Gene Summary

Name:
ubiquinol-cytochrome c reductase hinge protein
Synonyms:
2610041P16Rik,  2310021J10Rik,  2210416J04Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Uqcrh mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Uqcrh by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Mitochondrial Complex Iii Deficiency, Nuclear Type 11
OMIM:620137

The table below shows human diseases predicted to be associated to Uqcrh by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Mitochondrial Complex Iii Deficiency, Nuclear Type 11
OMIM:620137

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Uqcrh

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Uqcrh.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
AOX delays the onset of the lethal phenotype in a mouse model of Uqcrh (complex III) disease. Biochimica et biophysica acta. Molecular basis of disease (May 2023) Uqcrhtm1b(EUCOMM)Wtsi 37230398
Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction. Mammalian genome : official journal of the International Mammalian Genome Society (December 2022) Uqcrhtm1b(EUCOMM)Wtsi 36565314
Characterising a homozygous two-exon deletion in UQCRH: comparing human and mouse phenotypes. EMBO molecular medicine (November 2021) Uqcrhtm1a(EUCOMM)Wtsi Uqcrhtm1b(EUCOMM)Wtsi PMC8649870

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Uqcrhtm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Uqcrhtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Uqcrhtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Uqcrhtm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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