The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|enlarged urinary bladder||Tanc1em1(IMPC)Tcp||HOM||Early adult||0.00|
|increased circulating aspartate transaminase level||Tanc1em1(IMPC)Tcp||HOM||Early adult||6.35×10-05|
|abnormal skin morphology||Tanc1em1(IMPC)Tcp||HOM||Early adult||0.00|
|increased circulating alanine transaminase level||Tanc1em1(IMPC)Tcp||HOM||Early adult||7.60×10-05|
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Tanc1 by phenotypic similarity.
||Abnormality of circulating enzyme level, Abnormal urine carbohydrate level, Abnormal circulating ...||ORPHA:2843|
|Monoamine Oxidase A Deficiency||
|Cramps, Familial Adolescent||
||Elevated circulating creatine kinase concentration||OMIM:218050|
|Isolated Asymptomatic Elevation Of Creatine Phosphokinase||
||Elevated circulating creatine kinase concentration||ORPHA:206599|
|Muscle Cramps, Familial||
||Elevated circulating creatine kinase concentration||OMIM:158400|
|Amyotrophic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia||
||Frontotemporal dementia, Amyotrophic lateral sclerosis||OMIM:616208|
|Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 8||
||Frontotemporal dementia, Dementia, Amyotrophic lateral sclerosis, Memory impairment||OMIM:619132|
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|MGI Allele||Allele Type||Produced|