Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal skin morphology | Tanc1em1(IMPC)Tcp | HOM | Early adult | 0.00 | ||
increased circulating alanine transaminase level | Tanc1em1(IMPC)Tcp | HOM | Early adult | 8.27×10-05 | ||
enlarged urinary bladder | Tanc1em1(IMPC)Tcp | HOM | Early adult | 0.00 | ||
increased circulating aspartate transaminase level | Tanc1em1(IMPC)Tcp | HOM | Early adult | 6.35×10-05 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Tanc1 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Pentosuria | Abnormal urine carbohydrate level, Abnormal circulating carbohydrate concentration, Abnormality o... | ORPHA:2843 | |
Cramps, Familial Adolescent | Elevated circulating creatine kinase concentration | OMIM:218050 | |
Muscle Cramps, Familial | Elevated circulating creatine kinase concentration | OMIM:158400 | |
Isolated Asymptomatic Elevation Of Creatine Phosphokinase | Elevated creatine kinase after exercise, Elevated circulating creatine kinase concentration | ORPHA:206599 |
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