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Gene: Dync2li1 MGI:1913996

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
dynein cytoplasmic 2 light intermediate chain 1
Synonyms:
LIC3,  4933404O11Rik,  CGI-60,  D2lic,  mD2LIC

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dync2li1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dync2li1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Ellis Van Creveld Syndrome
Atrioventricular canal defect, Abnormal heart valve morphology, Situs inversus totalis, Ventricul... ORPHA:289
Short-Rib Thoracic Dysplasia 15 With Polydactyly
Atrioventricular canal defect, Polyhydramnios, Patent ductus arteriosus OMIM:617088
Jeune Syndrome
ORPHA:474

The table below shows human diseases predicted to be associated to Dync2li1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Frontal Encephalocele
Hydrocephalus, Encephalocele, Spina bifida ORPHA:1931
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida, Mitral valve prolapse OMIM:211960
Acalvaria
Hydrocephalus, Holoprosencephaly, Spina bifida ORPHA:945
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Hypoplastic left heart, Anencephaly, Spina bifida, Ventricular septal defect ORPHA:2476
Thoraco-Abdominal Enteric Duplication
Meningocele, Abnormal tricuspid valve morphology, Dextrocardia ORPHA:1759
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Hemihyperplasia, Isolated
Myelomeningocele OMIM:235000
Isolated Hemihyperplasia
Myelomeningocele ORPHA:2128
Neural Tube Defects, Susceptibility To
Myelomeningocele, Spina bifida occulta, Anencephaly, Hydrocephalus OMIM:182940
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Aminopterin/Methotrexate Embryofetopathy
Spinal dysraphism, Tetralogy of Fallot, Situs inversus totalis, Encephalocele, Ventricular septal... ORPHA:1908
Congenital Vertical Talus
Myelomeningocele ORPHA:178382
Subependymal Nodular Heterotopia
Myelomeningocele, Meningocele, Occipital encephalocele, Nasofrontal encephalocele ORPHA:101030
Meckel Syndrome, Type 4
Encephalocele, Ventricular septal defect, Atrial septal defect, Hydrocephalus, Meningocele, Anenc... OMIM:611134
Muscle-Eye-Brain Disease
Meningocele, Holoprosencephaly, Hydrocephalus ORPHA:588
Isolated Klippel-Feil Syndrome
Spina bifida, Ventricular septal defect ORPHA:2345
Chiari Malformation Type Ii
Myelomeningocele, Hydrocephalus, Cervical myelopathy, Spina bifida OMIM:207950
Schisis Association
Anencephaly, Encephalocele, Spina bifida ORPHA:63862
Wildervanck Syndrome
Meningocele ORPHA:3456
Humero-Radial Synostosis
Meningocele ORPHA:3265
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Caudal Duplication
Myelomeningocele, Spina bifida ORPHA:1756
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Atrioventricular canal defect, Abnormal aortic valve morphology, Bicuspid aortic valve, Atrial se... ORPHA:1120
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Diaphanospondylodysostosis
Myelomeningocele ORPHA:66637
Craniorachischisis
Spinal dysraphism, Myelomeningocele, Sirenomelia, Cervical spina bifida, Anencephaly ORPHA:63260
Triploidy
Hydrocephalus, Abnormal cardiac septum morphology, Polyhydramnios, Meningocele, Holoprosencephaly ORPHA:3376
Intellectual Developmental Disorder, Autosomal Dominant 72
Spina bifida OMIM:620439
Sirenomelia
Sirenomelia, Spina bifida ORPHA:3169
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Isolated Posterior Meningocele
Hydromyelia, Hydrocephalus, Lipomyelomeningocele, Meningocele, Occipital meningocele, Neural tube... ORPHA:268810
Czeizel-Losonci Syndrome
Myelomeningocele, Hydrocephalus, Spina bifida, Dextrocardia, Spina bifida occulta ORPHA:2437
Meckel Syndrome, Type 2
Meningocele, Anencephaly, Encephalocele OMIM:603194
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Alg3-Cdg
Cardiomyopathy, Neural tube defect ORPHA:79321
Fliedner-Zweier Syndrome
Bicuspid aortic valve, Meningocele, Ventricular septal defect OMIM:620511
Camptodactyly Syndrome, Guadalajara Type 1
Spina bifida ORPHA:1327
Joubert Syndrome 14
Hydrocephalus, Meningocele, Encephalocele, Ventricular septal defect OMIM:614424
Fountain Syndrome
Facial edema, Spina bifida occulta, Spina bifida ORPHA:3219
Enlarged Parietal Foramina
Myelomeningocele, Occipital encephalocele ORPHA:60015
Cleft Lip/Palate-Deafness-Sacral Lipoma Syndrome
Meningocele ORPHA:2003
Neurocutaneous Melanocytosis
Meningocele ORPHA:2481
Autosomal Recessive Spondylocostal Dysostosis
Spina bifida occulta, Meningocele, Anomalous pulmonary venous return, Umbilical hernia ORPHA:2311
Waardenburg Syndrome Type 1
Meningocele, Spina bifida ORPHA:894
Sacral Defect With Anterior Meningocele
Hydromyelia, Myelomeningocele, Myeloschisis, Hydrocephalus, Meningocele, Dermal sinus tract OMIM:600145
Neu-Laxova Syndrome 2
Polyhydramnios, Spina bifida, Edema OMIM:616038
Amish Lethal Microcephaly
Spina bifida ORPHA:99742
Iniencephaly
Spinal dysraphism, Myelomeningocele, Encephalocele, Spina bifida, Hydrocephalus, Polyhydramnios, ... ORPHA:63259
Spondylocostal Dysostosis 4, Autosomal Recessive
Myelomeningocele, Situs inversus totalis, Hydrocephalus, Dextrocardia, Spina bifida occulta OMIM:613686
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Meningocele ORPHA:2031
Cerebrocostomandibular Syndrome
Hydranencephaly, Myelomeningocele, Ventricular septal defect, Spina bifida, Meningocele ORPHA:1393
Mosaic Trisomy 9
Abnormal heart valve morphology, Endocardial fibroelastosis, Oligohydramnios, Ventricular septal ... ORPHA:99776
Lateral Meningocele Syndrome
Umbilical hernia, Ventricular septal defect, Bicuspid aortic valve, Hydrocephalus, Meningocele, P... OMIM:130720
Pelvis-Shoulder Dysplasia
Hydrocephalus, Hydranencephaly, Spina bifida ORPHA:2839
Lateral Meningocele Syndrome
Meningocele, Ventricular septal defect, Umbilical hernia ORPHA:2789
Acromelic Frontonasal Dysplasia
Meningocele, Encephalocele ORPHA:1827
Phakomatosis Pigmentokeratotica
Spina bifida, Lymphedema ORPHA:2874
Limb Body Wall Complex
Myelomeningocele, Abnormal heart morphology, Encephalocele, Short umbilical cord, Ventricular sep... ORPHA:2369
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Occipital meningocele, Hydrocephalus, Atrial septal defect, Polyhydramnios, Hydrops fetalis, Anen... OMIM:616546
Chromosome 17P13.1 Deletion Syndrome
Hydrocephalus, Oligohydramnios, Spina bifida, Umbilical hernia OMIM:613776
Heterotaxy, Visceral, 1, X-Linked
Ventricular septal defect, Atrial septal defect, Dextrocardia, Single ventricle, Aqueductal steno... OMIM:306955
Vacterl With Hydrocephalus
Hydrocephalus, Aqueductal stenosis, Polyhydramnios, Spina bifida ORPHA:3412
Pagod Syndrome
Hypoplastic left heart, Situs inversus totalis, Encephalocele, Spina bifida, Meningocele ORPHA:991
Trisomy 18
Oligohydramnios, Ventricular septal defect, Atrial septal defect, Spina bifida, Holoprosencephaly... ORPHA:3380
Lumbar Syndrome
Myelomeningocele, Spina bifida ORPHA:83628
Fibular Hemimelia
Abnormal heart morphology, Spina bifida ORPHA:93323
Basal Cell Nevus Syndrome 1
Hydrocephalus, Cardiac rhabdomyoma, Spina bifida, Cardiac fibroma OMIM:109400
Trisomy 20P
Spina bifida, Umbilical hernia ORPHA:261318
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida OMIM:193500
Focal Dermal Hypoplasia
Umbilical hernia, Ventricular septal defect, Spina bifida, Abnormal cardiac septum morphology, Pa... ORPHA:2092
Curry-Jones Syndrome
Occipital meningocele, Lipomyelomeningocele OMIM:601707
Cloacal Exstrophy
Myelomeningocele, Spina bifida ORPHA:93929
Neu-Laxova Syndrome
Polyhydramnios, Spina bifida ORPHA:2671
Neu-Laxova Syndrome 1
Generalized edema, Hydranencephaly, Small placenta, Short umbilical cord, Patent foramen ovale, V... OMIM:256520
Nail-Patella Syndrome
Spina bifida OMIM:161200
Lathosterolosis
Meningocele ORPHA:46059
Phocomelia, Schinzel Type
Meningocele, Hydrops fetalis ORPHA:2879
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Meningocele, Occipital encephalocele ORPHA:397715
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Tetralogy of Fallot, Atrioventricular canal defect, Truncus arteriosus, Ventricular septal defect... ORPHA:508498
Orofaciodigital Syndrome Vi
Hypoplastic left heart, Occipital meningocele OMIM:277170
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Meningocele ORPHA:1010
Thrombocytopenia-Absent Radius Syndrome
Tetralogy of Fallot, Atrioventricular canal defect, Ventricular septal defect, Edema of the dorsu... OMIM:274000
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Atrioventricular canal defect, Patent ductus arteriosus, Spina bifida OMIM:619480
Holoprosencephaly 7
Alobar holoprosencephaly, Semilobar holoprosencephaly, Hydrocephalus, Holoprosencephaly, Occipita... OMIM:610828
Neurofibromatosis, Type I
Hydrocephalus, Aqueductal stenosis, Spina bifida OMIM:162200
Fanconi Anemia
Umbilical hernia, Hypertrophic cardiomyopathy, Tetralogy of Fallot, Azoospermia, Oligohydramnios,... ORPHA:84
Vater/Vacterl Association
Occipital encephalocele, Tetralogy of Fallot, Ventricular septal defect, Transposition of the gre... OMIM:192350
Hallermann-Streiff Syndrome
Spina bifida OMIM:234100
22Q11.2 Deletion Syndrome
Umbilical hernia, Tetralogy of Fallot, Abnormal pulmonary valve morphology, Abnormal aortic valve... ORPHA:567
Jacobsen Syndrome
Aortic valve stenosis, Hypoplastic left heart, Spina bifida, Ventricular septal defect ORPHA:2308
Koolen-De Vries Syndrome Due To A Point Mutation
Cardiomyopathy, Abnormal heart morphology, Ventricular septal defect, Bicuspid aortic valve, Atri... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Cardiomyopathy, Abnormal heart morphology, Ventricular septal defect, Bicuspid aortic valve, Atri... ORPHA:363958
Campomelic Dysplasia
Spinal dysraphism, Abnormal heart morphology, Hydrocephalus, Spina bifida, Polyhydramnios OMIM:114290
Cutis Laxa, Autosomal Recessive, Type Ib
Oligohydramnios, Right ventricular dilatation, Spina bifida, Neonatal death OMIM:614437
Knobloch Syndrome 1
Spina bifida occulta, Occipital encephalocele, Patent ductus arteriosus, Occipital meningocele OMIM:267750
Aicardi Syndrome
Spina bifida OMIM:304050
Femoral-Facial Syndrome
Encephalocele, Truncus arteriosus, Ventricular septal defect, Spina bifida, Patent ductus arterio... OMIM:134780
Rubinstein-Taybi Syndrome 1
Hypoplastic left heart, Mitral valve prolapse, Ventricular septal defect, Patent foramen ovale, P... OMIM:180849
Semilobar Holoprosencephaly
Abnormal heart morphology, Hydrocephalus, Neural tube defect ORPHA:220386
Alobar Holoprosencephaly
Abnormal heart morphology, Hydrocephalus, Neural tube defect ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Abnormal heart morphology, Hydrocephalus, Neural tube defect ORPHA:93926
Lobar Holoprosencephaly
Abnormal heart morphology, Hydrocephalus, Neural tube defect ORPHA:93924
Exstrophy-Epispadias Complex
Abnormal heart morphology, Hydrocephalus, Spina bifida ORPHA:322
Marfan Syndrome
Tricuspid valve prolapse, Meningocele, Mitral valve calcification, Mitral valve prolapse ORPHA:558
Arima Syndrome
Occipital meningocele OMIM:243910
Holoprosencephaly 9
Holoprosencephaly, Alobar holoprosencephaly, Occipital meningocele, Hydrocephalus OMIM:610829
Otopalatodigital Syndrome, Type Ii
Umbilical hernia, Hydrocephalus, Atrial septal defect, Stillbirth, Spina bifida OMIM:304120
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Occipital meningocele OMIM:276820
Ellis Van Creveld Syndrome
Atrioventricular canal defect, Abnormal heart valve morphology, Situs inversus totalis, Ventricul... ORPHA:289
Short-Rib Thoracic Dysplasia 15 With Polydactyly
Atrioventricular canal defect, Polyhydramnios, Patent ductus arteriosus OMIM:617088
Jeune Syndrome
ORPHA:474

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dync2li1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dync2li1.

No publications found that use IMPC mice or data for Dync2li1.

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