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Gene: Sdhd MGI:1914175

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
succinate dehydrogenase complex, subunit D, integral membrane protein
Synonyms:
3110001M13Rik

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Sdhd mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Sdhd by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Carcinoid Syndrome
Right ventricular failure, Tricuspid regurgitation, Palpitations, Facial telangiectasia, Heart mu... ORPHA:100093
Sporadic Pheochromocytoma/Secreting Paraganglioma
Sinus tachycardia, Congestive heart failure, Cranial nerve compression, Positive regitine blockin... ORPHA:276621
Hereditary Pheochromocytoma-Paraganglioma
Sinus tachycardia, Congestive heart failure, Cranial nerve compression, Positive regitine blockin... ORPHA:29072
Isolated Succinate-Coq Reductase Deficiency
Hypertrophic cardiomyopathy, Abnormal atrioventricular conduction, Abnormal left ventricular func... ORPHA:3208
Mitochondrial Complex Ii Deficiency, Nuclear Type 3
Dilated cardiomyopathy, Tricuspid regurgitation, Left ventricular systolic dysfunction, Mitral re... OMIM:619167
Pheochromocytoma/Paraganglioma Syndrome 1
Tachycardia, Palpitations, Hypertension associated with pheochromocytoma OMIM:168000
Cowden Syndrome
Mucosal telangiectasiae ORPHA:201
Carney-Stratakis Syndrome
Gastrointestinal hemorrhage ORPHA:97286
Paraganglioma And Gastric Stromal Sarcoma
OMIM:606864

The table below shows human diseases predicted to be associated to Sdhd by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Friedreich Ataxia
Decreased pyruvate carboxylase activity, Optic atrophy, Decreased amplitude of sensory action pot... OMIM:229300
Oxoglutaric Aciduria
Abnormality of Krebs cycle metabolism ORPHA:31
Hereditary Leiomyomatosis And Renal Cell Cancer
Decreased fumarate hydratase activity OMIM:150800
Mitochondrial Dna-Associated Leigh Syndrome
Optic atrophy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Abnormality of Krebs cycle me... ORPHA:255210
Methylmalonic Aciduria, Cblb Type
Dilated cardiomyopathy, Decreased methylmalonyl-CoA mutase activity OMIM:251110
Fumarase Deficiency
Decreased fumarate hydratase activity, Optic atrophy, Lissencephaly, Polymicrogyria OMIM:606812
Friedreich Ataxia 2
Decreased pyruvate carboxylase activity, Congestive heart failure, Abnormal EKG, Concentric hyper... OMIM:601992
Methylmalonic Aciduria And Homocystinuria, Cblc Type
Hypotension, Decreased methylmalonyl-CoA mutase activity, Pulmonary arterial hypertension, Bradyc... OMIM:277400
Methylmalonic Aciduria And Homocystinuria, Cbld Type
Decreased methylmalonyl-CoA mutase activity OMIM:277410
Methylmalonic Aciduria, Cbla Type
Decreased methylmalonyl-CoA mutase activity OMIM:251100
Carcinoid Syndrome
Right ventricular failure, Tricuspid regurgitation, Palpitations, Facial telangiectasia, Heart mu... ORPHA:100093
Sporadic Pheochromocytoma/Secreting Paraganglioma
Sinus tachycardia, Congestive heart failure, Cranial nerve compression, Positive regitine blockin... ORPHA:276621
Hereditary Pheochromocytoma-Paraganglioma
Sinus tachycardia, Congestive heart failure, Cranial nerve compression, Positive regitine blockin... ORPHA:29072
Isolated Succinate-Coq Reductase Deficiency
Hypertrophic cardiomyopathy, Abnormal atrioventricular conduction, Abnormal left ventricular func... ORPHA:3208
Mitochondrial Complex Ii Deficiency, Nuclear Type 3
Dilated cardiomyopathy, Tricuspid regurgitation, Left ventricular systolic dysfunction, Mitral re... OMIM:619167
Pheochromocytoma/Paraganglioma Syndrome 1
Tachycardia, Palpitations, Hypertension associated with pheochromocytoma OMIM:168000
Cowden Syndrome
Mucosal telangiectasiae ORPHA:201
Carney-Stratakis Syndrome
Gastrointestinal hemorrhage ORPHA:97286
Paraganglioma And Gastric Stromal Sarcoma
OMIM:606864

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Sdhd

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Sdhd.

No publications found that use IMPC mice or data for Sdhd.

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MGI Allele Allele Type Produced
Sdhdtm264891(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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