Gene Summary

Name:
exosome component 1
Synonyms:
2610104C07Rik,  2610035C18Rik,  2610312F07Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal coat/ hair morphology Exosc1em1(IMPC)J HET Early adult 9.30×10-05
preweaning lethality, complete penetrance Exosc1em1(IMPC)J HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

12 Images

Electroretinography 3

Fundus file

6 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

12 Images

Electrocardiogram (ECG)

Waveform Image

16 Images

X-ray

XRay Images Whole Body Lateral Orientation

12 Images

X-ray

XRay Images Whole Body Dorso Ventral

12 Images

X-ray

XRay Images Forepaw

12 Images

Eye Morphology

Images Slit Lamp

2 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

Human diseases caused by Exosc1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Exosc1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Pontocerebellar Hypoplasia, Type 1F
OMIM:619304

The table below shows human diseases predicted to be associated to Exosc1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Pontocerebellar Hypoplasia, Type 1F
OMIM:619304

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Exosc1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Exosc1.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition. Developmental biology (December 2021) Exosc10tm1a(KOMP)Wtsi 34965385
EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis. Scientific reports (November 2017) Exosc10tm1c(KOMP)Wtsi Exosc10tm1a(KOMP)Wtsi PMC5678167

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Exosc1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Exosc1em1(IMPC)J Exon Deletion Mice
Exosc1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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