banner
Genes Phenotypes Help, News, Blog

Gene: Trp53rkb MGI:1914050

Log in to follow

Gene Summary

Name:
transformation related protein 53 regulating kinase B
Synonyms:
4933401B08Rik,  Trp53rk,  Nori-2,  5630401H01Rik,  mNori-2p,  PRPK

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

14 Images

View images
X-ray

XRay Images Skull Dorso Ventral Orientation

14 Images

View images
X-ray

XRay Images Whole Body Dorso Ventral

14 Images

View images
X-ray

XRay Images Forepaw

14 Images

View images
X-ray

XRay Images Skull Lateral Orientation

14 Images

View images
DSS Histology

Images

8 Images

View images
Eye Morphology

Images Slit Lamp

1 Images

View images
Anti-nuclear antibody assay

Images

6 Images

View images
Eye Morphology

Images Ophthalmoscopy

2 Images

View images
Ear epidermis immunophenotyping

Images

12 Images

View images
Legacy Phenotype Associated Images
Trp53rkbtm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Trp53rkbtm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Trp53rkbtm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Trp53rkbtm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Trp53rkbtm1a(EUCOMM)Wtsi
HOM, Male, WTSI

View all 70 images

Trp53rkbtm1a(EUCOMM)Wtsi
abnormal retinal pigmentation, HOM, Male, WTSI
Trp53rkbtm1a(EUCOMM)Wtsi
Fused cornea and lens, HOM, Female, WTSI
Trp53rkbtm1a(EUCOMM)Wtsi
abnormal retinal pigmentation, HOM, Female, WTSI
Trp53rkbtm1a(EUCOMM)Wtsi
HOM, Female, WTSI

Human diseases caused by Trp53rkb mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Trp53rkb by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Galloway-Mowat Syndrome 4
OMIM:617730
Galloway-Mowat Syndrome
ORPHA:2065

The table below shows human diseases predicted to be associated to Trp53rkb by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Galloway-Mowat Syndrome 4
OMIM:617730
Galloway-Mowat Syndrome
ORPHA:2065

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Trp53rkb

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Trp53rkb.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Trp53rkbtm1a(EUCOMM)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Trp53rkbtm1a(EUCOMM)Wtsi PMC7338221
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Trp53rkbtm1a(EUCOMM)Wtsi PMC5827107

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Trp53rkbtm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Trp53rkbtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter