Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal spleen morphology | Med28tm1.1(KOMP)Vlcg | HET | Early adult | 0.00 | ||
embryonic lethality prior to organogenesis | Med28tm1.1(KOMP)Vlcg | HOM | E9.5 | 0.00 | ||
abnormal auditory brainstem response | Med28tm1.1(KOMP)Vlcg | HET | Early adult | 2.90×10-06 | ||
increased respiratory quotient | Med28tm1.1(KOMP)Vlcg | HET | Early adult | 1.19×10-05 | ||
decreased circulating serum albumin level | Med28tm1.1(KOMP)Vlcg | HET | Early adult | 4.52×10-05 | ||
small spleen | Med28tm1.1(KOMP)Vlcg | HET | Early adult | 0.00 | ||
abnormal embryo size | Med28tm1.1(KOMP)Vlcg | HET | E9.5 | 0.00 | ||
embryonic lethality prior to tooth bud stage | Med28tm1.1(KOMP)Vlcg | HOM | E12.5 | 0.00 | ||
preweaning lethality, complete penetrance | Med28tm1.1(KOMP)Vlcg | HOM | Early adult | 0.00 | ||
increased body length | Med28tm1.1(KOMP)Vlcg | HET | Early adult | 3.38×10-30 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Wholemount images Section images | heterozygote | 75% (3 of 4) |
Brain | Wholemount images | heterozygote | 100% (4 of 4) |
Cecum | Section images | heterozygote | 75% (3 of 4) |
Cerebellum | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Chest bone | Wholemount images | heterozygote | 50% (2 of 4) |
Colon | Section images | heterozygote | 75% (3 of 4) |
Epididymis | Wholemount images Section images | heterozygote | 50% (2 of 4) |
Eye | Section images | heterozygote | 50% (2 of 4) |
Harderian gland | Section images | heterozygote | 50% (2 of 4) |
Ileum | Section images | heterozygote | 75% (3 of 4) |
Jejunum | Section images | heterozygote | 50% (2 of 4) |
Kidney | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Liver | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Midbrain | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Olfactory lobe | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Pancreas | Wholemount images Section images | heterozygote | 50% (2 of 4) |
Pituitary gland | Wholemount images Section images | heterozygote | 75% (3 of 4) |
Prostate gland | Section images | heterozygote | 25% (1 of 4) |
Quadriceps | Section images | heterozygote | 25% (1 of 4) |
Spinal cord | Wholemount images Section images | heterozygote | 75% (3 of 4) |
Stomach | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Sublingual gland | Section images | heterozygote | 25% (1 of 4) |
Testis | Wholemount images Section images | heterozygote | 50% (2 of 4) |
Thyroid gland | Wholemount images | heterozygote | 25% (1 of 4) |
Trachea | Wholemount images Section images | heterozygote | 75% (3 of 4) |
Urinary bladder | Wholemount images Section images | heterozygote | 75% (3 of 4) |
Vas deferens | Section images | heterozygote | 50% (2 of 4) |
Aorta | N/A | heterozygote | 0.0% (0 of 4) |
Blood | N/A | heterozygote | 0.0% (0 of 4) |
Bone marrow | N/A | heterozygote | 0.0% (0 of 4) |
Brainstem | N/A | heterozygote | Not available |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 4) |
Cartilage tissue | N/A | heterozygote | Not available |
Cerebral cortex | N/A | heterozygote | Not available |
Diaphragm | N/A | heterozygote | 0.0% (0 of 4) |
Duodenum | N/A | heterozygote | 25% (1 of 4) |
Esophagus | N/A | heterozygote | 0.0% (0 of 4) |
Gall bladder | N/A | heterozygote | Not available |
Gonadal fat pad | N/A | heterozygote | 0.0% (0 of 4) |
Heart | N/A | heterozygote | Not available |
Hindlimb | N/A | heterozygote | Not available |
Hippocampus | N/A | heterozygote | Not available |
Hypothalamus | N/A | heterozygote | Not available |
Large intestine | N/A | heterozygote | 75% (3 of 4) |
Lower urinary tract | N/A | heterozygote | Not available |
Lung | N/A | heterozygote | 0.0% (0 of 4) |
Lymph node | N/A | heterozygote | Not available |
Mammary gland | N/A | heterozygote | 0.0% (0 of 4) |
Mesenteric adipose tissue | N/A | heterozygote | 0.0% (0 of 4) |
Mesenteric lymph node | N/A | heterozygote | 0.0% (0 of 4) |
Ovary | N/A | heterozygote | 0.0% (0 of 4) |
Oviduct | N/A | heterozygote | 0.0% (0 of 4) |
Parathyroid gland | N/A | heterozygote | 0.0% (0 of 4) |
Parotid gland | N/A | heterozygote | 0.0% (0 of 4) |
Penis | N/A | heterozygote | 0.0% (0 of 4) |
Peripheral nervous system | N/A | heterozygote | Not available |
Peyer's patch | N/A | heterozygote | Not available |
Sciatic nerve | N/A | heterozygote | 0.0% (0 of 4) |
Skeletal muscle | N/A | heterozygote | Not available |
Skin | N/A | heterozygote | 0.0% (0 of 4) |
Small intestine | N/A | heterozygote | 75% (3 of 4) |
Spleen | N/A | heterozygote | 0.0% (0 of 4) |
Stomach pyloric region | N/A | heterozygote | Not available |
Striatum | N/A | heterozygote | Not available |
Submandibular gland | N/A | heterozygote | 0.0% (0 of 4) |
Thymus | N/A | heterozygote | 25% (1 of 4) |
Tongue | N/A | heterozygote | 50% (2 of 4) |
Trigeminal V nerve | N/A | heterozygote | 0.0% (0 of 4) |
Uterus | N/A | heterozygote | 25% (1 of 4) |
Vagina | N/A | heterozygote | 0.0% (0 of 4) |
Vascular system | N/A | heterozygote | Not available |
Vesicular gland | N/A | heterozygote | 0.0% (0 of 4) |
White adipose tissue | N/A | heterozygote | Not available |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Axial skeleton | N/A | heterozygote | 0.0% (0 of 2) |
Brain | N/A | heterozygote | 0.0% (0 of 7) |
Central nervous system ganglion | N/A | heterozygote | 0.0% (0 of 2) |
Ear | N/A | heterozygote | 0.0% (0 of 7) |
Embryo | N/A | heterozygote | 28.57% (2 of 7) |
Eye | N/A | heterozygote | 28.57% (2 of 7) |
Footplate | N/A | heterozygote | 0.0% (0 of 7) |
Forebrain | N/A | heterozygote | 0.0% (0 of 7) |
Forelimb | N/A | heterozygote | 28.57% (2 of 7) |
Gut | N/A | heterozygote | 0.0% (0 of 2) |
Handplate | N/A | heterozygote | 0.0% (0 of 7) |
Head | N/A | heterozygote | 0.0% (0 of 7) |
Heart | N/A | heterozygote | 28.57% (2 of 7) |
Hindbrain | N/A | heterozygote | 0.0% (0 of 7) |
Hindlimb | N/A | heterozygote | 28.57% (2 of 7) |
Liver | N/A | heterozygote | 0.0% (0 of 7) |
Lung | N/A | heterozygote | 0.0% (0 of 7) |
Mandibular process | N/A | heterozygote | 28.57% (2 of 7) |
Maxillary process | N/A | heterozygote | 28.57% (2 of 7) |
Midbrain | N/A | heterozygote | 0.0% (0 of 7) |
Nose | N/A | heterozygote | 0.0% (0 of 2) |
Oral cavity | N/A | heterozygote | Ambiguous |
Skeleton | N/A | heterozygote | 100% (2 of 2) |
Skin | N/A | heterozygote | 0.0% (0 of 7) |
Spinal cord | N/A | heterozygote | 0.0% (0 of 2) |
Tail somite | N/A | heterozygote | 0.0% (0 of 7) |
Tail | N/A | heterozygote | 0.0% (0 of 7) |
Trachea | N/A | heterozygote | 0.0% (0 of 2) |
Urinary system | N/A | heterozygote | 100% (2 of 2) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
blood | |
bone marrow | |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cecum | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
chest bone | |
colon | |
diaphragm | 0.0% |
duodenum | 0.0% |
epididymis | Unavailable |
esophagus | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
gonadal fat pad | 0.0% |
harderian gland | |
heart | 0.0% |
hindlimb | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
ileum | 0.0% |
jejunum | |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
mesenteric adipose tissue | 0.0% |
mesenteric lymph node | |
midbrain | 0.0% |
olfactory lobe | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
parotid gland | 0.0% |
penis | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
quadriceps | 0.0% |
sciatic nerve | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
stomach pyloric region | 0.0% |
striatum | 0.0% |
sublingual gland | 0.0% |
submandibular gland | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
tongue | 0.0% |
trachea | 0.0% |
trigeminal v nerve | 0.0% |
urinary bladder | |
uterus | 0.0% |
vagina | 0.0% |
vas deferens | Unavailable |
vascular system | 0.0% |
vesicular gland | Unavailable |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
axial skeleton | Ambiguous |
brain | 0.0% |
central nervous system ganglion | Ambiguous |
ear | 0.0% |
embryo | 0.0% |
eye | 0.0% |
footplate | 0.0% |
forebrain | 0.0% |
forelimb | 0.0% |
gut | Ambiguous |
handplate | 0.0% |
head | 0.0% |
heart | 0.0% |
hindbrain | 0.0% |
hindlimb | 0.0% |
liver | 0.0% |
lung | 0.0% |
mandibular process | 0.0% |
maxillary process | 0.0% |
midbrain | 0.0% |
nose | Ambiguous |
oral cavity | 0.0% |
skeleton | Ambiguous |
skin | 0.0% |
spinal cord | Ambiguous |
tail | 0.0% |
tail somite group | 0.0% |
trachea | Ambiguous |
urinary system | Ambiguous |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Med28 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Med28.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. | Nature communications (October 2017) | Med28tm1.1(KOMP)Vlcg | PMC5638796 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Med28tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
Med28tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | Mice, Tissue |
Med28tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Med28tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
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