Gene: Lrrk2

Name
leucine-rich repeat kinase 2
MGI ID
MGI:1913975
Synonyms
9330188B09Rik D630001M17Rik cI-46 4921513O20Rik LOC381026
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N/A
Other links
Significant phenotypes (0) All measurements (209) Expression & images (0) Disease models (0) Order (3)
View data by physiological system
Significant
Not Significant
Not tested

Filtered by: all phenotypes

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Allele Center Procedure / Parameter Zygosity Mutants Statistical
Method
P Value Status
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Alanine aminotransferase HOM 6f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.593 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Forepaw footpad size HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / External genitalia morphology HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / B cell number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / NKT cell number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Creatinine HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.367 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Dorsal coat/hair appearance HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Snout morphology HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Hematology / Mean cell hemoglobin concentration HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.861 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Limb coat/hair colour HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Eyelid Opening HOM 7f:7m Fisher Exact Test framework 0.219 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Incisors morphology HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Tail coat/hair colour HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Hematology / Mean platelet volume HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.323 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / NKT cell percentage HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Trunk curl HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Body Composition (DEXA lean/fat) / Body length HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.634 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Tail skin appearance HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Hindpaw nail morphology HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Head coat/hair presence HOM 7f:7m Fisher Exact Test framework 0.388 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Alpha beta T cell number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Limb skin appearance HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / LDL-cholesterol HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.309 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Forepaw digit fusion HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Ly6Clow monocyte percentage HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Hindlimb size HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Forepaw morphology HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Head skin colour HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Head coat/hair length HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Calcium HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.945 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Ventral coat/hair colour pattern HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Limb coat/hair length HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Pinna size HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Hematology / Hematocrit HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.211 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Vibrissae shape HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Creatine kinase HOM 6f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.452 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Ly6Clow monocyte number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / CD4+ alpha beta T cell percentage HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Tail length HOM 7f:7m Fisher Exact Test framework 0.0140 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / CD4+ CD44+ CD62L- alpha beta effector T cell number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Potassium HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0367 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Body Composition (DEXA lean/fat) / Fat mass HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.344 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / KLRG1+ mature NK cell number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Phosphorus HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.757 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Paw coat/hair appearance HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Thyroxine HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.120 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Viability Primary Screen / Outcome HOM 50f:51m Supplied as data Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Forelimb size HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Head bobbing/circling HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Tail elevation HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Dorsal skin colour HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Forepaw nail colour HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Digit coat/hair colour pattern HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Hindpaw morphology HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Triglycerides HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0481 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / B cell percentage HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Head size HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Hematology / Platelet count HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.160 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / CD4+ CD44+ CD62L- alpha beta effector T cell percentage HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / External genitalia HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Hindlimb morphology HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Tail coat/hair colour pattern HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Intraperitoneal glucose tolerance test (IPGTT) / Fasted blood glucose concentration HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0400 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Transfer arousal HOM 7f:7m Fisher Exact Test framework 0.215 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / CD8+ KLRG1+ alpha beta T cell number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Gamma delta T cell number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Hindpaw nail length HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Total protein HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.430 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Body Composition (DEXA lean/fat) / Fat/Body weight HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.310 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Dorsal coat/hair colour pattern HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Limb skin colour HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / CD8+ CD44+ CD62L- alpha beta effector T cell percentage HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Head coat/hair colour HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Incisor colour HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Ly6Chigh monocyte number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Neutrophil percentage HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Limb coat/hair colour pattern HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Gamma delta T cell percentage HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Aspartate aminotransferase HOM 6f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.490 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Forepaw digit morphology HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Head skin appearance HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Hematology / Hemoglobin HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.269 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Paw footpad skin appearance HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / CD8+ alpha beta T cell percentage HOM 7f:7m 0.0548 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Digit coat/hair appearance HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Total T cell number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Forelimb morphology HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Tail morphology HOM 7f:7m Fisher Exact Test framework 0.144 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / KLRG1+ mature NK cell percentage HOM 7f:7m 0.306 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Sodium HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.726 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Glycerol HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.299 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Vibrissae size HOM 7f:7m Fisher Exact Test framework 0.272 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Ventral coat/hair colour HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Body Composition (DEXA lean/fat) / Bone Mineral Content (excluding skull) HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.252 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Corneal touch reflex HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Contact righting reflex HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Dorsal skin appearance HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Vibrissae colour HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Forepaw nail morphology HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / HDL-cholesterol HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.119 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / CD4+ KLRG1+ alpha beta T cell number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / IgD+ mature B cell percentage HOM 7f:7m 0.0642 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Hindpaw footpad size HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Fertility of Homozygous Knock-out Mice / Gross Findings Male HOM f:m Supplied as data Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Paw coat/hair colour pattern HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Gait (inc. ataxia) HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Tail coat/hair appearance HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Intraperitoneal glucose tolerance test (IPGTT) / Initial response to glucose challenge HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.691 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Ventral skin appearance HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Hindlimb HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Hindpaw nail count HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Head morphology HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Dorsal coat/hair colour HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Body Composition (DEXA lean/fat) / Lean/Body weight HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.254 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / CD8+ alpha beta T cell number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / CD4+ CD25+ alpha beta regulatory T cell percentage HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Alpha-amylase HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.216 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Iron HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.995 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Magnesium HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.265 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Convulsions HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Total cholesterol HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.235 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Monocyte percentage HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Hindpaw HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Albumin HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.434 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Forepaw digit size HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Monocyte number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Hindpaw digit fusion HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Tail HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Ventral coat/hair appearance HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Pinna rotation HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Hematology / Mean cell volume HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.546 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Limb coat/hair appearance HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Eosinophil number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Pinna HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Free fatty acids HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.738 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Eosinophil percentage HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Body Composition (DEXA lean/fat) / Bone Mineral Density (excluding skull) HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.194 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Pinna position HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Hematology / Red blood cell count HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.137 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Paw coat/hair colour HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Pinna skin colour HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Hindpaw digit count HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Positional passivity HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Forepaw nail length HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Head coat/hair colour pattern HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Forepaw HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Digit coat/hair length HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / CD4+ KLRG1+ alpha beta T cell percentage HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Paw footpad skin colour HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Eye Morphology HOM 7f:7m Fisher Exact Test framework 0.403 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Vibrissae HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Startle response HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Ventral coat/hair presence HOM 7f:7m Fisher Exact Test framework 0.0789 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Pinna touch reflex HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Mouth morphology HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / NK cell number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Total T cell percentage HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Urea (Blood Urea Nitrogen - BUN) HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.00871 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Ly6Chigh monocyte percentage HOM 7f:7m 0.00541 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Limb coat/hair presence HOM 7f:7m Fisher Exact Test framework 0.00756 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Incisors HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Ventral skin colour HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Tail coat/hair length HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Hindpaw size HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Fructosamine HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.770 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Alkaline phosphatase HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.00481 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Forepaw digit count HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / External genitalia size HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Digit coat/hair presence HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / NK cell percentage HOM 7f:7m 0.320 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Paw coat/hair length HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / CD4+ alpha beta T cell number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Hindpaw nail colour HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Ventral coat/hair length HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Body Composition (DEXA lean/fat) / Bone Area HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0461 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Hematology / Mean corpuscular hemoglobin HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.426 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Tail coat/hair presence HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Forepaw size HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / IgD+ mature B cell number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Total bilirubin HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.786 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Hindpaw digit morphology HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Limb grasping HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Tail skin colour HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Dorsal coat/hair presence HOM 7f:7m Fisher Exact Test framework 0.0421 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Body Composition (DEXA lean/fat) / BMC/Body weight HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0780 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Paw coat/hair presence HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Pinna morphology HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Hindpaw digit size HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Head coat/hair appearance HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Forepaw nail count HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Neutrophil number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / CD8+ KLRG1+ alpha beta T cell percentage HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Glucose HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.136 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Fertility of Homozygous Knock-out Mice / Gross Findings Female HOM f:m Supplied as data Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / CD8+ CD44+ CD62L- alpha beta effector T cell number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Pinna skin appearance HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Hematology / Red blood cell distribution width HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.183 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Forelimb HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Snout size HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Digit coat/hair colour HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / Alpha beta T cell percentage HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Clinical Chemistry / Chloride HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withWeight 0.743 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Insulin Blood Level / Insulin HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.785 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Whole blood peripheral blood leukocyte immunophenotyping / CD4+ CD25+ alpha beta regulatory T cell number HOM 7f:7m 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Intraperitoneal glucose tolerance test (IPGTT) / Area under glucose response curve HOM 7f:6m Mixed Model framework, generalized least squares, equation withoutWeight 0.292 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Body Composition (DEXA lean/fat) / Lean mass HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.846 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Tremor HOM 7f:7m Fisher Exact Test framework 1.00 Success
Lrrk2tm1.1(KOMP)Mbp WTSI Combined SHIRPA and Dysmorphology / Dorsal coat/hair length HOM 7f:7m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrrk2tm1.1(KOMP)Mbp WTSI Hematology / White blood cell count HOM 7f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0422 Success

 Expression

Expression data not available

 Associated Images

Phenotype associated images not available

 Disease Models

Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Lrrk2tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Lrrk2tm1.1(KOMP)Mbp Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Lrrk2tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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