Atg4b | autophagy related 4B, cysteine peptidase

GeneMGI:1913865Synonyms: 2510009N07Rik, autophagin 1, +1 more

Physiological systems

19 / 24 physiological systems tested

11 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Growth/size/body region Limbs/digits/tail Hearing/vestibular/ear Vision/eye Nervous system Hematopoietic system Behavior/neurological Skeleton Craniofacial

8 No significant impact

5 Not tested

Gene metrics:22Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

increased basophil cell number1 supporting datasetAtg4bem1(IMPC)MarchomozygoteEarly adult1.48x10-5 
decreased blood urea nitrogen level1 supporting datasetAtg4bem1(IMPC)MarchomozygoteEarly adult4.2x10-11 
increased circulating alkaline phosphatase level1 supporting datasetAtg4btm1b(EUCOMM)HmguhomozygoteEarly adult1.87x10-8 
decreased circulating total protein level1 supporting datasetAtg4btm1b(EUCOMM)HmguhomozygoteEarly adult1.09x10-5 
abnormal auditory brainstem response1 supporting datasetAtg4bem1(IMPC)MarchomozygoteEarly adult8.75x10-5 
increased circulating alkaline phosphatase level1 supporting datasetAtg4bem1(IMPC)MarchomozygoteEarly adult7.08x10-8 
decreased circulating total protein level1 supporting datasetAtg4btm1b(EUCOMM)HmguhomozygoteLate adult1.67x10-7 
abnormal retina morphology1 supporting datasetAtg4bem1(IMPC)MarchomozygoteEarly adult2.47x10-6 
increased leukocyte cell number1 supporting datasetAtg4btm1b(EUCOMM)HmguhomozygoteLate adult1.79x10-5 
limb grasping1 supporting datasetAtg4btm1b(EUCOMM)HmguhomozygoteLate adult1.5x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Atg4bem1(IMPC)MarcDeletionmouse
Atg4btm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Atg4btm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Atg4btm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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