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Gene: Plin3 MGI:1914155

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
perilipin 3
Synonyms:
Tip47,  1300012C15Rik,  M6prbp1

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Plin3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Plin3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Obesity
Decreased resting energy expenditure OMIM:601665
Idiopathic Congenital Hypothyroidism
Neonatal hyperbilirubinemia, Hypothermia, Umbilical hernia ORPHA:95717
Riboflavin Deficiency
Elevated circulating acylcarnitine concentration, Hypothermia OMIM:615026
Coenzyme Q10 Deficiency, Primary, 5
Hyperalaninemia, Hypothermia OMIM:614654
Familial Thyroid Dyshormonogenesis
Abnormal circulating thyroglobulin concentration, Neonatal hyperbilirubinemia, Hypothermia, Umbil... ORPHA:95716
Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal
Hypothermia, Inguinal hernia, Joint contracture OMIM:614498
N-Acetylglutamate Synthase Deficiency
Hyperammonemia, Hypothermia, Hyperglutamatemia, Hyperglutaminemia, Low plasma citrulline, Hyperal... OMIM:237310
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
Hypertaurinemia, Hyperglycinemia, Hypothermia OMIM:245400
Primary Erythromelalgia
Hypothermia ORPHA:90026
Developmental And Epileptic Encephalopathy 78
Hypothermia OMIM:618557
Carnitine-Acylcarnitine Translocase Deficiency
Elevated circulating acylcarnitine concentration, Decreased circulating carnitine concentration, ... ORPHA:159
Spontaneous Periodic Hypothermia
Hypothermia ORPHA:29822
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Hypothermia OMIM:610006
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Hypothermia, Umbilical hernia ORPHA:226313
Mitochondrial Complex Iv Deficiency, Nuclear Type 13
Hypothermia OMIM:616501
Isolated Thyroid-Stimulating Hormone Deficiency
Neonatal hyperbilirubinemia, Umbilical hernia, Hypothermia, Abnormal circulating thyroglobulin co... ORPHA:90674
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Increased circulating free fatty acid level, Hyperammonemia, Hypocalcemia, Elevated circulating c... ORPHA:26793
Hypothyroidism Due To Tsh Receptor Mutations
Neonatal hyperbilirubinemia, Hypothermia, Increased circulating thyroglobulin concentration, Umbi... ORPHA:90673
Menkes Disease
Decreased circulating ceruloplasmin concentration, Hypothermia OMIM:309400
Genetic Transient Congenital Hypothyroidism
Hypothermia, Increased circulating thyroglobulin concentration, Umbilical hernia ORPHA:226316
Timothy Syndrome
Hypothermia, Hypocalcemia OMIM:601005
Sudden Infant Death-Dysgenesis Of The Testes Syndrome
Hypothermia ORPHA:168593
Meningococcal Meningitis
Elevated circulating C-reactive protein concentration, Hypothermia ORPHA:33475
Hypotonia, Hypoventilation, Impaired Intellectual Development, Dysautonomia, Epilepsy, And Eye Abnormalities
Elbow flexion contracture, Hypothermia, Hip contracture OMIM:618493
Congenital Enterovirus Infection
Hypoalbuminemia, Hypothermia, Hyperammonemia ORPHA:292
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome
Hypotriglyceridemia, Corneal scarring, Decreased resting energy expenditure, Decreased LDL choles... ORPHA:404454
Combined Oxidative Phosphorylation Deficiency 37
Hypoalbuminemia, Hyperalaninemia, Hypothermia OMIM:618329
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hypoalbuminemia, Hyperbilirubinemia, Hypothermia, Elevated circulating alpha-fetoprotein concentr... OMIM:251880
Sepsis In Premature Infants
Elevated circulating C-reactive protein concentration, Hypothermia, Cyanosis ORPHA:90051
Neuroleptic Malignant Syndrome
Hyperphosphatemia, Hypomagnesemia, Hypocalcemia, Hyperuricemia, Elevated circulating creatine kin... ORPHA:94093
Mitochondrial Dna-Associated Leigh Syndrome
Abnormality of Krebs cycle metabolism, Low plasma citrulline, Hyperalaninemia, Hypothermia ORPHA:255210
Sudden Infant Death With Dysgenesis Of The Testes Syndrome
Hypothermia OMIM:608800
Dopamine Beta-Hydroxylase Deficiency
Elevated circulating creatinine concentration, Hypothermia, Increased blood urea nitrogen ORPHA:230
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Hypothermia, Elevated circulating creatine kinase concentration OMIM:618775
3-Hydroxy-3-Methylglutaric Aciduria
Hypothermia, Hyperammonemia, Hyperuricemia ORPHA:20
Ethylene Glycol Poisoning
Cyanosis, Hypothermia, Hyperkalemia, Hypocalcemia ORPHA:31826
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Elevated circulating palmitoleylcarnitine concentration, Hyperammonemia, Hypomethioninemia, Hypot... ORPHA:79282
Tbck-Related Intellectual Disability Syndrome
Hypothermia, Abnormal circulating lipid concentration ORPHA:488632
Menkes Disease
Atypical scarring of skin, Chondrocalcinosis, Umbilical hernia, Inguinal hernia, Hypothermia, Hernia ORPHA:565
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Flexion contracture, Hypothermia, Methylmalonic acidemia ORPHA:17
Hypothyroidism, Congenital, Nongoitrous, 2
Hyperbilirubinemia, Hypothermia, Increased circulating thyroglobulin concentration, Umbilical hernia OMIM:218700
Adult-Onset Autosomal Dominant Leukodystrophy
Flexion contracture, Hypothermia ORPHA:99027
Occipital Horn Syndrome
Atypical scarring of skin, Keloids, Inguinal hernia, Hypothermia, Hiatus hernia, Scarring, Femora... ORPHA:198
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Hyponatremia, Hypothermia, Hyperlipidemia, Cyanosis ORPHA:293987
Alexander Disease
Hypothermia ORPHA:58
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Hypothermia, Umbilical hernia ORPHA:226307
Marburg Hemorrhagic Fever
Hypoalbuminemia, Elevated circulating creatinine concentration, Hyperamylasemia, Hyperammonemia, ... ORPHA:99826
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Decreased circulating iron concentration, Hypothermia, Uterine prolapse ORPHA:438213
Sarcoidosis
Scarring, Hypercalcemia, Hypothermia ORPHA:797
Hereditary Sensory And Autonomic Neuropathy Type 4
Hypothermia, Atypical scarring of skin, Corneal scarring, Fasciitis ORPHA:642

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Plin3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Plin3.

No publications found that use IMPC mice or data for Plin3.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Plin3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Plin3tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Plin3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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