrv30M Amyloidosis
Weight loss, Cardiomegaly, Cardiomyopathy ORPHA:85447
Cleft Lip/Palate With Characteristic Facies, Intestinal Malrotation, And Lethal Congenital Heart Disease
Large for gestational age, Visceromegaly OMIM:601165
Halothane Hepatitis
Obesity OMIM:234350
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Obesity ORPHA:329249
Joubert Syndrome 32
Hypertrophic cardiomyopathy, Large for gestational age, Tall stature OMIM:617757
Obesity-Hypoventilation Syndrome
Obesity OMIM:257500
Hypogonadism-Mitral Valve Prolapse-Intellectual Disability Syndrome
Obesity, Mitral valve prolapse ORPHA:2233
Overgrowth-Macrocephaly-Facial Dysmorphism Syndrome
Overgrowth, Tall stature, Large for gestational age, Pulmonic stenosis, Abnormal pulmonary valve ... ORPHA:137634
Hypothyroidism, Central, With Testicular Enlargement
Overweight OMIM:300888
Abdominal Obesity-Metabolic Syndrome 3
Truncal obesity, Coronary artery stenosis, Abdominal obesity OMIM:615812
Congenitally Uncorrected Transposition Of The Great Arteries
Hepatomegaly, Ventricular septal defect, Biventricular hypertrophy, Small for gestational age, Ab... ORPHA:860
Macrocephaly/Autism Syndrome
Hepatomegaly, Obesity, Splenomegaly OMIM:605309
Body Mass Index Quantitative Trait Locus 19
Obesity OMIM:617885
Cardiomyopathy, Familial Hypertrophic 27
Cardiomegaly OMIM:618052
Congenital Tricuspid Valve Dysplasia
Hepatomegaly, Pericardial effusion, Small for gestational age, Right ventricular hypertrophy, Car... ORPHA:555874
Noonan Syndrome 8
Hypertrophic cardiomyopathy, Ventricular septal defect, Failure to thrive, Large for gestational ... OMIM:615355
Mitochondrial Dna Depletion Syndrome 12B (Cardiomyopathic Type), Autosomal Recessive
Hypertrophic cardiomyopathy, Obesity, Achilles tendon contracture, Left ventricular hypertrophy OMIM:615418
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Increased body weight ORPHA:276608
Coenzyme Q10 Deficiency, Primary, 2
Obesity OMIM:614651
Acth-Independent Macronodular Adrenal Hyperplasia 2
Abdominal obesity, Increased body weight OMIM:615954
Wilson Disease
Hepatomegaly, Failure to thrive, Weight loss, Splenomegaly, Increased body weight ORPHA:905
Narcolepsy 7
Obesity OMIM:614250
Pigmented Nodular Adrenocortical Disease, Primary, 4
Dorsocervical fat pad, Increased body weight OMIM:615830
Smith-Magenis Syndrome
Abnormal heart morphology, Increased body weight OMIM:182290
Pseudohypoparathyroidism, Type Ib
Obesity OMIM:603233
Heterotaxy, Visceral, 1, X-Linked
Dextrocardia, Omphalocele, Ventricular septal defect, Failure to thrive, Mitral atresia, Double o... OMIM:306955
Blue Diaper Syndrome
Increased body weight ORPHA:94086
Hyperinsulinism Due To Hnf4A Deficiency
Hepatomegaly, Increased body weight, Large for gestational age ORPHA:263455
Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type
Increased body weight OMIM:300860
Proprotein Convertase 1/3 Deficiency
Obesity OMIM:600955
Joubert Syndrome 39
Hypoplastic left heart, Joint contracture of the 5th finger, Overweight OMIM:619562
Aorta Coarctation
Bicuspid aortic valve, Perimembranous ventricular septal defect, Cardiomegaly, Abnormal left vent... ORPHA:1457
Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young
Hepatomegaly, Large for gestational age OMIM:616026
Primary Pigmented Nodular Adrenocortical Disease
Cardiac myxoma, Dorsocervical fat pad, Abnormal subcutaneous fat tissue distribution, Abdominal o... ORPHA:189439
Pruritic Urticarial Papules And Plaques Of Pregnancy
Increased body weight ORPHA:64745
Joubert Syndrome 8
Hepatomegaly, Obesity OMIM:612291
Congenital Analbuminemia
Obesity, Lipodystrophy, Small for gestational age ORPHA:86816
Insulinoma
Increased body weight ORPHA:97279
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Hepatomegaly, Failure to thrive, Cardiomyopathy, Splenomegaly, Increased body weight ORPHA:264580
Cushing Syndrome Due To Macronodular Adrenal Hyperplasia
Dorsocervical fat pad, Abdominal obesity, Increased body weight ORPHA:189427
Magel2-Related Prader-Willi-Like Syndrome
Failure to thrive, Atrial septal defect, Abdominal obesity, Flexion contracture, Increased body w... ORPHA:398069
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Hepatomegaly, Increased body weight, Splenomegaly ORPHA:79240
Adrenocortical Carcinoma
Weight loss, Increased body weight ORPHA:1501
Insulin-Resistance Syndrome Type B
Abnormality of body weight, Enlarged ovaries, Weight loss, Increased body weight, Decreased body ... ORPHA:2298
Cushing Disease
Dorsocervical fat pad, Increased body weight, Truncal obesity, Abdominal obesity ORPHA:96253
Hellp Syndrome
Increased body weight ORPHA:244242
Cushing Syndrome Due To Ectopic Acth Secretion
Dorsocervical fat pad, Weight loss, Truncal obesity, Abdominal obesity, Increased body weight ORPHA:99889
Carney Complex
Cardiac myxoma, Tall stature, Dorsocervical fat pad, Abdominal obesity, Increased body weight ORPHA:1359

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dnajb4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dnajb4.

No publications found that use IMPC mice or data for Dnajb4.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Dnajb4tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Dnajb4tm264488(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Dnajb4tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Dnajb4em1(IMPC)J Exon Deletion Mice

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