Xpo5 | exportin 5

GeneMGI:1913789Synonyms: Exp5, 2700038C24Rik, +1 more

Physiological systems

22 / 24 physiological systems tested

11 Significantly impacted by the knock-out

 Reproductive system Immune system Integument Endocrine/exocrine gland Embryo Growth/size/body region Nervous system Vision/eye Hematopoietic system Cardiovascular system Mortality/aging

11 No significant impact

2 Not tested

Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal ovary morphology1 supporting datasetXpo5em1(IMPC)MbpheterozygoteLate adultN/A * 
enlarged ovary1 supporting datasetXpo5em1(IMPC)MbpheterozygoteLate adultN/A * 
spina bifida1 supporting datasetXpo5em1(IMPC)MbpheterozygoteE15.5N/A * 
abnormal spleen morphology1 supporting datasetXpo5em1(IMPC)MbpheterozygoteLate adultN/A * 
prenatal lethality prior to heart atrial septation1 supporting datasetXpo5em1(IMPC)MbphomozygoteE15.5N/A * 
microphthalmia1 supporting datasetXpo5em1(IMPC)MbpheterozygoteEarly adultN/A * 
embryonic lethality prior to organogenesis1 supporting datasetXpo5em1(IMPC)MbphomozygoteE9.5N/A * 
hemorrhage1 supporting datasetXpo5em1(IMPC)MbpheterozygoteE15.5N/A * 
preweaning lethality, complete penetrance3 supporting datasetsXpo5em1(IMPC)MbphomozygoteEarly adultN/A * 
enlarged spleen1 supporting datasetXpo5em1(IMPC)MbpheterozygoteLate adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Xpo5em1(IMPC)MbpExon Deletionmouse
Xpo5tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Xpo5tm1e(EUCOMM)HmguTargeted, non-conditional allelees cell

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