banner
Genes Phenotypes Help, News, Blog

Gene: Sdhd MGI:1914175

Log in to follow
Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
succinate dehydrogenase complex, subunit D, integral membrane protein
Synonyms:
3110001M13Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Sdhd mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Sdhd by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Carcinoid Syndrome
Tricuspid regurgitation, Right ventricular failure, Heart murmur, Palpitations, Facial telangiect... ORPHA:100093
Sporadic Pheochromocytoma/Secreting Paraganglioma
Cerebral hemorrhage, Congestive heart failure, Cranial nerve compression, Palpitations, Positive ... ORPHA:276621
Hereditary Pheochromocytoma-Paraganglioma
Cerebral hemorrhage, Congestive heart failure, Cranial nerve compression, Palpitations, Positive ... ORPHA:29072
Isolated Succinate-Coq Reductase Deficiency
Abnormal left ventricular function, Noncompaction cardiomyopathy, Hypertrophic cardiomyopathy, Ab... ORPHA:3208
Mitochondrial Complex Ii Deficiency, Nuclear Type 3
Optic disc pallor, Tricuspid regurgitation, Dilated cardiomyopathy, Mitral regurgitation, Left ve... OMIM:619167
Pheochromocytoma/Paraganglioma Syndrome 1
Tachycardia, Palpitations, Hypertension associated with pheochromocytoma OMIM:168000
Cowden Syndrome
Mucosal telangiectasiae ORPHA:201
Carney-Stratakis Syndrome
Gastrointestinal hemorrhage ORPHA:97286
Paraganglioma And Gastric Stromal Sarcoma
OMIM:606864

The table below shows human diseases predicted to be associated to Sdhd by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Friedreich Ataxia
Abnormal EKG, Congestive heart failure, Optic atrophy, Decreased pyruvate carboxylase activity, H... OMIM:229300
Oxoglutaric Aciduria
Abnormality of Krebs cycle metabolism ORPHA:31
Hereditary Leiomyomatosis And Renal Cell Cancer
Decreased fumarate hydratase activity OMIM:150800
Friedreich Ataxia 2
Abnormal EKG, Congestive heart failure, Concentric hypertrophic cardiomyopathy, Decreased pyruvat... OMIM:601992
Mitochondrial Dna-Associated Leigh Syndrome
Cardiac conduction abnormality, Abnormality of Krebs cycle metabolism, Dilated cardiomyopathy, Op... ORPHA:255210
Fumarase Deficiency
Optic atrophy, Decreased fumarate hydratase activity, Polymicrogyria, Lissencephaly OMIM:606812
Methylmalonic Aciduria And Homocystinuria, Cbld Type
Decreased methylmalonyl-CoA mutase activity OMIM:277410
Methylmalonic Aciduria, Cblb Type
Decreased methylmalonyl-CoA mutase activity OMIM:251110
Methylmalonic Aciduria, Cbla Type
Decreased methylmalonyl-CoA mutase activity OMIM:251100
Methylmalonic Aciduria And Homocystinuria, Cblc Type
Decreased methylmalonyl-CoA mutase activity OMIM:277400
Carcinoid Syndrome
Tricuspid regurgitation, Right ventricular failure, Heart murmur, Palpitations, Facial telangiect... ORPHA:100093
Sporadic Pheochromocytoma/Secreting Paraganglioma
Cerebral hemorrhage, Congestive heart failure, Cranial nerve compression, Palpitations, Positive ... ORPHA:276621
Hereditary Pheochromocytoma-Paraganglioma
Cerebral hemorrhage, Congestive heart failure, Cranial nerve compression, Palpitations, Positive ... ORPHA:29072
Isolated Succinate-Coq Reductase Deficiency
Abnormal left ventricular function, Noncompaction cardiomyopathy, Hypertrophic cardiomyopathy, Ab... ORPHA:3208
Mitochondrial Complex Ii Deficiency, Nuclear Type 3
Optic disc pallor, Tricuspid regurgitation, Dilated cardiomyopathy, Mitral regurgitation, Left ve... OMIM:619167
Pheochromocytoma/Paraganglioma Syndrome 1
Tachycardia, Palpitations, Hypertension associated with pheochromocytoma OMIM:168000
Cowden Syndrome
Mucosal telangiectasiae ORPHA:201
Carney-Stratakis Syndrome
Gastrointestinal hemorrhage ORPHA:97286
Paraganglioma And Gastric Stromal Sarcoma
OMIM:606864

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Sdhd

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Sdhd.

No publications found that use IMPC mice or data for Sdhd.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Sdhdtm264891(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter