Gene: Dnase1l2

Name
deoxyribonuclease 1-like 2
MGI ID
MGI:1913955
Synonyms
4733401H14Rik
Viability
Homozygous - Viable
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased lean body mass Dnase1l2tm1b(KOMP)Wtsi HOM postnatal 6.46×10-07
short tibia Dnase1l2tm1(KOMP)Wtsi HOM postnatal 1.45×10-05
abnormal head morphology Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 2.96×10-06
increased lean body mass Dnase1l2tm1b(KOMP)Wtsi HOM postnatal 8.70×10-05
hypoactivity Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 2.19×10-07
decreased startle reflex Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 9.78×10-07
abnormal tail length Dnase1l2tm1(KOMP)Wtsi HOM postnatal 7.98×10-11
abnormal optic disk morphology Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 1.35×10-05
decreased body length Dnase1l2tm1(KOMP)Wtsi HOM postnatal 2.12×10-06
abnormal spleen morphology Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 0.00
abnormal eye morphology Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 0.00
decreased bone mineral density Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 5.19×10-08
abnormal heart left ventricle morphology Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 5.46×10-06
abnormal vocalization Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 9.24×10-06
abnormal motor capabilities/coordination/movement Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 3.27×10-05
decreased grip strength Dnase1l2tm1(KOMP)Wtsi HOM postnatal 2.38×10-05
abnormal stomach morphology Dnase1l2tm1.1(KOMP)Wtsi HET postnatal 0.00
abnormal autopod morphology Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 6.13×10-05
abnormal maxilla morphology Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 2.41×10-06
abnormal bone structure Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 2.25×10-08
brachydactyly Dnase1l2tm1b(KOMP)Wtsi HOM postnatal 1.20×10-10
decreased lean body mass Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 1.10×10-14
abnormal digit morphology Dnase1l2tm1b(KOMP)Wtsi HOM postnatal 2.11×10-12
decreased grip strength Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 4.10×10-29
scoliosis Dnase1l2tm1b(KOMP)Wtsi HOM postnatal 4.94×10-09
decreased circulating insulin level Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 1.32×10-05
abnormal heart morphology Dnase1l2em2(IMPC)Mbp HOM postnatal 0.00
hydrometra Dnase1l2em2(IMPC)Mbp HOM postnatal 0.00
decreased bone mineral density Dnase1l2em1(IMPC)Bay HOM postnatal 8.65×10-05
abnormal digit morphology Dnase1l2tm1(KOMP)Wtsi HOM postnatal 3.21×10-13
abnormal tibia morphology Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 2.13×10-11
abnormal behavior Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 2.42×10-07
decreased total body fat amount Dnase1l2tm1(KOMP)Wtsi HOM postnatal 1.10×10-05
increased grip strength Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 2.18×10-05
increased lean body mass Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 3.00×10-05
decreased total body fat amount Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 7.02×10-11
abnormal spine curvature Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 6.34×10-05
decreased bone mineral content Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 1.41×10-20
decreased circulating HDL cholesterol level Dnase1l2tm1(KOMP)Wtsi HOM postnatal 1.38×10-06
abnormal spleen morphology Dnase1l2em1(IMPC)Bay HOM postnatal 0.00
abnormal digit morphology Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 5.99×10-19
decreased grip strength Dnase1l2tm1b(KOMP)Wtsi HOM postnatal 1.37×10-09
small superior vagus ganglion Dnase1l2em2(IMPC)Mbp HOM postnatal 0.00
abnormal joint morphology Dnase1l2tm1b(KOMP)Wtsi HOM postnatal 1.20×10-10
abnormal retinal vasculature morphology Dnase1l2tm1b(KOMP)Wtsi HOM postnatal 1.57×10-05
increased circulating HDL cholesterol level Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 8.59×10-05
brachydactyly Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 1.76×10-07
vertebral fusion Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 1.97×10-06
abnormal cranium morphology Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 1.38×10-06
decreased body length Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 7.04×10-19
decreased bone mineral content Dnase1l2em1(IMPC)Bay HOM postnatal 1.78×10-05
short tibia Dnase1l2tm1b(KOMP)Wtsi HOM postnatal 4.45×10-05
decreased lean body mass Dnase1l2tm1(KOMP)Wtsi HOM postnatal 9.22×10-06
increased circulating amylase level Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 3.03×10-05
abnormal nail morphology Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 6.68×10-08
abnormal joint morphology Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 4.88×10-14
abnormal pelvic girdle bone morphology Dnase1l2tm1b(KOMP)Wtsi HOM postnatal 2.77×10-05
short tibia Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 4.33×10-08
decreased circulating glucose level Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 9.47×10-05
increased bone mineral content Dnase1l2em1(IMPC)Bay HOM postnatal 1.78×10-05
abnormal autopod morphology Dnase1l2tm1(KOMP)Wtsi HOM postnatal 3.21×10-13
brachydactyly Dnase1l2tm1(KOMP)Wtsi HOM postnatal 1.18×10-08
decreased food intake Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 2.32×10-07
cataract Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 1.35×10-05
fusion of vertebral arches Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 2.42×10-07
abnormal lens morphology Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 1.23×10-10
enlarged heart Dnase1l2em2(IMPC)Mbp HOM postnatal 0.00
increased fasted circulating glucose level Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 1.81×10-07
abnormal tail morphology Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 1.12×10-08
abnormal tail morphology Dnase1l2tm1(KOMP)Wtsi HOM postnatal 2.24×10-12
abnormal vertebrae morphology Dnase1l2tm1b(KOMP)Wtsi HOM postnatal 1.20×10-10
increased blood urea nitrogen level Dnase1l2tm1.1(KOMP)Wtsi HOM postnatal 5.16×10-05

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Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 18 Yes  (2/584)  Wholemount images
Aorta 18 No N/A
Blood 2 No N/A
Blood vessel 4 No N/A
Bone 12 Yes  Wholemount images
Bone marrow 2 No N/A
Brain 18 No  (2/20) N/A
Brainstem 18 No  (2/20) N/A
Brown adipose tissue 16 No N/A
Cartilage tissue 18 No N/A
Cecum 8 Yes  (12/383)  (1/10)  Wholemount images
Cerebellum 18 No  (2/20) N/A
Cerebral cortex 18 No N/A
Chest bone 6 No N/A
Colon 6 No  (12/127)  (1/8) N/A
Cranium 4 No N/A
Diaphragm 6 No N/A
Duodenum 6 No  (2/127) N/A
Epididymis 8 Yes  (18/134)  (2/10)  Wholemount images
Esophagus 14 Yes  (7/415)  (2/16)  Wholemount images
Eye 18 No N/A
Gall bladder 14 Yes  Wholemount images
Gonadal fat pad 6 No N/A
Harderian gland 6 Yes  Wholemount images
Heart 18 No N/A
Hindlimb 6 No N/A
Hippocampus 18 No N/A
Hypothalamus 18 No  (2/20) N/A
Ileum 6 Yes  (14/127)  (1/8)  Wholemount images
Jejunum 6 No  (6/127)  (1/8)  Wholemount images
Kidney 18 Yes  (18/584)  (2/20)  Wholemount images  Section images
Large intestine 18 Yes  (10/584)  Wholemount images
Liver 18 No N/A
Lower urinary tract 18 No N/A
Lung 18 Yes  Wholemount images
Lymph node 18 No  Wholemount images
Main olfactory bulb 4 No N/A
Mammary gland 18 No N/A
Mesenteric adipose tissue 6 No N/A
Mesenteric lymph node 6 Yes  (1/8)  Wholemount images
Midbrain 8 No  (2/10) N/A
Esophagus 4 No N/A
Olfactory lobe 18 No N/A
Oral epithelium 8 No N/A
Ovary 18 Yes  (1/584)  Wholemount images
Oviduct 18 Yes  Wholemount images
Pancreas 18 No  (5/584) N/A
Parathyroid gland 14 Yes  Wholemount images
Parotid gland 6 Yes  Wholemount images
Penis 6 No  (1/8)  Wholemount images
Peripheral nervous system 18 No N/A
Peyer's patch 4 No N/A
Peyer's patch 14 Yes  Wholemount images
Pituitary gland 18 Yes  Wholemount images
Prostate gland 18 Yes  (12/584)  (1/20)  Wholemount images  Section images
Quadriceps 6 No N/A
Sciatic nerve 6 No N/A
Skeletal muscle 14 No N/A
Skeletal muscle tissue 4 No N/A
Skin 18 No  (2/20) N/A
Small intestine 18 No  (9/584)  (2/20) N/A
Spinal cord 18 No  Wholemount images
Spleen 18 Yes  (2/584)  Wholemount images
Stomach 18 Yes  (12/584)  (1/20)  Wholemount images
Stomach pyloric region 6 No N/A
Striatum 18 No N/A
Sublingual gland 6 Yes  Wholemount images
Submandibular gland 8 Yes  (2/132)  (1/10)  Wholemount images
Testis 18 Yes  (2/584)  (9/20)  Wholemount images  Section images
Thalamus 6 No  (2/8) N/A
Thymus 18 No  Wholemount images
Thyroid gland 18 Yes  (15/584)  (1/20)  Wholemount images
Tongue 6 Yes  (5/127)  (6/8)  Wholemount images
Trachea 18 No  (1/20) N/A
Trigeminal V nerve 8 No N/A
Urinary bladder 8 Yes  Wholemount images
Uterus 18 Yes  Wholemount images
Vagina 6 No  Wholemount images
Vas deferens 8 No  (15/388)  (2/10)  Wholemount images
Vascular system 14 No N/A
Vesicular gland 8 Yes  Wholemount images
White adipose tissue 18 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 6  (6/485) N/A
Dorsal root ganglion 2  (1/47) N/A
Ear 6  (1/485) N/A
Embryo 6  (1/485)  Wholemount images
Eye 6  (1/485) N/A
Foot 6  (1/485) N/A
Forearm 2  (1/282) N/A
Forebrain 6  (1/485) N/A
Forelimb 6  (1/485) N/A
Fronto-nasal process 2  (1/48) N/A
Hand 6  (1/485) N/A
Head 6  (5/485)  Wholemount images
Heart 6  (1/485) N/A
Hindbrain 6  (6/485) N/A
Hindlimb 6  (1/485) N/A
Liver 6  (1/485) N/A
Lower leg 2  (1/282) N/A
Lung 6  (1/485) N/A
Mandibular process 6  (1/485) N/A
Maxillary process 6  (1/485) N/A
Midbrain 6  (1/485) N/A
Nose 2  (1/51) N/A
Oral cavity 6  (1/485) N/A
Skin 6  (1/485) N/A
Spinal cord 2  (1/50) N/A
Tail 6  (1/485) N/A
Tail somite 6  (1/485) N/A
Upper arm 2  (1/282) N/A
Upper leg 2  (1/282) N/A

 Associated Images

Eye Morphology: Images Ophthalmoscopy
14 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
53 Images
X-ray: XRay Images Hind Leg and Hip
26 Images
Combined SHIRPA and Dysmorphology
42 Images
X-ray: XRay Images Dorso Ventral
195 Images
X-ray: XRay Images Lateral Orientation
167 Images
Electroretinography: Rod waveform (pdf format)
1 Images
X-ray: XRay Images Forepaw
37 Images
X-ray: XRay Images Skull Lateral Orientation
26 Images
Electroretinography: Cone waveform (pdf format)
1 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Dnase1l2tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Dnase1l2em1(IMPC)Bay Exon Deletion Mice, Tissue
Dnase1l2tm1.1(KOMP)Wtsi Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Dnase1l2em2(IMPC)Mbp Null reporter Mice, Tissue
Dnase1l2em1(IMPC)J Exon Deletion Mice
Dnase1l2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice